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PubMed1999

[Authors of "Classified Collection of Medical Prescriptions"].

In this study, the career and official ranks of the authors of the Sejong text (1443-1445), Sejo text (1451-1464), and Seongjong text (1475-1477) of "Classified Collection of Medical Prescriptions" were investigated. In the completion of Sejong text, Kim Rye-mong (1406-1469), Ryu Seong-won (?-1456), and Min Bohua (?) collected and arranged all medical books inside and outside of Choseon; Kim Moon (?-1448), Shin Seok-jo (1407-1459), Lee Ye (1419-1480), Kim Soo-on (1410-1481), Jeon soon-eui (?), Choi Yun (?), and Kim Yu-ji (?-1469) took part in the edition; Lee Yong (1418-1453), Lee Sa-cheol (1405-1456), Lee Sa-soon (?-1455), and Rho Joon-g-rye (?-1452) participated in the editorial supervision. Ryang Seong-ji (1415-1482), Son So (1433-1484), Ryu Yo (?), Han Chi-ryang (?), An Geuk-sang (?), Han Kye-mi (1421-1471), and Choi Young-rin (?) took part in the completion of Sejo text. Han Kye-heiu (1423-1482), Rym Won-joon (1423-1500), Kueon Chan (1430-1487), Ryu Seo (?), and Baek Soo-heui(?) participated in the completion of Seongjong text. All 96 persons participated in the completion of draft text, revision text, and first-publication text of "Classified Collection of Medical Prescriptions". 14 persons (14.58%) participated in the completion of draft text. 77 persons (80.21%) participated in revision text, and 5 persons (5.21%) participated in first-publication text. Even though "Classified Collection of Medical Prescriptions" is a medical book, civil officials participated in its completion together with medical officials. The scholars of Jiphyeonjeon (The Jade Hall of Scholars) who led the academy at those days and famous medical officials were ordered to complete it by Sejong (1419-1450), Sejo (1455-1468), and Seongjong (1470-1494) who showed special interest in their own health and the health of common people.

Books↗
PubMed2002

[Comparison of the epidemiological characteristics of neural tube defects classified according to failure of the different points of closure].

OBJECTIVES: To study the epidemiological characteristics of neural tube defects (NTD) classified according to the theory of multi-site closure of the neural tube and to correlate several factors with the failure of different closure sites. MATERIAL AND METHODS: We used the data from the Spanish Collaborative Study of Congenital Malformations (ECEMC), collected from April 1976 to April 1995. During this time, 757 NTD of non-syndromic origin were diagnosed. These were classified into groups according to the failure of the point of closure and a range of variables were analyzed by comparing the different groups of NTD with each other. RESULTS AND CONCLUSIONS: Among non-syndromic NTD, 2.11 % recurred in siblings. However, the real recurrence rate in our population is 2.63 %, which corresponds with the recurrence rate observed before 1986. From this year the recurrence rate was modified by the legal possibility of abortion after prenatal diagnosis. The infants with NTD classified according to multi-site closure failure of neural tube differed in weight, mortality, maternal use of valproic acid, and maternal diabetes mellitus. While valproic acid is more specific to failure of closure sites 1 and 1 5, maternal diabetes mellitus preferentially affects failure of closure site 4. Closure site 4 is clearly genetically determined: it is frequently observed in genetic syndromes, predominantly affects females and is associated with a higher rate of maternal abortions and higher recurrence. Moreover, it is frequently observed in infants with multiple congenital anomalies and is associated with a higher rate of malformations among relatives.

Humans↗
PubMed2002

Assessment of the possibility to classify patients according to cholesterol guideline screening criteria using routinely recorded electronic patient record data.

BACKGROUND: Computerised decision support systems (CDSS) can be categorised as either being inquisitive or non-inquisitive. The non-inquisitive system uses routinely entered electronic patient data, to generate patient specific feedback based on guidelines. The Dutch College of General Practitioners' (DCGP) cholesterol guideline classifies patients into risk groups, eligible for screening. The availability of sufficient routinely recorded electronic patient data to classify patients according to the DCGP cholesterol guideline is unknown. OBJECTIVE: To assess whether it is possible to classify patients according to the screening criteria of the DCGP cholesterol guideline, using data routinely recorded by general practitioners. METHODS: We analysed the DCGP cholesterol guideline to identify selection criteria for screening. These selection criteria were subsequently used to create a cohort of patient records eligible for screening in the Integrated Primary Care Information (IPCI) Database. We calculated incidence and prevalence of risk factors and selected patient records for active management according to the identified screening selection criteria. RESULTS: 145866 valid patient records were selected for classification. In the retrieved records 9741 (13.6%) males and 5756 (7.8%) females were identified for active management according to the selection criteria of the DCGP cholesterol guideline. CONCLUSION: The classification of patients into risk groups, eligible for screening, according to the criteria of the DCGP cholesterol guideline using routinely recorded electronic patient data is feasible. Care should be taken when using only diagnostic codes, as it gives higher than expected incidence and prevalence of risk factors. Based on these findings we are currently building Cholgate, a non-inquisitive decision support system for cholesterol management.

