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Results for “Chronic sinusitis”

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PubMed1984

Serum bactericidal effect on capsulated and non-capsulated Haemophilus influenzae in chronic sinusitis.

Study on the incidence of bactericidal (BC) antibodies to a Haemophilus influenzae type b and a non-capsulated H. influenzae was carried out on sera from 50 healthy subjects, and from 30 patients with chronic sinusitis. Of the 50 sera from normal subjects, only one (2.0%) lacked BC antibodies to the H. influenzae type b, whereas 13 (26.0%) lacked BC antibodies to the non-capsulated H. influenzae. All of the 30 sera from patients with chronic sinusitis were bactericidal for the H. influenzae type b, whereas only three (10.0%) lacked BC antibodies to the non-capsulated H. influenzae. Specific IgG, IgM and IgA antibodies to the non-capsulated H. influenzae in serum were determined by the indirect fluorescent antibody assay. Of the 22 sera tested in this study, 15 (68.0%) had antibodies of at least the IgG, IgM, or IgA classes; with IgG occurring most often. These data suggest that a lack of circulating BC antibodies to both H. influenzae isolates is not associated with the chronic carriage of these organisms by patients with chronic sinusitis.

Adolescent↗
PubMedDate not supplied

The treatment of chronic sinusitis in six cats by ethmoid conchal curettage and autogenous fat graft sinus ablation.

Six cats with chronic recurrent rhinitis and frontal sinusitis were treated by surgical ablation of their frontal sinuses by the implantation of autogenous fat grafts and curettage of the remaining ethmoid conchae. Deep nasal bacterial cultures and skull radiographs were performed before surgery. Excellent results were achieved in four of six cats and there was significant improvement in two of six cats. Median follow-up time was 15 months. Subcutaneous emphysema over the temporal area was managed by needle aspiration and bandaging. Frontal sinus ablation with autogenous fat graft in combination with ethmoid conchal curettage appears to be an effective treatment for chronic sinusitis in cats.

Adipose Tissue↗
PubMed2001

Heating of air in the nasal airways in patients with chronic sinus disease before and after sinus surgery.

The main goal of this study was to determine the influence of sinus surgery on the heating of inspired air in the nose. Intranasal temperature values of 22 patients with chronic sinus disease were measured after inspiration at different locations in the nasal cavity. Measurements were done before and 6-8 weeks after sinus surgery. The patients were compared to 22 healthy control subjects. Nasal airway temperature did not differ between the two study groups at any location in the nasal cavity. Nasal decongestion was without significant influence on temperature values in the patients and the volunteers. There was no significant difference of nasal airway temperature before and after sinus surgery. Even after sinus surgery the main area of heating of inspired air seemed to be the anterior part of the nose. Sinus surgery in patients with chronic sinus disease does not seem to influence heating of air in the nasal cavity.

Adult↗
PubMedDate not supplied

[Radiologic imaging of chronic sinusitis in the adult].

The diagnosis of chronic sinusitis is based on clinical presentation, nasal endoscopy and CT scan. As a matter of fact, the CT scan of the paranasal sinuses is absolutely necessary to characterise the lesions, to visualise anatomic variations which are risk factors for the endoscopic surgery and to follow up treated and/or operated patients with recurrent symptoms. Nowadays, plain films of paranasal sinuses do not have any indication. MR Imaging may be indicated in selected cases of complicated sinusitis and of pseudotumors associated to sinusitis.

Adult↗
PubMed2001

Concentrations of serum immunoglobulins and antibodies to pneumococcal capsular polysaccharides in patients with recurrent or chronic sinusitis.

A study was carried out to search for underlying immunoglobulin deficiencies in 25 patients with recurrent or chronic sinusitis. The mean duration of the patient histories of recurrent or chronic sinusitis was 7.2 years. Concentrations of serum immunoglobulins and specific pneumococcal antibodies were measured in the patients and in 25 age- and sex-matched control individuals. The mean serum IgA concentration (1.6 g/L) was lower in the patients than in the control individuals (2.1 g/L, p = .024). On the other hand, the mean serum concentration of IgG antibodies to pneumococcal type 14 polysaccharide was higher in the patients (2.54 microg/mL) than in the control individuals (0.92 microg/mL, p = .008). However, elevated concentrations of IgG antibodies to pneumococcal type 14 polysaccharide were detected mainly in patients with the highest serum IgA concentrations. The results suggest that in a subpopulation of patients with a long-lasting history of sinusitis, a low serum IgA concentration may be associated with a susceptibility to sinusitis.

