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PubMed1990

The effects of polyunsaturated fat vs monounsaturated fat on plasma lipoproteins.

The effect on plasma lipoproteins of exchanging fat type within currently recommended reduced-fat diets was studied in a free-living group of 19 men and 20 women who consumed both a polyunsaturated fat-enriched diet and a monounsaturated fat-enriched diet, each for a 12-week period, with saturated fat and cholesterol held constant. Mean plasma concentrations of low-density lipoprotein cholesterol and low-density lipoprotein total mass (analytic ultracentrifuge), and high-density lipoprotein (HDL) cholesterol and HDL total mass, did not change significantly on exchanging fat type. However, HDL2 cholesterol concentration was 50% higher and HDL3 cholesterol concentration was 7% lower for polyunsaturated compared with monounsaturated fat. Mean total mass of HDL2 was also 23.5% higher and concentration of apolipoprotein B was 5.4% lower on transfer to the polyunsaturated fat diet. Contrary to frequent assertions, we find no advantage with respect to plasma HDL concentrations in using predominantly monounsaturated rather than polyunsaturated fats in subjects who consumed reduced-fat, solid-food diets.

Adult↗
PubMed1989

Familial lipoprotein lipase-activity deficiency: study of total body fatness and subcutaneous fat tissue distribution.

Total body fatness and subcutaneous fat tissue distribution were evaluated in 19 hyperchylomicronemic patients. Eleven were males, aged 10 to 57 years, and eight were females, aged 13 to 46 years. Familial lipoprotein-lipase-activity deficiency was diagnosed by the absence of lipoprotein-lipase activity in the plasma withdrawn ten and 20 minutes after intravenous injection of ten units of heparin per kilogram of body weight. The 19 patients had skin-fold measurements for evaluation of subcutaneous fat distribution. Fifteen also underwent body density measurements by underwater weighing. Percent body fat was calculated from body density. These anthropometric data were plotted against the regression curves of 1638 normal controls of both sexes (aged 10 to 54 years) for fat tissue weight, percent body fat, subcutaneous fat/total fat mass ratio and trunk/extremity skin-fold ratio. Impairments in the process of building fat tissue reserves could not be shown in the 19 hyperchylomicronemic patients, in spite of the absence of lipoprotein-lipase activity in their postheparin plasma. It is hypothesized that normal fat tissue mass in these patients could be due partly to de novo synthesis of fatty acids by adipocytes, hydrolysis of plasma triglycerides by hepatic lipase, and/or contribution of a specific fat-tissue lipase to the catabolism of plasma triglyceride-rich lipoproteins.

Adipose Tissue↗
PubMed1992

Effect of fat and fat-free mass deposition during pregnancy on birth weight.

OBJECTIVES: The purposes of our study were to describe the patterns and location of fat and fat-free mass deposition during pregnancy and to evaluate their effects on fetal growth. STUDY DESIGN: Our study is a prospective follow-up of 105 healthy pregnant women who were delivered of term infants. Body composition was evaluated eight times during gestation with anthropometric measures and bioimpedance techniques. Body fat and fat-free mass were calculated with equations specifically developed for this population. RESULTS: Total weight gain was 10.0 +/- 3.5 kg; net weight gain was 3.7 +/- 0.31 kg; birth weight was 3211 +/- 467 gm (values are mean +/- SEM). In these women fat was deposited mostly in the thigh and subscapular region for a total of 6.23 +/- 0.19 kg at term. The period of pregnancy of the largest maternal fat deposition per week is between the twentieth and thirtieth weeks. After adjusting by prepregnancy weight, birth weight is associated with maternal changes in thigh skin folds and fat gain before the thirtieth week of gestation. Infants born to mothers with low fat gain before the thirtieth week were 204 gm lighter than infants born to mothers with fat gain > or = 25th percentile of this population. CONCLUSION: Maternal nutritional status at the beginning of gestation and the rate of fat gain early in pregnancy are the two nutritional indicators most strongly associated with fetal growth in this population.

Adipose Tissue↗
PubMed1984

Monozygotic twin resemblance in fatness and fat cell lipolysis.

