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Results for “Chemosterilants”

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PubMed1981

Antimicrobial, insect sterilizing and ovicidal activity of some cobalt(II) and cobalt(III) complexes.

Twenty-one mixed-ligand complexes of cobalt(II) and cobalt(III) have been screened for their antimicrobial, insect sterilizing and ovicidal activities. Three of these cobalt(III) complexes exhibit broad antimicrobial spectra, including against human bacterial pathogens, dermatophytes and plant pathogenic fungi, while one exhibits feeble activity against a human pathogenic bacterium. These results have been compared with the activity of the corresponding cobalt(II) complexes, which have been found to be inactive, while the free ligands show reduced activity compared with the cobalt(III) complexes. Change in biological activity induced by a particular complex appears to be dependent on the composition of the first co-ordination sphere. Two of these complexes showed 50% inhibition of the conidial germination of Helminthosporium oryzae and Alternaria triticina. These results indicate their potential for use against human and plant pathogenic microbes. Minimum inhibitory concentrations of the cobalt(III) complexes were determined. Three of these cobalt(III) complexes have been tested for insect sterilizing and ovicidal activities on Dysdercus koenigi F. Positive sterilizing and ovicidal actions of [Co(BSOP)(NH3)2]NO3 (where BSOP-H2 is the Schiff base derived from salicylaldehyde and orthophenylene-diamine) were obtained. Possible mechanism(s) of all these activities are discussed qualitatively.

Animals↗
PubMed1980

An outpatient approach to female sterilization with methylcyanoacrylate.

MCA is a tissue adhesive which can be delivered transcervically to the Fallopian tubes by means of the FEMCEPT device. In the patients treated with this system, both prior to hysterectomy and on an ambulatory basis, there have been no significant complications or side effects. In the most recent series of ambulatory patients treated with the REMCEPT-MCA system, the bilateral tubal closure rate was 78%.

Ambulatory Care↗
PubMed1989

Transcervical sterilization with use of methyl 2-cyanoacrylate and a newer delivery system (the FEMCEPT device).

The increasing use of sterilization as a means of permanent contraception prompts the search for simpler, safer methods. Methyl 2-cyanoacrylate 0.6 ml was administered to the uterocornual tubal junction with the use of the FEMCEPT transcervical delivery system in 35 healthy parous women aged 30 to 44 years. Hysterosalpingography 4 months after the procedure showed bilateral tubal occlusion in 88.2% of the study participants. There were no complications in the study group, and there were no pregnancies among those who demonstrated bilateral tubal occlusion. The technique, which is safe, effective, and simple, could consideraly reduce anesthetic and operative risk in sterilization.

Adult↗