Fetoscopy in prenatal diagnosis.
Explore the source record for details and available documents.
Blood Coagulation Disorders↗
SEARCH · Search PubMed
Results for “Fetoscopes”
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
[Preliminary experience with foetoscopy (author's transl)].
Explore the source record for details and available documents.
Female↗
Transabdominal needle embryofetoscopy: a new technique paving the way for early fetal therapy.
OBJECTIVE: To explore the feasibility of using a newly devised needle endoscope to conduct transabdominal first-trimester endoscopy for both embryonic visualization and blood sampling. METHODS: Following informed consent, 12 patients at 8-12 weeks' gestation undergoing first-trimester termination were invited to participate in this study. Transabdominal needle embryofetoscopy was also performed in one continuing pregnancy. A specially designed 16-gauge, double-barrel instrument sheath equipped with 0.8-mm fiberoptic endoscope and a customized 27-gauge heparinized needle were passed transabdominally under ultrasound guidance through the uterine wall and into the exocoelomic space. RESULTS: Using first-trimester transabdominal needle embryofetoscopy, we were able to identify the normal anatomical landmarks of the embryo and were also able to gain access to the embryonic circulation by advancing the 27-gauge needle into the umbilical vessels. In addition, we were able to infuse indigo carmine dye into the fetal circulation of three subjects. Needle embryofetoscopy was also used in a continuing pregnancy for prenatal diagnosis. CONCLUSION: Our experience establishes the feasibility of first-trimester transabdominal needle embryofetoscopy for embryonic visualization and access to the circulation. This new development is expected to serve as a basis for further studies attempting to diagnose and treat congenital diseases in early pregnancy.
Abdomen↗
Fetoscopy-guided fetal endoscopy in a sheep model.
Video-endoscopic surgical treatment of the fetus may, in the future, become an alternative to open fetal operation. Six 95-day-old fetal lambs were examined through intrauterine endoscopy using amnioinfusion and specially designed balloon-tipped cannulas. The fetuses were monitored endoscopically for oxygen saturation, heart rate and temperature throughout the procedure. With a rigid 5 millimeter telescope and a flexible 3 millimeter endoscope, the respiratory and upper gastrointestinal tracts could be examined. No mucosal or other trauma was noted upon completion of the endoscopy; all lambs survived the procedure. While the applications of fetal endosurgery are likely to be similar to those of open fetal operation, fetal endoscopy (looking in the fetus) is a new entity for which clinical relevance (rather than mere feasibility) remains to be demonstrated. This technique, however, could become a valuable research tool to study fetal gastrointestinal and pulmonary physiologic factors in situ.
Animals↗
A new modification of spectrophotometry in the investigation of amniotic fluid by amnioscopy.
A new spectrophotometric application to amnioscopy for the estimation of the colour of amniotic fluid is presented. Three light-emitting diodes (LEDs) with peak wavelengths of 565 nm (green), 581 nm (yellow), and 645 nm (red) act as the light sources, and the light reflected from the amniotic fluid is measured using a photodiode. The greatest advantages of our new application are the short recording time of about 15 s. and the simplified mechanical performance of the measurement, which reduce errors. Preliminary clinical results show that green colouration can be easily discriminated from yellow and clear amniotic fluid. Sources of error and improvements to the method are discussed.
Amniotic Fluid↗