Six skinfold measurements, and percent body fat and fat-free weight derived from the underwater weighing technique were obtained in 43 pairs of male and 44 pairs of female monozygotic (MZ) twins. A fat tissue biopsy was performed in the suprailiac region in 20 male and 16 female pairs in order to determine mean adipocyte diameter and basal lipolysis as well as epinephrine maximally stimulated lipolysis (10(-4) M). Twin resemblance in body fatness is clearly demonstrated by the analysis of the between MZ sibships over the within MZ shibship means of squares for all skinfold measurements, percent body fat and fat free weight (P less than 0.01). Within MZ pair similarity is as high in female as in male pairs for body fatness. Moreover, members of the same twin pair resemble one another significantly for fat cell size and fat cell lipolytic activities, particularly when epinephrine stimulated. In female MZ pairs, additional studies with control over the menstrual cycle are needed to clarify the case of isolated fat cell basal lipolysis.

Adipose Tissue↗
PubMed1999

Altered biosynthesis and secretion of pro-opiomelanocortin in the intermediate and anterior pituitary of carboxypeptidase E-deficient, Cpe(fat)/ Cpe(fat)mice.

The biosynthesis and secretion of pro-opiomelanocortin (POMC) was examined in the pituitary of Cpe(fat)/ Cpe(fat)mice, which are deficient in carboxypeptidase E, a sorting receptor for the regulated secretory pathway (Cool D R, Normant E, Shen F S, et al. Cell 1997; 83: 73-83). Dopamine inhibited forskolin-stimulated accumulation of cAMP in the intermediate lobe of Cpe(fat)/ Cpe(fat)mice, showing that their dopamine receptors were fully functional. This result indicates that the elevated, dopamine-insensitive POMC secretion previously observed in the intermediate pituitary of Cpe(fat)/ Cpe(fat)mice was constitutive, rather than due to defective dopamine receptors. Concomitant with the increase in POMC secretion was a twofold increase in POMC mRNA levels and [(35)S]-methionine incorporation into POMC. In the anterior pituitary of Cpe(fat)/ Cpe(fat)mice, a 1.6-fold increase in basal release of POMC was accompanied by a similar increase in [(35)S]-methionine incorporation into POMC, although POMC mRNA levels were unchanged. Thus, the intermediate and anterior pituitary of Cpe(fat)/ Cpe(fat)mice compensate for the constitutive secretion of POMC by upregulating biosynthesis.

Animals↗
PubMed1995

To what extent is bone mass determined by fat-free or fat mass?

One hundred sixty-four healthy black and white women aged 24-79 y were studied to determine to what extent bone mass is determined by fat-free mass (FFM). A multicomponent approach to body composition, with techniques that are not interdependent, was used. The measurements included dual x-ray absorptiometry (DXA), prompt gamma-neutron-activation analysis, inelastic neuron scattering, tritiated water dilution, and whole-body counting. Univariate correlations showed significant relationships of all the fat-free measures and most of the fat measures with bone mass measured by total body calcium (TBCa). Data from pre- and postmenopausal women were analyzed separately. The average FFM by itself explained 50-55% of the variability in TBCa whereas the average fat mass by itself explained only 5-18% of the variability. The contribution of fat mass was consistently greater in postmenopausal than in premenopausal women. When stepwise multiple regression with TBCa was performed to determine the influence of adding fat mass, height, and race to the relationship of FFM with TBCa, the variation explained by average FFM was 56% premenopausal, 50% postmenopausal; by height 3% premenopausal, 6% postmenopausal; by race 4% premenopausal, 8% postmenopausal; and average fat mass was not significant. Average values for fat mass and FFM were obtained by averaging all the methods used. In conclusion, in black and white healthy women, although bone mass may be partially influenced by fatness or race, the major determinant of bone mass is FFM. Fat mass may play a more important role in postmenopausal women.

Absorptiometry, Photon↗
PubMed1998

High body fatness, but not low fat-free mass, predicts disability in older men and women: the Cardiovascular Health Study.

Using data from the Cardiovascular Health Study, we studied the relation between body composition (fat mass and fat-free mass, assessed by bioelectrical impedance) and self-reported, mobility-related disability (difficulty walking or stair climbing) in 2714 women and 2095 men aged 65-100 y. In a cross-sectional analysis at baseline (1989-1990), disability was reported by 26.5% of the women and 16.9% of the men. A positive association was observed between fat mass and disability. The odds ratio for disability in the highest quintile of fat mass was 3.04 (95% CI: 2.18, 4.25) for women and 2.77 (95% CI: 1.82, 4.23) for men compared with those in the lowest quintile. Low fat-free mass was not associated with a higher prevalence of disability. In a longitudinal analysis among persons not reporting disability at baseline, 20.3% of the women and 14.8% of the men reported disability 3 y later. Fat mass at baseline was predictive of disability 3 y later, with odds ratios of 2.83 (95% CI: 1.80, 4.46) for women and 1.72 (95% CI: 1.03, 2.85) for men in the highest quintile of fat. The increased risk was not explained by age, physical activity, chronic disease, or other potential confounders. Low fat-free mass was not predictive of disability. The results showed that high body fatness is an independent predictor of mobility-related disability in older men and women. These findings suggest that high body fatness in old age should be avoided to decrease the risk of disability.