Adult↗
PubMed1983

Studies on proactivator from the paranasal mucous membrane in chronic sinusitis.

We succeeded in differentiating the proactivator (PA) in tissue extract of paranasal mucous membrane with chronic sinusitis by the gel filtration technique. Furthermore, the results demonstrated that PA in the tissue extracts of the paranasal mucous membrane with chronic sinusitis and antrochoanal polyp was unrelated to the antigenicity of plasminogen. In particular, it was clarified that the tissue extract of antrochoanal polyp as a source of PA was not related to the antigenicity of plasminogen.

Antigen-Antibody Complex↗
PubMed1995

[Olfactory disturbance caused by chronic sinusitis].

Sinusitis has been reported to be one of the major causative etiologies of olfactory disorder. According to our data during last 3 years, 47.5% of all cases of olfactory disorder were attributed to sinusitis. Persistent olfactory disturbance was often critical even after resection of the pathological sinus mucosa by surgery for chronic sinusitis. Accordingly, olfactory epithelial inflammation involved in sinusitis may be considered another important causative factor disturbing the restoration of olfactory acuity. To elucidate this hypothesis, the following experimental and clinical studies were carried out. (1) A morphological study was done with specimens taken from the olfactory cleft of rabbits with experimentally induced sinusitis to analyze the inflammatory effects, and the degree of inflammatory damage was compared, histopathologically between olfactory and respiratory epithelium. SEM observation in the morphological study showed delayed healing in the olfactory portion in comparison with the respiratory portion (p < 0.01). Cell proliferation activity as determined by immunohistochemical study with bromodeoxyuridine (BrdU) was significantly greater in the respiratory area of the cases with sinusitis than in the control (p < 0.01). Cell proliferation status may play a significant role in this delay. (2) Olfaction tests were performed in patients with sinusitis accompanied with olfactory disturbance. In addition to both T&T olfactometry and intravenous olfactometry using fursultiamine (Alinamin Test), Smell Identification Test (SIT) and Threshold Test by graded Phenyl Ethyl Alchol (PEA) were applied to estimate the olfactory acuity of the patients with sinusitis. The results of SIT and PEA tended to parallel not the Alinamin Test but T&T olfactometry. Results showed that the olfactory disorder caused by sinusitis tended to be severe. The results showed that the epithelial factor is important in explaining olfactory disorder etiologically in cases of sinusitis. In particular, olfactory disturbance tended to persist.

Animals↗
PubMed1997

[Ultrastructural observation on the uncinate process of chronic sinusitis].

The ultrastructures of the uncinate processes (UP) obtainel from 16 patients with clinical diagnosis of chronic sinusitis were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results showed that there were three main surface cell types on the UP: Most of the cilia was leaned, fractured and in disorder; Gaps of the cells increased obviously; Squamous cell metaplasia was seen; The endoplasmic reticulums and mitochondria in cytoplasm were expanded moderatly or seriously. The morphological changes indicated that mucus transportation functions in the anterior ethmoid region and the middle meatus were damaged. It is of great importance in occurrence and development of chronic sinusitis. The demaged nasal mucosa epithlial cells are repairable and reproducible.

Adult↗
PubMed2004

Protein nitration in chronic sinusitis and nasal polyposis: role of eosinophils.

