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[Lymphotropic therapy for acute purulent odontogenic jaw periostitis].

The structure of the gingival mucosa was studied by optic microscopy in patients with acute purulent odontogenic maxillary periostitis treated traditionally and receiving lymphotropic therapy. Lymphotropic administration of the antibiotic during 2 days resulted in less pronounced dilatation of the interstitial spaces and lymph vessels adjacent to the molars and higher counts of lymphocytes, monocytes, and macrophages. This indicated high efficiency of lymphotropic therapy of acute purulent maxillary periostitis for molars. Microcirculation parameters and tissue leukocyte cytogram in gingival mucosal tissue adjacent to the canines and premolars differed negligibly in patients treated by different methods.

Acute Disease↗

Pediatric update #15. Florid reactive periostitis of the digits.

Benign fibrous lesions of the digits can present a considerable diagnostic challenge. Some lesions may resemble sarcomas, resulting in needless amputation. One such benign entity resembles myositis ossificans histologically but presents as an aggressive hand lesions. Unfortunately, this lesion has been given multiple names. It is most appropriately termed florid reactive periostitis. This paper reports a case of florid reactive periostitis in a 12-year-old girl.

Bone Neoplasms↗

[Diagnostic difficulties in one patient with chronic periostitis of the lower jaw].

The problem of chronic periostitis of the jaws and the difficulties that sometimes arise in differentiation from a tumourous process is briefly discussed. A case of a ten year old child with chronic ossifying periostitis is described that caused considerable differentiation-diagnostic difficulties, mainly because of the X-ray findings of orthopantomography and computer tomography, presenting data suggesting more a tumourous disease of the lower jaw. After the extraction of the sixth tooth of the lower jaw, with a chronic periapical process, and after antibiotic treatment, the disease was healed.

Child↗

[Psoriatic onycho-pachydermo-periostitis of the big toe. Anatomo-clinical study and physiopathogenic approach apropos of 4 cases].

The authors report 4 cases of rheumatoid psoriasis in which involvement of the great toe, associating psoriatic onychosis, thickening of the distal soft tissues and osteo-periostitis of the distal phalanx without lesions of the interphalangeal joint, is the result of a direct repercussion of the ungual lesion on the distal phalanx. This is explained by very close anatomic links between nail and distal phalanx. They advocate the term of psoriatic onycho-pachydermo-periostitis of the great toe or OP3GT, when referring to this radio-clinical syndrome highly evocative of rheumatoid psoriasis.

Adult↗

[Diagnostic difficulties of isolated symptomatic unilamellar periosteal appositions. Uncommon form of fatigue fracture in children].

We describe five cases of painful periosteal reaction occurring in children. The initial radiographic appearance of stress fracture may be troublesome since the new bone formation may be confused with malignant bone lesion. Because of the importance of making a correct diagnosis multiple imaging techniques will often be employed. We discuss the radiographic signs and their usefulness in the differential diagnostic of periosteal reaction.

Adolescent↗

Florid reactive periostitis.

Florid reactive periostitis (FRP) is a benign entity, mostly involving the tubular bones of the hands and feet. It is important to distinguish FRP from malignant processes such as periosteal osteosarcoma and parosteal osteosarcoma, to give an adequate treatment and to avoid amputation of the total digit. The final diagnosis of FRP is usually based on the combination of clinical, radiological, and pathological findings. The pattern seen on the isotope bone scan can be very helpful in orienting the differential diagnosis.

Bone Neoplasms↗

[Correlation between meteorologic factors and periostitis of dental origin in Debrecen].

Correlation between bioclimatical and meteorological factors is well documented. The aim of this study was to investigate the correlation between dental periostitis and meteorological fronts, cyclon and anticyclon. We found a positive, statistically significant correlation between occurrence of warm meteorological front, cyclon, anticyclon and prevalence of dental periostitis. It could have important implications in organizing the work of dental teams.

Climate↗

Periostitis of the upper extremity: a report of 2 cases and literature review.

Periostitis in the athlete is a common overuse clinical entity often found in the lower extremity. An analogous overuse syndrome also may occur in the upper extremity. These 2 case reports describe the history, physical findings, radiographic changes, and treatment for periostitis of the upper extremity rarely seen in the athletic population.

Adult↗

Periostitis ossificans.

Mandibular periostitis ossificans was assessed in a 18-year-old black boy. This form of chronic osteomyelitis (Garré osteomyelitis) resulted from a periostitis on the 4.8 in association with an infected and ankylosed 4.7. Clinically a firm swelling of the right mandibular angle was noticeable. The diagnosis was confirmed by computed tomography and biopsy. After extraction of the causative teeth, in combination with an antibiotic treatment, a good evolution was obtained. The possible pathogenesis and the differential diagnosis are discussed.

Adolescent↗

Polyarthritis and periostitis induced by Escherichia coli. Lipopolysaccharide injection in young male hamsters.

