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At least 325 records · Page 18Linked to original sources
PubMed1984

Antibodies and thermolabile opsonins in the phagocytosis of human red and white blood cells pretreated with formaldehyde.

Erythrophagocytosis is conditioned by serum immunoglobulins. The extent of phagocytosis depends on the haematocrit of the red cell suspension pretreated with formaldehyde. The higher the haematocrit value, the lower will be the extent of phagocytosis. Phagocytosis of white blood cells pretreated with formaldehyde by granulocytes and monocytes is conditioned mainly by a thermolabile fraction of the serum, probably the complement.

Blood Physiological Phenomena↗
PubMedDate not supplied

[An opsonin-independent strain of Staphylococcus epidermidis].

Human neutrophils, subjected to stimulation under different conditions (phorbol myristate acetate, opsonized zymosan, formylmethionyl-leucinephenylalanine, nonopsonized staphylococci), produced a factor (denoted as clumping factor, or CF) with a capacity for highly selective clumping and opsonization of staphylococci. Out of 68 strains of different species of staphylococci, only a single strains (S.epidermidis) was sensitive of CF. CF negative staphylococci were capable of inducing the release of CF by neutrophils, but were not bound by this factor. Extracts, obtained by the mechanical destruction of neutrophils (sonication, repeated freezing and thawing), had no clumping activity. CF had a mol. wt. exceeding 100 kD, was positively charged and disintegrated at 100 degrees C. The capacity of S.epidermidis 178 M for binding CF completely disappeared after the treatment of bacteria with pronase and partially disappeared after boiling and treatment with trypsin and periodate. Neuraminidase and heating at 80 degrees C produced no effect. These data are the first demonstration of highly selective (strain-specific) interaction between secretory products of neutrophils and bacteria.

Antibodies, Bacterial↗
PubMed1984

Uterine defense mechanisms in the mare: Serum opsonins affecting phagocytosis of Streptococcus zooepidemicus by equine neutrophils.

The addition of serum to uterine secretions was shown to opsonize Streptococcus zooepidemicus and significantly enhance bacterial phagocytosis by equine neutrophils. Treatment of serum by heat inactivation at 56 degrees C, EDTA treatment, and C3 consumption reduced phagocytosis and therefore demonstrated that the process was complement-dependent. The amount of C3 present in uterine secretions was measured in a series of 14 mares infected with Streptococcus zooepidemicus . Ten of the 14 mares had detectable amounts of C3; however, the C3 had been cleaved and rendered nonfunctional. The importance of these findings in relationship to chronic uterine infections in the mare is discussed.

Journal Article↗