OBJECTIVES: To investigate the possible role of eosinophil peroxidase (EPO) in 3-nitrotyrosine (3NT) formation. STUDY DESIGN AND SETTING: Observational study employing immunocytochemistry to assess the presence of 3NT, inducible nitric oxide synthase (iNOS), eosinophils, mast cells, neutrophils, and lymphocytes in ethmoid sinus mucosal biopsies from normal controls and subjects with allergic and nonallergic chronic sinusitis and nasal polyposis. RESULTS: 3NT was more evident in biopsies from sinusitis patients (2.67 +/- 0.14, n = 21) than in healthy mucosa (0.43 +/- 0.2, n = 7, P < 0.01), but scores in atopic and nonatopic subjects were similar. Colocalization studies confirmed that 3NT was largely confined to eosinophils. No relationship was found between 3NT and other immune cells. 3NT detection was not correlated with the amount of immunostaining for iNOS. SIGNIFICANCE: Chronic sinusitis is accompanied by 3NT formation, which is largely restricted to the eosinophils, and likely driven by the action of eosinophil peroxidase, rather than by nitric oxide levels. EBM RATING: B-2.

Adult↗
PubMedDate not supplied

Effects of fibrin sealant-containing antibiotics in a rabbit model of chronic sinusitis.

Postoperative complications of sinus surgery include bleeding, infection, and synechiae. Improved subjective outcomes in humans treated with fibrin sealant (FS) after endoscopic sinus surgery (ESS) have been reported. Streptococcus pneumoniae was used to initiate chronic sinusitis in occluded rabbit sinuses in order to evaluate the role of FS in mucosal healing. Six weeks later, all animals had maxillary antrostomies. Homologous FS-containing ciprofloxicin (100 mg/mL) and clindamycin (15 mg/mL) was applied topically to treatment rabbits (n = 9). Control rabbits (n = 10) received no antibiotics. Two weeks into the recovery phase after antrostomies, all animals were re-examined. Mucociliary transport velocity (mean +/- standard deviation in mm/minute) was measured in all sinuses (n = 38) during healthy (100% measurable, 13.82 +/- 4.16), infected (18% measurable, 4.74 +/- 0.42), and recovery phases (5% measurable, 6.30 +/- 4.67). In both groups, mucopurulent discharge was present in the majority of sinuses (control group 18/20, FS group 16/18). In addition, there was no significant difference in the recovery phase between the two groups when comparing changes in the size of antrostomies, light microscopy, or culture clearance. Scanning electron microscopy did suggest a possible improvement in ciliary regeneration in the FS group. Application of FS-containing antibiotics did not appear to improve healing after ESS in our rabbit model of chronic sinusitis.

Animals↗
PubMed1995

Antimicrobial management of chronic sinusitis in children.

This study retrospectively investigated the microbiology and management of 40 children who suffered from chronic sinusitis. The sinuses infected were the maxillary (15 cases), ethmoid (13), and frontal (seven). Pansinusitis was present in five patients. All aspirates were cultured for aerobic and anaerobic bacteria. A total of 121 isolates (97 anaerobic and 24 aerobic) were recovered. Anaerobes were recovered from all 37 culture-positive specimens, and in 14 cases (38 per cent) they were mixed with aerobes. Twenty-three beta-lactamase-producing bacteria were isolated from 16 (43 per cent) patients. The 15 patients who received clindamycin had the most rapid response to therapy and a change of therapy and surgical drainage was required in one case. Of the 16 patients who received amoxycillin or ampicillin, 16 responded to therapy, six needed a change of therapy, including four who also had surgical drainage. Of the six who were treated with erythromycin, three needed antibiotic change, two with surgical drainage. Of the three that received cefaclor, two were cured, and one had an antibiotic change. Resistant organisms were recovered in all the cases that required therapeutic change. These findings support the important role of anaerobic bacteria in the polymicrobial cause of chronic sinusitis in children, and the superiority of therapy effective against these organisms.

Adolescent↗
PubMed2003

Radiographic pattern of chronic sinusitis in Ilorin, Nigeria.

