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Effects of mild hypoxia on perceptual-motor performance: a signal-detection approach.

Twelve healthy male subjects were required to make speeded judgements concerning the orientation of visual stimuli while breathing air at reduced partial pressure in a hypobaric chamber at altitudes of 7000 and 12,000 ft. A control condition was also conducted at sea level, and subjects received practice on the task at sea level prior to the commencement of the experiment. Significantly slower response times were obtained at 7000 and 12,000 ft relative to sea level. A signal-detection analysis showed that accuracy of judgement was significantly poorer at 12,000 ft, but oxygen deprivation has no systematic effect on response criterion.

Adult↗

Body image distortion in anorexics as a non-sensory phenomenon: a signal detection approach.

Body image in anorexic and normal weight female subjects was investigated with a video TV monitor. Eighteen subjects were presented with a task in which they manipulated their body size to obtain "ideal" and actual images and a task wherein they judged the accuracy of a projected image of their body. There were no differences in estimated actual body size between anorexics and control subjects. For both groups, ideal images were below their actual image. For the second task, a signal detection analysis revealed no sensory sensitivity differences between weight groups. Anorexic subjects were more likely to report an image of themselves as distorted, regardless of whether distortion was present. Both weight groups adopted a strict criterion when they were viewing a heavy image of themselves. The finding that body estimation difference between anorexics and controls is non-sensory are discussed, and ramifications for treatment of anorexia are described.

Adult↗

Stimulus processing of glycine is dissociable from that of sucrose and glucose based on behaviorally measured taste signal detection in Sac 'taster' and 'non-taster' mice.

Mouse strains have been divided into 'tasters' and 'non-tasters' based on their relatively high and low preference, respectively, for low concentrations of sucrose and saccharin. These phenotypic differences appear to be due to a polymorphism in the gene at the Sac locus encoding for the T1R3 taste receptor selectively affecting the functionality of the T1R2+3 heterodimer. To psychophysically examine whether these phenotypes are due to sensory sensitivity as opposed to hedonic responsiveness, we measured taste signal detection of sucrose, glucose, and glycine by Sac taster (C57BL/6J and SWR/J) and non-taster (129P3/J and DBA/2J) strains in an operant conditioning paradigm using a gustometer. The taster mice had lower detection thresholds for sucrose and glucose compared with the non-taster mice. The detection thresholds corresponded well with reported responsiveness to low concentrations of these sugars in two-bottle intake tests suggesting that the Sac taster phenotype has a sensory basis and is not simply a matter of strain differences in the hedonic evaluation of weak intensities of the stimuli. Taster status did not entirely account for the strain differences in detection thresholds for glycine, a 'sweet' tasting amino acid. Collapsed across strains, detection thresholds for sucrose and glucose were highly correlated with each other (r = 0.81), but only modestly correlated with those for glycine (r < or = 0.43). This suggests that stimulus processing of glycine in the perithreshold intensity domain can be dissociated from that of sucrose and glucose. The mechanism underlying this difference may be related to the ability of glycine to bind with the T1R1+3 heterodimer.

Animals↗

Neural networks in radiology: an introduction and evaluation in a signal detection task.

Neural networks are a computer architecture, implementable in software or hardware, that allow an entirely new approach to the computerized perception of data. These so-called connectionist models are inspired by what is known about the architecture of biological neurons, in which the "intelligence" or processing capability of the network is a result of the interconnection strengths between large arrays of nonlinear processing nodes. Neural networks are described and then are used to analyze the common radiological problem of pattern recognition on a noisy background. Classical signal detection theory is used to compare network performance against that of human observers, using computer-generated sets of very simple "nodules." The neural network performed with better accuracy, relative to human observer performance, in the detection of this elementary test object. Although these results may not scale up with more complex images, the favorable performance of neural networks at this level suggests that further investigation is warranted.

