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[Pediatric vesical lithiasis. 70 case reports].

The study focuses on 70 vesicals lithiasis, with a sample consisting of 60 boys (86%) and ten girls (14%). The age varies from one year to 14 years. The revealing signs are dominated by mictional troubles in 47 cases (67%), macroscopic hematurie in 26 cases (37%), the pyurie in 12 cases (17%) and acute retention of urine in 7 cases (10%). The most frequent germs are the staphylococcus aureus with 28% of cases, the protéus mirabilis with 24% of cases and the Echerichia coli with 24% of the cases. Associated malformations were observed in 9% of the cases. The treatment was essentially surgical (99%). The evolution was simple in 97% of the cases.

Adolescent↗

Vesical lithiasis: open surgery versus cystolithotripsy versus extracorporeal shock wave therapy.

We compare the different methods of treating vesical calculi to establish the most effective and safe modality. Of 128 patients with bladder calculi 5 underwent an open operation, 80 underwent mechanical cysto-lithotripsy and 43 underwent extracorporeal shock wave therapy. Severe complications included hematuria, bladder perforation and mucosal injury in the mechanical cystolithotripsy group. We find extracorporeal shock wave therapy to be a simple, effective and safe modality for the management of vesical lithiasis.

Adolescent↗

Management of the choked ureter in obstructive renal failure due to uric acid lithiasis.

We report on 8 azotemic patients with anuria or progressive oliguria owing to bilateral uric acid lithiasis. In 7 patients the precipitating cause of acute obstructive renal insufficiency was choking of at least 1 distal ureter with numerous small uric acid stones. In 6 of these ureters contrast retrograde ureterography showed relief of obstruction, which was believed to be owing to the stone dissolution properties of the contrast medium used. In situ alkalization via nephrostomy catheters achieved dissolution of obstructing stones in 3 tracts and systemic alkalization dissolved the stones in 3 others. An operation was necessary in 4 cases of large calculi, all of which showed some radiodensity, either because of super added calcification or phosphatic incrustation, rendering dissolution unfeasible. Methods of management of the obstructed tract caused by uric acid stone disease are evaluated and discussed.

Acute Kidney Injury↗

The stone-forming kidney: a study of functional differences between individual kidneys in idiopathic renal lithiasis.

The 24-hour urinary excretion of various electrolytes, as well as the glomerular filtration rate, renal plasma flow and maximal rate of tubular excretion of para-aminohippuric acid was measured in each kidney of 10 patients with idiopathic renal lithiasis. Results in hypercalciuric patients indicate that, in contrast to earlier views, actively stone-forming, normally functioning kidneys are normocalciuric but hypophosphaturic in comparison to their mates with inactive or no stone disease, which are hypercalciuric but normophosphaturic. Therefore, hypophosphaturia rather than hypercalciuria may be an important calculogenic factor in some patients.

Adult↗

Salmonella lithiasis.

A case of Salmonella lithiasis in a 60-year-old woman is presented and the relevant literature is discussed. Nephrectomy instead of lyelolithotomy was undertaken to eliminate the carrier state, and cholecystectomy and exploration of the common bile duct were required.

Carrier State↗

[Effects of water diuresis on the urinary ph of patients under relapsing lithiasis].

INTRODUCTION: It has been observed that in healthy individuals the increase in urinary flow induced by water overload may be enough to alter the urinary Ph to obtain values considered safe in the prophylaxis of lithogenesis. The aim of the present paper is to determine the effects of water diuresis on the urinary Ph of patients suffering from relapsing lithiasis. MATERIAL AND METHOD: 26 patients were included in the present study. The urinary Ph of all patients was measured along two consecutive days, at 8.30 and again at 12.30, under normal conditions (the first day) and once they had received a water load equivalent to 1.5% of their weight (the second day). RESULTS: The altered mean value of the Ph induced on the first day by the circadian rhythm showed a mean of 0.13 units of Ph, which lacks statistical significance (p > 0.05). However, on the second day we obtained a value of 0.42, which is statistically significant (p < 0.01). The normal tendency after the water overload was towards a positive increase of the Ph in those patients whose urine showed a preload Ph value < 6.1, whereas those individuals with a preload Ph value > 6.48 suffered negative increases. CONCLUSIONS: The increase of diuresis induced by water load proved enough to provoke an increase of urinary Ph when its baseline value is < 6.1, or either a decrease when its baseline value is > 6.48. In both cases, Ph values ranged between 6-6.5 which are considered safe values in the prophylaxis of lithogenesis. The more separated the baseline urinary Ph is from the 6.1-6.48 range, the greater the effect of the water load.