OBJECTIVE: To describe the clinicopathological manifestations of lipopolysaccharide (LPS) induced arthritis in the hamster and to compare its time of onset, duration, and severity with other forms of experimentally induced arthritis. METHODS: A preparation containing 30 microg LPS from Escherichia coli was injected subcutaneously for 5 to 21 days into young male hamsters (Mesocricetus auratus). Arthritis was quantified by measuring soft tissue swelling of affected joints with calipers. After decalcification, paraffin sections were cut and stained with hematoxylin and eosin, Giemsa, and azan. Acute phase reactant apolipoprotein serum amyloid A (apoSAA) levels were determined by ELISA. RESULTS: Symmetrical polyarthritis developed within 3 days and persisted for 14-21 days, provided the hamsters received daily LPS injections. Most prominent were lesions in the carpal-metacarpal joints of the front legs and in the tarsal-metatarsal joints of the hind legs. Animals in whom LPS injections were discontinued after 4 or 7 days recovered completely. Histological findings of exudative synovitis, periarticular soft tissue swelling, and juxtaarticular periostitis were associated with a sharp rise in serum titers of apoSAA. CONCLUSION: The unusually rapid onset of arthritis and periostitis in this experimental animal model suggests that its systemic manifestations were not mediated by a classical immune response, and may represent an "innate" response of targeted cells within the synovial membrane and periosteum to bacterial cell wall endotoxins.

Animals↗

[Magnetic resonance imaging of tibial periostitis].

Tibial periostitis frequently occurs in athletes. We present our experience with MRI in a series of 7 patients (11 legs) with this condition. The clinical presentation and scintigraphic scanning suggested the diagnosis. MRI exploration of 11 legs demonstrated a high band-like juxta-osseous signal enhancement of SE and IR T2 weighted sequences in 6 cases, a signal enhancement after i.v. contrast administration in 4. Tibial periostitis is a clinical diagnosis and MRI and scintigraphic findings can be used to assure the differential diagnosis in difficult cases with stress fracture. MRI can visualize juxta-osseous edematous and inflammatory reactions and an increased signal would appear to be characteristic when the band-like image is fixed to the periosteum.

Adult↗

Strength and histological characteristics of periosteal fixation to bone after elevation.

BACKGROUND: Loss of brow elevation in the early postoperative period has been well documented; however, there has been no study quantifying the minimum time necessary to achieve lasting brow elevation. Previous work in our laboratory has demonstrated that complete readherence of periosteum to bone can take 12 weeks to occur after periosteal elevation. The correlation between adherence and the development of strength has never been examined. OBJECTIVE: To correlate histological characteristics of raised forehead periosteum with the strength of the periosteum-bone union postoperatively. SUBJECTS: Eighteen New Zealand white rabbits. METHODS: Rabbit foreheads were elevated in a subperiosteal plane and the flap reapproximated with chromic sutures. Animals were killed at 14, 28, 45, 63, or 84 days postoperatively, and all tissue superficial to the periosteum removed. The tension required to avulse sections of periosteum was then measured. Skulls were then sectioned and prepared for histological analysis of remaining periosteum. Avulsion forces and histological findings were compared with those unoperated-on controls. RESULTS: The forces necessary to avulse periosteum in the 14- and 28-day groups were significantly lower than for control animals; values at 45, 63, and 84 days were not significantly different from control animals. Healing periosteum displayed varying degrees of thickness, cellularity, edema, and vascular congestion. These features peaked at 28 days postoperatively then gradually resolved to near-control values by 84 days. Significant periosteal-to-bone contact did not appear until 45 days postoperatively. CONCLUSION: Our results promote the use of methods of brow fixation that support mobilized soft tissues for a minimum of 6 weeks, until the elevated periosteum has significantly readhered to the underlying bone.

Animals↗

Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.

Collagenase-3 (MMP-13) is a novel matrix metalloproteinase, the expression of which has so far only been documented in human breast carcinomas and osteoarthritic cartilage. In this study we have examined the expression of MMP-13 during human fetal development. Northern blot hybridizations revealed abundant expression of MMP-13 mRNAs in total RNA from fetal cartilage and calvaria at gestational age of 15 weeks. By in situ hybridization MMP-13 transcripts were detected in chondrocytes of hypertrophic cartilage in vertebrae of the spinal column and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. In contrast, no expression of MMP-13 could be detected in osteoclasts. Furthermore, expression of MMP-13 mRNA was detected in osteoblasts and fibroblasts primarily on the inner side of calvarial bone of the skull at 16 weeks of gestation. Expression of MMP-13 mRNA by primary human fetal chondrocytes in culture was enhanced by transforming growth factor-beta (TGF-beta) and inhibited by bone morphogenetic protein-2 (BMP-2). No expression of MMP-13 mRNA could be noted in other fetal tissues, including the skin, lungs, neural tissue, muscle, and liver. These results suggest that MMP-13 plays an important role in the extracellular matrix remodeling during fetal bone development both via endochondral and intramembranous ossification.