Artificial Intelligence↗

Some evidence in support of a relationship between human auditory signal-detection performance and the phase of the alpha cycle.

This study concerned the hypothesis presented by Lindsley in 1961 that human sensorimotor performance should vary with the phase of the alpha cycle. Although there have been a number of studies which have supported this hypothesis, there has been no work from a modality other than the visual modality. Since eye tremor is correlated in phase and frequency with the alpha rhythm, these visual results might be explained by the peripheral eye tremor and not necessarily by the central alpha rhythm. The present study measured human auditory signal-detection performance at four different phases of the temporally (T5-linked mastoids) measured alpha rhythm. These four different phases were defined on an a priori basis by a computer algorithm. Detection performance was significantly better at the negative peak of this alpha cycle than at the positive peak, but there was no significant difference between the positively and negatively going zero cross performances. These results are consistent with the Lindsley hypothesis.

Adult↗

Quantifying the information value of clinical assessments with signal detection theory.

The aim of clinical assessment is to gather data that allow us to reduce uncertainty regarding the probabilities of events. This is a Bayesian view of assessment that is consistent with the well-known concept of incremental validity. Conventional approaches to evaluating the accuracy of assessment methods are confounded by the choice of cutting points, by the base rates of the events, and by the assessment goal (e.g. nomothetic vs idiographic predictions). Clinical assessors need a common metric for quantifying the information value of assessment data, independent of the cutting points, base rates, or particular application. Signal detection theory (SDT) provides such a metric. We review SDT's history, concepts, and methods and provide examples of its application to a variety of assessment problems.

Journal Article↗

Computer-aided detection of clustered microcalcifications: an improved method for grouping detected signals.

A computerized scheme for the automated detection of clustered microcalcifications from digital mammograms is being developed. This scheme is one part of an overall package for computer-aided diagnosis (CAD), the purpose of which is to assist radiologists in detecting and diagnosing breast cancer. One important step in the computer detection scheme is to group or cluster microcalcifications, since clustered microcalcifications are more clinically significant than are isolated microcalcifications. Previously a "growing" technique in which signals (possible microcalcifications) were clustered by grouping those that were within some predefined distance from the center of the growing cluster was used. In this paper, a new technique for grouping signals, which consists of two steps, is introduced. First, signals that may be several pixels in area are reduced to single pixels by means of a recursive transformation. Second, the number of signals (nonzero pixels) within a small region, typically 3.2 x 3.2 mm, are counted. Only if three or more signals are present within such a region are they preserved in the output image. In this way, isolated signals are eliminated. Furthermore, this method can eliminate falsely detected clusters, which were identified by a previous detection scheme, based on the spatial distribution of signals within the cluster. The differences in performance of the CAD scheme for detecting clustered microcalcifications using the old and new clustering techniques was measured using 78 mammograms, containing 41 clusters.(ABSTRACT TRUNCATED AT 250 WORDS)

Breast Diseases↗

Attention and the detection of signals.

Detection of a visual signal requires information to reach a system capable of eliciting arbitrary responses required by the experimenter. Detection latencies are reduced when subjects receive a cue that indicates where in the visual field the signal will occur. This shift in efficiency appears to be due to an alignment (orienting) of the central attentional system with the pathways to be activated by the visual input. It would also be possible to describe these results as being due to a reduced criterion at the expected target position. However, this description ignores important constraints about the way in which expectancy improves performance. First, when subjects are cued on each trial, they show stronger expectancy effects than when a probable position is held constant for a block, indicating the active nature of the expectancy. Second, while information on spatial position improves performance, information on the form of the stimulus does not. Third, expectancy may lead to improvements in latency without a reduction in accuracy. Fourth, there appears to be little ability to lower the criterion at two positions that are not spatially contiguous. A framework involving the employment of a limited-capacity attentional mechanism seems to capture these constraints better than the more general language of criterion setting. Using this framework, we find that attention shifts are not closely related to the saccadic eye movement system. For luminance detection the retina appears to be equipotential with respect to attention shifts, since costs to unexpected stimuli are similar whether foveal or peripheral. These results appear to provide an important model system for the study of the relationship between attention and the structure of the visual system.

