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Results for “Foreign-Body Reaction”

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At least 325 records · Page 18Linked to original sources
PubMed1977

Grafting in dentistry today (author's transl).

Enossal grafts are common practice in dentistry. The prognosis of such grafts fluctuates between primary failure and 10 years, and is largely determined by the indication: the more accurate the indication, the better the prognosis! In partial diastemata in the lower jaw, satisfactory results for a longer time are to be expected if the concurrently blocked remaining denture is periodontally sound.

Animals↗
PubMed1979

Schistosomiasis--cancer: etiological considerations. A review.

Evidence for a causal connection between Schistosoma haematobium-infection and carcinoma of the urinary bladder is discussed. A group relationship of schistosomiasis cancer to cancers as+sociated with asbestosis, foreign body implants, and cicatrization is suggested on the basis of several criteria. Results of experimental foreign body tmuorigenesis in mice are presented and elaborated in relationship to schistosomiasis cancer. Carcinogenic development at the cellular level is discussed with emphasis on the essential role of tissue-environmental conditions, especially fibrotic changes and macrophage quiescence.

Adult↗
PubMed1975

[Infected endoprosthesis of the hip - an actuel problem (author's transl)].

Out of 49 infected total hip replacements which were treated at the Orthopedic Hospital of the University of Heidelberg, 39 were taken out and not replaced by a new one. The advantage of such doing was an almost total cure of the infection and a relief of pain. The functional result is the same found in head-neck-resections. The patient's opinion about this method is surprisingly good. It is worth to be considered as an alternative to a replacement of a new prosthesis.

Foreign-Body Reaction↗
PubMedDate not supplied

Giant cell synovitis associated with failed polyethylene patellar replacements.

Destroyed patellar articular surfaces were replaced with a high molecular weight polyethylene prosthesis in two patients. The patellofemoral articulation of the femur consisted of eburnated bone in one case and degenerative cartilage in the other. Both operations failed within one year because of a giant cell synovitis caused by a high volume (0.2 cc) of fine polyethylene (1-100 mu) wear particles. Ultra high molecular weight polyethylene should not be used as a prosthetic bearing surface to articulate against cortical, cancellous or eburnated bone or against degenerative articular cartilage in a major joint.

Aged↗
PubMed1978

Polyvinylchloride (PVC) particles implantation in mouse liver. A technique for experimental study of schistosome eggs-induced liver pathology.

An injection of suspended PVC particles in the caecal vein of mice induces a foreign-body portal granuloma reaction in the liver. Plastic casts of the portal system, after PVC particles implantation, show modifications in the portal bed and are compared with plastic casts obtained in mice infested by Schistosoma mansoni. This technique can be useful to study the cellular dynamics of the portal granuloma and can be a model for schistosomal eggs induced liver pathology.

Animals↗
PubMed1978

The osteoninductive property of decalcified bone matrix. An experimental study,.

Demineralised homologous bone-matrix implant was used to bridge a large circumferential osteoperiosteal gap in the diaphysis of the ulna of rabbits. Periodic observations of the graft were made clinically, radiologically, histologically and by tetracycline fluorescence up to forty-two weeks. By the twelfth week after operation 81 per cent of the animals revealed bone formation in the implant and complete bridging of the gap. The new bone was laid on the surface and in the substance of the matrix, suggesting that the inductive principle was acting locally. The bone, once formed, remodelled to the texture of a mature tubular bone and did not undergo absorption during a long follow-up period. Demineralise bone-matrix proved to be a highly osteoinductive and readily osteoconductive material. The graft did not evoke any appreciable local foreign-body or immunogenic reaction. The high degree of success in bridging massive bone defects justifies further serious studies and hopes for a useful substitute for massive autologous bone grafts.

Animals↗
PubMed1979

Fc-receptor-bearing macrophages isolated from hypersensitivity and foreign-body granulomas. Delineation of macrophage dynamics, fc receptor density/avidity and specificity.