Adipose Tissue↗
PubMed1997

Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing.

In order to assess the possible role of carboxypeptidase E (Cpe) in pro-CCK processing, tissues from the Cpe(fat)/Cpe(fat) mice were analyzed for CCK content and molecular forms using specific RIAs directed against different portions of the prohormone. Levels of amidated CCK were decreased by about 74% in whole brain of Cpe(fat)/Cpe(fat) mice in comparison to control mice, while levels of amidated CCK in intestine were only reduced by about 36%. In contrast, using an antiserum specific for CCK Gly Arg Arg, Cpe(fat)/Cpe(fat) mice brain had about 13-fold higher levels of this peptide relative to controls, while levels were identical in mutant and control duodenal tissue. This study demonstrates a regional difference in the involvement of Cpe in pro-CCK processing. The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33. The Cpe(fat)/Cpe(fat) mouse phenotype obviously involves multiple endocrine defects, however, it is tempting to speculate that this severe CNS deficiency in CCK 8 may be related to the adult-onset obesity seen in this mutant mouse.

Animals↗
PubMed1990

Body fat mass, body fat distribution, and plasma hormones in early puberty in females.

We examined whether there is a relationship between body fat mass or body fat distribution and hormonal profiles in the plasma of early pubertal girls. Thirty-five apparently healthy caucasian schoolgirls were selected for Tanner's breast development stage M2; they had all been classified as being stage M1 6 months earlier. Body fat mass had no relationship with the total plasma sex steroid concentration or gonadotropins. However, body fat mass was correlated with the fraction of testosterone that was not bound to sex hormone-binding globulin and considered the fraction available for biological activity. Body fat distribution, rather than body fat mass, was different in relation to the total concentrations of estrone, estradiol (E2), and testosterone as well as the percentage of available E2 or testosterone. Girls with fat localized predominantly on the hips had the highest levels of sex steroids and gonadotropins. It seems likely that this type of fat distribution is a result of ovarian activity. Girls with predominantly abdominal fat were also more obese and showed increased plasma levels of total E2 and a lower androgen/estrogen ratio in plasma, possibly due to increased aromatization, especially in abdominal adipose tissue. The findings suggest a reciprocal relationship among body fat distribution, plasma sex hormone levels, and availability of sex steroids in early female puberty.

Adipose Tissue↗
PubMed1993

Relationship of body fat percentage and fat distribution with dehydroepiandrosterone sulfate in premenopausal females.

Dehydroepiandrosterone (DHEA) has an antiobesity effect in rodents, and elevated endogenous levels of its sulfate ester (DHEAS) are associated with reductions in risk for cardiovascular disease (CVD) in men. To examine the association of body fat and fat distribution, established correlates of CVD and CVD risk factors, with circulating DHEAS levels in women, we measured trunk and limb skinfold thicknesses and circumferences, total and regional body fat from dual energy x-ray absorptiometry (DXA), and serum levels of DHEAS in 96 healthy Caucasian females aged 28-39 yr. Body mass index, percentage fat from DXA and the waist-to-hip ratio were not significantly correlated (r < or = 0.15, P > or = 0.156) with serum DHEAS levels, regardless of statistical control for age, smoking behavior, and fasting status. However, the ratio of trunk/total skinfold thicknesses (r = 0.23, P = 0.030) and the percentage of total fat located on the trunk from DXA (r = 0.32, P = 0.002) were positively correlated with DHEAS, whereas the ratio of leg/total skinfold thicknesses (r = -0.25, P = 0.015) and the percentage of total fat located on the legs from DXA (r = -0.25, P = 0.015) were inversely correlated with DHEAS after adjusting for age, smoking, and fasting status. With the exception of the trunk/total skinfold thickness ratio, the correlations of DXA- and skinfold-derived estimates of fat distribution remained significant (P < or = 0.033) even after further adjustment for percentage fat or body mass index. It is concluded that increased amounts of total fat located on the trunk and decreased amounts of total fat located on the legs are associated with increased serum DHEAS concentrations in normally menstruating females.