Adolescent↗
PubMed2005

[A novel spectral classifier based on coherence measure].

Classification and discovery of new types of celestial bodies from voluminous celestial spectra are two important issues in astronomy, and these two issues are treated separately in the literature to our knowledge. In the present paper, a novel coherence measure is introduced which can effectively measure the coherence of a new spectrum of unknown type with the training sampleslocated within its neighbourhood, then a novel classifier is designed based on this coherence measure. The proposed classifier is capable of carrying out spectral classification and knowledge discovery simultaneously. In particular, it can effectively deal with the situation where different types of training spectra exist within the neighbourhood of a new spectrum, and the traditional k-nearest neighbour method usually fails to reach a correct classification. The satisfactory performance for classification and knowledge discovery has been obtained by the proposed novel classifier over active galactic nucleus (AGNs) and active galaxies (AGs) data.

English Abstract↗
PubMed2006

SPECT-guided CT for evaluating foci of increased bone metabolism classified as indeterminate on SPECT in cancer patients.

UNLABELLED: Hybrid cameras combining SPECT and spiral CT offer the opportunity to obtain a diagnostic-quality CT image of scintigraphically suggestive lesions that directly correlates with the SPECT image. The field of view of the CT scan can be adapted on the basis of the SPECT findings ("SPECT-guided CT"). The aim of the present study was to investigate the value of SPECT-guided CT in the assessment of foci of increased bone metabolism classified as indeterminate on SPECT. METHODS: Of 272 consecutively examined patients with histologically confirmed malignancy who underwent bone scintigraphy, 112 (41%) required further workup by SPECT because a definite diagnosis could not be established using whole-body planar scintigraphy alone. In 57 of these patients, SPECT was accompanied by inline CT over the body region of interest; the remaining 55 subjects underwent only stand-alone SPECT for logistic reasons. The 57 SPECT/CT studies were retrospectively evaluated by readers who were unaware of the clinical pretest probability and the findings on the planar scans. In total, 52 lesions in 44 patients were rated as indeterminate on the SPECT images. Afterwards, the corresponding SPECT/CT images were analyzed and the findings previously rated as indeterminate were classified either as definitely benign, indeterminate, or definitely malignant. RESULTS: Of the 52 indeterminate findings on SPECT, 33 (63%) could be correlated with benign findings on CT. These findings involved mostly osteochondrosis, spondylosis, and spondylarthrosis of the spine. Fifteen lesions (29%) could be correlated with osteolysis or sclerotic metastases on CT. Even after analysis of the SPECT/CT images, 4 lesions (8%) remained indeterminate. These lesions were in the ribs and the scapula. CONCLUSION: SPECT-guided CT was able to clarify more than 90% of SPECT findings classified as indeterminate in an analysis that was masked as to clinical pretest probability and the planar scan findings. Further studies carefully addressing the cost efficiency of this new technology and its actual clinical value are encouraged by this observation.

Bone and Bones↗
PubMed2006

[Clinical classify and therapy of unusual feeling symptom of pharynx].

OBJECTIVE: Through the observation, analysis, and treatment to lots of clinical patients with unusual feeling symptom of pharynx (UFSP), followed by the functional examination of autonomic nerve, putting forward the clinical classify and therapy of UFSP. METHODS: Through the clinical history inquired, routine examination, 24 hours pH value determined of esophagus, erect experiment, and coefficient of variation of the R-R(CVR-R) examination of electrocardiogram etc, divided the UFSP into two types: the type of pathogeny clear and the type of pathogeny unclear. The clear-type was further classified into five subtypes: the type of a mental scar, the type of morbid state of mind, the type of reflux esophagitis, the type of climacteric syndrome and menstrual disorder, and the type of functional disturbance of independence nerve. RESULTS: In the cases of 256, 106 were cured,76 were positive effective, 41 were effective, with total effective rate of 87.1%. Thirty three (12.9%) cases were not cured. Forty six (18.0%) of them with the type of a mental scar were whole cured. One hundred and thirty six (53.1%) of them with the type of morbid state of mind had a 93.4% (127) effective rate. Twenty one (8.2%) of them with the type of reflux esophagitis had 71.4% (15) effective rate. Among 35 (13.7%) cases of climacteric syndrome and menstrual disorder type, 29 cases were cured with a 82.9% effective rate. Twelve (4.7%) cases of the type of functional disturbance of independence nerve had 50% effective rate. Six (2.3%) cases of the pathogeny unclear type'were not cured. CONCLUSIONS: UFSP could be clinical classified and treated followed the detail inquiry of medical history and relative examination.

