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Hazardous materials management and control program at Oak Ridge National Laboratory--environmental protection.

At a large research laboratory facility the management and control of hazardous materials, and their subsequent wastes can be an unmanageable task. Environmental regulations, mandated by the Resource Conservation and Recovery Act of 1976, established a Federal program to provide comprehensive regulation of hazardous solid waste materials from their generation time to their disposal. In an effort to comply with these regulations, a Hazardous Materials Management and Control Program was created at Oak Ridge National Laboratory. The program provides personnel with specific guidelines for the procurement, use, storage, transportation and disposal of hazardous materials/wastes, and ensures that they are managed in a manner which adequately protects all personnel, the general public, and the environment.

Legislation as Topic↗

Soybean (Glycine max [L.] merrill) as a short-term assay for study of environmental mutagens. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

The soybean (Glycine max [L.] Merrill) spot test is suggested as a preliminary screening test for environmental mutagens. This system makes use of various types of spots that originate from the treatment of seeds or seedlings with mutagens. The homozygous dominant y11y11 dark green leaves may show light green and very dark green spots; the heterozygous y11y11 light green leaves may show dark green, yellow or twin spots; and the homozygous recessive y11y11 yellow leaves show light green receptors. The interpretation is that twin spots on the y11y11 leaves originate from somatic crossing-over, and the singles originate primarily from losses or gains of the segments or chromosome carrying the gene y11 or y11. The yellow plants (y11y11) can produce light green sectors if y11 mutates to y11. Studies carried out with a host of chemical and physical agents lend support to the idea that the soybean system can distinguish between several genetic mechanisms underlying the formation of spots. Spots are detected against their native genetic and phenotype background, thus minimizing the effects due to physiological changes. The system is rapid (4-5 weeks per chemical), inexpensive, and involves an eukaryotic organism. It has the advantage of being adaptable for liquid solutions of chemicals, solid wastes, emulsions of chemicals (e.g., in lanolin), and gaseous products.

Crossing Over, Genetic↗

The clinician's role in environmental protection.

The clinically working medical doctors are insufficiently trained in epidemiology and community medicine. They are, therefore, not sufficiently aware of health related environmental factors. They cannot avoid the difficulties of generalizing clinical observations because of small numbers and the long latency period in chronic disease evolution. As centralization of treatment is not generally possible we must improve our systems for registration of environmentally induced disease and health monitoring of the population. Finally, the clinicians should be more concerned with follow-up of administrative disease preventing actions.

Environmental Health↗