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Technological advances in avalanche survival.

Over the last decade, a proliferation of interest has emerged in the area of avalanche survival, yielding both an improved understanding of the pathophysiology of death after avalanche burial and technological advances in the development of survival equipment. The dismal survival statistics born out of the modern era of winter recreation unmistakably reveal that elapsed time and depth of burial are the most critical variables of survival and the focus of newer survival devices on the market. Although blunt trauma may kill up to one third of avalanche victims, early asphyxiation is the predominant mechanism of death, and hypothermia is rare. A survival plateau or delay in asphyxiation may be seen in those buried in respiratory communication with an air pocket until a critical accumulation of CO2 or an ice lens develops. The newest survival devices available for adjunctive protection, along with a transceiver and shovel, are the artificial air pocket device (AvaLung), the avalanche air bag system (ABS), and the Avalanche Ball. The artificial air pocket prolongs adequate respiration during snow burial and may improve survival by delaying asphyxiation. The ABS, which forces the wearer to the surface of the avalanche debris by inverse segregation to help prevent burial, has been in use in Europe for the last 10 years with an impressive track record. Finally, the Avalanche Ball is a visual locator device in the form of a spring-loaded ball attached to a tether, which is released from a fanny pack by a rip cord. Despite the excitement surrounding these novel technologies, avalanche avoidance through knowledge and conservative judgment will always be the mainstay of avalanche survival, never to be replaced by any device.

Asphyxia↗

Comparing behavioral and chronic endpoints to evaluate the response of Lumbriculus variegatus to 3,4,3',4'-tetrachlorobiphenyl sediment exposures.

The response of Lumbriculus variegatus to 3,4,3',4'-tetrachlorobiphenyl (TCBP) was examined with feeding behavior and changes in carbon assimilation by using stable carbon isotopes at 22 and 10 degrees C. The classical measure of feeding behavior determined on a subset of sediment for which the biological burial rate was determined in a companion study allowed direct method comparison. This comparison helped address relationships between biological burial rate, feeding rate, and bioaccumulation. The change in stable isotope composition reflects the total metabolic activity by measuring carbon assimilation rate and was compared to feeding rate, biological burial rate (as determined in the companion study), and reproduction. Decreasing the temperature from 22 to 10 degrees C resulted in a twofold reduction in feeding rate and carbon assimilation. The fractional decline in feeding rate relative to the control mimicked the decline in the biological burial rate with increasing TCBP concentration that was found in the companion study. The bioaccumulation factor declined with increasing TCBP sediment concentration, tracking the feeding rate decline. Stable isotope measures showed differences in metabolic rates between the exposure temperatures but did not distinguish a metabolic rate change at 22 degrees C among TCBP treatments. Likewise, reproduction declined from 22 to 10 degrees C, with no reproduction at 10 degrees C. Like the stable isotope measure, no dose response was found among TCBP treatments at 22 degrees C. The reduction in carbon assimilation rate tracked the reduction in reproduction with lower temperature.

Animals↗

[Adaptation strategies of seed germination and seedling growth to sand dune environment].

Sand dune plants possess many adaptation strategies to withstand sand environment, e. g., some desert plant seeds are dormant when matured, which helps them to escape from unfeasible environment conditions and be preserved as seed bank. The seed germination and seedling establishment of psammophytes need moderate sand burial, while excessive burial will inhibit seed germination and seedling emergence. Seeds without germination in deeper sand are in enforced dormancy, and form soil seed bank. Sand dune plant seedlings could tolerant finite sand burial by increasing the number of nodes per culm and elongating internodes. When the seedlings are partially buried, they could survive through the maintenance of photosynthesis organism. Once sand burial exceed the threshold of the plant, seedlings growth will be restrained and the growth ability even permanently lost. Other factors such as salt spray, insect herbivory, and lack of soil nutrients also affect seed germination and seedling establishment. The precipitation in desert and sand land is unpredictable and irregular. Sand erosion leads roots be exposed to the air and dehydrated to die. However, seedlings of some desert plant have the ability to tolerate desiccation for a period of time after germination. Once there is rain, the seedlings will rivive.

Adaptation, Physiological↗

[Epidemiological surveillance of mortality based on burrial records].

