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At least 325 records · Page 18Linked to original sources

Ambulatory infusional cancer chemotherapy: nursing role in patient management. The Cancer Center of Boston.

The role of nursing in infusional cancer chemotherapy (ICC) may vary depending on the practice setting. Nurses in free-standing centers and office practices perform many duties that nurses in other facilities may not, because of the lack of many of the supports that benefit hospitals with their multidepartmental and hierarchical structures. Nurses function collaboratively with physicians in the planning and the implementation of patient treatment. Patient-related nursing responsibilities include patient/family education, drug preparation and administration, patient assessment for treatment toxicity, recognition and management of complications related to the catheter or infusion device, and telephone triage. Other duties more removed from patient care might include inventory management, research data collection and management, quality assurance and improvement, compliance with regulatory issues, and a myriad of other responsibilities. The transition of patient care to the outpatient setting has broadened the scope of nursing to include nonpatient care responsibilities due to financial constraints brought about by health care reform, changes in reimbursement patterns, and overhead required to maintain and deliver quality patient care. As a result of nursing responsibilities, it becomes paramount that the aforementioned constructs for program support are in place and that all nurses are consistently trained and have a template to follow for patient treatment and management. Nursing ability to perform patient-related tasks should be proven by formal written and practical competencies repeated annually and as procedural changes are implemented. The paragraphs to follow suggest nursing management of patients receiving ICC using a model developed at The Cancer Center of Boston (TCC).

Ambulatory Care↗

Surveillance of the patient receiving infusional cancer chemotherapy: nursing role in recognition and management of catheter-related complications. The Cancer Center of Boston.

Surveillance of the patient on infusional cancer chemotherapy (ICC) is paramount to patient safety. Key to this issue is diligence in monitoring for complications of infusion catheters. Nursing knowledge and awareness are essential for the early detection of such complications. The following is a composite of the manifestations of commonly experienced catheter-related complications. The incidence, detection and management issues are presented from the perspective of 15 years experience with ICC at The Cancer Center of Boston (TCC).

Ambulatory Care↗

Virtual consolidation of Boston's Beth Israel and New England Deaconess Hospitals via the World Wide Web.

With the advent of Integrated Healthcare Delivery Systems, medical records are increasingly distributed across multiple institutions. Timely access to these medical records is a critical need for healthcare providers. The CareWeb project provides an architecture for World Wide Web-based retrieval of electronic medical records from heterogeneous data sources. Using Health Level 7 (HL7), web technologies and readily available software components, we consolidated the electronic records of Boston's Beth Israel and Deaconess Hospitals. We report on the creation of CareWeb (freya.bidmc.harvard.edu/careweb.htm) and propose it as a means to electronically link Integrated Health Care Delivery Systems and geographically distant information resources.

Boston↗

Cytomegalovirus immune globulin (CMVIG) prophylaxis is associated with increased survival after orthotopic liver transplantation. The Boston Center for Liver Transplantation CMVIG Study Group.

Cytomegalovirus (CMV) causes considerable morbidity and mortality in orthotopic liver transplant (OLT) recipients. Several prophylactic strategies against CMV have been studied in solid organ transplant recipients, including cytomegalovirus immune globulin (CMVIG). We examined the effect of CMVIG prophylaxis on first-year and long-term survival after liver transplantation. Data were analysed for 162 OLT recipients from four transplant centers in Boston who participated in two CMVIG prophylaxis trials. Ninety patients received CMVIG (median follow-up 5.6 yr), and 72 patients received placebo (median follow-up 5.4 yr). CMVIG prophylaxis was shown to be associated with increased first-year (86% vs. 72%, p = 0.029) and long-term (68% vs. 54%, p = 0.055) survival. The distribution of baseline characteristics including donor and recipient demographics, donor CMV serostatus, United Network for Organ Sharing (UNOS) status, pre-transplant renal and liver function tests, transplantation surgical time, number of units of blood products administered during transplantation, primary immunosuppressive regimen, use of solumedrol or antilymphocyte therapy for induction of immunosuppression or treatment of rejection, and surgical complications was similar for CMVIG and placebo recipients. CMVIG recipients were more likely to have primary biliary cirrhosis than placebo recipients (21% vs. 8%, p = 0.025). Using a Cox proportional hazards multivariate model to control for pre-transplant liver disease, CMVIG was shown to be independently associated with increased first-year survival (p = 0.042); a trend toward association with increased long-term survival (p = 0.098) was also shown. These data support that CMVIG prophylaxis, beyond its proven efficacy in decreasing the incidence of severe CMV-associated disease, is associated with increased survival when used prophylactically in OLT recipients.