Adolescent↗
PubMed2006

[Application of boosting-based decision tree ensemble classifiers for discrimination of thermophilic and mesophilic proteins].

In this paper, the Boosting-based decision tree ensemble classifiers were applied to discriminate thermophilic and mesophilic proteins. Three methods, namely, self-consistency test, 5-fold cross-validation and independent testing with other dataset, were used to evaluate the performance and robust of the models. Logitboost, as a novel classifier in Boosting algorithm, performed better than Adaboost. The overall accuracy of the three methods was 100%, 88.4% and 89.5%, respectively. It was demonstrated that LogitBoost performed comparably or even better than that of neural network, a very powerful classifier widely used in biological literatures. The influence of protein size on discrimination was addressed. It is anticipated that the power in predicting many bio-macromolecular attributes will be further strengthened if the Boosting and some other existing algorithms can be effectively complemented with each other.

Algorithms↗
PubMed1986

Within- and between-person variation in dietary surveys: number of days needed to classify individuals.

The variation from day to day, between individuals and within individuals, in the consumption of energy and a variety of nutrients is presented for two groups of executive grade civil servants aged 40-49, numbering 83 and 68 and working in London in 1970-1971, and for 98 drivers and 83 conductors aged 30-67 of London's double decker buses in 1958-1967, a total of 332 men. Each man weighed and recorded his food for at least a week. The reliability with which these men could be classified into extreme thirds of the distribution of individual consumption of the various 'nutrients' or foods on the basis of a single day's or of several days' measurement was calculated. The number of days of measurement required to achieve a given reliability of classification into extreme thirds of the distribution was also estimated. The key is the ratio of the 'between-person' to the 'within-person' variance for the particular nutrient. A diagram is presented of how this ratio is related to the number of days of survey required for a given reliability. Nutrients fall into three main groups--those consumed in relatively large amounts each day (eg protein, fat), those found in moderate amounts in many or most foods but in very large quantities in a few foods (eg dietary cholesterol, calcium), and those which may not be consumed at all by some people but are taken in large quantities by others (eg alcohol). The number of days of survey required for 80 per cent reliable classification of individuals varies from 2 or 3 days for some nutrients like sugar or total carbohydrates to 2 or 3 weeks for others like dietary cholesterol or the ratio of polyunsaturated fatty acids to saturated fatty acids. One day's survey classified no nutrients with 80 per cent reliability in our data, whereas one week's survey classified most nutrients with this reliability or better, although for a few the figure is lower. The precision of a week's survey is also shown in absolute quantities such as grams as distinct from thirds of the distribution. The relevance of these observations to the use of the results of 24-hour surveys in population surveys and correlation and regression analysis is discussed.

Adult↗
PubMed1984

Stabilized binary hierarchic classifier in cytopathologic diagnosis.

A binary tree classifier (BTC) algorithm for computer-assisted cell image analysis has been developed that overcomes the problem of overtraining due to inadequate sample size/dimensionality ratio at the higher-order nodes of a hierarchic decision structure. Provisions have been introduced that ensure that decision rules created at each node are based on samples representative of the subpopulation routed to the node. These provisions eliminate problems caused by truncation effects resulting from the application of decision rules at preceding decision nodes. The BTC performs better than do single-stage classifiers in situations where the categories' mean vectors are not well separated and no equality of covariance matrices exists. In applications in which noticeable deterioration of classifier performance on test-set data is common, the classification success rate of the BTC algorithm is not statistically significantly different between the training-set and test-set data.

Cells↗
PubMedDate not supplied

Single step immunophenotyping of acute leukemias not classifiable by standard morphology and cytochemistry: a practical approach.