The purpose of this work is to build a prediction model of weekly general mortality in Barcelona, using weekly burials as a quick indirect indicator of mortality, and to illustrate its use in the detection of a suspected epidemic of influenza. Mortality data have been modelled following the methodology proposed by Box and Jenkins, and have been regressed using a simple linear model against burial data, so that for every week the expected number of deaths is computed. The model identified that best fitted mortality data was an ARI-MA (3,0,0). The lineal regression model relating mortality and burial data was deaths = 15.94 + 0.80 burials. The use of this methodology allowed the detection of the increase in deaths which occurred during an influenza epidemic in the beginning of 1987. This method allows the rapid weekly monitoring of mortality in a well defined geographic area, and it is a potentially useful tool to support public health departments in their epidemiologic surveillance responsibilities.

Death Certificates↗

[Avalanche emergency. New aspects of the pathophysiology and therapy of buried avalanche victims].

A series of investigations on the pathophysiology and management of persons buried in an avalanche has been undertaken over the past few years in response to increased awareness of the importance of emergency medical treatment of avalanche victims and the fact that the high mortality rate has not decreased in spite of the improvement in rescue techniques. This paper is the very first review of the problems encountered in avalanche disasters. The developments over the past 20 years, in particular, are summarized and discussed. Furthermore, current opinions and recommendations on optimal rescue procedure, as well as the prevention of such emergencies are presented. Precise assessment of the survival probability after burial under an avalanche and recognition of the prognostic importance of an air pocket, but only limited role of hypothermia, provide the basis for new concepts governing therapy and triage by the emergency doctor. Resulting guidelines have been endorsed by the Emergency Medicine Subdivision of the International Commission of the Alpine Rescue Services (ICAR) and these recommendations are intended for implementation by organised rescue teams in order to reduce secondary deaths following successful extrication of victims from the avalanche masses. However, the chance of being rescued alive depends primarily on the rapidity of extrication, i.e. how quickly the rescue teams are alerted and transported to the disaster area in the first instance, then how quickly the victims are located and extricated. In order to reduce the mortality additional preventive measures must be introduced to avoid complete burial if possible, or appreciably hasten the rescue procedure. The very steep drop ("fatal kink") in survival probability as from 15 minutes after burial underlines the absolute necessity of the mastery of efficient rescue procedure by uninjured companions. Improvement of the technical developments for the avoidance of total burial (avalanche air bag) and optimization of the electronic location (transceiver) of buried skiers by uninjured companions are essential future requirements. Nonetheless, primary prevention remains of paramount importance in governing decision making by offpiste skiers. Correct assessment of the inherent risks according to the prevailing circumstances and strict adherence to safety rules take precedence over all other considerations.

Asphyxia↗

Matrix decomposition model for investigating prehistoric intracemetery biological variation.

A matrix decomposition model for analyzing prehistoric intracemetery biological variability is presented. The model, based on the correlation between interindividual biological and burial distance matrices, provides an estimate of the number of distinct burial populations interred within a single cemetery, which effectively ameliorates identifiability problems typical of general variability analyses (Raemsch [1995] Ph.D. dissertation, SUNY at Albany). Unlike other methods for analyzing intrasite variability analysis (e.g., kinship analysis and microchronology), this method is not reliant on a priori subgroup definition. Assuming a kin-structured burial pattern, a residual matrix is defined based on the raw data matrices; the proportion of negative or zero residuals to the total number of residuals provides an estimate of the number of hidden subgroupings (lineages) within the cemetery. The comparative utility of the model is demonstrated on a series of protohistoric and historic period skeletal samples from the Georgia coast, where it demonstrated that the increase in phenotypic variability during the early mission period is the result of population aggregation at the missions and not necessarily genetic admixture between local and nonlocal groups.

Anthropology, Physical↗

Age and sex biases in the preservation of human skeletal remains.

Inaccuracies introduced through biases in preservation are a major source of error in paleodemographic reconstructions. Although it is generally assumed that such biases exist, little is known about their magnitude. To investigate this problem, we studied age and sex differences in the preservation of skeletal remains from Mission La Purisima and a prehistoric cemetery (Ca-Ven-110). Comparison of mortality profiles obtained through analysis of skeletal remains and burial records from the mission indicates that biases in preservation can be very significant in poorly preserved skeletal collections. The Purisima burial records show that most of the people interred in the cemetery were either infants or elderly adults. The skeletal remains, in contrast, are predominantly those of young adults. The burial records and skeletal collection produced comparable sex ratios. These results show that age biases in preservation are much more important than sex biases. This conclusion is supported by data on the completeness of the skeletons from La Purisima and Ca-Ven-110. At both sites, the remains of young adults were better preserved than those of children or elderly adults, and the completeness of male and female skeletons was comparable.

