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At least 325 records · Page 18Linked to original sources
PubMed1998

Clinical study of multi-drug resistance gene (MDR1) expression in primary ovarian cancer.

This study was designed to measure the multi-drug resistance gene (MDR1) mRNA content and analyze clinical relationship between MDR1 expression and drug resistance in primary ovarian cancer. Reverse transcription PCR (RT-PCR) was used to measure MDR1 mRNA content in biopsy sample of 31 primary ovarian cancers (experimental group) and 30 gynecological tumors (control group). The level of 95.2% (20/21) MDR1 expression was relatively low, and the detected rate of MDR1 expression was 67.7% (21/31) in experimental group, which was higher than that in control group (40.0%, P < 0.05). The differences of MDR1 expression between the effective group and no effect group after combined chemotherapy was significant (P < 0.05). No significant relationship was found between MDR1 expression and clinical stage or histological classification or grade of differentiation in experimental group. We are led to concluded that primary ovarian cancers have drug-resistance clones which might express MDR1 spontaneously and expression of MDR1 may be used as a prognostic and predictive indicator for clinical response of ovarian cancers to combined chemotherapy.

Adolescent↗
PubMed2003

[Endocrine-active tumors of the ovary].

Most hormonally active ovarian tumors belong to the category of tumors of the gonadal stroma. These account for less than 5% of all ovarian tumors. About two-thirds of tumors of the gonadal stroma produce steroid hormones. The pathologic secretion of estrogenic or androgenic hormones leads to specific effects on the hormone-sensitive target organs. The clinical manifestations depend on both the amount of hormones secreted and the age of the patient. Tumors of the gonadal stroma are potentially malignant, ranging between noninvasive (borderline) tumors and invasive epithelial tumors of the ovary. Besides the specifically steroid hormone-producing tumors, a wide variety of ovarian tumors other than those in the stroma of the ovary and steroid cell tumors may be hormonally active as the result of an increase in and/or stimulation of nonneoplastic ovarian stromal cells within or adjacent to the tumor.

Diagnosis, Differential↗