BACKGROUND: Immunophenotyping is at present a useful aid and often an essential step for correct diagnosis of acute leukemia and for this purpose some investigators have proposed several immunomarker panels. This approach is particularly important in the differential diagnosis of acute leukemias not classifiable by standard morphology and cytochemistry. METHODS: We have tested peripheral blood and/or bone marrow samples from 125 patients not classifiable by FAB criteria. In all the cases, the reactivities of the same panel of 17 monoclonal antibodies were analyzed by flow cytometry, using both single and double fluorescent labeling. RESULTS: Of the 125 patients investigated, 75 (60%) were classifiable as ALL, 58 as B-lineage ALL and 17 as T-lineage ALL; 33 (26.4%) as AML, of which 2 M7; 6 (4.8%) as biphenotypic and 11 (8.8%) as immunophenotypically undifferentiated. CONCLUSIONS: From a critical analysis of our cases and a review of the literature, we suggest that a panel of 9 monoclonal antibodies (CD2, CD5, CD7, CD10, CD19, CD20, CD13, CD33, CD41), is sufficient for reliable, rapid and reasonably low cost typing of acute leukemia, useful for an immediate therapeutic decision.

Acute Disease↗
PubMed1995

Sagittal plane correction in "King-classified" idiopathic scoliosis patients treated with Cotrel-Dubousset instrumentation.

INTRODUCTION AND AIM OF THE STUDY: Whereas Harrington instrumentation (HI) has demonstrated satisfactory frontal plane correction, sagittal plane realignment is difficult. Sagittal plane control is reported to be easier with Cotrel-Dubousset instrumentation (CDI). This study was undertaken to determine if in our series sagittal realignment was achieved with CDI in idiopathic curves classified according to King. MATERIAL AND METHODS: Ninety-seven patients with idiopathic scoliosis classified according to King and treated with CDI underwent coronal and sagittal plane analysis by an unbiased observer. The sagittal curves were measured with the Cobb method from T4-T12 (normals: +25 to +40 degrees) and L1-L5 (normals: -40 to -55 degrees). The thoracolumbar junction (TJ) was divided into an upper TJ (T10-T12) and a lower TJ (T12-L2) with normals between 0 and +10 degrees for the former and 0 and -10 degrees for the latter. RESULTS: In all types of scoliosis with associated thoracic hypokyphosis a significant realignment could be achieved, ranging from 8 degrees in King 1 and 3 curves to 19 degrees in King 4 curves. In normokyphotic curves no significant changes of the thoracic spine were measured postoperatively. Concerning the upper TJ, pathological lordosis was corrected by 7 degrees on the average, whereas correction of kyphosis ranged from 8 to 18 degrees Cobb. Pathologic kyphosis and hyperlordosis of the lower TJ showed a mean correction of 7 degrees and 11 degrees, respectively. There was no significant direct influence of CDI on the sagittal plane of the lumbar spine. CONCLUSION: The data from this study suggest that correction in the sagittal plane can be achieved with CDI in King-classified scoliotic deformities.

Follow-Up Studies↗
PubMed2004

Local control after supracricoid partial laryngectomy for "advanced" endolaryngeal squamous cell carcinoma classified as T3.

OBJECTIVES: To determine the incidence of local control in patients with "advanced" moderately to well-differentiated endolaryngeal invasive squamous cell carcinoma classified as T3, treated with a supracricoid partial laryngectomy; to identify any statistical relationship; and to analyze the consequences of local recurrence. DESIGN: Retrospective nonrandomized case series. SETTING: A tertiary referral care center and university teaching hospital. PATIENTS: An inception cohort of 118 patients. Tumor stage was T3 N0 M0 in 90 patients, T3 N1 M0 in 21 patients, T3 N2 M0 in 5 patients, and T3 N3 M0 in 2 patients. INTERVENTIONS: All patients underwent supracricoid partial laryngectomy. A platin-based induction chemotherapy regimen was used in 100 patients. Postoperative radiotherapy was used for 24 patients. MAIN OUTCOME MEASURES: Local recurrence, nodal recurrence, distant metastasis, and survival; univariate and multivariate analysis of local recurrence. RESULTS: Nine patients developed a local recurrence. The 1-, 3-, and 5-year actuarial local control estimates were 97.3%, 93.5%, and 91.4%, respectively. In a stepwise regression model, the presence of positive margins of resection was the only variable that statistically increased the risk of local recurrence (P =.008). Local recurrence resulted in a significant increase in nodal recurrence (P<.001) and distant metastasis (P<.001) and a significant decrease in survival (P =.03). An overall 89.8% laryngeal preservation rate and 98.3% local control rate were achieved. CONCLUSION: Supracricoid partial laryngectomies should be considered when an organ preservation strategy is discussed in patients with advanced endolaryngeal squamous cell carcinoma classified as T3.