Adolescent↗

The Accelerated Medical Program and the Liberal Arts at Boston University.

Since September 1961, fifteen classes have matriculated in Boston University's Six- Year College of Liberal Arts--Medical Education Combined Degree Program. The applicant pool is approximately three to four times larger now than in the earlier years, with classes averaging 50 students. Academic qualifications (high-school class rank and Scholastic Aptitude Test and College Board Achievement Test results) of the entering classes have been at a consistently high level. Fifty percent or more of the graduates receive the BA degree with honors; 10% or more receive the MD degree with honors. The degree of flexibility in the liberal arts component of the program has increased and currently exceeds that of the traditional four-year premedical curriculum. These data, together with additional information concerning postgraduate professional activities, indicate that the combined accelerated program has been successful.

Boston↗

Effects of aspirin and acetaminophen in gastrointestinal hemorrhage. Results from the Boston Collaborative Drug Surveillance Program.

All patients observed in this analysis of the Boston Collaborative Drug Surveillance Program data had no known disease predisposing them to gastrointestinal (GI) bleeding. Major GI bleeding occurred in hospitalized patients recently exposed to ethacrynic acid (5/111; 4.5%), heparin sodium (7/575; 1.2%), corticosteroids (7/1,484; 0.5%), aspirin (6/2,081; 0.3%), and warfarin sodium (1/423; 0.2%); combinations of two or more of these drugs also resulted in substantial incidences of bleeding. The rates for minor GI bleeding in hospitalized patients varied from 8.3% for heparin to 1.6% for aspirin. In outpatients admitted because of serious GI bleeding, 14/88 (16%) had a history of heavy, regular aspirin use compared with 1,015/14,813 (6.9%) control subjects admitted for other reasons (relative risk, 2.1). No association between light regular use of aspirin and GI bleeding was noted. No association between the use of acetaminophen and GI bleeding was noted in any of the patients studied.

Acetaminophen↗

Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982.

We analyzed the data on 15,438 consecutive medical inpatients monitored by the Boston Collaborative Drug Surveillance Program from June 1975 to June 1982 to determine the rates of allergic cutaneous reactions to drugs introduced since 1975 and to confirm and extend findings from an earlier study of the preceding 22,227 patients. There were 358 reactions occurring in 347 patients, for an overall reaction rate among patients of 2.2%. Each patient received a mean of eight different drugs. Rashes were attributed to 51 drugs, and 75% of the allergic cutaneous reactions were attributed to antibiotics, blood products, and inhaled mucolytics. Amoxicillin (51.4 reactions per 1000 patients exposed), trimethoprim-sulfamethoxazole (33.8/1000), and ampicillin (33.2/1000) had the highest reaction rates. Drug-specific reaction rates ranged from zero to 51.4 per 1000 and were determined for 180 drugs or drug groups. These results provide physicians with quantitative data that will be helpful in clinical decision making when drug-induced exanthems, urticaria, or generalized pruritus occurs.

Anti-Bacterial Agents↗

The East Boston Memory Test: a clinical screening measure for memory impairment in the elderly.

Comparisons between the East Boston Memory Test (EBMT), a brief verbal memory measure used in epidemiological studies with dementia, selected Wechsler Memory Scale-Revised (WMS-R) subtests, and the Mini-Mental State Examination (MMSE) were investigated with 23 geriatric patients diagnosed with dementia. Significant correlations between the EBMT and WMS-R verbal subtests were predicted and occurred (r = .42 to .64). A five minute EBMT recall correlated most highly with the WMS-R Logical Memory subtests. The sensitivity of the EBMT in detecting cognitive impairment was investigated and compared with the sensitivity of the MMSE. The EBMT correctly classified 78% of subjects, compared to a 70% correct classification rate with the MMSE. Implications of these findings and suggestions for future research directions are discussed.

Aged↗

DNA 2000: International Symposium on the State-of-the-Art in Genetic Analysis, June 1-3, 2000, Boston, U.S.A.

DNA 2000, an international symposium on state-of-the-art genetic analysis, was held at the Back Bay Hilton in Boston, Massachusetts, on 1-3 June, 2000. Meeting highlights are described. The meeting was organized and sponsored by the California Separation Science Society (CaSSS; www.casss.org) and other co-sponsors including the Human Genome Organisation (HUGO). DNA 2000 brought together a group of specialists in DNA detection and analysis methods from around the world in a venue presenting not only new technologies but also their applications in candidate gene studies, molecular diagnosis, analysis of complex diseases, and even studying the origin and evolution of humans.

DNA↗

Linkage analysis of the hemoglobin F determinant(s) in an Australian hemoglobin Lepore (Boston) kindred.

