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[Enzootic calcinosis in 16 cows from 6 dairy farms in Unterengadin].

Enzootic calcinosis was diagnosed in 16 cows, which originated from 6 dairy farms located in the Unterengadin valley in Switzerland between 1,402 and 1,650 metres above sea level. During the winter, the cows were fed haylage, which contained up to 50 per cent golden oat-grass (Trisetum flavescens), and hay and grain. The first symptoms of enzootic calcinosis were noted in March 1998, when some of the cows developed locomotor abnormalities. Additional cases were diagnosed during the following three months. The most important clinical findings were decreased milk production, weight loss, frequent recumbency, difficulty in rising, kneeling while rising and feeding, stilted gait, arched back, shifting weight from one foot to another and reluctance to remain standing after being roused. Of the 16 cows, 5 had elevated concentrations of serum calcium and 10 had decreased concentrations of serum magnesium. All cows had normal or decreased concentrations of serum phosphorus, because the feeding of haylage containing golden oat-grass had been discontinued two months previously. In all of the cows, the most important postmortem findings were severe calcification of the aorta, iliac artery, brachiocephalic trunk and pulmonary artery.

Animals↗

Fingertip calcinosis cutis.

Calcinosis cutis, a rare disorder caused by an abnormal deposit of calcium phosphate into the skin, is observed in a variety of disorders. Peculiar conditions feature skin calcifications in children and may have an iatrogenic origin. The unusual case of a baby showing periodic transepidermal elimination of calcified nodules from her fingertips is reported. In this case, fingertip calcinosis cutis was probably caused by ischemic damage due to the venous obstruction that occurred during intensive care in the neonatal period.

Calcinosis↗

Periarticular calcinosis associated with anti-Jo-1 antibodies sine myositis. Expanding the clinical spectrum of the antisynthetase syndrome.

We describe a 58-year-old woman who developed interstitial lung disease (ILD), polyarthritis, and anti-Jo-1 antibodies, with no clinical evidence of myositis. Despite successful treatment with corticosteroid and azathioprine for her arthritis and pulmonary condition, she developed deforming arthropathy of the hands, with periarticular calcinosis. The association of anti-Jo-1 antibodies, ILD, and periarticular calcinosis with subluxing arthropathy sine myositis is rare, with few cases reported. This report expands the clinical spectrum of the antisynthetase syndrome, which is broader than previously reported.

Adult↗

Enzootic calcinosis in sheep: soil-plant-animal relationship.

Chemical compositions of soil, water, feeds, and forages on a farm where sheep were affected with calcinosis (experimental site) and a farm with sheep not affected with calcinosis (control site) were determined. The study lasted 1 year. It was observed that water from the experimental site had higher electrical conductivity and calcium level than from the control site. Higher conductivity indicated greater mineral content in the water. Soil from the experimental site had lower levels of potassium, nitrogen, and phosphorus and higher content of exchangeable calcium as compared with these values of the control site. Exchangeable Ca:Mg ratio for soil of the experiemntal site was twice greater than that of the control site. Forage plants of the experimental site had lower concentrations of nitrogen, phosphorus, calcium, magnesium, and copper, but higher values of potassium and sulfur. The K:Ca + Mg, K:P, and K:Ca ratios for plants from the experimental site were higher and Ca:P ratio was lower than those of the control site. Analysis of ruminal content of the affected sheep revealed higher K:Ca + Mg, K:P, and Ca:P ratios than those of the control sheep. Due to the close relationship of metabolism of calcium, phosphorus, potassium, and magnesium, evidence of the existance of their imbalances in feeds and forages of the affected farm possibly contributing to the causation of the pathologic calcification of soft tissues of the sheep has been presented.

Animal Feed↗

[The chief types of calcinosis of the coronary arteries of the heart].