Actuarial Analysis↗
PubMed1997

Validity of clinic biopsy specimens in classifying histopathologic characteristics of recurrent nasopharyngeal carcinoma.

OBJECTIVE: To evaluate nasopharyngeal carcinoma resection specimens for heterogeneity of histologic patterns to determine if preoperative histologic characteristics of the clinic biopsy specimen are representative of the entire lesion. The null hypothesis is that clinic biopsy specimens are not necessarily representative. DESIGN: Preoperative clinic biopsy specimens were measured to calculate their average size. Resection specimens were then sectioned and evaluated in increments corresponding to this size. Each of these increments was then histologically classified according to the World Health Organization (WHO) criteria. This classification of the preoperative biopsy specimens was compared with that of the resection specimen as a whole. SETTING: University referral center. PATIENTS: Twenty-six consecutive patients with recurrent nasopharyngeal carcinoma who underwent surgical resection. Radiation therapy failed in all patients. MAIN OUTCOME MEASURE: The presence or absence of WHO histologic heterogeneity in the nasopharyngectomy specimen was recorded. Disparity between preoperative clinic biopsy and resection specimens was recorded. RESULTS: The mean clinic biopsy specimen size was 13.9 mm2 or less than 1% of the available surface area of the nasopharynx. Of 26 resection specimens classified in 5 increments of this size, 15 (57.7%) were a single WHO type, and 11 (42.3%) were found to be mixtures of WHO types I, II, and III. Of 16 cases with preoperative biopsy specimens available, 4 (25%) were a different WHO classification than their corresponding resection specimen. CONCLUSIONS: Most clinic biopsy specimens were representative of their corresponding tumor resection specimens in their entirety; however, tumor heterogeneity is such that some biopsy specimens will not be representative. This finding may interfere with WHO classification data determined on the basis of clinic biopsy specimens and hence confound any meaningful data on treatment outcomes. It is recommended then that multiple nasopharyngeal biopsy specimens be obtained from disparate areas of the lesion and each subjected to independent histopathologic review.

Adult↗
PubMed1979

Newer experimental methods for classifying depression. A report from the NIMH collaborative pilot study.

A total of 83 patients receiving diagnoses of major depressive disorder in the pilot phase of the National Institute of Mental Health Collaborative Study of the Psychobiology of Depression were used to evaluate two newer methods of classifying depressive disorders on the basis of family history or course. A third subtype based on family history, nonfamilial depression, was compared with the two subtypes originally proposed by Winokur and colleagues, pure depression and depression spectrum diseases. The system for classifying depressions on the basis of course and antecedent disorder, primary vs secondary depression, was also compared. These data from the pilot study indicate that two newer systems for classification have some predictive, construct, and content validity, but both are in need of further investigation before they become accepted methods for the classification of depressive disorders.

Depression↗
PubMed1996

Classifying visual field data.

We develop a prediction model for classifying an eye according to glaucoma status based on its visual field. We develop measures of both diffuse and localized defects in the visual field as potential predictors of glaucoma. To identify predictors of abnormal fields, we must describe the variability in the fields of normal eyes, hence we first model the mean, variance and correlation structures of normal fields with use of generalized estimating equations. The best measures of diffuse loss include a field's mean level, contrasts of the upper and lower halves, and contrasts of the nasal and temporal halves. Local loss is measured by the depth, area, volume and location of the field's largest defect. We develop logistic regression models to classify eyes as having glaucoma or not. We present ROC curves of the results that are highly competitive with current clinical methods of classification.

Adult↗
PubMed1998

Observer variation in classifying chest radiographs for small lung opacities and pleural abnormalities in a population sample.