Attention↗

Three-dimensional electromagnetic model of the human eye: advances towards the optimisation of electroretinographic signal detection.

Classical electromagnetic theory is used to examine the topographical variation in electrical potentials over the corneal surface resulting from specific retinal stimuli. Results from a three-dimensional mathematical model show that over 97% of calculated electromagnetic field potentials lie within 3% of previous analytical model data for an axially symmetric case. Maps of corneal potentials are produced that are shown to be characteristic of specific retinal stimuli and location. The maximum variation in corneal potential for a full field global stimulus is found to be approximately 1%. This is considered encouraging, as current electrophysiology techniques measure ocular potentials from a single corneal or scleral site, the position of which is often difficult to localise and reproduce. The model is used to simulate both central and peripheral stimuli and scotoma conditions. A 20 degrees central scotoma simulation shows an overall reduction in central corneal potential of only 3%, whereas peripheral stimuli are found to cause up to 10% variations in this potential. There is therefore a possibility that a single recording site for multifocal retinal stimulation is not ideal. These data may be used to suggest more appropriate electrode recording positions for maximum signal recovery, not least in optimising signal detection for multi-focal electroretinography stimulation.

Electromagnetic Fields↗

Measurement of olfactory signal detectability using an air-dilution olfactometer.

The Cheesman air dilution olfactometer, although designed for group threshold measurements, was modified to allow individual testing of subjects. However, adaptation effects of olfactory stimuli precluded use of interstimulus intervals of less than 30 sec. so that 3-hr. testing sessions were necessary to obtain a single measurement of sensitivity. Four subjects were tested intensively with isopropyl alcohol (CH3CH(OH)CH3) at concentration levels determined by previous group threshold studies. In the first condition, one concentration only was presented in testing sessions, while in the second condition, six concentrations were presented and the limits of concentrations adjusted to allow subthreshold presentations. Signal detectability indices (dc') were calculated more frequently and more reliably in the second condition than in the first.

1-Propanol↗

Comparison of the Pseudomonas aeruginosa and Escherichia coli PhoQ sensor domains: evidence for distinct mechanisms of signal detection.

The PhoP-PhoQ two-component system is present in a number of Gram-negative bacteria where it has roles in Mg(2+) homeostasis and virulence. PhoQ is a transmembrane histidine kinase that activates PhoP-mediated regulation of a set of genes when the extracellular concentration of divalent cations is low. Divalent cations are thought to interact directly with the periplasmic PhoQ sensor domain. The PhoP-PhoQ systems of Escherichia coli and Pseudomonas aeruginosa are similar in their biological response to extracellular divalent cations; however, their sensor domains display little sequence identity. Here we have begun to explore the consequences of this sequence divergence by comparing the biophysical properties of the P. aeruginosa PhoQ sensor domain with the corresponding E. coli sensor domain. Unlike the E. coli protein, the P. aeruginosa PhoQ sensor domain undergoes changes in the circular dichroism and fluorescence spectra as well as destabilization of its dimeric form in response to divalent cations. These results suggest that distinct mechanisms of signal detection are utilized by these proteins. A hybrid protein in which the E. coli sensor domain has been substituted with the corresponding P. aeruginosa sensor domain responds normally to the presence of extracellular divalent cations in vivo in E. coli. Thus, despite apparent differences in the structural response to its stimulus, the P. aeruginosa sensor domain transduces signals to the E. coli PhoQ cytoplasmic kinase domain in a manner that mimics normal E. coli PhoQ function.

Amino Acid Sequence↗

Influencing non-verbal expressions of pain: signal detection analyses.

