Studies concerning the antibiotic actinonin. Part III. Synthesis structural analogues of actinonin by the anhydride-imide method.
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The preparation is described of a number of new N-substituted derivatives of dibenzo[e.h]bicyclo[2.2.2]octane-2,3-dicarboximide with potential anxiolytic activity.
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The preparation of a potential anxiety-relieving compounds N-[4-(4-aryl)-1-piperazinyl)butyl]-1-acetoxy-7,7-dimethyl-bicyclo[2.2.2]octan-5-one-2,3-dicarboximides has been described. N-[4-(4-2-methoxyphenyl)-1-piperazinyl)butyl]-1-acetoxy-7,7-dimethyl-bicyclo[2.2.2]octan-5-one-2,3-dicarboximide III showed a strong sedative effect in Writh's test.
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