[Diagnosis of mesodermal mixed tumors of the uterus].
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A 40-year old woman with a history of rapidly growing tumor of the brachio-radialis muscle is described. By light microscopy, the tumor had typical features of proliferative myositis, with alternating areas of well preserved muscular fibres and strands of proliferating spindle shaped cells and ganglion like cells. Electron microscopic study showed non specific degenerative muscle changes, fibroblasts and giant cells. The histogenesis and the nosologic place of proliferative myositis are discussed.
The authors report 35 cases of bony tumours of the thoracic wall and emphasize:--the necessity of wide removal even in the case of benign tumours to avoid possible relapses;--the use of rigid material which in the case of anterior parietal breaches, is alone able to give satisfactory solidity to the thoracic wall which is essential to ensure satisfactory respiratory mechanics;--the interest of surgery whether or not associated with radiotherapy or chemotherapy.
An autopsy observation of alveolar soft tissue sarcoma of the left hip muscles in a man of 66 is described. Predominantly lymphogenic metastasizing of the alveolar sarcoma was observed and two hypes of tumour cells, "dark" and "light" were distinguished. PAS-positive substances, lipids and mucus were found in the cytoplasm of the "light" cells. Histogenetically, the alveolar soft tissue sarcoma is assumed to be close to striated muscles.
The Anaesthesia and Recovery Service at the Galeazzi Orthopaedic Centre in Milan has an HOT unit where various cases of necrosis following radiotherapy for neoplasias have been and are still being treated. Some cases of radiodermitis and osteoradionecrosis only cured after HOT treatment are presented. The recovery of the scarring and granulation processes in these cases is attributable to the increased perfusion and above all diffusion of oxygen which activates the heating processes in the hypoxic tissues. An additional advantage of HOT is that patients can be treated in outpatients department (for periods ranging from 25 to 70 days according to the seriousness of the case), thus avoiding long-term hospitalisation and withdrawal from normal working life.
During the 28-yr-period from 1949-1977, 285 patients with sarcoma of the head and neck region were seen and treated at Memorial Cancer Center. Two hundred forty-two cases were determinate, and none was lost to follow-up study. The determinate and absolute 5-yr cure rate was 32%. More than 50% of the cases were seen in children (8 cases were congenital) and were almost universally anaplastic and prone to generalized metastasis with fatal outcome. Combined modalities of radical surgery, postoperative radiotherapy, and chemotherapy over a prolonged period have markedly altered the prognosis of these tumors. Soft part sarcomas are an unusual group of tumors with a common fibrosarcomatous background. The qualified pathologist can identify quite accurately the different histologic entities and their varying grade, a point of great significance as to clinical course and treatment.
Non-epithelial tumors originating in the uterus are a relatively rare affliction, accounting for less than 3% of all malignant uterine neoplasms. For this reason, there are at present few cytological reports on these sarcoma, so that histological determination on the basis of cytological diagnosis becomes quite difficult. On this occasion, We are privileged to report on cytological examinations we have made over the past decade on six cases involving uterine sarcomas in the course of our practise at the Iwate Medical University School of Medicine. The histological diagnosis of these tumor were Leiomyosarcoma (1 case) Mixed mesodermal tumor (1 case). Rhabdomyosarcoma (1 case). Carcinosarcoma (2 cases), and Mixed cell sarcoma (1 case). The cytologic findings of these tumor cells in vaginal smear and aspiration smear of uterine cavity are as follows: 1) In all cases, We observed the appearance of tumor cells of undifferentiated non-epithelial origin, showing an almost identical configuration. 2) Also, in these various sarcomas, We confirmed distinctive tumor cells from which histologic type could be inferred. This suggested the possibility of histologic type diagnosis on the basis of cytological diagnosis.
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We report 24 cases of sarcoma of the corpus uteri treated by sole irradiation. The 5-year-survival-rate was 20,8%. The prognosis seems to be poor in this group treated by sole irradiation. Only inoperable cases of sarcoma of the corpus uteri ought to be treated by radiotherapy alone.
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