Blotting, Northern↗

The ultrastructure of conventional, parosteal, and periosteal osteosarcomas.

Twenty-seven osteosarcomas of bone were examined by electron microscopy. Eighteen cases were conventional osteosarcomas, one case was an osteosarcoma that developed in Paget's disease of bone, two cases were metastasis to the lungs of conventional osteosarcomas, five were parosteal osteosarcomas (and the recurrence of one of them), and one was periosteal osteosarcoma. In addition to the basic neoplastic cell, the osteoblast-like tumor cell, seven tumor cell types could be differentiated in varying numbers in the 27 cases examined: (1) chondroblast-like; (2) fibroblast-like; (3) histiocyte-like; (4) myofibroblast; (5) osteoclast-like; (6) malignant multinucleated osteoblast-like; and (7) atypical primitive mesenchymal cells. Moreover, endothelial cells and pericytes were also present. The tumor cells showed common neoplastic features in relation with general cell configuration and fine structures. No cytoplasmic organelle was considered to be cell-specific, and only the amount and distribution of the organelles allowed us to differentiate the above mentioned cell types. The presence of malignant appearing tumor cells with abundant and dilated cisternae of RER, in an intercellular matrix containing collagen fibers with areas of focal collections or puffs of hydroxyapatite crystals, are the most characteristic ultrastructural features of osteosarcoma. However, those features are not pathognomonic and do not allow in all cases the differential diagnosis with osteoid-osteoma and benign osteoblastoma. Fields of chondroblastic, fibroblastic, or fibrohitiocytic character are indistinguishable of chondrosarcomas, fibrosarcomas, or malignant fibrous histiocytoma of bone, respectively. The comparative study of parosteal and conventional osteosarcomas revealed a marked difference in the cell population: fibroblast-like cells and myofibroblasts were the main cell types in parosteal osteosarcoma; on the contrary, myofibroblasts were very scarce or absent in conventional osteosarcomas. This difference may correlate with the better outcome of parosteal osteosarcoma. The ultrastructural features of a periosteal osteosarcoma are reported for the first time. The tumor was comprised mostly of chondroblast-like tumor cells. However, in the more cellular peripheric areas of the neoplasm, the cells were predominantly of the fibroblast-like type and showed anaplastic features.

Bone Neoplasms↗

Periosteal Ewing's sarcoma.

Ewing's sarcoma is a small cell malignant tumor that usually arises in the medullary cavity of bone. Less frequently, it originates in soft tissue and may secondarily invade underlying bone. The origin of Ewing's sarcoma in a periosteal location without extension into either the bone or adjacent soft tissue has not been clearly documented. Other malignant tumors of bone (e.g., osteosarcoma) appear to have a somewhat better prognosis when confined between periosteum and bone. The case of a patient with a periosteal Ewing's sarcoma who received a radical excision and postoperative chemotherapy and who is without evidence of disease with over 2 years follow-up is reported.

Adolescent↗

Periosteal chondromyxoid fibroma: a case study using imprint cytology.

Bone surface is an exceptional location for chondromyxoid fibroma. Only 14 cases of juxtacortical chondromyxoid fibroma have been reported to date and, to our knowledge, none of these cases are documented with imprint cytology. We report a case of periosteal chondromyxoid fibroma located in the distal tibial metaphysis of a 4-yr-old boy. The clinical diagnosis was metaphyseal fibrous defect. Cytologic examination revealed a mixoid matrix, with stellate and spindle-shaped cells seen singly, focus of chondroid material, and epithelioid cells. Multinucleate giant cells were not seen. The diagnosis of periosteal chondromyxoid fibroma can be made by fine-needle aspiration or imprint cytology with clinico-radiologic correlation.

Biopsy, Fine-Needle↗

Severe trismus secondary to periosteal osteogenesis after fibula free flap maxillary reconstruction.

BACKGROUND: Fibula free tissue transfer is routinely used for reconstruction of bony defects in the head and neck. During flap preparation, well-vascularized periosteum is left adjacent to the proximal vascular pedicle. It is known that periosteum can have significant osteogenic potential in the proper settings. Complications related to periosteal osteogenesis of a fibula free flap pedicle have not been previously reported. CASE HISTORY: A 12-year-old girl with a history of squamous cell carcinoma of the maxilla underwent delayed fibula free flap reconstruction of a maxillary defect. The patient had severe trismus develop postoperatively and was found to have osteogenesis along the vascular pedicle. This bone formed a solid bridge from the maxilla to the mandible. Two resections were required, which included excision of the vascular pedicle, to eliminate further osteogenesis and resolve the patient's trismus. CONCLUSIONS: The potential for periosteal osteogenesis does exist with fibula free tissue transfer and can have significant consequences. Potential promoters of osteogenesis should be identified and if possible altered in certain clinical scenarios to prevent complications from new bone growth.

Child↗