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Are the limits of the mind expandable?

Considering the faculty for learning as a primary human characteristic and means to adaptation, any influence that may reduce this faculty becomes a hazard. Sensory and cognitive stimulation of inappropriate strength, both underload and overload, appears to be one such hazard. The central theme of this paper is overload, in contrast to writings in the 1950s and 1960s which dealt mainly with the ill effects of sensory and cognitive deprivation. The presentation consists of four parts: An account of the author's investigation in which the learning performance of students was correlated with varying input loads; critiques of overload by commentators of different backgrounds; the effects of input on man in the perspective of evolution and of brain-mind identity; a recommendation of physiological and biochemical testing of students exposed to varying input loads in correlation with their learning performance. The physical testing is either to ratify or to invalidate two conclusions reached in observations on the behavioral level. These conclusions are (1) that overload, quantitative or qualitative, obstructs the human capacity for learning, and that such interference may to some extent be a reflection of undesirable changes in autonomic conditions; and (2) that preventive measures can be taken by the structure of an input that reduces it in the perception of its receivers.

Biological Evolution↗

Secondary theorem of natural selection in biocultural populations.

The "Secondary Theorem of Natural Selection," an extension of Fisher's fundamental theorem, states that the rate of change in the mean of an arbitrary character in response to selection is proportional to the additive genetic covariance between the character and fitness. Here I derive an expression for the change in the mean value of a trait subject to both genetic and cultural transmission. I start with the one-locus case under generalized mating and cultural transmission from parents to offspring, then proceed to the two-locus case. My results support previous work on the effects of nongenetic inheritance by showing that (i) cultural transmission introduces a timelag in the population response to selection; (ii) with cultural transmission the effects of selection persist even after selection is relaxed; and (iii) cultural transmission can either enhance or retard phenotypic evolution relative to that obtained under purely genetic transmission.

Biological Evolution↗

Is there an evolutionary mismatch between the normal physiology of the human dopaminergic system and current environmental conditions in industrialized countries?

A large body of evidence has recently defined a field theory known as 'evolutionary mismatch', which derives its attributes largely from the fact that current environmental conditions are completely different from those in which the human central nervous system evolved. Current views on the evolutionary mismatch theory lack, however, any attempts to define which brain areas or neuronal circuits should be mostly involved in coding such misevolved traits and to what extent our neurobiological knowledge can be applied to the topographical localization of a specific psychopathology. In this respect the mesocorticolimbic dopaminergic circuits have long been misconceptualized as simple reward or reinforcement systems. Instead, they motivate and coordinate the functions of the higher brain areas that mediate planning and foresight and direct finalized movement in both animals and humans. These systems make animals intensely interested in exploring the world around them, but by the same means they also make them susceptible to the environmental stimuli that have been sought and consumed. It is has been speculated that the cortical dopamine targets that developed most recently in phylogeny are of particular functional value, and that the mesocorticolimbic dopaminergic system is involved in more complex integrative functions than previously assumed. In the present paper I will argue that some mental disorders may have their deep roots in the evolutionary mismatch between the normal physiology of the mesocorticolimbic dopaminergic system and the current environmental conditions in affluent societies.

Animals↗

Fundamental theorem of natural selection under gene-culture transmission.

A generalized fundamental theorem of natural selection is derived for populations incorporating both genetic and cultural transmission. The phenotype is determined by an arbitrary number of multiallelic loci with two-factor epistasis and an arbitrary linkage map, as well as by cultural transmission from the parents. Generations are discrete but partially overlapping, and mating may be nonrandom at either the genotypic or the phenotypic level (or both). I show that cultural transmission has several important implications for the evolution of population fitness, most notably that there is a time lag in the response to selection such that the future evolution depends on the past selection history of the population.

Animals↗

The double-eyelid operation in Japan: its evolution as related to cultural changes.

Of the many aspects of aesthetic surgery, the double-eyelid operation generates the most interest for Japanese surgeons, as there has been an enormous demand for it by patients who are fashion-conscious. It has been possible to locate 32 operative procedures that have been published in the Japanese literature over the past ninety years. Some of these procedures have been reviewed here in relation to the cultural and social changes which are important factors determining the extent of the demand for the operation and which correlate with various changes in surgical technique. This study chronologically describes each of the principal methods related to these social changes and also considers the influence of cultural fads and fashions.

Asian People↗

[The nature of personality: a co-evolutionary perspective].

Personality psychologists' attempts to explain human diversity have traditionally focused upon processes of person-situation interaction, and genotype-environment interaction. The great variability of genotypes and environments within cultures has remained unexplained in these efforts. Which processes may be responsible for the genetic and environmental variability within cultures? Answers to this question are sought in processes of genetic-cultural coevolution: mutation and sexual recombination of genes, innovation and synthesis of memes (units of cultural transmission), genotype-->environment and meme-->environment effects, and frequency-dependent natural and cultural selection. This twofold evolutionary explanation of personality differences within cultures suggests that a solid foundation of personality psychology requires bridging biology and cultural science.

Biological Evolution↗

Cultured epidermal sheet grafting with Hemaseel HMN fibrin sealant on nude mice.

Grafting of cultured epidermal sheets is a promising technique for skin restoration in extensive burns, but the technique has some limitations, resulting in variable graft takes. These experiments were designed to evaluate the innocuity of Hemaseel HMN fibrin sealant in the grafting process and in vivo evolution of cultured epidermis. A total of 30 mice were grafted, 15 were controls, 15 received tissue sealant application before the deposition of the cultured human epidermal sheets. Seven days after transplantation, compared to controls, the percentage of graft take over the total surface area grafted was greater in animals that had received the tissue sealant application. No difference was found 14 and 21 days postgrafting. In contrast, the percentage of graft take over the bony area (spinal) was significantly increased in animals grafted with previous application of sealant compared to controls at 7, 14 and 21 days postgrafting. Immunohistological and ultrastructural analysis showed that the evolution of the cultured human epidermis after transplantation was similar in both groups. The basement membrane was well structured 21 days after transplantation. The sealant was present at 4 days but not at 21 days postgrafting. Therefore, we conclude that the application of fibrin sealant before cultured epidermal sheet deposition on nude mouse graft bed is innocuous and enhances their mechanical stability. Since in this nude mouse system Hemaseel HMN fibrin sealant increased the percentage of graft take over areas difficult to engraft, we think that it may be advantageous in cultured epidermal sheet grafting on burn patients.

Animals↗

The population genetics of phenotypic deterioration in experimental populations of Bacillus subtilis.

Although many examples of trait loss exist in nature, the underlying population genetic mechanism responsible for the loss is usually unknown. Selective or neutral processes can result in the deterioration of a trait, and often one of these is inferred based on indirect evidence. Furthermore, selective pressures that are unique to particular environments and the effect these might have on the population genetic cause of trait loss are not well understood. Here we describe an experimental evolution system where two different environments were used for addressing the population genetic cause of trait loss throughout evolutionary time. We found that growth in minimal medium (i.e., prototrophy) was lost in all populations regardless of the experimental environment and that the pattern of trait loss in one environment was due to selection, whereas in the other environment the cause remains inconclusive.

Bacillus subtilis↗