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Results for “RETINAL VESSELS”

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At least 325 records · Page 18Linked to original sources
PubMed1975

[Drugs with unwanted side-effects on the retinal vessels (author's transl)].

A review is given on systemically applied drugs, which may cause vascular disturbances of the retina with possible irreversible involvment of the ocular function. Based upon personal observations and reports in the literature a series of drugs with such side effects is reported. In particular, besides retrolental fibroplasia and complications which can be induced by oestrogens, drugs are described, which on the basis of an allergic reaction may produce retinal haemorrhages or occlusions of retinal blood vessels.

Adult↗
PubMed1994

Reduced responses of retinal vessels of the newborn pig to prostaglandins but not to thromboxane.

The upper blood pressure limit of retinal blood flow autoregulation is lower in the newborn than in the adult; this suggests an insufficient vasoconstrictor response in the newborn when perfusion pressure is increased. Because prostaglandins (PGs) have an important role in autoregulation of retinal blood flow, we compared the effects of PGE2, PGF2 alpha, carbacyclin (PGI2 analogue), and U46619 (thromboxane analogue), as well as that of agonists for the three different PGE2 receptor subtypes, 17-phenyl trinor PGE2 (EP1), butaprost (EP2), and M&B 28,767 (EP3), on the retinal vasculature of newborn and adult pigs, using isolated eyecup preparations. PGF2 alpha and PGE2 caused a markedly greater constriction of retinal arteries and veins of the adult than of the newborn animals. Further analysis of the response to PGE2, using receptor subtype agonists, revealed that the EP1 receptor agonist, 17-phenyl trinor PGE2, and the EP3 receptor agonist, M&B 28,767, caused a significant constriction of adult arteries and veins but produced minimal effects on newborn vessels; the EP2 receptor agonist, butaprost, caused a small and comparable dilation of newborn and adult arteries and veins. The PGI2 analogue, carbacyclin, caused a greater dilation of the adult than of the newborn arteries, but produced comparable dilation of veins from both newborn and adult animals. In contrast to the effects of PGF2 alpha and PGE2, the thromboxane analogue, U46619, as well as the alpha 1-adrenoceptor agonist, phenylephrine, significantly constricted newborn arteries and veins, and this effect was comparable with that observed on retinal vessels of the adult.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1977

[Treatment of obstruction of retinal vessels (author's transl)].

The treatment of retinal thrombosis is an unresolved problem, mainly because of the numerous factors which participate in their formation; modifications in the walls of veins and arteries, external compressions, changes in the blood count--particularly of the platelets--slowing down of the blood flow, increase in blood viscosity etc. No drug provides constant results. Some widely employed drugs such as vasodilators may be useless or even contra-indicated. Emphasis is placed on anti-coagulants, fibrinolytics, antiaggregating agents and methods of lowering blood viscosity. Their action is difficult to test objectively. Some do appear to be useful, especially in cases of central vein thrombosis. Thrombi of branches of the central vein are apparently inacessible to medical therapy, but occasionally improvement is seen after laser coagulation. This seems to apply also to hemorrhagic glaucoma secondary to retinal obstruction.

Anticoagulants↗