Adolescent↗

Bioarchaeological evidence for trophy-taking in prehistoric central California.

Fourteen adult burials in a large (N = 224) prehistoric central California cemetery (CA-SCL-674) lack forearm bones. Twelve of these otherwise well-articulated primary interments have distal humeri bearing cutmarks with a distribution like that seen in fur seals butchered by Native Californians. Most of the burials with missing forearms are young adult males, a demographic profile that differs significantly from the full sample. Three of these males show evidence of perimortem trauma in addition to forearm amputation. Drilled and polished human radii and ulnae were recovered from the CA-SCL-674 cemetery in archaeological contexts separate from burials with missing forearms. A warfare-related trophy-taking practice is strongly suggested by these bioarchaeological data. Based on these data, it seems likely that 20% (N = 10) or more of the adult males (N = 59) in this population were victims of violence. Evidence of perimortem violence was much less common among women, with only about 2% (N = 2) of adult females (N = 86) subjected to trophy-taking. Examination of museum collections produced further evidence for perimortem forearm amputation among the Native American inhabitants of this area during the transition between the Early and Middle periods. The emergence of more hierarchical social systems during this period may have fostered warfare-related trophy-taking as a symbolic tool for enhancing the power and prestige of individuals within competing social groups.

Adolescent↗

Biological structure and health implications from tooth size at Mission San Luis de Apalachee.

This study analyzes dental metric variation to examine the biological structure of the native population at Mission San Luis de Apalachee, a late 17th century mission located in the Apalachee Province of Spanish colonial Florida. Three topics are addressed: (1) comparison of tooth sizes among adult and subadults, (2) analysis of the bio-spatial structure of skeletons within the church area, and (3) comparison of phenotypic profiles of individuals interred within coffins in the ritual nucleus of the church: the altar region. Analyses indicate that subadults had smaller average tooth sizes than adults for the posterior dentition that was particularly evident in mandibular nonpolar molars and premolars. This disparity, also documented in two other mission populations, likely represents ontogenetic stress and resulting increased mortality among those most at risk for early death. Analysis of the spatial structure of graves failed to document biological structuring by side of the aisle or by burial row, although some gross differences were evident when front, middle, and rear church burials were compared. Individuals buried in coffins within the same row were phenotypically similar to one another. However, inter-row comparisons indicated lack of phenotypic similarity among all coffin interments. These analyses suggest maintenance of kin-structured burial for elites alone within the San Luis community.

Age Factors↗

New ages for human occupation and climatic change at Lake Mungo, Australia.

Australia's oldest human remains, found at Lake Mungo, include the world's oldest ritual ochre burial (Mungo III) and the first recorded cremation (Mungo I). Until now, the importance of these finds has been constrained by limited chronologies and palaeoenvironmental information. Mungo III, the source of the world's oldest human mitochondrial DNA, has been variously estimated at 30 thousand years (kyr) old, 42-45 kyr old and 62 +/- 6 kyr old, while radiocarbon estimates placed the Mungo I cremation near 20-26 kyr ago. Here we report a new series of 25 optical ages showing that both burials occurred at 40 +/- 2 kyr ago and that humans were present at Lake Mungo by 50-46 kyr ago, synchronously with, or soon after, initial occupation of northern and western Australia. Stratigraphic evidence indicates fluctuations between lake-full and drier conditions from 50 to 40 kyr ago, simultaneously with increased dust deposition, human arrival and continent-wide extinction of the megafauna. This was followed by sustained aridity between 40 and 30 kyr ago. This new chronology corrects previous estimates for human burials at this important site and provides a new picture of Homo sapiens adapting to deteriorating climate in the world's driest inhabited continent.

Adaptation, Physiological↗

The law relating to dealing with dead bodies.

