Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “BLOODLETTING”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 325 records · Page 18Linked to original sources

Mozart's chronic subdural hematoma.

No commemoration of the bicentennial of Mozart's death would be complete without some consideration of that premature yet predictable demise. Mozart's premonitions of death are well known and apparently played a role in the composition of the K.626 Requiem and perhaps other works. His death has traditionally been ascribed to infectious causes, chiefly rheumatic fever or post-streptococcal glomerulonephritis, exacerbated by intemperance and chronic penury. Pathology has been difficult because of his supposed burial in a pauper's grave, the location and contents of which were later supposedly lost. Mozart's burial place in St. Mark's Cemetery in Vienna was known and, in the parlance of the day, "reorganized" a decade later, as the occupants of plots were disinterred to make room for the more recently decreased. A skull believed to the Mozart's was saved by the successor of the gravedigger who had supervised Mozart's burial, and then passed into the collections of the anatomist Josef Hyrtl, the municipality of Salzburg, and the Mozarteum museum (Salzburg). Forensic reconstruction of soft tissues related to this skull reveals substantial concordance with Mozart's portraits. The skull suggests premature closure of the metopic suture, which has been suggested on the basis of his physiognomy. A left temporal fracture and concomitant erosions raise the question of chronic subdural hematoma, which would be consistent with several falls in 1789 and 1790 and could have caused the weakness, headaches, and fainting he experienced in 1790 and 1791. Aggressive bloodletting to treat suspected rheumatic fever could have decompensated such a lesion to produce his death on December 5, 1791.

Austria↗

Charles Skinner Hallpike and the beginnings of neurotology.

Although the symptom of vertigo had been well-recognized for several thousand years, it was not until the pioneering work of Prosper Ménière in the mid-19th century that it was appreciated that vertigo could originate from damage to the inner ear. Before that time, patients with vertigo (regardless of the cause) were said to have "cerebral congestion," a condition resulting from excessive blood filling the brain. Bloodletting and leeches to relieve the congestion were the treatment of choice. The discovery of endolymphatic hydrops in temporal bone specimens from patients with Ménière's disease by Hallpike and Cairns in 1938 marked the beginning of modern neurotology. For the first time, vertigo was correlated with specific pathophysiology. Propelled by his temporal bone work, Charles Hallpike received an appointment at the National Hospital at Queen Square, where he developed an internationally renowned neurotology clinic. His bithermal caloric test and positional tests are still routinely used in evaluation of the vertiginous patient.

Caloric Tests↗

The myeloproliferative disorders. An historical appraisal and personal experiences.

According to strict morphological, biochemical and cytogenetic criteria Philadelphia chromosome positive essential thrombocythemia and chronic granulocytic leukemia constitute a separate malignant and individual disease entity, whereas Philadelphia chromosome negative essential thrombocythemia, polycythemia vera and agnogenic or megakaryocytic myeloid metaplasia form a chronic proliferation of three hematopoietic cell lines. Histopathology from bone marrow biopsies permits the characterization and diagnostic differention of the various myeloproliferative disorders and appears to be a main and specific diagostic criterion for polycythemia vera and essential thrombocythemia. Hemorrhagic thrombocythemia is a clinical syndrome of recurrent spontaneous mucocutaneous and secondary hemorrhages often preceded by thromboses, extremely high platelet counts, pseudohyperkalemia, increased bone marrow cellularity and frequently splenomegaly. The diagnostic criteria of essential thrombocythemia with paradoxical occurrence of thrombotic events and hemorrhagic manifestations are a platelet count in excess of 1000 x 10(9)/L and increased bone marrow cellularity in the majority of the cases. Erythromelalgia and other microcirculatory ischemic or thrombotic events or accidents in essential thrombocythemia and polycythemia vera already occur at platelet counts in excess of the upper limit of normal. First line treatment options in essential thrombocythemia and polycythemia vera are control of platelet function with low-dose aspirin and reductive control of platelet count and erythrocytes by bloodletting, interferon and busulfan or hydroxyurea monochemotherapy.

Bone Marrow↗

Effect of neo red cells on hemodynamics and blood gas transport in canine hemorrhagic shock and its safety for vital organs.