Adult↗

[Anesthesia for extracorporeal lithotripsy in the treatment of renal lithiasis].

Extracorporeal shock wave lithotripsy has become the main technique for treating renal lithiasis. It has many repercussions on anaesthesia. The fundamental technical concepts of lithotriptors are reviewed. The problems due to the different systems (electrohydraulic or piezoelectric--the most widespread in France) are discussed. Electrohydraulic systems, which are more adapted to the treatment of large stones (diameter greater than 2 cm), require the immersion of the patient. As a result, there are analgesic, cardiovascular, respiratory and temperature repercussions on the anaesthetic management of these patients. General anaesthesia is generally more appropriate for this technique. On the other hand, piezoelectric systems are more adapted to the treatment of medium-sized or small calculi (diameter less than 2 cm), and do not require immersion. Anaesthesia is often not required for the use of this technique, but, if necessary, local, regional or general anaesthesia may be used. For either technique, the anaesthetic protocol must be adapted to the patient's and the surgical indications.

Anesthesia↗

Improved sonographic visualization by fluid challenge method of renal lithiasis in the nondilated collecting system. Experience in seven cases.

Ultrasound is an effective means of detecting renal stones in patients with hydronephrosis. The filled urinary bladder in a normal person under hydration frequently results in the sonographic appearance of minimal or moderate hydronephrosis. For optimal visualization of stones and associated acoustic shadows, six patients with radiographically opaque renal stones were evaluated with fluid-loaded renal ultrasonography, which was compared to conventional renal sonogram in basal state. Although ultrasound in basal state can be used for detection of intrarenal lithiasis, fluid-challenged renal sonogram appears more accurate for the determination of contour, location, size, and number of small stones. In one case, this fluid-loaded ultrasound well demonstrated the tramline appearance of an isolated renal artery, which mimics stone before fluid challenge.

Adult↗

Kinetic versus thermodynamic factors in calcium renal lithiasis.

Calcium renal lithiasis formation depends on the balance between thermodynamic (supersaturation) and kinetic (inhibitors, nucleants) factors. In this paper, the importance of both groups was evaluated using (a) the complete urine analysis data obtained from 32 healthy volunteers and 141 active stone-formers, and (b) a comprehensive computer model to calculate the supersaturation values of calcium oxalate monohydrate, hydroxyapatite and brushite in each urine sample. The results of this evaluation were used to assess the possible effectiveness of a given pharmacological treatment.

Calcium↗

Radiopaque 2,8-dihydroxyadenine lithiasis.

2,8-Dihydroxyadenine (DHA) lithiasis is a rare type of urinary stone disease and the deficiency of adenine phosphoribosyltransferase (APRT) activity is known to be the cause of this disease. To identify a 2,8-DHA stone is important because this stone is well managed by medical therapy. Regarding a radiological finding, previous reports have considered 2,8-DHA to be radiolucent like uric acid stone. This report is a case of radiopaque 2,8-DHA stone and proposes that the composition of urinary stones should always be investigated for adequate medical treatment.

Adenine↗

Metabolic evaluation of infected renal lithiasis: clinical relevance.

Complete metabolic evaluation was performed in 21 patients with infected renal lithiasis. Patients with pure struvite stones (struvite +/- carbonate apatite) were significantly less likely to have metabolic abnormalities than patients who had struvite +/- carbonate apatite+calcium oxalate (2 of 14 v 7 of 7, P = 0.0003). Urine calcium excretion was markedly higher in the mixed stone group than the pure struvite group (342 +/- 98 mg/24 h v 136 +/- 82 mg/24 h; P < 0.0001). The differing opinions among researchers regarding the likelihood of finding metabolic abnormalities in patients with urolithiasis and infection probably reflect differences in the definitions of the populations studied. If patients with calculi containing only struvite +/- carbonate apatite are evaluated, we believe that few significant metabolic abnormalities will be identified.