Genetic determinants that influence the levels of fetal hemoglobin (Hb F) in a single Australian kindred with heterozygous Hb Lepore (Boston) were sought. There were 22 affected individuals, some of whom had high Hb F and others with Hb F levels within the normal range. Family members were typed for restriction fragment length polymorphisms (RFLPs) associated with the beta-globin gene complex and the nearby genetic markers D11S12, INS, HRAS, and PTH. Prior to linkage analysis, a cohort of 54 unrelated Hb Lepore heterozygotes was analyzed to establish the distribution of Hb F levels measured by alkaline denaturation (Hb FAD). An Hb F level of > 2.0% was used as the cutoff point for linkage analysis of the putative hereditary persistence of fetal hemoglobin (HPFH) determinant(s) in this kindred. Positive peak lod scores were obtained for the entire pedigree between the HPFH determinant and Hb Lepore (Zm+f = 2.35 at theta = 0.15) and beta-globin cluster (HBBC) (Zm+f = 2.38 at theta = 0.20) marker loci, indicating the possibility of an independent HPFH gene at some distance from the beta-globin gene cluster. However, most of these lod scores result from the non-Hb Lepore members of the family who, with one exception, do not have high Hb F, and when only those affected with Hb Lepore were analyzed the lod score values at these loci fell to small positive values (< 1.0). These data do not support an independent cosegregating HPFH determinant separate from the Hb Lepore locus in this pedigree. The results favor a pleiotropic effect of the Hb Lepore lesion itself influencing Hb F levels by genetic or environmental factors not yet elucidated.

Adolescent↗

Geometrical validation of intravascular ultrasound radiofrequency data analysis (Virtual Histology) acquired with a 30 MHz boston scientific corporation imaging catheter.

Recently, the plaque characterization field was explored with the use of the substrate (frequency domain analysis) rather than the envelope (amplitude or gray-scale imaging) of the intravascular ultrasound (IVUS) radiofrequency data. However, there is no data about the agreement of quantitative outcome between the two methods. The aim of this study was to assess the correlation and agreement between quantitative coronary ultrasound and the geometrical measurements provided by the spectral analysis of ultrasound radiofrequency data [IVUS-Virtual Histology (IVUS-VH), Volcano Therapeutics). Twenty-five patients were included in this study. The IVUS catheter used was a commercially available mechanical sector scanner (Ultracross 2.9 Fr 30 MHz catheter, Boston Scientific) covered with an outer sheath. IVUS-VH significantly underestimated lumen [relative difference (RD)=14.8+/-5.6; P<0.001], vessel (RD=14.1+/-4.8; P<0.001), and plaque (RD=11.5+/-10.8; P<0.001) cross-sectional areas (CSAs). Nevertheless, when adjusted for the ultrasound propagation delay caused by the sheath, relative differences of measurements were remarkably low (0.49%+/-6.3%, P=0.64 for lumen; 2.33%+/-4.6%, P=0.007 for vessel; and 4.2%+/-10.4%, P=0.005 for plaque CSA). These data suggest that the volumetric output of the IVUS-VH software underestimates measurements when acquired with a 30 MHz catheter. However, after applying a mathematical adjustment method for the ultrasound propagation delay caused by the outer sheath of the 30 MHz catheter, relative differences of direct measurements were negligible. These results suggest that ultrasound radiofrequency data analysis could provide, aside from precise compositional data, an accurate geometrical output.

Cardiac Catheterization↗

Educational and gender normative data for the Boston Naming Test in a group of older adults.

The 60-item version of the Boston Naming Test (BNT) was administered to a group of 176 normal older adults in Middle Tennessee ranging in age from 60 to 93 years. Results are reported in five age groupings by gender and education. Although a few studies have previously examined the performance of the elderly on the BNT, the current study attempted to recruit individuals in proportion to the demographics of the regional population including gender, race, and, as much as possible, education and occupation. The results indicate that while age significantly affected confrontational naming ability, the interaction of age and education appeared to be a better predictor of performance. As with previous studies, more variability was found in higher age groups and in those with less education. Naming ability remained stable in the higher education group (> or = 12th grade) until 80 years, whereas those patients with less than a high school education demonstrated a decrement in naming ability at 70 years. Current results also revealed a gender bias for this population, with males scoring higher on 17 of 19 items where a significant difference existed.

Aged↗

Normative data for the Boston naming test in native Dutch-speaking Belgian elderly.

