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[Diagnostic and therapeutic value of lymphography in persistent postoperative chylothorax].

Chylothorax is a rare but generally severe complication of surgery of congenital heart disease. The authors report the clinical history of a young boy with complex congenital heart disease operated on several occasions and who developed severe and recurrent unilateral chylothorac after a bicavo-bipulmonary derivation. Conservative treatment followed by continuous somatostatin infusion was ineffective. Diagnostic Lipiodol lymphography was required before the chylothorax was cured. The authors describe management of this difficult case and discuss the therapeutic possibilities with reference to a brief review of the literature.

Child↗

Pelvic lymph node metastases in cervical cancer: comparison of lymphography, inspection, radiography, and histologic examination of lymph nodes.

Lymphangiography is commonly performed in the pretreatment evaluation of patients with cervical carcinoma, but its value is controversial. The purpose of this report is to determine the reliability of lymphography in the indication of metastatic pelvic lymph nodes by comparing data from preoperative lymphangiography, inspection of lymph nodes during laparotomy, radiography of surgically removed lymph nodes, and postoperative histologic report. Twenty-one patients (mean age 51.1 years, SD 14.5) with cervical cancer FIGO stages I b to II b were enrolled in this study. They all underwent Wertheim's radical hysterectomy with pelvic lymphadenectomy. With reference to histologic report this series included 8 squamous carcinomas (38%), 10 adenocarcinomas (48%) and 3 sarcomas (14%). Seven patients (33%) had a positive preoperative lymphangiography, in 9 patients (43%) lymph nodes were considered positive at the inspection during laparotomy, postoperative radiography of the lymph nodes was considered probably positive in 7 patients (33%) and positive in 2 patients (10%), histologic report was positive for lymphonodal metastases in 4 patients (19%). A total of 335 lymph nodes were studied, and with reference to the evaluated methods (lymphangiography, inspection, radiography, histology), 1 positive method was found in 40 lymph nodes (12%), 2 positive methods in 6 lymph nodes (2%), 3 or 4 positive methods in none of the lymph, nodes, and 4 negative methods in 289 lymph nodes (86%). Histologic report was positive in 4 lymph nodes (1%). Lymphangiography in the pretreatment evaluation in cases of cervical carcinoma is not reliable in indicating possible metastatic lymph nodes. It remains a useful exam fixation to be routinely performed.

Adult↗

Lymphography--technique, indications and principles of interpretation.

The findings in 277 patients investigated by ethiodol lymphography are reviewed, and the applications and limitations of the procedure are presented. The non-specificity of findings is the principal reason for the lack of acceptance of this procedure, and the confusing entity of tuberculous lymphadenitis is discussed.

Diagnosis, Differential↗

[Complications of lymphography. A propos of 5 cases].

Complications noted following lymphography have been published by several authors. The authors report here a series of 5 cases occurring in patients with mediastinal and lung cancer. They report the various clinical manifestations resembling fat embolism, the free interval and general signs, pulmonary, neurological, hematological and dermatological symptoms associated with inconstant laboratory abnormalities which permit one to suggest a complex pathogenesis: --Immuno-allergic (early shock due to circulating antibodies). --Mechanical and vascular: incomplete removal of low viscosity lipiodol by the pulmonary macrophage system permits liberation of micro-vascular emboli. --By abnormality of blood coagulation and the onset of a syndrome of widespread intravascular coagulation. Better recognition of the pathogenesis associated with the development of new therapeutic principles, should permit better prevention and control of these complications.

Adult↗

[Isotopic lymphography tests in post-thrombotic syndrome].

Isotopic lymphography offers a very useful method to assess pre-fascial and subfascial lymph transport in the leg. Labelled microcolloids are injected either subcutaneously (pre-fascial lymph-drainage) or into the calf muscle (subfascial lymph-transport) and a standardized walking exercise is performed. Today we prefer a quantitative measurement which consists mainly in a combination of a transmission and an emission-scintigraphy. In the acute stage of a deep vein thrombosis and also in the post-thrombotic limb the deep lymphatic transport is constantly diminished or absent. At the same time the pre-fascial lymph-drainage is enhanced except in cases with recurrent erysipelas or after injection of the tracer into the border of an ulcer.

Fascia↗

[Lymphography and the possibility of tumor cell dissemination].

It is concluded that endolymphatic infusion of X-ray contrast substance in the presence of migrating tumor cells in lymphatic routes is inherent in a potential danger of tumor dissemination. Although getting of tumor cells in blood does not always result in metastases, nevertheless, a due account should be taken of the fact that lymphography is frequently performed in poor immunological resistance patients, preliminarily subjected to chemo- and radiotherapy. The decrease of immune resistance of the organism, in which the lymphatic system is of primary importance, is known to contribute per se to generalization of the tumor process. Another important conclusion is that the principal mass of tumor cells is ejected in the immediate period after endolymphatic injection of X-ray contrast substance. Thus, the cannulation of the thoracic duct during this period may prevent or reduce getting of massive amounts of tumor cells into the total blood flow.

Animals↗

Lymphatic dynamics of liver by hepatic lymphography using lipiodol ultra fluid.