Since March 1999 there have been three inquiries concerned either in whole or in part with the removal of human tissue from bodies during post-mortem examinations and its retention thereafter. Two of these at least have had to consider the law relating to the matter, and a commissioned paper and a submission about it to one, the Bristol Royal Infirmary Inquiry, have been mounted on the Inquiry's Web site. The main part of this article consists of the slightly revised text of a submission to the Inquiry by way of comment on these. Among the major points made in this submission are that (a) insufficient consideration has been given to the present status of the common law right of a person arranging a funeral to have the body of the deceased given Christian burial in the burial ground of the parish in which he or she died or of which he or she was a parishoner; (b) insufficient account has been taken of the scope of permissible modes of dealing with a dead body; and that (c) the implications this has for the common law offence of preventing Christian (or decent) burial have not been fully explored.

Autopsy↗

A Greek perspective on concepts of death and expression of grief, with implications for practice.

Death has been conceptualised in different ways by different cultures and civilizations. It is increasingly entering into the public consciousness and society is now more ready to discuss and lessen the fear of dying and grief than it has been in the past few decades. In Greece, by Classical times there was an increase in burial rituals and commemorative practices compared to earlier periods. When Christianity was introduced into Greece it attempted to change the way the dead were mourned, preaching immortality of the soul and resurrection of the dead. Nevertheless, the way people grieve and bury their dead in Greece has not changed greatly since before the introduction of Christianity, except for the difficulty experienced in witnessing burial procedures observed in the large cities. Burial and bereavement traditions were introduced to help Greeks cope with death and bereavement. In Greece today beliefs about grief and death are based both on the ancient and the Christian Orthodox traditions. Healthcare professionals need to develop cultural competence to improve nursing and future health care. If care is culturally informed and tailored its quality is improved.

Adaptation, Psychological↗

Decompositional odor analysis database.

This study, conducted at the University of Tennessee's Anthropological Research Facility (ARF), describes the establishment of the Decompositional Odor Analysis (DOA) Database for the purpose of developing a man-portable, chemical sensor capable of detecting clandestine burial sites of human remains, thereby mimicking canine olfaction. This "living" database currently spans the first year and a half of burial, providing identification, chemical trends and semi-quantitation of chemicals liberated below, above and at the surface of graves 1.5 to 3.5 ft deep (0.45 to 1.0 m) for four individuals. Triple sorbent traps (TSTs) were used to collect air samples in the field and revealed eight major classes of chemicals containing 424 specific volatile compounds associated with burial decomposition. This research is the first step toward identification of an "odor signature" unique to human decomposition with projected ramifications on cadaver dog training procedures and in the development of field portable analytical instruments which can be used to locate human remains buried in shallow graves.

Adult↗

[Legal and practical aspects of perinatal death].

There is some debate as to whether the Dutch Burial Act applies to neonatal deaths after a gestation of less than 24 weeks. It is recommended that the Act be considered applicable in these situations, leading to a compulsory (external) post mortem examination, the issue of an official death certificate, and registration of the birth and death at the official registry office, followed by burial or cremation according to the law. The Act should be amended to this effect. It is also recommended that the Burial Act no longer apply in cases of known intra-uterine death before 24 weeks of gestation where birth takes place after 24 weeks. The stipulated cut-off point in the Act for defining a miscarriage as opposed to a birth or stillbirth, i.e. 24 weeks of gestation, should preferably be replaced by the international (WHO) criterion of a birth weight of 500 g, as this will lead to less ambiguity and a better comparison of Dutch and international data concerning perinatal mortality.

Burial↗

Outside St. Jørgen: leprosy in the medieval Danish city of Odense.