The purpose of this study was to evaluate the effects of liposome encapsulated hemoglobin named "Neo Red Cells (NRC)" on canine hemorrhagic shock model and its safety for the vital organs in a whole blood exchange model. HEMORRHAGIC SHOCK: Nine adult mongrel dogs were used. Under mechanical ventilation inhaling room air, blood was withdrawn via an artery at a rate of 40 ml/min in order to induce hemorrhagic shock (systolic pressure below 60 mm Hg) and then NRC was transfused. For each animal, three to five cycles of bloodletting and NRC transfusion were performed. After blood exchange, total peripheral resistance index (TPRI) decreased and cardiac index (CI) increased. These changes were more marked in the high exchange group (exchange rate over 88%; five animals) than in the low exchange group (less than 88%; four animals), indicating that the low viscosity NRC reduced the load on the circulatory system. The A-V difference in oxygen content per lg hemoglobin was greater after blood exchange, indicating that oxygen binding capacity of NRC is higher than that of red blood cells. WHOLE BLOOD EXCHANGE: Five beagles were used for the blood exchange. The blood was withdrawn from an artery at a rate of 15 ml/min and NRC was infused at the same time. A dog whose blood was exchanged with hydroxyethylstarch instead of NRC died within 15 hours after blood exchange. Three dogs whose blood was exchanged with NRC (exchange rate was from 82 to 90%) have been living over a year without any side effects. A dog sacrificed on the 15th postoperative day for autopsy, microscopically showed no side effects in vital organs. We conclude that NRC is more suitable than natural blood for treatment of hemorrhagic shock and safe for vital organs.

Animals↗

Medicine's great journey. One hundred years of healing.

At the close of the 19th century, bloodletting was state-of-the-art medical practice and life expectancy in the United States was about 40 years. Excerpts from a newly published photo collection chronicle the dizzying changes that have occurred since then.

Disease Outbreaks↗

[Possibility of early operations in severe traumatic shock under the protection of assisted circulation].

The results of treatment in 28 patients with extremely severe multiple injuries are analysed: 21 of them had open, comminuted, crushed fractures or tearing of 44 extremities. After a failure of antishock measures an assist extracorporeal circulation with oxygenation was instituted, and surgery was performed. In 128 experiments on dogs a explosive bullet wound was inflicted on the knee joint: a comminuted intraarticular fracture of 2-3 bones was produced, followed by 25-30% bloodletting and additional trauma of the damage site. In 23 control experiments without using the heart-lung machine but with routine antishock measures 83% of animals died after the amputation and 17%--survived. A conclusion is made on the rationale and efficacy of an assist extracorporeal circulation in severe traumatic shock, that would make is possible to perform an early operation and to eliminate "the trigger mechanism" of shock.

Adult↗

Therapeutic apheresis: treatment in search of a disease.

Blood has been recognized as the essence of life since ancient times. Bloodletting, however, was performed centuries ago to treat disease and prolong life. Seventy years ago selective removal of blood components from circulating blood was advocated as a therapeutic measure. However, manual procedures for blood removal, separation, and reinfusion were quite cumbersome and did not really lend themselves to daily clinical practice. In the last 15 years, technologies have been developed to allow separation of blood into its component fractions, selective removal of specific elements--either cellular products or liquid plasma--an reinfusion of the remaining blood. Early cell separators were designed to collect specific blood components from healthy donors for subsequent transfusion to critically ill patients. Apheresis techniques were found to reduce the amounts of some normal elements circulating in the donors' blood, and the procedure thus began to be used therapeutically to remove abnormal components and to reduce excessive quantities of otherwise normal blood components. Diffusion of automated cell separators quickly followed and apheresis procedures were applied as treatment for a variety of diseases and conditions. The efficacy of therapeutic apheresis in many rare or exotic diseases is well established. In others, the role of apheresis is less clear. By reviewing the medical benefits of therapeutic apheresis, access to treatment, and the costs resulting from broad applications, this assessment will assist health care professionals and policymakers to evaluate therapeutic apheresis technology.

Blood Component Removal↗

[Cardiac rupture in acute myocardial infarction].

Free wall rupture of the heart is the most common cause of death following pump failure. The incidence of death is 10-16% of all deaths because of acute myocardial infarction (AMI). In respect of time between the onset of AMI to Cardiac Rupture (CR), early (80%) and late CR are distinguished. Other clinical classification distinguishes acute and subacute CR. CR is considered subacute if the time between the onset of typical symptoms of CR and irreversible shock is longer as 30 min. There are three problems to solve: 1) selection of patient particularly threatened with CR, 2) defining the prodroms of CR and early diagnosis, 3) advancing the methods of surgical treatment. CR occurs more often in women, hypertensive patients and patient > 60 years old sustaining the first infarction. Thrombolytic agents diminish overall mortality in AMI, but do not influence frequency of CR. There are three mechanisms of CR incidence: 1) blood effusion into the ischemic zone resulting in the loss of tissue strength, 2) influence of thrombolytic therapy on degradation and inhibition collagen synthesis, 3) absorption of collagen by lymphocyte infiltration in infarction zone. Cardiac insufficiency with cardiogenic shock and rapid increase of pericardial effusion in echo examination and electro-mechanical discordance are considered to be clinical signs of CR and tamponade. CRP is an independent marker of subacute CR. Surgical treatment is possible only in case of subacute CR. Pericardiocentesis and bloodletting could temporary diminish cardiac tamponade and allow transfer to the operating room.