Adipose Tissue↗
PubMed2000

Prediction of crude fat content of longissimus muscle of beef using the ratio of fat area calculated from computer image analysis: comparison of regression equations for prediction using different input devices at different stations.

Crude fat content of longissimus (ribeye) muscle of beef cattle was predicted from a ratio of fat area (RFA) to area of ribeye muscle calculated from computer image analysis (CIA). Cross sections of 64 ribeyes taken from the 6-7th rib from cattle at experiment station A and cross sections of 94 ribeyes taken from the 6-7th rib from cattle at Experiment Station B were used in this study. Slices (1 to 1.5 cm in thickness) of just the Longissimus dorsi were homogenized and sampled for chemical estimation of crude fat content using petroleum ether. Crude fat content as determined from chemical analysis was used as the true estimate of fat content. A CCD (charge-coupled device) camera was used as the input device at Experiment Station A, and a single-lens reflex camera was used at Experiment Station B to photograph ribeyes for CIA. The contour comparison method, which assigns a threshold value for each marbling particle, was used to obtain accurate binarization in this study. Minimum and maximum of chemical measurements of crude fat were 2.1 and 39.8%, and for CIA calculation of the RFA were 6.1 and 56.8%, respectively. This range covered almost the complete range of the beef marbling standard used in carcass grading in Japan. The equation for the regression of the crude fat content (Y) on RFA (X) calculated from CIA for all of the data was Y = .793X-3.04 with r2 = .96. Regression equations for prediction of crude fat percentage from RFA taking into consideration the effect of experiment station were Y = .741X-2.22 with r2 = .91 for Experiment Station A, and Y = .782X-2.54 with r2 = .91 for Experiment Station B. Analysis of covariance showed that the effects of experiment stations on intercepts and slopes were not significant (P > .10). The ranges of differences between actual and predicted crude fat content from the prediction equation that was calculated without consideration of the effect of station were -6.4 to 4.0%. CIA of cross sections of the ribeye muscle seems to have potential for prediction of crude fat content.

Adipose Tissue↗
PubMed2000

Gravity separation of raw bovine milk: fat globule size distribution and fat content of milk fractions.

This project determined effects of time and temperature on changes of fat globule size distribution and fat content in milk fractions during gravity separation. Fresh raw bovine milk was gravity separated at 4 or 15 degrees C. After 2, 6, 12, and 48 h, seven fractions, from bottom fraction (F1) to top fraction (F7), were successively drained from a separation column. Higher temperature resulted in a faster rate of fat separation. Within 2 h, large fat globules had already moved to the top, and the volume mean diameter of F7 increased from 3.13 microm (without separation) to 3.48 and 3.64 microm, respectively, at 4 and 15 degrees C. In F7, there was little change in globule size distribution after 2 h, but fat content continued to increase with separation time. The fat content of F7 reached 26.6% after 48 h at 4 degrees C, achieving a 58.8% creaming capacity. For F1 to F6, longer separation time resulted in smaller fat globule sizes and lower fat contents, especially for F1. After 48 h at 4 degrees C, the volume mean diameter of F1 decreased from 3.23 microm (without separation) to 1.16 microm, and fat content decreased from 3.75% (without separation) to 0.20%. Gravity separation may have unique applications in the dairy industry today. Its simplicity makes it an effective procedure for small-scale dairy product manufacturers to produce milks with a range of fat contents without using a centrifugal cream separator.

Animals↗
PubMed1988

Fat deposition in a broiler sire strain. 3. Heritability of and genetic correlations among body weight, abdominal fat, and feed conversion.