Leprosy was a common and dreaded disease in the Danish Middle Ages (AD 1050-1536). Starting in the second half of the 13th century, leprosaria were established in many Danish towns and cities. In the city of Odense (on the island of Funen, Denmark), the cemetery of the leprosarium was totally excavated, and four nonleprosarium medieval and early modern cemeteries have been partly excavated. This paper explores the frequency of leprosy in the nonleprosarium cemeteries in Odense, and looks for evidence of selective exclusion from the ordinary population. The analyses are based on 733 skeletons from four cemeteries in Odense: the Gray Friars monastery, St. Albani parish church, St. Knuds cathedral, and Black Friars monastery. Seven lesions are scored and, based on known epidemiological properties (i.e., specificity and sensitivity) of these lesions, scores were transformed to statistics characterizing an individual's risk of having suffered from leprosy. This statistical approach remains of primary theoretical value, pending confirmation by independent research groups at other sites. Prevalence of the skeletal manifestation of leprosy at death varied between 0-17% among the different cemeteries in Odense. The highest prevalence was seen in cemeteries with many burials before AD 1400. It is estimated that before AD 1400, between 14-17% of those buried in the nonleprosarium cemeteries suffered from leprosy. In all nonleprosarium cemeteries, there was evidence for selective exclusion of people with facial leprosy lesions. For a short period just up to AD 1300, the cemetery of the Odense leprosarium had, on average, more than 20 yearly burials. The establishment of the leprosarium was followed within a relatively short period by a dramatic decline in the number of sufferers of leprosy in the nonleprosarium cemeteries. The number of yearly burials in the leprosarium cemetery also declined rapidly during the 14th century. The present analyses do not permit conclusions about the reasons for this decline in leprosy prevalence.

Bone and Bones↗

Docking enzyme-inhibitor complexes using a preference-based free-energy surface.

We present a docking scheme that utilizes both a surface complementarity screen as well as an energetic criterion based on surface area burial. Twenty rigid enzyme/inhibitor complexes with known coordinate sets are arbitrarily separated and reassembled to an average all-atom rms (root mean square) deviation of 1.0 A from the native complexes. Docking is accomplished by a hierarchical search of geometrically compatible triplets of surface normals on each molecule. A pruned tree of possible bound configurations is built up using successive consideration of larger and larger triplets. The best scoring configurations are then passed through a free-energy screen where the lowest energy member is selected as the predicted native state. The free energy approximation is derived from observations of surface burial by atom pairs across the interface of known enzyme/inhibitor complexes. The occurrence of specific atom-atom surface burial, for a set of complexes with well-defined secondary structure both in the bound and unbound states, is parameterized to mimic the free energy of binding. The docking procedure guides the inhibitor into its native state using orientation and distance-dependent functions that reproduce the ideal model of free energies with an average rms deviation of 0.9 kcal/mol. For all systems studied, this docking procedure identifies a single, unique minimum energy configuration that is highly compatible with the native state.

Enzyme Inhibitors↗

Folding pathway of guanidine-denatured disulfide-intact wild-type and mutant bovine pancreatic ribonuclease A.

The refolding kinetics of guanidine-denatured disulfide-intact bovine pancreatic ribonuclease A (RNase A) and its proline-42-to-alanine mutant (Pro42Ala) have been studied by monitoring tyrosine burial and 2'-cytidine monophosphate (2'CMP) inhibitor binding. The folding rate for wild-type RNase A is faster in the presence of the inhibitor 2'CMP than in its absence, indicating that the transition-state structure in the rate-determining step is stabilized by 2'CMP. The folding rate monitored by 2'CMP binding to the major slow-folding species of Pro42Ala RNase A is faster than the folding rate monitored by tyrosine burial; however, the folding rate monitored by inhibitor binding to the minor slow-folding species is decreased significantly over the folding rate monitored by tyrosine burial, indicating that the major and minor slow-folding species of Pro42Ala fold to the native state with different transition-state conformations in the rate-determining step.

Alanine↗

Decomposition of buried corpses, with special reference to the formation of adipocere.

The unrestrained decomposition of a corpse involves the consecutive processes of autolysis, putrefaction and decay. Ideally, decomposition is completed within the regular resting time (15-25 years) and leads to the entire skeletalisation of the corpse. Adipocere, a greyish fatty substance formed during decomposition, is regarded as a spontaneous inhibition of post-mortem changes; it makes the corpse almost entirely resistant to decomposition and makes it impossible to use the same graves again. This creates problems for local governments with regard to the generally growing demand for burial ground. Apart from corpse-specific characteristics (e.g. sex, age, physique, cause of death), method of burial (e.g. material of the coffin, depth of grave, individual or mass grave, clothing) and time of burial, the conditions of the resting place (geology, topography, soil properties and frequency of use, air, water, and heat budget), in particular, have a special impact on adipocere formation. This study summarises the present knowledge on this phenomenon, combining results gained both in forensic medicine and in geosciences.

Cadaver↗