Non-verbal expressive behaviour may provide important information about pain not available through verbal report. Nevertheless, it has received little attention in pain research. In the present study, changes in expressive behaviour resulting from electric shock were related to shock intensity, self-report of discomfort, observers' judgements of subjects' distress and social modelling influences. Subjects were videotaped while they rated low-, medium- and high-intensity shocks. Simultaneously, they were exposed to a tolerant social model or an inactive companion. Observers then viewed videotapes of subjects and judged the level of shock being delivered on the basis of non-verbal behaviour. Observers' judgements were analysed by signal detection methods to quantify expressive behaviour. Change in expressive reactions to the shocks was directly related to stimulus intensity, self-report of pain, and observers' judgements of subjects' distress. Expressive behaviour resulting from high shocks was diminished by exposure to a tolerant model. These findings establish the feasibility of pain measurement based on expressive behaviour, suggest that expressive behaviour provides a sensitive and valid index of pain, and indicate that tolerant modelling reduces evidence of pain across multiple measures.

Discrimination, Psychological↗

A similarity between weak normal memory and amnesia with two and eight choice word recognition: a signal detection analysis.

Two and eight choice recognition memory was compared in a group of normal individuals shortly after learning a list of words and seven days later. In addition to selecting the correct response, subjects were required to indicate the confidence of their choices. The results showed that eight choice recognition performance was differentially worse than two choice recognition at delayed compared to immediate test. These results were similar to some reported by Miller (1977) in which he compared recognition in dementing amnesics and controls at immediate test. While Miller interpreted his data in terms of a selective retrieval deficit in amnesics, our data suggests that both sets of results arise because Signal Detection Theory is applicable to recognition memory data. An additional result was that subjects felt they guessed correctly selected words more frequently after a delay.

Adult↗

Types of responding in a signal-detection task.

Four pigeons were trained to discriminate between two line orientations in a two-alternative forced-choice procedure. The distribution of reinforcers for the two types of correct response was varied across conditions. Performance on each trial was recorded separately, including the time taken to make a choice response. Discriminability and response-bias measures were calculated for overall performance, and, following a median split of the data from each condition, for faster and slower choice responses in each condition. Discriminability between the stimuli did not vary systematically as a function of choice latency. Variations of the reinforcer distributions produced larger response biases for the faster responses than for the slower responses. Responses on trials following reinforcers were faster and showed a greater effect of the reinforcer distribution than did other responses. Behavioral models of signal detection should consider the speed of the choice response as a factor modulating the effects of reinforcer distributions.

Journal Article↗

Behavioral estimates of interhemispheric transmission time and the signal detection method: a reappraisal.

On the basis of a review of the literature, Bashore (1981) concluded that only simple reaction time experiments with manual responses yielded consistent behavioral estimates of interhemispheric transmission time. A closer look at the data, however, revealed that these experiments were the only ones in which large numbers of observations were invariably obtained from many subjects. To investigate whether the methodological flaw was the origin of Bashore's conclusion, two experiments were run in which subjects had to react to lateralized light flashes. The first experiment dealt with manual reactions, the second with verbal reactions. Each experiment included a condition without catch trials (i.e., simple reaction time) and two conditions with catch trials. Catch trials were trials in which no stimulus was given and in which the response was to be withheld. Both experiments returned consistent estimates of interhemispheric transmission time in the range of 2-3 msec. No differences were found between the simple reaction time condition and the signal detection conditions with catch trials. Data were analyzed according to the variable criterion theory. This showed that the effect of catch trials, as well as the effect of interhemispheric transmission, was situated at the height of the detection criterion, and not in the rate of the information transmission.

Brain↗

A signal detectability analysis of the effect of physostigmine on memory in patients with Alzheimer's disease.

