[SUBMICROSCOPICAL STRUCTURE OF THE HUMAN CHORION TILL THE 3RD MONTH OF GRAVIDITY].
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BACKGROUND: We exposed pregnant mice to magnetic or sham fields for 24 hr/day during Gestation Day (GD) 5.5-8.5 to study the effects of 50-Hz 0.1-mT sinusoidal magnetic fields on early pregnancy in mouse embryos and mice. METHODS: Mice were sacrificed on GD 8.5. Embryos and blood samples were collected. Reverse transcription polymerase chain reaction (RT-PCR) was used to detect the expression of embryo c-fos mRNA. The blood samples were tested through radioimmunoassay for serum estradiol levels and general examinations. RESULTS: We found that the expression of c-fos mRNA of embryos under exposure was enhanced. We reported that 50-Hz 0.1-mT magnetic exposure induced the decline of serum estradiol levels of pregnancy mice on GD 8.5. General examinations of blood including white blood cell (WBC) count, red blood cell (RBC) count, and hemoglobin (HGB) did not show significant differences between the exposure group and the control group (sham exposure). CONCLUSIONS: Under the experimental conditions, 50-Hz 0.1-mT sinusoidal magnetic fields affected the development of early pregnancy mouse embryos and the dams to some extent.
A case-control study of 1358 pregnant and nonpregnant women with and without symptoms of a lower genital tract infection were investigated for evidence of venereal disease. The prevalence of gonorrhea, Trichomonas and Candida in pregnancy was 15.0%, 20.6% and 41.3%, respectively, while the equivalent percentages in the nonpregnant women varied from 16.5% to 21.6%, 2.4% to 22.8% and 33.3% to 39.3%. However, these differences are not statistically significant. The implications of the findings are discussed and a screening program suggested.
Fetal weight in utero was estimated sonographically within one week of delivery in 70 live-born fetuses of diabetic gravidas. The best estimates of weight were obtained with formulas dependent on biparietal diameter, abdominal circumference, and femur diaphysis length, and with formulas using the two variables of femur diaphysis length and abdominal circumference. Use of a special formula for the fetus of a diabetic mother was not of additional benefit. Acceptable weight estimates for the macrosomic diabetic fetus were not obtained.
Ultrasound examinations were performed to determine the prevalence of cholelithiasis in 585 pregnant Hispanic patients. The ultrasound findings were correlated with age and country of birth. The overall prevalence of gallstones was 5.3%. This is not statistically different from the prevalence of gallstones in age-matched groups from previously published studies not selected for country of birth or ethnic background. We found no statistically significant different in prevalence rates for gallstones between Mexican-born and non-Mexican-born pregnant Hispanic women in the 20-year to 49-year age group. Unlike prior studies, this study does not support the use of increased ultrasound examination for cholelithiasis in a pregnant Hispanic population.
Transabdominal sonograms of 68 consecutive pregnant women were reviewed retrospectively. Images of fetal parts obtained through the umbilical window (UW) were compared with those obtained through the paraumbilical window (PUW) as to (1) thickness of tissue to amniotic cavity, (2) clarity of the part imaged, and (3) noise produced. The paraumbilical tissue thickness had a mean of 18 mm; the umbilical tissue thickness, a mean of 11 mm. In patients where the difference in thickness of their paraumbilical tissue and umbilical tissue was only 0 mm to 6 mm (group 1), the UW improved clarity in 10 of 34 (29%), reduced clarity in 3 of 34 (9%), and did not change clarity in 21 of 34 (62%). Improvement of images with use of the UW was not statistically significant. However, in the group of patients with the difference in tissue thickness between the paraumbilical and umbilical areas of > 6 mm (group 2), clarity was improved in 19 of 32 (60%), reduced in 2 of 32 (6%), and was unaltered in 11 of 32 (34%). In this group the image improvement with the UW was statistically significant. Images through the UW had relatively less noise. In group 1, noise was reduced in 12 of 35 (34%). The effect of the UW on noise reduction was more significant in group 2 (tissue thickness difference > 6 mm): 24 of 31 (77%) of cases.
This study showed that the LD50 values for morphine sulfate, cobalt chloride, and phenytoin sodium did not vary significantly on Day 9 of gestation in CF-1 mice when compared to values of nongravid animals.
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