Body weight, abdominal fat, and feed conversion were measured in ad libitum-fed pedigreed chickens of four lines selected from a broiler sire strain. Lines were selected for four generations for a low amount of abdominal fat (AF), a favorable feed conversion (FC), a high body weight after restricted feeding (GR), and a high body weight after ad libitum feeding (GL). A total of 2,400 pedigreed chickens from three hatches were reared by line in groups on litter and 864 chickens were tested for individual feed conversion in individual cages. The h2 from the sire component for the four lines combined were for body weight, .27 (litter) and .22 (cages); for weight of abdominal fat, .54 (litter) and .40 (cages); for percentage abdominal fat, .53 (litter) and .45 (cages); and for feed conversion, .44 (cages). Analysis within line and sex indicated that, in the relatively fat GR and GL lines, sex-linked inheritance could be involved for abdominal fat. In the leaner AF and FC lines this was not the case. Genetic correlations (sire estimate) for the four lines combined were, between body weight and weight of abdominal fat, .58 (litter) and .55 (cages); between body weight and percentage abdominal fat, .36 (litter) and .47 (cages); between body weight and feed conversion, .16 (cages); between weight of abdominal and feed conversion, .43 (cages); and between percentage abdominal fat and feed conversion, .44 (cages). Genetic correlations did not differ significantly between sexes, but in the AF and FC lines, the genetic correlation between body weight and abdominal fat was higher (AF: .80, FC: .76) than in the GR (.14) and GL (.68) lines.

Abdomen↗
PubMed1993

Early feed restriction of broilers: effects on abdominal fat pad, liver, and gizzard weights, fat deposition, and carcass composition.

A total of five experiments were conducted to investigate the effects of early feed restriction on organ weights, fat deposition, and carcass composition in broilers. In Experiments 1 and 2, broiler chicks were reared in litter pens for 49 days, whereas Experiments 3, 4, and 5 were conducted in battery cages for 28 days. Feed restriction in all experiments was accomplished by providing male broiler chicks 40 kcal per bird per day for 7 (Experiments 1 and 2) or 6 (Experiments 3, 4, and 5) days, starting at 4 days of age. Feed restriction of broiler pullets in Experiment 1 was imposed from 4 to 9 days of age. Furthermore, the starter and grower diets in Experiment 2 contained either 1 or 4% added fat and the starter diets in Experiments 3, 4, and 5 contained either 21 or 26% protein. No significant differences were observed for abdominal fat pad and gizzard weights, liver and carcass fat, or carcass protein between early restricted birds and ad libitum controls at 49 days of age in Experiments 1 and 2. Furthermore, with the exception of Experiment 4, no differences in abdominal fat pad weights were observed among the different feeding regimens. Significant increases in abdominal fat pad weights, percentage liver, and percentage carcass fat were noted for females at 49 days of age when compared with male broilers. Carcass fat was significantly higher and carcass protein was significantly lower in broilers fed commercial versus reduced fat diets. Broilers fed a 21% protein diet had significantly heavier abdominal fat pad weights at 28 days of age than birds fed a 26% protein diet.

Adipose Tissue↗
PubMedDate not supplied

[Interchangeability of the fat-to-fat-free mass ratios obtained by means arm anthropometric measures, skinfold thickness, and bioelectrical impedance].

BACKGROUND: Body fat, fat free mass and the relationship between both, the fat-to-fat-free mass ratio are useful parameters in the nutritional evaluation of the patient. The aim of this study is to evaluate the degree of agreement among the fat-to-fat-free mass ratios obtained by arm anthropometric measures (fat-muscle index, FMI), Siri equation for the sum of four skinfold thickness (body fat-muscle index, BFMISiri) and triceps skinfold (BFMItriceps) and bioelectrical impedance (BFMIOmron) methods. METHODS: This is a cross-sectional study. A total of 145 patients were evaluated by anthropometry and bioelectrical impedance (Omron BF 300), being estimated the agreement through the Intraclass Correlation Coefficient (ICC) and Bland-Altman method. The reference method was BFMISiri. RESULTS: The ICC between BFMISiri-BFMItriceps were 0.9304 (0.9035; 0.9498), between BFMISiri-FMI of 0.7726 (0.6846; 0.8361) and between BFMISiri-BFMIOmron of 0.9114 (0.8771; 0.9361). BFMItriceps (limits of agreement -0.171 to 0.117) show the best agreement according to Bland-Altman analysis with BFMISiri, followed by BMFISiri-BFMIOmron (-0.186; 0.178). The agreement limits between FMI and BFMISiri (-0.2; 0.42), BFMItriceps (-0.26; 0.42) or BFMIOmron (-0.292; 0.504) were beyond of the established cut-off points (-0.2; 0.2). CONCLUSIONS: Due to the nature of the statistical agreement BFMItriceps and BFMIOmron are methods interchangeable methods between them and with BFMISiri. FMI is not interchangeable with BFMISiri, BFMIOmron or BFMItriceps. These results suggest that FMI cannot estimate properly the body composition. BFMItriceps and BFMIOmron are valid alternative methods to be used instead BFMISiri in the fat-to-fat-free mass ratio assessment.