One hundred and thirteen patients (62 males and 51 females, aged 5-70 years) with chronic sinusitis seen between January 1995 and December 1998 in the Ear, Nose and Throat (ENT) Diseases Clinic of University of Ilorin Teaching Hospital, Ilorin, Nigeria are presented. A provisional diagnosis of chronic sinusitis was made if there were at least two of the following signs and symptoms: nasal blockage, nasal discharge, post nasal drip, excessive sneezing or halitosis. The radiographic abnormalities observed include gross mucosal thickening; haziness; complete opacity and air-fluid level. Seventy-eight (69.0%) showed abnormality in one or both maxillary antra; 39 (34.5%) in the ethmoid; 13 (11.5%) in the frontal; and 1(0.9%) in the sphenoidal sinuses. Thus the maxillary sinus was observed to be the most commonly involved in the disease process, while the sphenoidal sinus is the least commonly involved. This is consistent with findings in most similar studies.

Adolescent↗
PubMed2004

Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis.

BACKGROUND: Nasal polyps (NP) are characterized by pseudocyst formation, whereas the mucosa in chronic sinusitis (CS) only shows a limited oedema. Matrix metalloproteinases (MMPs) are a family of endopeptidases able to degrade the extracellular matrix. Differences in histological features between CS and NP might be related to the respective expression of MMPs and their tissue inhibitors (TIMPs). OBJECTIVE: The aim of this study was to investigate MMP-7, MMP-9 and TIMP-1 proteins in NP and CS in comparison with normal mucosa. METHODS: Nasal samples, obtained from controls (n = 10), from NP (n = 8) and from CS (n = 10), were analysed by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA). RESULTS: In NP, compared with controls, staining for MMP-9 and MMP-7 appeared in blood vessels. Matrix metalloproteinase-9-positive inflammatory cells could be detected in increased numbers in pseudocyst formations. Concentrations of MMP-9 protein was found significantly increased in both CS and NP compared with controls, while MMP-7 was significantly increased in NP compared with controls and CS. Tissue inhibitors of metalloproteinase-1 protein was significantly increased in CS and NP when compared with controls. CONCLUSIONS: Chronic sinusitis and NP show different pattern of MMP-7/-9 and TIMP-1 expression. We suggest that this difference in regulation of enzymes is related to the respective tissue remodelling observed in both diseases.

Biomarkers↗
PubMed2005

[Stenosed spaces of ostiomeatal complex and chronic sinusitis (an analysis of 94 cases)].

OBJECTIVE: To discuss the relationship between the stenosed spaces of ostiomeatal complex (OMC) and chronic sinusitis, and the relative factors causing the stenosed spaces. METHOD: Having nasal obstructing, discharging, headache and other clinical symptoms, 94 patients (179 sides of nasal cavity and sinus) were examined with coronal and high resolution CT scanning. The CT manifestations of the stenosed spaces and the anatomic variations of OMC were comparatively analyzed between the inflammatory sinuses and the normal ones. RESULT: The incidence of the stenosed spaces was difference between the inflammatory sinuses and the normal ones and there was significant statistically (P < 0.01). But, the incidence of the anatomic variations was not (P > 0.05). CONCLUSION: A significant correlation exists between the stenosed spaces of OMC and chronic sinusitis. It is helpful to the functional endoscopic sinus surgery (FESS) to understand various kinds of the stenosed space of OMC with sinusitis.

Adolescent↗
PubMed1995

Acute and chronic sinusitis. How to ease symptoms and locate the cause.

Patients with acute sinusitis often have purulent nasal discharge, facial pain, and congestion, whereas those with chronic sinusitis have more subtle signs. Infection, hyperreactivity reactions, anatomic obstruction, and underlying disease are among the causes and must be differentiated before appropriate care can be offered. Plain films and sinus transillumination may provide clues in adults but are of little value in young children. Computed tomography is much more sensitive but should be reserved for patients in whom maximal medical therapy has failed, who have a confusing presentation, or who are being considered for endoscopic surgery. Antibiotic therapy is still effective for bacterial infections, but penicillin-resistant organisms are on the increase. If there is no clinical improvement in 3 days, an agent with a broader spectrum of activity should be considered. A combination of agents and prolonged administration may be required for chronic sinusitis, and patients with recurrent symptoms may need endoscopic surgery. Such adjunctive agents as decongestants and saline or steroid nasal sprays may promote drainage. Antihistamines have no role in the treatment of sinusitis.

Acute Disease↗