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Changes in nutrient intake during a behavioral weight control program.

Behavioral modification holds promise of being an effective mode of therapy for obesity. It focuses on changing clients' eating habits and does not always include specific dietary guidance. This study was conducted to learn whether such behavior modification training results in the adoption of nutritionally sound dietary patterns. Originally, the diets of fifteen individuals met two-thirds of all Recommended Dietary Allowances. After a twenty-week program, the only nutrients below this level were iron, thiamin, and calcium. Other changes involved an increase in nutrient density for protein, fiber, phosphorus, iron, vitamin A, thiamin, riboflavin, niacin, ascorbic acid, and cholesterol. Nutrient density for carbohydrates, fat, and calcium decreased.

Adult

Evidence for success of behavior modification in weight loss and control.

Behavior modification applied to the treatment of obesity has evolved from the environmental control of eating behavior to a broader approach characterized by systematic manipulation of all factors associated with eating and exercise patterns. This approach has shown success in helping obese persons lose modest amounts of weight. The average length of treatment is 18 weeks, and the average weight loss is 9.9 kg. About 66% of these weight losses are maintained at 52 weeks of follow-up. Because obesity is a chronic condition with a substantial potential for relapse, longer-term treatments are needed. In the future, behavioral modification is likely to be further combined with other treatment methods.

Behavior Therapy

Behavioral effects of toluene are modulated by stimulus control.

Behavior that is strongly controlled by environmental stimuli is less susceptible to disruption by certain chemicals than is such behavior not under strong external control. To determine whether toluene's effects can also be minimized by environmental stimuli, two varieties of a fixed consecutive number schedule were studied. With one, a lever press response was reinforced with milk only if preceded by a minimum of eight consecutive responses on a second lever, no cues indicating that the minimum number had been reached. With the other, a combination of lights and a tone served as a discriminative stimulus signaling the completion of the minimum response number. In an experiment studying these schedules separately, rats were exposed to toluene concentrations up to 3000 ppm for 4-hr periods immediately before their performance was tested. Toluene reduced the accuracy of both types of behavior in a concentration-related fashion. Clear differential effects occurred, with the signaled behavior, i.e., that under stronger stimulus control, showing less disruption by toluene. Similar results were produced after 2-hr exposures with a multiple schedule in which the signaled and unsignaled performances alternated within a single session. Response rate changes were observed at 560 ppm, but changes in rate were independent of effects on the accuracy of performance. The EC50 for significant behavior disruption was 1081 ppm for the unsignaled component of the multiple schedule; the EC10 was 480 ppm. No performance disruption was observed in the signaled component below 1780 ppm. The finding of differential sensitivity could be useful in guiding the development of more sensitive tests of performance impairment.

Animals

A scatter plot for identifying stimulus control of problem behavior.

Line graphs that average response frequency over long periods obscure the major rate changes that indicate sources of behavioral control. A scatter plot can make patterns of responding identifiable and, in turn, suggest environmental features that occasion undesirable behavior. Use of scatter diagrams is illustrated in three cases.

Adolescent

Behavioral science in translational research and cancer control.

Behavioral science plays an integral, essential role in cancer control. This review examines that role in two broad areas: (1) in the development and implementation of cancer control technologies, and (2) in the emerging focus on the process of translating cancer research into clinical practice. In developing and implementing cancer control technologies, what we know of human processes as a result of behavioral science is identified as the common link in all stages of the cancer process (prevention, detection, treatment, rehabilitation, terminal care). The value of behavioral science is shown in conservative projections (incorporating likely rates of patient noncooperation) of the health benefits obtainable by the year 2000 if effective behavioral strategies in three key areas were broadly implemented. Smoking prevention and cessation programs could lead to 7.2 million fewer smokers; application of cancer screening programs might result in 45,000 additional 5-year cancer survivors each year; and behavioral programs could lead to improved quality of life in 150,000 patients per year who experience treatment side effects despite the use of antiemetics. Behavioral science also is shown to contribute to translational science by providing a pragmatic conceptual model for clinical practice and facilitating collaborative research between basic scientists and clinical researchers. As an example of behavioral science's contribution to translational research, behavioral issues in genetic screening for cancer risk are outlined based on the experience of several families with the BRCA1 genetic marker and patients with Huntington's disease.

Behavioral Sciences

Membrane properties of mesopontine cholinergic neurons studied with the whole-cell patch-clamp technique: implications for behavioral state control.