Acute Disease↗

Transfusion medicine in the new millennium.

Blood is a tissue like all other tissues, however, it has always had a special meaning for man. Blood used to be attributed characteristics of the man whose body it was circulating through. Attempts were made to influence the person's character, properties, or disease, such as strength, old age and illness, by the bloodletting or blood administration. Blood was for centuries considered an elixir of life, and was ascribed various meanings at different times, e.g., mystic, religious, symbolic, racial, patriotic, biological, medical, scientific, industrial, and economic. Nowadays, the meaning of blood is most pronounced in the science, medicine, and economy.

Blood Component Transfusion↗

[Textual research on diagnosis by lingual vessels].

Being a unique Chinese diagnostic measure, this method focussing its observation on the ventral vessels of the tongue, is first recorded in Neijing, saying that it is indicated when the vessels are varicose by puncturing for bloodletting in malaria, mad, and sadness. Ge Hong and Cao Yuanfan applied it for juandice, also for prognosis. Yimenfang predicts by this method the diagnosis for prognosis of the mother and foetus in difficult delivery, while Chen Zhiming popularized it in his Chan Nan sheng Si Jue. Inherited from the theory of Collateral Vessel Diagnosis, this approach pays attention to the observation of the forms and colors of collateral vessel, claiming that dark green color and congestion have bad diagnosis. Though not well developed, it was applied as extra-acupoints for swelling tongue, sore throat and jaundice. While Zhou Xuehai elaborated Liu Shouzhen's idea and put forward a theory of minute-vessel-stasis which is wonderfully conincided with modern microciroulation theory. In 1964, Zhang Zanchen again advocated its diagnostic value in tumor, hepatopathy and cor pulmonale.

China↗

Working conditions and duties of nurses in Byzantium.

From the beginning of the Christian Era, nurses in Byzantium were female and belonged to the Church. These women were called deaconesses and received no payment. Later on, there were professional nurses; the men were called hypourgoi and the women hypourgisses. Their main duties were: Psychological support of patients, everyday care of patients' bodily needs and elementary comfort, cleaning of patients and providing them with proper food, the administration of medicines according to a doctor's instructions, supervising wards when the physicians were not present, the performance of enemas, cuppings and bloodletting, the main therapeutic means used at that time, the placing of patients on the operating table and the performance of minor operations. In the present study details are also given about woking hours and the nourishment and payment of nurses.

Byzantium↗

[Sociocultural aspects of rheumatological practices in Sub-Saharan Africa].

Conceived by the patient as the result of a surnatural origin, rheumatism, as most diseases in Black Africa, justifies the consultation of a witch or a quack. This consultation occurring upstream or downstream that of the modern physician aims to determine the exact cause of the disease in order to prescribe a suitable treatment. The recourse to traditional medicine is far from being influenced by the level of instruction of the patient. It occurs frequently during rheumatic diseases of which the symptomatology is dominated by pain and the physiopathology often obscure. The patient while looking for a solution to his problem does not act alone. He must take notice of the advice and requirements of his family of which he constitutes an indissociable element. The theory of humours is still present in the minds and is expressed by the recourse to purgative and vomitive drugs and to bloodletting. Thus by some of its conceptual and practical features, traditional African medicine reminds that which had prevailed in the west before the scientific and technical discoveries or the 19th century.

Africa↗

Beneficial effects of fructose 1,6-diphosphate on hemorrhagic shock in rats.

OBJECTIVE: To investigate the effects of fructose 1,6-diphosphate (FDP) on experimental hemorrhagic shock in rats. METHODS: Sixty rats were randomly divided into three groups: the normal saline control group (group A), the 5% glucose solution control group (group B) and the 5% FDP solution treated group (group C). Shock models were made by bloodletting until the mean arterial pressure (MAP) reduced to 39.75 mmHg (1 mmHg=0.133 kPa) for 60 minutes, and then normal saline, 5% glucose and FDP were given to the rats, respectively. RESULTS: FDP could significantly increase MAP and the survival rate, elevate pH value, partial oxygen pressure (PaO(2)) and superoxide dismutase (SOD) activity, and decrease partial carbon dioxide pressure (PaCO(2)) and malondialdehyde (MDA) in arterial blood of the shocked animals. CONCLUSIONS: It suggests that FDP has a good protective effect on hemorrhagic shock by improving tissue metabolism and preventing acidosis and tissue injury caused by free radicals.

Journal Article↗

Austin Flint in New Orleans and the origins of evidence-based medicine.

