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PubMed1987

Are pituitary and thyroid function tests useful for the monitoring of antithyroid drug treatment and the post therapeutic control of Graves' disease?

The control of Graves' disease patients treated with antithyroid drugs (ATD) involves monitoring the dose of ATD, the duration of therapy and the prediction of the long-term outcome of the disease. The sequential follow-up of free thyroid hormones and ultrasensitive TSH (USTSH) helps in monitoring of ATD therapy, except in patients complemented with thyroid hormones. The normalization of early thyroid uptake of radioiodine or pertechnetate, which seems to be closely related to circulating thyroid-stimulating immunoglobulins, confirms the remission that leads to stopping ATD therapy. The raise of plasma USTSH in a normal range within the six months following ATD withdrawal is another indicator of remission. However, the post therapeutic course of Graves' patients remains unpredictable: late relapses and hypothyroidism may occur despite the normalization of the pituitary-thyroid axis, leading to a yearly clinical control with USTSH evaluation.

Antithyroid Agents↗
PubMed1977

Thyroid function tests during the early phase of subacute thyroiditis.

Six patients with subacute thyroditis were followed with serial measurements of T4, FT4, TSH and RAI uptake. Five of the six underwent TRH stimulation early in the course of their illness. All six patients had elevated or high normal values for T4 and FT4 at the time of their clinical presentation (mean = 13.8 microgram per 100 ml and 3.9 ng per 100 ml, respectively). RAI uptakes were 1% or less in all six. TRH testing revealed a suppressed TSH response (mean deltaTSH less than0.1 muU/ml) in all five patients tested, suggesting hyperthyroidism. After initial studies were performed, five patients were treated with L-triiodothyronine (L-T3) and one with aspirin. All patients improved over a two to four week period of time, no relapses being noted.

Adult↗
PubMedDate not supplied

Effects of salted food consumption on urinary iodine and thyroid function tests in two provinces in the Islamic Republic of Iran.

We evaluated sources of difference in urinary iodine between two neighbouring Iranian provinces, Gilan and Mazandaran. In the cities of Rasht (Gilan) and Sari (Mazandaran), 340 and 343 participants respectively were selected by cluster sampling. Urinary iodine in Rasht was significantly higher than in Sari (31 microg/dL versus 21 microg/dL). Sodium and potassium urine levels in Rasht were also higher than Sari. Mean daily intake of iodized salt and thyroid function tests were not significantly different. Average annual consumption of some salted foods was significantly higher in Rasht than Sari. We conclude that higher consumption of salted foods in Rasht is responsible for an increase in urinary iodine.

Adult↗