1. The whole-cell patch-clamp technique was used to study the membrane properties of identified cholinergic and noncholinergic laterodorsal tegmental neurons in slices of rat brain maintained in vitro. 2. On the basis of their expression of the transient outward potassium current IA and the transient inward calcium current IT, three classes of neurons were observed: type I neurons exhibited a large IT; type II neurons exhibited a prominent IA; and type III neurons exhibited both IA and IT. 3. Combining intracellular deposition of biocytin with NADPH diaphorase histochemistry revealed that the vast majority of type III neurons were cholinergic, whereas only a minority of type I and type II neurons were cholinergic. Thus mesopontine cholinergic neurons possess intrinsic ionic currents capable of inducing burst firing. 4. Delineation of the intrinsic membrane properties of identified mesopontine cholinergic neurons, in concert with recent results regarding the responses of these neurons to neurotransmitter agents, has led us to present a unifying and mechanistic hypothesis of brain stem cholinergic function in the control of behavioral states.

4-Aminopyridine

Ethnic/racial and socioeconomic differences in dieting behaviors and body image perceptions in adolescents.

This study examined differences in perceptions of body weight, dieting, unhealthy eating behaviors, and weight control methods among adolescent males and females of various racial/ethnic and socioeconomic (SES) subgroups. Data were derived from a comprehensive health survey administered to 36,320 students in grades 7 through 12 in Minnesota. Differences among ethnic/racial and SES groups were assessed using multivariate logistic regression controlling for grade and body mass index (BMI). Results showed that unhealthy weight control behaviors are not confined to upper SES white females. Compared to white females, Hispanic females reported greater use of diuretics; Asians reported more binge eating; and blacks reported higher rates of vomiting. Black and American Indian females were more likely to be satisfied with their body. Among males and females, higher SES was associated with greater weight satisfaction and lower rates of pathological weight control behaviors. Findings from this study suggest that future research should focus on the validity of self-reports of dieting and weight control behaviors in different ethnic subgroups.

Body Image

An effect of immediate reinforcement and delayed punishment, with possible implications for self-control.

Behavior said to show self-control occurs virtually always as an alternative to behavior that produces conflicting consequences. One class of such consequences, immediate reinforcement and delayed punishment, is especially pervasive. Three experiments are described in which an effect of immediate reinforcement and delayed punishment is demonstrated. The results suggest that when immediate reinforcement and delayed punishment are imminent, the reinforcer alone controls the organism's behavior (in other words the organism behaves "impulsively"). The key to self-control, therefore, may be the acquisition of a large number of avoidance behaviors relevant to reinforcers that are correlated with delayed punishment. Human self-control may indeed involve such a process but undoubtedly involves others as well.

Animals

Copulatory behavior is controlled by the sexually dimorphic nucleus of the quail POA.

The medial preoptic nucleus (POM) of the quail preoptic area is sexually dimorphic and testosterone sensitive. Stereotaxic implantation of needles filled with crystalline testosterone demonstrated that the POM is a critical site of steroid action in the control of copulatory behavior. Only implants located in the POM reliably restored the behavior in castrated birds. Implants around the nucleus weakly activated the behavior; those which were distant by more than 200 microns were totally inactive. Electrolytic lesions confirmed the role of the POM in the control of copulatory behavior. The percentage of the POM which was lesioned was highly correlated to the behavioral deficit while the absolute size of the lesion was not. Electrolytic lesions in or around POM also significantly decreased the volume of the nucleus suggesting that the afferents and efferents of the nucleus are required for its full development. The total volume of the POM was correlated with the sexual behavior of the birds. The morphological changes in POM observed following exposure to testosterone probably represent the signature of the behavioral effects of the steroid. The sexually dimorphic testosterone-sensitive POM is therefore an excellent animal model to study the brain-steroid interactions which mediate the activation of male reproductive behavior.

Animals

Effects of a structured behavior modification treatment program on locus of control in behaviorally disturbed children.

The effect of a 10-day behavior modification treatment program on locus of control was investigated. The subjects were children (N = 130; 6 to 12 years old) with severe behavioral disorders who were predominantly from low socioeconomic backgrounds, from broken homes, and socially deprived. Pre- and post-testing was done with the Nowicki-Strickland Preschool and Primary Internal-External Control Scale (Nowicki & Duke, 1974) and the Nowicki-Strickland Locus of Control Scale for Children (Nowicki & Strickland, 1973). Children between the ages of 10 and 12 responded to therapy with a significant increase in internality, but younger children did not.

Age Factors

Control of behavior by intravenous nicotine injections in laboratory animals.