Adipose Tissue↗
PubMed1992

Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women.

In this study, total body fat content and fat topography were related to glucose metabolism in the basal and insulin-stimulated states in 18 nonobese and 18 obese premenopausal nondiabetic women. All subjects received a euglycemic insulin (20 mU.min-1.m2) clamp study in combination with [3-3H]-D-glucose infusion and indirect calorimetry to quantitate total body glucose uptake, glucose oxidation, and nonoxidative glucose disposal. Total body fat content was determined with tritiated water, whereas body fat distribution was estimated from the WHR, the STR, and the VSR (measured by magnetic resonance imaging). In the postabsorptive state, total body glucose utilization, glucose oxidation, and nonoxidative glucose disposal rates were similar in nonobese and obese women, whereas during the insulin clamp all three metabolic parameters were reduced significantly in the obese group. In nonobese women, total body fat content was related inversely to both total and nonoxidative glucose disposal during the insulin clamp, whereas no relationship was found between glucose metabolism (total, oxidative, and nonoxidative) and WHR, STR, or VSR. In contrast, in obese women, no relationship was observed between total body fat content and any measure of insulin-mediated glucose metabolism. However, both WHR and VSR were related inversely to total, oxidative, and nonoxidative glucose disposal rates during the insulin clamp. These results suggest that total body fat content and body fat topography are associated differently with insulin-mediated glucose metabolism in nonobese and obese women. In the nonobese women, total body fat mass appears to be a primary determinant of tissue sensitivity to insulin, whereas in obese women, body fat topography exerts a more dominant effect.

Adipose Tissue↗
PubMed1988

Relation between energy expenditure and body composition in man: specific energy expenditure in vivo of fat and fat-free tissue.

The relationship between energy expenditure and body composition, in terms of fat and fat-free masses, has previously been described by a variety of predictive regression equations with parameters devoid of physiological content. We present here results obtained by calculating the specific energy expenditure, ie, the energy expenditure per unit of mass, of fat and fat-free tissue on the basis of measurements of the total energy expenditure (EE), the masses of fat (FM), and fat-free (FFM) tissue using the following simple model: EE = k1.FM + k2.FFM where k1 and k2 are the specific energy expenditures of fat and fat-free tissue, respectively. The results of observations on 104 women at rest yielded values for k1 and k2 of 0.31 and 1.35 watts/kg of fat and fat-free mass, respectively, with standard errors of estimate of 0.074 and 0.052 watts/kg, respectively. Analysis of several series of measurements, from other sources and on smaller samples of subjects, yielded similar values at rest but with larger standard errors of estimate. Data from subjects performing varying amounts of work in 24-h measurements showed, as expected, larger values for both tissues. The results explain to a very large extent the well-established relation between resting metabolic rate and body weight, ie, a linear relation with a non-zero intercept. The results also offer a clear-cut explanation for the well known difference in energy expenditure between men and women with the same body weight.

Adipose Tissue↗
PubMed1987

The effects of fat-free, saturated and polyunsaturated fat diets on rat liver and plasma lipids.

The liver and plasma lipids and fatty acid composition of rats fed synthetic diets of differing fat type and content were studied. All animals were starved for 48 hr and then refed a high carbohydrate, fat-free diet for 48 hr. They were then divided into three groups and fed for an additional 48 hrs the following: group 1, the fat-free diet; group 2, a diet containing 44% of calories from corn oil; and group 3, a diet containing 44% calories from completely hydrogenated soybean oil. The total lipid concentration of the liver in the animals on the fat-free diet was elevated at 72 and 96 hr. The addition of either saturated or unsaturated fat in the diet at 48 hr prevented this accumulation. The total phospholipid and cholesterol concentrations of the liver were relatively uninfluenced by any diet in this study. Plasma total fatty acid concentration was elevated at 72 hr in the animals on a fat-free diet compared to those fed the stock diet, starved for 48 hr or fed the fat-containing diets. By 96 hr, however, plasma fatty acid concentrations in all groups were similar to those in animals fed only the stock diet. The release of de novo synthesized fatty acids into plasma from the liver was strongly inhibited by dietary fat, either saturated or polyunsaturated. With the fat-free diet there was a significant increase in the saturated and monounsaturated fatty acids in both liver and plasma.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