BACKGROUND: The purpose of this study was to assess inter-and intraobserver variation in the radiographic categories of small lung opacities (profusion) and pleural abnormalities classified according to the ILO classification of pneumoconioses with some modifications. METHODS: Chest radiographs derived from a representative adult population sample (n = 7,095) were classified by two radiologists. Observer variation was assessed on the basis of kappa (kappa)-type statistics. RESULTS: The observers agreed on profusion categories in 69% of cases of the total material. Up to 98% of the classifications fell into the same category or deviated by no more than one category. The corresponding kappa (kappa) coefficient was 0.48 (95% CI = 0.46=0.49) and the weighted kappa 0.72. When a selected subsample was reclassified by the observers, the proportions of crude agreement on profusion of small opacities ranged from 42% to 47% (weighted kappa 0.52-0.55). The proportions of agreement on the main pleural abnormalities were 92% or over, and the corresponding kappa coefficients at least 0.73. CONCLUSION: The classification of lung opacities was subject to considerable observer variation, which calls for caution when results from different studies are compared. This variation, however, rarely exceeded one category, and thus appears to be small enough for meaningful comparisons between groups, at least within a single study.

Adult↗
PubMed1999

Analysis of the velocity curve for height by the wavelet interpolation method in children classified by maturity rate.

The Wavelet Interpolation Method (WIM) developed by Meyer ([1992] Wavelets and Operators. Cambridge: Cambridge University Press) has been proposed as an analytical method for the accurate description of longitudinal growth velocity in height and identification of the age at maximum peak velocity (MPV) in the curve. The distance curve in height was determined by interpolating the longitudinal records of 98 boys and 88 girls, 6-17 years old, with the WIM. The distance curve was then differentiated to obtain a velocity curve. Age at MPV estimated from the velocity curve was utilized as a criterion of maturity rate (timing), and five maturity groups (early, little early, average, little late and late) were defined in both sexes. Four type models were derived from the occurrence of secondary peaks (mid-growth spurt and after-growth spurt): type model A, appearance of a mid-growth spurt and MPV; type model B, appearance of an after-growth spurt and MPV; type model C, appearance of a mid-growth spurt, an after-growth spurt and MPV; and type model D, appearance of MPV only. The individual growth data of boys and girls classified by maturity rate were sorted into the four type models. The frequency of occurrence of the four type models in groups classified by maturity rate was then analyzed, and the characteristics of height growth velocity was examined in boys and girls. Am. J. Hum. Biol. 11:13-30, 1999. Copyright 1999 Wiley-Liss, Inc.

Journal Article↗
PubMed2001

Chemotherapy alone with curative intent in patients with invasive squamous cell carcinoma of the pharyngolarynx classified as T1-T4N0M0 complete clinical responders.

BACKGROUND: The current studies documented the results achieved with chemotherapy alone with curative intent in a series of 67 patients with invasive squamous cell carcinoma of the pharyngolarynx classified as T1-T4N0M0 complete clinical responders after a platin-based induction chemotherapy regimen. METHODS: Group I consisted of 36 patients with tumors originating from the glottis. Group II consisted of 31 patients with tumors originating from sites within the pharyngolarynx other than the glottis. A minimum of 3 years of follow-up was achieved. Statistical analyses of survival, local control, lymph node control, distant metastasis, and second primary tumor rates were based on the Kaplan-Meier life-table method. Laryngeal preservation rates and local control rates are presented. RESULTS: The 5-year actuarial survival estimate was 85.1% in Group I patients and 54.8% in Group II patients. Survival was statistically more likely to be reduced in Group II patients compared with Group I patients (P = 0.01). The 5-year actuarial local control estimate was 65.7% in Group I patients and 37.5% in Group II patients. Local failure was statistically more likely to occur in Group II patients compared with Group I patients (P = 0.02). Local control rates after salvage treatment were 100% in Group I patients and 83% in Group II patients. Laryngeal preservation rates after salvage treatment were 100% in Group I patients and 64% in Group II patients. The 5-year actuarial lymph node control estimate was 90% in Group I patients and 73.7% in Group II patients. Lymph node failure was statistically more likely to occur in Group II patients compared with Group I patients (P = 0.04). The 5-year actuarial estimate for patients without distant metastasis was 100% in Group I patients and 90% in Group II patients. Distant metastasis was statistically more likely to occur in Group II patients compared with Group I patients (P = 0.03). The 10-year actuarial estimate for patients without metachronous second primary tumors was 56.4% in Group I and 46.1% in Group II. CONCLUSIONS: The current report 1) contradicts the old dogma of nonchemocurability for invasive squamous cell carcinoma of the upper aerodigestive tract and 2) suggests that the use of a platin-based chemotherapy-alone regimen with curative intent in patients with invasive squamous cell carcinoma of the pharyngolarynx who are classified as T1-T4N0M0 complete clinical responders after receiving an induction chemotherapy regimen is best indicated when the tumor originates from the glottis.

Adult↗