A series of recent studies are reviewed which demonstrate that behavior can be controlled by nicotine injections in different ways depending on the behavioral history of the subject and the schedule of reinforcement under which nicotine is administered. Lever-pressing responses by squirrel monkeys and beagle dogs were maintained well above saline-substitution levels by injections of 10 to 30 micrograms/kg of nicotine under fixed-ratio schedules of nicotine injection. Lever-pressing responses by squirrel monkeys also were well maintained by injections of 30 to 300 micrograms/kg of nicotine under a fixed-interval schedule of nicotine injection. The highest rates of responding were maintained by injections of 10 to 30 micrograms/kg of nicotine under second-order schedules in which responding by squirrel monkeys produced brief-light presentations which were only occasionally paired with nicotine injection. Under other conditions, however, response-produced injections of these same injection doses of nicotine (10 to 30 micrograms/kg) suppressed food-maintained fixed-ratio responding by squirrel monkeys during the punishment component of a multiple schedule. Finally, under a schedule of nicotine postponement, injection doses of 30 to 56 micrograms/kg of nicotine maintained responding that prevented, rather than produced, nicotine injections. These findings indicate that nicotine may control smoking behavior of humans in very complex and divergent ways depending on prevailing environmental conditions.

Animals

Variables associated with weight loss and improvements in glycemic control in type II diabetic patients in behavioral weight control programs.

Because weight loss is difficult to achieve, it would be helpful to determine whether there are subgroups of obese type II diabetic patients who benefit most from participation in a behavioral weight loss program. We studied 178 obese patients with type II diabetes, who participated in a 12-20 week behavioral weight loss program and were followed for 1 year after the program to determine whether age, gender, percent overweight, medication, duration of diabetes or fasting glucose were related to weight loss and/or to the magnitude of improvement in glycemic control experienced with weight loss. Gender was the only variable related to weight loss; males lost more weight and had greater decreases in percent overweight than females. The variable most strongly related to improvement in glycemic control was pretreatment fasting glucose level; patients with higher initial glucose levels experienced the greatest improvements in control. There was no evidence to support the belief that patients on insulin have poorer weight losses or that patients with long-duration diabetes benefit less from weight reduction than those with recent-onset diabetes.

Behavior Therapy

Neurophysiological effects of vasotocin and corticosterone on medullary neurons: implications for hormonal control of amphibian courtship behavior.

Research on a wide variety of vertebrates, from fish to mammals, reveals that corticosteroid hormones and vasotocin-like neuropeptides can potently modulate reproductive behaviors. But, it is not clear how the behavioral effects of these chemical messengers relate to functional properties of behavior-controlling neurons. This problem was investigated in the roughskin newt, Taricha granulosa, an amphibian in which the administration of arginine vasotocin (AVT) facilitates and corticosterone (CORT) inhibits courtship clasping of females by males. In waking, immobilized male newts, neurophysiological effects of AVT and CORT were studied in neurons in the rostral medulla due to the probable role of these neurons in the control of clasping. Topical medullary application of a clasp-facilitating dose of AVT produced a rapid increase in neuronal responsiveness to pressure on the cloaca, a trigger stimulus for clasping responses. Neuronal responses to noncloacal somatic stimuli and to moving visual stimuli were also enhanced. Systemic CORT administration, which has previously been shown to depress newt medullary neuronal sensory responsiveness, reversed the action of AVT such that the peptide depressed sensory responsiveness when applied 30 min after CORT. When AVT application preceded CORT injection by 10-17 min, however, the usual suppressive CORT effect was reversed and this treatment resulted in a rapidly appearing potentiation of neuronal activity and enhanced somatic sensory responsiveness. If the interval between AVT and CORT was increased to 30 min, the steroid caused a rapid depression of firing and a diminished somatic sensory responsiveness in most neurons, similar to what occurs in newts treated with CORT alone.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals

Electrosensory maps form a substrate for the distributed and parallel control of behavioral responses in weakly electric fish.