A normative study of the 60-item version of the Boston Naming Test (BNT) was performed in a group of 200 native Dutch-speaking Flemish elderly. Analysis of test results revealed that BNT performance in Dutch is significantly affected by age, years of education, and gender. Error analysis disclosed verbal semantic paraphasias to occur as the most frequent error type (1/3 errors). "Don't know responses," verbal semantic paraphasias, and adequate circumlocutions were found on at least 30 different BNT items and constituted the most diffusely distributed error types. Following a careful review of other normative BNT studies, group characteristics rather than cultural differences were found to account for the difference in the overall mean scores. Our study surprisingly revealed that, as far as American-English, Australian-English and Dutch-speaking elderly are concerned, linguistics do not have an impact on the overall mean BNT score. A linguistic impact, however, clearly holds on the qualitative levels of performance, reflected by fundamental differences in the error distribution in different languages. Language-related BNT characteristics therefore stress the need for specific adaptations of norms.

Aged↗

Bilingual performance on the boston naming test: preliminary norms in Spanish and English.

A total of 100 young educated bilingual adults were administered the Boston Naming Test (BNT) (Kaplan, Goodglass, & Weintraub, 1983) in both Spanish and English. Three group performance scores were obtained: English only, Spanish only, and a composite score indicating the total number of items correctly named independent of language. The scores for the entire group were significantly greater in English than in Spanish. An additional set of analyses explored individual differences in picture naming performance across the two languages as measured by the BNT. For a subset of the larger group (n = 25) there were significant differences in composite over single language scoring, but no significant differences between Spanish and English. Item analyses of correct responses were conducted in both languages to explore the construct validity of the standardized administration of the BNT with this population. There was much greater variability in responses over the Spanish items for this bilingual group. The results of a correlation analysis of information obtained from the initial questionnaire with the BNT scores in each language is also reported. The practical implications of this preliminary bilingual BNT normative data are discussed.

Adolescent↗

Effects of running the Boston marathon on plasma concentrations of large neutral amino acids.

Plasma large neutral amino acid concentrations were measured in thirty-seven subjects before and after completing the Boston Marathon. Concentrations of tyrosine, phenylalanine, and methionine increased, as did their "plasma ratios" (i.e., the ratio of each amino acid's concentration to the summed plasma concentrations of the other large neutral amino acids which compete with it for brain uptake). No changes were noted in the plasma concentrations of tryptophan, leucine, isoleucine, nor valine; however, the "plasma ratios" of acid patterns may influence neurotransmitter synthesis.

Amino Acids↗

Spontaneous fracture of the sternum in a child being treated in a Boston brace for kyphoscoliosis. A case report and review of the literature.

We report a child who suffered from short stature of unknown aetiology and rigid thoracolumbar kyphoscoliosis and developed a symptomatic spontaneous fracture of the sternum while being treated in a Boston brace. Modification of the brace was followed by uneventful healing of the sternal fracture. To our knowledge no mention has been previously made of this extremely rare complication, but the spine surgeon who treats complex spinal deformities in early childhood with braces should be aware of this potential complication, particularly if they are associated with rigid rotational kyphosis.

Braces↗

Career development among residents completing primary care and traditional residencies in medicine at the Boston City Hospital, 1974-1983.

A primary care (PC) pathway was initiated within the medical residency program at Boston City Hospital (BCH) in 1974. The authors studied the PC and traditional (TD) track graduates of the program to compare career development, goals, and practice patterns. The 185 graduates of the nine resident cohorts from 1974 through 1983 were surveyed; the overall response rate was 74%. Primary care careers have been chosen by 81% of PC graduates, compared with 38% of TD graduates (p less than 0.001); career satisfaction is equally high in the two groups. Among the PC graduates, 68% are practicing in high-need areas, compared with only 37% of TD graduates (p less than 0.001). PC graduates are more likely to make house calls, provide extended office hours, round in nursing homes or chronic care facilities, and co-practice with nurse practitioners or physician's assistants, and they are more active in women's health care, care of the terminally ill, and treating patients with sexual dysfunction (all p less than 0.05). PC graduates utilize various community agencies more frequently and supplement patient education with outside resources more intensively (p less than 0.001). The career choices and practice locations of PC graduates reflect the training goals of the PC curriculum and differ from the career choices and practices of the TD graduates from the same program.

Career Choice↗

Multiple myeloma: VI International Workshop, June 14-18, 1997, Boston, Massachusetts, USA.

The VI International Workshop on Multiple Myeloma was organised by Professor Kenneth C Anderson, Dana Farber Cancer Institute, and held on June 14-18, 1997, in Boston, MA, USA. More than 500 participants from all over the world joined this workshop. Several subjects were introduced and one of the most exciting items of news was the identification of Kaposi's sarcoma-associated herpes virus in the bone marrow stromal cells of patients with MM. The aim of this overview is to give a glimpse of the subjects discussed and the statements made.

Humans↗