Foreign-body and delayed hypersensitivity granulomas were induced in mice; and the dynamics of macrophages isolated from dispersed, 1--4-week-old lesions was delineated. The size and histologic complexity of the lesions increased as shown: adjuvant greater than schistosome egg greater than methylated bovine serum albumin greater than bead. Esterase staining, spreading on glass, and the percentage of Fc-receptor--bearing macrophages present in the various granulomas reflected the same gradient. The Fc receptors were examined by rosetting with rabbit-antibody--SRBC complex (EA). Whereas more than 90% of the population of macrophages of the dermal adjuvant granuloma contained undiminished numbers of receptor-bearing macrophages throughout the 4 weeks, the percentage of macrophages that displayed receptors in pulmonary foreign-body (40%) and delayed hypersensitivity granulomas (70%) peaked at 1 week and subsequently declined. The EA rosetting of the foreign-body and delayed hypersensitivity granuloma macrophages was strongly inhibited by monomeric IgG2a-specific and weakly by aggregated IgG2b-specific mouse myeloma proteins. Also, macrophages of the delayed hypersensitivity granulomas rosetted in higher percentages with SRBCs coupled with monomeric IgC2a than with those coupled with aggregated IgG2b myeloma proteins. Macrophages of the foreign-body lesion did not react with aggregated IgG2b--SRBC. Rosetting with monomeric IgG2a--SRBC or aggregated IgG2b--SRBC could not be cross-inhibited by the myeloma proteins. Both the monomeric IgG2a--SRBC and aggregated IgG2b--SRBC complexes were readily phagocytized. Trypsin treatment of the macrophages inhibited rosetting with EA or myeloma-protein--coupled SRBCs. The display of Fc receptors on the granuloma macrophages seems to be related to the etiology of the lesion and the intensity and duration of the inflammatory reaction.

Animals↗
PubMed1975

[Histometrical studies on induced paw inflammation by carrageenan and Freund's complete adjuvant in rats].

A group of male Wistar rats (strain AF/HAN) received carrageenin in a tragacanth suspension and saline solution by subplantar injection into the right and left hind paws, respectively. Another group was treated similarly with Mycobacterium butyricum in Freund's adjuvant given in the right hind paw while the left paw served as control. The experiments ran for 20 days. The paw volume was measured plethysmometrically and general histological examination was carried out on samples of the dorsal paw epidermis and dermis. The mast cell count and thickness of epidermis were also determined. Epidermal and dermal changes developed in distinct stages following carrageenin or adjuvant treatment. During the acute phase (from 0 to 12 h post-treatment) the paw volume as well as the thickness of the epidermis increased while the dermal mast cell count decreased. Furthermore, hyperemia, edema and leukocytic infiltration of the connective tissue was observed. Eosinophilia and focal necrosis appeared only in the adjuvant treated animals. In the subacute phase (from 1 to 3 days post-treatment) paw swelling and epidermal hyperplasia recessed slightly in the carrageenin treated group. On the other hand, paw volume of the adjuvant treated animals continued to rise. These changes were accompanied by proliferative and degenerative processes of the connective tissue (fibroplasia, histiolymphocytic infiltration, focal necrosis). A chronic phase of inflammation (from 4 to 20 days post-treatment) developed only in the adjuvant treated group. Epidermal hyperplasia reappeared and the paw volume increased significantly (secondary reaction). Also granulomatous chronic inflammation and foreign-body giant cells proliferated in the connective tissue.

Animals↗
PubMedDate not supplied

On skeletal muscle pathology in trichinosis.

A study was carried out on the pathology of trichinosis in human muscle biopsy sample and comparatively in experimental trichinosis in the rat, by current microscopic techniques and Troitsky's method of block silver impregnation of the nerve endings. Stress is laid upon the incipient changes in the parasitized muscle fibers, the sarcolemmic origin of the parasite capsule, the myogenic nature of certain periparasitary but intracapsular clear cells of precocious appearance and other associated, non-specific lesions, such as common myositis changes or giant myogenic foreign-body cells. The intimate relationships between parasitized muscle fibres, cellular interstitial reactions, local new-growth vessels and proliferation of the nerve endings are also described. The morpho-functional significance of such morphological synergic manifestations is discussed as an adaptation to the new local conditions brought about by the appearance of the peculiar muscle fibre-parasite unit in trichinosis.

Animals↗