Hepatic lymphography by intra-parenchymal injection of four to ten millilitres (ml) of lipiodol ultrafluid, our modification of functional hepatography, performed on sixty one patients helped study lymphatic dynamics of liver. In conditions associated with significant hepatic venous outflow obstructions, such as hepatic cirrhosis, inflammatory diseases of liver and primary or secondary malignant lesions of the liver, this study delineated liver lymphatics and portal and para aortic lymph nodes. In one case mediastinal nodes were also delineated by flow of lipiodol from the bare area of the liver via trans-diaphragmatic and pleural lymphatic. The lymphangio-architecture of the opacified nodes depicted the nature of pathology inflicting them and the liver. Lipiodol in the lymphatic system, staying longer than the freely diffusible aqueous contrast, provided more detail and better information.

Hodgkin Disease↗

[Lymphography in tuberculosis in black African immigrants].

Lymphographic data in 23 negro immigrants with lymph nodes tuberculosis almost always mediastinal and/or superficial are reported. In six cases, including two cases with abdominal latero-aortic lymph nodes clinically obvious, lymphography showed abnormalities without doubt. These aspects are compared with data of literature and discussed according to interpretation and significance in tuberculosis very peculiar in negro immigrants.20

Adult↗

[Endolymphatic curietherapy by lymphography with labelled lipiodol in Hodgkin's disease. A report on 408 cases (author's transl)].

The results of 373 lymphography examinations with radioactive lipiodol, conducted in 408 patients with Hodgkin's disease for diagnostic and prophylactic therapeutic purposes, during investigations carried out from 1966 to 1973 are analyzed. Tolerance was always excellent, especially from the hematological point of view. The efficacy of the procedure can be assessed by the fact that there were only 6% of failures (21/373) in glandular regions irradiated in this way for prophylactic purposes. Relapses occur more frequently in the inguino-iliac and lumbo-aortic regions than in the pelvic chains which were perfectly protected. This technique also enables both pelvic irradiation and ovarian protection in young women without any risk of failure. The procedure is particularly indicated in the following cases: supradiaphragmatic stages I and II, whatever the sex, and stage III especially in women. In sub-diaphragmatic stages I and II, it allows, in favourable cases, the ovarian function in women to remain intact by limiting external irradiation to invaded regions only.

Brachytherapy↗

[Lymphography in clinical variants of posttraumatic edema].

Early experience with lymphography, used in 28 patients with edema of the legs, descending from the site of injury (13) or ascending to the damaged area (15), is summarized. Purposive identification of the location of lymph reflux to abducting lymphatic vessels of the skin and subcutaneous fat helped to detect anatomic zones of lymph stasis, identify the cause and site of origin of the edema and exclude impaired lymph passage through neighbouring lymphatic vessels and collectors. Local or generalized disorders of lymph flow were shown to be at different distances from the damaged lymphatic vessels. The emergence of different clinical variants of descending and ascending edema is caused by the movement of the lymph reflux area from the original site of edema.

Edema↗

[Indirect lymphography of sub-mental and sub-maxillary lymph nodes (author's transl)].

This report presents our observations in 81 cases; and we have used indirect lymphography only, we injected the contrast medium, lipiodole ultra fluide, intramuscularly to both sides of the tongue. The injection sites are first anaesthetized. The amount of contrast medium should not exceed 5 cc. It is injected in about 10 mn. The first radiological examination is performed 4, 8 and 12 hours after the injection. X-rays are taken using the occipitomental and also lower intraoral occlusal views. The following radiological studies are made after 24 and 48 hours. If necessary further x-rays can be taken as well.

Chin↗

[Lymphography of the upper limb in malignant melanoma].

Owing to its technical difficulty and to an imperfect knowledge of its semiology, lymphography of the upper limb is rarely used. However, experience makes it easy to perform and of considerable value and reliability for diagnostic purposes. Its main advantage in patients with palpable lymphadenopathy is that lymph node excision can be avoided in many cases provided the subjects are regularly followed up.

Arm↗

[Diagnosis of malignant thyroid tumors by indirect thyroid lymphography].

Indirect thyroidolymphography was used for 38 patients with malignant thyroid tumors. A conclusion has been made that indirect lymphography of the thyroid is a simple and rather informative diagnostic method for malignant thyroid tumors and should be followed by spot biopsy.

Adolescent↗

[Pulmonary microlithiasis following iodine lipiodol lymphography?].

Pulmonary fibrosis with marked calcifications in an 83 year old female patient is reported. Following previously inconspicuous thoracic x-ray findings (1975 and 1978) a bipedal oil lymphography was carried out for diagnosis of a systemic malignant lymphoma. The calcifying pulmonary fibrosis was investigated with the help of tomography, computed tomography, xeroradiography and scintigraphy of the lung and the skeletal system as well as magnetic resonance imaging. A biopsy was refused by the patient. The etiological possibilities of an idiopathic disease as well as an induction by the oil contrast medium and a concomitant malignant lymphoma are discussed.

Aged↗

Clinical use of indirect lymphography in different forms of leg edema.

Indirect lymphography by subepidermal infusion of newly developed nonionic, dimeric contrast media (e.g., Iotrolan) opacifies peripheral lymphatics of the skin. Using this method we examined 159 patients with primary and secondary lymphedema, chronic venous insufficiency, and lipedema and compared the findings to normal individuals. A variety of characteristic patterns were uncovered. The technique causes little patient discomfort and takes on the average only 30 minutes.

Contrast Media↗