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Results for “17-Hydroxycorticosteroids”

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PubMed1978

[Clinical value of the dexamethasone-HCG test in females with hirsutism with special reference to 17-beta-hydroxyandrogens].

The dexamethasone-hcg-test was administered to 34 hospitalized patients, aged 17 to 45, who were suffering from hirsutism in order to reveal the source of their androgen levels, which in most cases were elevated. In addition to the usual estimation of urinary 17-ketosteroids and urinary 17-OH-corticosteroids plasma 17-beta-hidroxiandrogens and androstendione were measured by RIA. The results of the tests varied to a high degree and could not be related to the clinical findings. The authors conclude that administration of dexamethasone-hcg-test is of small value in detecting the source of hirsutism.

17-Hydroxycorticosteroids↗
PubMed1978

On the appearance, levels and regulation of pancreatic enzyme serum concentrations.

The evaluation of serum pancreatic enzyme activity on whole and diluted serum permits the estimation of serum enzyme inhibitor activity via a ADS/AWS ratio. This has diagnostic value in chronic pancreatic disease. The serum pancreatic ferment activity appears to be regulated in part by serum steroid levels. It is responsive to high protein diet. A physiologic rationale is presented for the use of steroids and high protein diet in the treatment of acute and chronic pancreatic inflammation.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Effect of dexamethasone on water-salt metabolism and renal function in healthy humans].

Dexamethazone at a single dose of 2 mg caused in the next 24 hours retention in the organism of a healthy man of a liquid and salts against the background of an abrupt fall of excretion by the kidneys of 17-oxycorticosteroids. Most distinctly this effect manifested itself after an aqueous test (20 ml/kg). A functional test with dexamethazone may be used clinically in assessing the condition of the hormonal link of the water-electrolyte metabolism regulation and renal function.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Degree and frequency of activation of different adrenal cortex functions in diabetes mellitus patients].

The indices of three adrenal cortex functions were investigated in 517 patients with a moderately severe and severe forms of diabetes mellitus of various duration, outside of the ketoacidosis and hypoglucemia states. Both during decompensation and at the period of unstable compensation (subcompensation) of the disease 3--60% of the patients displayed increased indices of glucocorticoid and mineralocorticoid functions, and 20--38%--of the androgenic ones. Along with different frequency of detection, there was revealed a distinct non-uniformity of different indices elevation. A prevalence of the mineralocorticoid function activation was noted. As suggested, at the mentioned periods of diabetes mellitus functional activity of the adrenal cortex reflected various phases of the oscillatory adaptation process to the frequently repeated stress actions (metabolic disturbances). Possible causes of prevalent aldosterone excretion elevation are discussed.

17-Hydroxycorticosteroids↗
PubMed1978

Is the rhythm amplitude related to the ability to phase-shift circadian rhythms of shift-workers?

The magnitude of the circadian acrophase adjustment deltaphi to a phase shift of socio-ecologic synchronizers (as in shift-work) varies from subject to subject. According to J. Aschoff, the ability to adjust rapidly to a phase-shift could be associated with having a small amplitude for certain circadian rhythms. To test this hypothesis, the correlation coefficient (r) between the mean circadian rhythm amplitude A and the acrophase shift deltaphi (measured after the first night-shift) were calculated from estimates of chronobiological time series analyses (Halberg's single cosinor method). Data were obtained from two groups of selected shift-workers (20 and 5 subjects, respectively). A negative correlation between A and deltaphi (the smaller the amplitude, the greater the delpaphi) was observed in the circadian rhythms of the following variables: oral temperature (r = .63;P less than .01), peak expiratory flow (r = . 53: P less than . 01), and urinary 17-OHCS (r = . 60; P less than . 01), but not for other variables such as : grip strength, urinary K+ and Na+. The small amplitude of certain circadian rhythms could be considered as an index of an individual's ability to phase-shift easily. However, chronobiological characteristics, other than the small circadian rhythm ampliture, remain to be identified, for both a better detection of one's ability to do shift-work and a better knowledge for practical applications.

17-Hydroxycorticosteroids↗