Adolescent↗

Urinary supersaturation with respect to brushite in patients suffering calcium oxalate lithiasis.

The urines of 23 stone-formers presenting repeated calcium oxalate lithiasis and 12 control subjects were collected at six different time periods daily. Supersaturations for calcium oxalate and brushite (DCPD) were calculated using ionic and solubility products. Urines of both groups were supersaturated for calcium oxalate but only urines of the stone-formers were supersaturated for brushite, the most simple calcium phosphate which nucleates very easily at the urinary pH. This fact suggests that the core of the calcium oxalate stone could be made of either a calcium oxalate crystallite or a brushite seed onto which hetergeneous nucleation of calcium oxalate can take place.

Adolescent↗

Prevalence of biliary lithiasis in a Sicilian population of chronic renal failure patients.

BACKGROUND: The aim of this study was to evaluate the prevalence of biliary lithiasis (BL) and associated risk factors in a population of undialysed patients with chronic renal failure (CRF), and to compare these with findings we had obtained previously in chronic haemodialysis (HD) patients and in subjects from the general population located in the same geographic region. METHODS: A total of 118 CRF patients on conservative treatment were included in the study. In all subjects, we measured several clinical and humoral parameters potentially correlated with BL. Liver and biliary tract ultrasonography was performed with a 3.5 MHz linear probe after at least 12 h of fasting. RESULTS: The prevalence of BL in CRF patients was 22%, which was higher than in the general population (chi(2) = 9.4, P < 0.002) but lower than in HD patients (chi(2) = 25.9, P < 0.0001). Age was similar in the three groups. Body mass index (BMI) was significantly higher in the CRF group than in both HD patients (P < 0.0001) and the general population (P < 0.0001). When the CRF group was divided into subjects with or without BL, the only difference was lower serum calcium levels in the subgroup with BL (P < 0.04). CONCLUSIONS: The prevalence of BL in a Sicilian population of CRF patients was higher than in the general population, but lower than in patients with CRF on chronic HD. Apart from BMI, none of the risk factors traditionally associated with BL in the general population were related to BL in the CRF patients. These data suggest that other factors inherent to kidney pathology contribute to the high prevalence of BL in CRF patients.

Aged↗

Reliability of pre- and intraoperative tests for biliary lithiasis.

The records of 242 patients, operated consecutively for biliary lithiasis, were analyzed to determine the reliability of oral cholecystography (OCG), ultrasonography (US), and HIDA in detecting biliary calculi. Preoperative interpretations were correlated to operative findings. OCG obtained in 138 patients was accurate in 92%. US obtained in 150 was correct in 89%. The accuracy of HIDA was 92% in acute and 78% in chronic cholecystitis. Intraoperative cholangiography (IOC) done in 173 patients indicated the need for exploratory choledochotomy in 24; 21 had choledocholithiasis. These observations suggest that OCG and US are very accurate, but not infallible, in detecting cholelithiasis. US should be done first; when doubt persists, the addition of OCG allows the preoperative diagnosis of gallstones in 97% of the cases. HIDA is highly accurate but not infallible in detecting acute calculous cholecystitis. IOC is very reliable in detecting choledocholithiasis; thus, its routine is justifiable.

Adolescent↗

Gallbladder sludge and lithiasis in an infant born to a morphine user mother.

We report a 3-month-old boy with gallbladder sludge formation and lithiasis. The known associated factors causing cholelithiasis in infancy were not present. We postulate that maternal chronic use of morphine during pregnancy may result in biliary sludge formation in utero in the fetus with progression and manifestation of cholelithiasis at 3-months of age.

Cholelithiasis↗

Familial renal hypouricaemia: two additional cases with uric acid lithiasis.

Two families are reported affected with hereditary renal hypouricaemia associated with uric acid lithiasis. The propositi of both families were found also to have hyperabsorptive hypercalciuria. Based on the study of the effect of pyrazinamide and probenecid on uric acid excretion in both propositi, it is suggested that the defect in uric acid reabsorption is most probably at the pre-secretory site.

Adult↗