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[On the behavior of the antistreptolysin titer in dermatoses].
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Multiple giant disseminated pyogenic granuloma in three patients burned by boiling milk.
BACKGROUND: Pyogenic granuloma is a common benign skin tumor. The multiple disseminated form of the disease is relatively rare. METHODS: We examined three patients who developed giant pyogenic granuloma after burns from boiling milk. The patients were a 1.5-year-old boy, a 5-year-old girl, and a 35-year-old woman, All three patients had second-degree burns over their face and trunk. RESULTS: In these patients, pyogenic granuloma had developed over the previously burned areas 2-3 weeks after exposure. The general condition of the patients remained good and all lesions involuted spontaneously. In a 6-month follow-up period no relapse of the lesions was seen. CONCLUSIONS: The cause for development of multiple giant pyogenic granulomas after burns from milk remains unknown, but milk proteins or other components of milk, microorganisms, or the burn itself may be causative factors.
Keratosis extremitatum (Greither's disease): clinical features, histology, ultrastructure.
Keratosis palmoplantaris progrediens et transgrediens (Greither's disease) was first described by Greither in 1952. The inheritance pattern is autosomal dominant with variable expression. The clinical manifestation is characterized by diffuse palmoplantar keratoderma associated with hyperhidrosis and progressive extension of keratoderma to the dorsum of the hands and feet. In addition, hyperkeratotic plaques may occur on the elbows and knees. We describe a 44-year-old patient with typical features of Greither's disease. Immunohistologic and ultrastructural investigations are presented.
Cutaneous sarcoidosis and foreign bodies.
A histopathological diagnosis of sarcoidosis is, by convention, one of exclusion and is reached only when other potential causes of granulomatous disease, such as foreign bodies, are eliminated. We report herein three cases of systemic sarcoidosis with cutaneous manifestations of the disease, in which polarizable foreign particles were associated with the granulomata in the skin. We submit (a) that a granulomatous foreign body reaction and sarcoidosis are not mutually exclusive, (b) that particulate foreign matter may actually serve as a nidus for granuloma formation in sarcoidosis, and (c) that the occasional presence of extraneous material within the granulomata of sarcoidosis requires greater recognition by pathologists.
[Dermatoses in scar tissue: necrobiosis lipoidica diabeticorum, erythema elevatum diutinum, pretibial myxedema, anetoderma, etc].
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[How should I photograph the legs?].
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Idiopathic cold-induced urticarial vasculitis and monoclonal IgG gammopathy.
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[Use of interferon-alpha (IFN-alpha) in the treatment of keratoacanthoma].
BACKGROUND AND OBJECTIVE: Keratoacanthoma are benign epithelial tumors. The aim of this study was to determine the effects of interferon alpha on keratoacanthoma. PATIENTS/METHODS: Six patients presented with histologically proven keratoacanthoma which were large or otherwise difficult to excise. Intra and perilesional interferon-alpha treatment with 3 million IU weekly was started. RESULTS: In 6-15 weeks all tumors were cured. CONCLUSIONS: Treatment with intralesional interferon-alpha offers a new possibility in cases of large keratoacanthomas, or those which are not surgically excisable.
Regional dermatoses in the African black. III. Pretibial lesions.
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A report of two cases of pigmented purpuric dermatoses treated with PUVA therapy.
This is a report of 2 patients with pigmented purpuric dermatosis treated successfully with Psoralen photochemotherapy (PUVA). Treatment for pigmented purpuric dermatosis is generally unsatisfactory, and we believe this to be the first report of successful response of this condition to PUVA.
Lichen striatus in an adult.
A 58-year-old Japanese woman with lichen striatus had asymptomatic multiple erythemato-papular plaques in arranged linear or band-like patterns over the right half side of her chest, back, and the right upper and lower extremities, following Blaschko's lines. A biopsy specimen demonstrated a dermoepidermal interface inflammation with a lichenoid lymphoid cell infiltrate into the upper and middle dermis. All lesions spontaneously cleared within 2 months. Lichen striatus in an adult should be differentiated from other acquired erythemato-papular dermatoses which may follow Blaschko's lines. Its histopathological features may mimic those of lichen planus, but it can be distinguished because of its consistent distribution on Blaschko's lines, not only in children but also in adults.
Familial pigmented purpuric dermatoses.
Pigmented purpuric dermatoses (PPD) are chronic, asymptomatic dermatoses characterized by petechiae, pigmentation and rarely telangiectasias. Familial occurrence of PPD is very rare. We report four individuals in a family over three generations. The inheritance is suggestive of an autosomal dominant pattern.
Erythema gyratum repens and acquired ichthyosis associated with transitional cell carcinoma of the kidney.
Both erythema gyratum repens (EGR) and acquired ichthyosis are distinctive dermatoses which have strong associations with internal malignancy. EGR usually precedes the diagnosis of malignancy whereas acquired ichthyosis commonly manifests after the detection of malignancy. We report a patient who initially presented with a figurate eruption of EGR which later developed into a widespread ichthyosis with disappearance of the serpiginous rash. Further investigations revealed an underlying transitional cell carcinoma of the kidney, an association which has not previously been reported with either EGR or acquired ichthyosis. The occurrence of two paraneoplastic skin disorders in the same patient may be explained by tumour cell secretion of transforming growth factor alpha, which has been shown to be mitogenic for keratinocytes.
Interstitial granulomatous dermatitis with arthritis.
BACKGROUND: Interstitial granulomatous dermatitis with arthritis is an uncommon systemic disorder involving the cutaneous and musculoskeletal systems. The eruption may mimic other dermatoses including granuloma annulare, erythema chronicum migrans, and the inflammatory stage of morphea. Key histopathologic characteristics, along with clinical correlation, allow accurate diagnosis. OBJECTIVE: We describe the clinical, serologic, and histologic features in three patients with interstitial granulomatous dermatitis with arthritis. METHODS: Skin biopsy specimens were examined and correlated with the clinical and laboratory findings. RESULTS: Erythematous, annular, indurated plaques on the extremities were present in two women. An erythematous, papular eruption on the head and neck was present in a third patient. All patients had myalgia and migratory polyarthralgias of the extremities along with various serologic abnormalities. Histologic examination revealed a dense lymphohistiocytic interstitial infiltrate involving primarily the reticular dermis. Foci of necrobiotic collagen were present. Vasculitis was absent. CONCLUSION: Interstitial granulomatous dermatitis with arthritis is unique multisystem disease with variable cutaneous expression. Abnormal serologic findings indicate a possible connection to collagen vascular disease.
Artifact or vasculitis.
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