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Discrimination learning as the summation of excitation and inhibition.

Pigeons received either excitatory, inhibitory, or combined excitatory and inhibitory (intradimensional) training to discriminate line-tilt stimuli. Algebraic summation of relative-generalization gradients obtained after separate excitatory and inhibitory training sessions was used to predict characteristics of gradients after intradimensional training. The good agreement between obtained and predicted gradients provided support for gradient-interaction theory.

Animals

Discrimination learning of an instrumental response in individual Drosophila melanogaster.

By using a unique methodology and a versatile series of choice points in two distinct apparatuses, individual Drosophila were shown to possess the ability to learn. This behavior can be controlled by a discriminative stimulus (substrate texture). Following a correct response in the presence of the discriminative stimulus at a horizontal choice point, fruit flies bred for negative geotaxis were given the opportunity to ascend a vertical alley leading to another choice point. When cues were consistent, reliable learning occurred. When cues were inconsistent, learning did not occur. Cue reversal produced the classic temporary increase in "incorrect" responses. The success of this paradigm is due, in large part, to the reduction of noxious and competing stimuli.

Animals

Absence of impairments in spatial and temporal discrimination learning in Lewis rats after chronic ethanol consumption.

Many studies reported that chronic ethanol consumption leads to cognitive dysfunction in rodents. It has been suggested that the effects of chronic ethanol consumption resemble those of aging because of the behavioral and neurochemical similarities between the two processes. The present study examined the effects of a chronic ethanol treatment (20% aqueous solution) in Lewis rats on performance in three different tasks: the Morris spatial navigation task, a cone-field task, and a temporal discrimination task. Although an age-related deficit was found in water escape learning, chronic ethanol consumption did not affect the performance of adult and old rats. The results of this experiment were, however, not conclusive. No differences between old control and ethanol-treated rats were found for spatial (cone-field task) and temporal discrimination learning. However, old ethanol-treated rats showed a transient tendency to perseverate in the temporal discrimination task. The present results are at variance with the generally found cognitive impairments after chronic ethanol consumption using aqueous solutions. It is suggested that the effects of ethanol could be related to strain of rat, task complexity, method of ethanol administering, and housing conditions and may explain the discrepancy between results.

Aging