Electroreceptors, distributed over the body surface of weakly electric fish, code the local amplitude and phase, or timing of zerocrossing, of the animal's electric signals. These signals are generated by rhythmic discharges of the electric organ and form a dipole-like field around the animal. This field is perturbed by interference with electric fields of other fish as well as by the appearance of objects electrically different from water. The spatial and temporal structure of such perturbations can be interpreted as the electric image of interfering fields and moving objects. This strategy of assessing the environment is called 'electrolocation', a form of 'seeing' with the body surface. Electric images are analyzed in somatotopically ordered strata of neurons within the central nervous system. Primary electrosensory afferents project to somatotopically ordered layers of higher-order neurons in the electrosensory lateral line lobe (ELL) of the hindbrain. Phase and amplitude information are processed in separate layers of the ELL. The phase of the signal in a given region of the body surface is coded by the timing of spikes of spherical cells marking the zerocrossings of the electric signal. This phase information is relayed to lamina 6 of the torus semicircularis of the midbrain. Rises and falls in local amplitude are coded by the activity of different pyramidal cell types, E- and I-units, which project to various laminae of the torus above and below lamina 6. The somatotopic organization of the torus allows for computations of spatial patterns in electrosensory information. Within lamina 6, differences in the phase of signals from different parts of the body surface are computed. Differential-phase information is then relayed to deeper laminae of the torus and remains in topographic register with amplitude information. This organization allows for joint evaluation of spatially related patterns of amplitude and phase modulations on the animal's body surface within local neuronal circuits of the torus. A topographic projection of the torus relays amplitude and differential-phase information to the optic tectum where a further joint evaluation of amplitude and phase serves to control behavioral responses. The control of a particular behavioral performance, the 'jamming avoidance response', is of a distributed nature in that the representations of individual sites on the body surface contribute cumulatively to shift the electric organ pacemaker frequency.(ABSTRACT TRUNCATED AT 400 WORDS)

Action Potentials

The support of autonomy and the control of behavior.

In this article we suggest that events and contexts relevant to the initiation and regulation of intentional behavior can function either to support autonomy (i.e., to promote choice) or to control behavior (i.e., to pressure one toward specific outcomes). Research herein reviewed indicates that this distinction is relevant to specific external events and to general interpersonal contexts as well as to specific internal events and to general personality orientations. That is, the distinction is relevant whether one's analysis focuses on social psychological variables or on personality variables. The research review details those contextual and person factors that tend to promote autonomy and those that tend to control. Furthermore, it shows that autonomy support has generally been associated with more intrinsic motivation, greater interest, less pressure and tension, more creativity, more cognitive flexibility, better conceptual learning, a more positive emotional tone, higher self-esteem, more trust, greater persistence of behavior change, and better physical and psychological health than has control. Also, these results have converged across different assessment procedures, different research methods, and different subject populations. On the basis of these results, we present an organismic perspective in which we argue that the regulation of intentional behavior varies along a continuum from autonomous (i.e., self-determined) to controlled. The relation of this organismic perspective to historical developments in empirical psychology is discussed, with a particular emphasis on its implications for the study of social psychology and personality.

Emotions

Maternal polydrug use including cocaine and postnatal infant sleep architecture: preliminary observations and implications for respiratory control and behavior.

Twelve-hour overnight pneumocardiograms were assessed for sleep architecture and sleep efficiency in two groups of healthy term newborn infants: a group exposed prenatally to cocaine alone or in combination with other drugs and a non-exposed group. Sleep was differentiated from wakefulness by an increase in heart rate, an increase in or variation in the duration and amplitude of the respiration and increased artifacts on the heart rate channel. Quiet and active sleep were determined by the regularity or irregularity of heart rate and respiration. In a sub-set of infants, the number of arousals during active sleep was calculated. Overall significance was confirmed by ANOVA followed by paired comparisons using the Student's-test. When compared to non-exposed infants within the first week of life, infants exposed prenatally to cocaine alone or in combination with other drugs demonstrated more wakefulness and less sleep (P < 0.05), more frequent arousals during active sleep (P < 0.01), and the tendency of a higher proportion of active sleep compared to quiet sleep. These findings may have implications to both behavioral and respiratory control findings associated with prenatal cocaine exposure.

Black People

Neuroleptic interference with the cocaine cue: internal stimulus control of behavior and psychosis.

The ability of cocaine to exert internal stimulus control of behavior was investigated by training rats to discriminate 10 mg/kg cocaine from saline in a discrete-trial, two-lever, food-reward procedure. Acquisition of response control by cocaine (1) succeeded in all animals tested, (2) proceeded rapidly, and (3) was associated with a high Commission Error: Omission Error ratio. These findings support the hypothesis that cocaine, a prototype of drugs inducing a psychotic condition in humans, can act as a powerful internal stimulus in rats. The cocaine cue was also responsive to the action of the dopamine-receptor-blocking agents spiperone (ED50: 0.06 mg/kg), haloperidol (0.24 mg/kg), and pimozide (1.90 mg/kg). d, l-Amphetamine (1.25 mg/kg) induced stimulus generalization with cocaine, and this generalization was blocked by dosages of the same neuroleptics comparable to those of cocaine antagonism. The results are discussed in terms of internal stimulus control of behavior and its relevance to the psychophysiology of schizophrenia.

Amphetamine