Ten patients with clinically diagnosed Alzheimer's disease were given tests of recognition memory while receiving placebo or physostigmine, a cholinesterase inhibitor, given intravenously over 30 min. Doses of 0.0, 0.125, 0.25, and 0.5 mg were given in random order on 4 separate days. All patients had their best performance following one of the doses of physostigmine rather than saline although dose-response curves varied from one patient to another. The dose associated with the best performance in each patient was compared with saline in a replication study using a double-blind cross-over design. In the replication study the total number of correct responses on the recognition memory task was significantly greater following physostigmine than following saline. To determine whether this improvement in performance was a result of an increase in the amount of information stored in memory or was secondary to a change in the patients' criteria for saying that they recognized an item, the results were subjected to a signal detectability analysis. This analysis indicated that studied items and new items were more discriminable following physostigmine, as evidenced by an increase in d', and that the criteria for saying which items had been studied also changed following physostigmine, as evidenced by an increase in C. The increase in d' indicates that physostigmine enhanced storage of information in memory while the change in C is consistent with the view that patients altered their decision criteria to maximize the number of correct responses in both conditions.

Aged↗

Decision rules and signal detectability in a reinforcement-density discrimination.

Two probabilistic schedules of reinforcement, one richer in reinforcement, the other leaner, were overlapping stimuli to be discriminated in a choice situation. One of two schedules was in effect for 12 seconds. Then, during a 6-second choice period, the first left-key peck was reinforced if the richer schedule had been in effect, and the first right-key peck was reinforced if the leaner schedule had been in effect. The two schedule stimuli may be viewed as two binomial distributions of the number of reinforcement opportunities. Each schedule yielded different frequencies of 16 substimuli. Each substimulus had a particular type of outcome pattern for the 12 seconds during which a schedule was in effect, and consisted of four consecutive light-cued 3-second T-cycles, each having 0 or 1 reinforced center-key pecks. Substimuli therefore contained 0 to 4 reinforcers. On any 3-second cycle, the first center-key peck darkened that key and was reinforced with probability .75 or .25 in the richer or leaner schedules, respectively. In terms of the theory of signal detection, detectability neared the maximum possible d' for all four pigeons. Left-key peck probability increased when number of reinforcers in a substimulus increased, when these occurred closer to choice, or when pellets were larger for correct left-key pecks than for correct right-key pecks. Averaged over different temporal patterns of reinforcement in a substimulus, substimuli with the same number of reinforcers produced choice probabilities that matched relative expected payoff rather than maximized one alternative.

Journal Article↗

Signal-detection properties of verbal self-reports.

The bias (B'H) and discriminability (A') of college students' self-reports about choices made in a delayed identity matching-to-sample task were studied as a function of characteristics of the response about which they reported. Each matching-to-sample trial consisted of two, three, or four simultaneously presented sample stimuli, a 1-s retention interval, and two, three, or four comparison stimuli. One sample stimulus was always reproduced among the comparisons, and choice of the matching comparison in less than 800 ms produced points worth chances in a drawing for money. After each choice, subjects pressed either a "yes" or a "no" button to answer a computer-generated query about whether the choice met the point contingency. The number of sample and comparison stimuli was manipulated across experimental conditions. Rates of successful matching-to-sample choices were negatively correlated with the number of matching-to-sample stimuli, regardless of whether samples or comparisons were manipulated. As in previous studies, subjects exhibited a pronounced bias for reporting successful responses. Self-report bias tended to become less pronounced as matching-to-sample success became less frequent, an outcome consistent with signal-frequency effects in psychophysical research. The bias was also resistant to change, suggesting influences other than signal frequency that remain to be identified. Self-report discriminability tended to decrease with the number of sample stimuli and increase with the number of comparison stimuli, an effect not attributable to differential effects of the two manipulations on matching-to-sample performance. Overall, bias and discriminability indices revealed effects that were not evident in self-report accuracy scores. The results indicate that analyses based on signal-detection theory can improve the description of correspondence between self-reports and their referents and thus contribute to the identification of environmental sources of control over verbal self-reports.

Adult↗