The famous nineteenth century American physician and medical educator, Austin Flint, Sr., was a professor at the New Orleans School of Medicine and a visiting physician at Charity Hospital in New Orleans from 1858 to 1861. Best remembered for the heart murmur that bears his name, Flint was also responsible for advances in the diagnosis and treatment of infectious diseases in the era that preceded the germ theory and the discovery of antibiotics. His experiences at Charity Hospital and his exposure to the French style of medicine as practiced by the Creole physicians of New Orleans encouraged him to advocate conservative treatment for pneumonia, in contrast to the bloodletting and other heroic measures that were popular at the time. His recommendations, based on statistical analysis of his clinical data from Charity Hospital, were one of the earliest examples of evidence-based medicine in America.

Education, Medical↗

[Health and death of Wolfgang Amadeus Mozart].

Not much is known about the medical history and cause of death of the composer Wolfgang Amadeus Mozart (1756-1791). Contrary to popular opinion, Mozart was not an exceptionally ill child and as an adult he generally enjoyed good health. At the age of 9 years he experienced a life-threatening illness, which was probably typhoid fever. On the left-hand side he had what has since become known as 'Mozart's ear', a pinna with under-development of the anthelical fold. His psychological condition gives rise to the notion that he was not exceptional, but that he responded to the events in his life in a normal manner. His terminal illness was characterised by edema of hands and feet, without any associated dyspnoea being described. The medical treatment was aggressive: enema, bloodletting on several occasions and treatment with a laxative substance. He was burried in an anonymous grave. The skull that was later ascribed to him was not his own, as no element of the denture fits with the tooth abscess he was known to have experienced. An overdose of mercury during the treatment of syphilis seems to be unlikely, as equally Henoch-Schönlein-purpura and the consequences of acute rheumatism. Trichinosis is a recent hypothesis which fits the terminal symptoms and the fact that Mozart was fond of pork. The diagnosis of his physician Closset was 'hitsiges Frieselfieber', which was possibly caused by one of the many infectious diseases prevalent at that time.

Austria↗

[Experimental study on protective effective of congsheng capsule in acute cerebral ischemia and improvement of cerebral blood flow and energy metabolism].

OBJECTIVE: To investigate the protective effect of Congsheng capsule (CSC) on acute cerebral ischemia in mice and rats. METHODS: Cerebral ischemia model was established by adding FeCl3 to block the blood flow of unilateral middle cerebral artery (MCA) for 30 mins. Acute incomplete cerebral ischemia was induced by ligation of bilateral carotid arteries in rats. Bilateral carotid arteries of old mice were repeatedly ischemia and reperfusion combined with caudal bloodletting to build the cerebral ischemia model. The effect of CSC on neurologic symptom, cerebral infarction size, cerebral water content, cerebral blood flow and cerebral tissue energy metabolism were observed. RESULTS: CSC 1, 3, 6 g/kg obviously reduce the size of cerebral infarction and cerebral water content, markedly improve the neurological symptoms and cerebral blood flow; 3, 6 g/kg significantly ameliorate the energy burden. CONCLUSION: CSC has anti-cerebral ischemia function through increasing blood supply of cerebral tissue and improve the energy metabolism.

Animals↗

[Diagnosis of 5 patients with possible primary hemochromatosis].

In a 49-year-old man and a 28-year-old woman, both of whom complained of fatigue, HFE-gen related respectively non-HFE-gen related primary haemochromatosis was diagnosed, based on the elevated serum transferrin saturation, the elevated serum ferritin levels, DNA studies and liver biopsy with qualitative respectively quantitative iron measurements. Their complaints diminished after bloodletting. Three women respectively 64, 61 and 46 years of age, were also suspected of primary haemochromatosis. The latter two presented with complaints of fatigue and malaise and chronic hepatitis C respectively. All three showed an elevated serum transferrin saturation and serum ferritin concentration. Further investigation showed the presence of secundary iron overload. Causes for it being excessive alcohol consumption, overweight and a poorly regulated diabetes mellitus type 2, and chronic hepatitis C respectively. These patients received specific therapy. Primary haemochromatosis is a common disorder of iron metabolism in individuals of Northern European descent. Diagnosis is based on an elevated serum transferrin saturation in combination with both elevated serum ferritin levels and homozygosity for the Cys282Tyr-mutation in the HFE-gen. The presence of an elevated serum transferrin saturation in combination with an elevated serum ferritin level is not always sufficient for the diagnosis, since these may be affected by other disorders. Moreover, iron overload may be caused by a form of haemochromatosis that is not HFE-related. In case of doubt as to the diagnosis, histological examination of the liver with a qualitative or quantitative iron determination is the golden standard.

Adult↗