On the basis of histological and some histochemical investigations of the coronary arteries of 150 persons who had died in the age of 10-79 year it was established that the main types of calcification of these arteries were the following: calcification of the inner elastic membrane (it can be determined only in a histological investigation); microgranular calcifications observed, as a rule, in the region of atherosclerotic plaques; laminar calcification which develops on places of necrotic areas in the fibrotically-changed intima of the arteries. Laminar calcification is responsible for the gravest forms of calcinosis. Calcification of atherosclerotic plaques, identified in macroscopic investigations of the arteries as microgranular, was closely connected with the evolution of atherosclerotic plaques and not infrequently progressed with their sclerosing. Vascularization of the changed vascular wall and the degree of its calcinosis were found as a rule to be inversely proportional.

Adolescent↗

Spontaneous regression of multiple tumoral calcinosis in a child.

We report a case of multiple tumoral calcinosis on the head and back of a one-year-old boy who had no renal diseases. After an excisional biopsy of one of the tumors from the occipital region, all of the tumors spontaneously regressed without any further surgical or medical treatment. Although he had neonatal hepatitis, his liver function improved as well as the course of the spontaneous regression of the tumoral calcinosis. There has been only one case of a child with this condition in the literature.

Calcinosis↗

Regression of cutis calcinosis with diltiazem in adult dermatomyositis.

Calcinosis cutis is common in several connective tissue diseases such as dermatomyositis, scleroderma or lupus erythematous. In dermatomyositis, it is more likely to concern children than adults but it is not exceptional in adults. Several treatments have been used empirically with inconsistent success. We report a case of adult cutis calcinosis associated with dermatomyositis which responded dramatically to treatment with diltiazem.

Calcinosis↗

Tumoral calcinosis: a case report.

Tumoral calcinosis is a rare tumour-like mass characterized by soft tissue calcification of obscure aetiology. A case of tumoral calcinosis is presented here, and its clinical, radiological and pathological features are described. The differential diagnosis versus hydatid cyst is discussed. Diagnosis is possible with imaging techniques but histopathological study is essential to establish it with certainty. Complete surgical excision appears to be the only effective treatment.

Calcinosis↗

[Successful subtotal parathyroidectomy for giant tumor calcinosis with secondary hyperparathyroidism].

A 54-year-old woman was referred to our hospital for the treatment of secondary hyperparathyroidism due to chronic renal failure. She was on hemodialysis for 7 years and suffered from giant tumor calcinosis of the major joints associated with severe hypercalcemia and hyperphosphatemia. The largest one of the left hip joint caused gait disturbance. Medical therapy was unsuccessful and she underwent subtotal parathyroidectomy. After the operation, although the levels of serum calcium and phosphate were not normalized, the level of parathyroid hormone was lowered to the normal range. The volume of the tumor calcinosis gradually reduced and she became able to walk for a short distance 10 months after the operation.

Calcinosis↗

Calcinosis circumscripta in a common marmoset (Callithrix jacchus jacchus).

A 2.5-y-old, male common marmoset (Callithrix jacchus jacchus) developed a 2-cm, interscapular, subcutaneous mass with variably firm and cystic areas. Radiographs demonstrated a radiodense mass in close proximity to a previously implanted microchip. Fine-needle aspiration yielded a chalky liquid that, on cytologic examination, contained amorphous debris. Aerobic and anaerobic cultures were negative. Surgical excision required extensive dissection, with the mass infiltrating deep to the scapula and extending to the mammary gland. The mass weighed 30 g and comprised 10% of the animal's body weight. Microscopic examination demonstrated multifocal, variably sized, amorphous aggregates of granular, basophilic material (mineral) in the subcutis and extending to skeletal muscle. Mineral deposits were surrounded by macrophages, giant cells, and fibrous connective tissue. A focal area of ectopic bone production was present. Crystallographic analysis and x-ray diffractometry determined the material to be comprised of 100% hydroxyapatite. These findings were consistent with a diagnosis of calcinosis circumscripta. Systemic metabolic abnormalities were excluded based on examination of complete blood count, serum chemistry, and ionized calcium. Calcinosis circumscripta in the common marmoset has not previously been reported, although the lesion has been reported to occur in rhesus macaques and is well described in man and dogs. Accumulation of calcium deposits and production of ectopic bone in a marmoset is interesting in light of this species's unique calcium and vitamin D metabolism.

Animals↗

[The degree of coronary artery calcinosis as a prognostic factor of asymptomatic cardiovascular complications: results of meta-analysis].

AIM: To investigate prognostic implications of the calcium index estimated tomographycally for identification of patients at high risk to develop cardiovascular complications (non-fatal myocardial infarction, lethal coronary hear disease, coronary revascularization) in the absence of clinical manifestations. MATERIAL AND METHODS: Meta-analysis of the results of studies on prognostic implications of coronary arteries calcinosis was made with standardized risk ratio as a metameter. The meta-analysis included tests for systemic error related to publishing primarily positive results and data heterogenicity. RESULTS: Overall risk ratios for cardiovascular complications ranged from 2.1 to 9.3 for different degrees of coronary artery calcinosis. CONCLUSION: Calcium index is an independent risk factor of complications of cardiovascular diseases.

Aged↗

Hypercalcemia during the resolution of calcinosis universalis in juvenile dermatomyositis.

Dystrophic calcification is seen in more than 50% of children with juvenile dermatomyositis and tends to resolve spontaneously in some patients. Calcinosis universalis is the least common type of calcification seen and rarely regresses. We describe a boy with juvenile dermatomyositis and calcinosis universalis who developed hypercalcemia during spontaneous regression of dystrophic calcification. The treatment and possible mechanisms of this complication are discussed.

Calcinosis↗

[Sub-epidermal calcinosis of the eyelid].

We report on a 17-year-old male with an asymptomatic yellowish-grayish solitary tumor of the right medial upper lid margin. An excisional biopsy was performed and histopathologic examination revealed subepidermal calcinosis. The other eye showed a granulomatous chrorioretinits of unknown etiology. The relative rare occurrence of subepidermal calcification should be kept in mind when making a differential diagnosis of superficial lid tumors. In our histopathology laboratory this is the first diagnosis of subepidermal calcinosis among 1,400 comparable specimens from 1980 to 1990. A possible relationship between the subepidermal calcification and granulomatous chorioretinitis of the other eye is discussed.

Adolescent↗

Subcutaneous cholesterol crystals mimicking calcinosis cutis in systemic sclerosis.

A patient is described with systemic sclerosis (SSc) and subcutaneous cholesterol crystals mimicking calcinosis cutis. Though not detectable radiographically, basic calcium phosphate crystals were identified by alizarin red staining of aspirate from one digit. The value of crystal identification by microscopy in cases of SSc with presumed calcinosis cutis, but without radiographic evidence of subcutaneous calcific deposits, is emphasized.

Calcinosis↗

[The question of reversibility of tissue calcification in enzootic calcinosis of cattle and in experimental hypervitaminosis D].

In rabbits calcinosis was induced experimentally by feeding of Trisetum flavescens or Vitamin D3 injections. Calcifications in kidneys and lungs were proved by biopsies and x-ray examination respectively. Histological examination at intervals up to 26 months following the calcinogenic insult indicated signs of limited reversibility of calcification in lung, kidney and aortic wall. The degree of resorption of calcified deposits apparently was dependent on dosage, time and kind of tissue affected. Aortic wall and tendons had the least tendency to demineralisation and developed focal cartilage metaplasia. Two cows with proven enzootic Trisetum-calcinosis were kept under altered conditions for 31 and 32 months. At slaughter besides severe calcification and cartilage or osseous metaplasia in soft tissues a limited reabsorption of the calcifications could be observed. There were focal fibrous scars in the aortic wall.

Animals↗

[Idiopathic skin calcinosis with transepithelial elimination].

A case of universal cutaneous calcinosis developed without apparent cause is reported. It had an evolution towards epidermic perforation and was treated with aluminium hydroxide. A discussion was made on the rarity of the idiopathic calcinosis as well as on the interesting phenomenon of transepidermal elimination.

Adolescent↗