Transfer, synonymity, and anticipatory interval in paired-associate verbal learning.
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Word list learning was studied in patients with a definite diagnosis of Multiple Sclerosis and in Normal Control subjects by means of the selective reminding procedure of Buschke and Fuld in two learning conditions: (1) using unrelated items and (2) paired-associate items. The Multiple Sclerosis patients displayed poor learning in both conditions. To identify the functional locus of their deficit, stochastic Markov chain analyses were performed, which allowed individual measurements of encoding, automatic and intentional retrieval abilities. On both tasks, encoding on the first trial and automatic retrieval on the subsequent trials were impaired in Multiple Sclerosis patients, whereas intentional retrieval, both with and without reminding by the examiner, appeared to be preserved. As all of the impaired abilities require a normal speed of information processing, the salient learning deficit of the Multiple Sclerosis patients could be tentatively traced back to the slowing down of their mental activity.
We studied word list and paired associates learning in patients with idiopathic Parkinson's disease and normal controls by means of a two-stage stochastic model, which allows independent measurements of encoding, storage and retrieval abilities. We preliminarily ascertained that the model components were both sufficient and necessary to account for the overall performance of the subjects, and then compared the learning abilities between the two groups. Parkinson's disease patients were selectively impaired in identifying well-known engrams, for which learning is superfluous, and in automatic retrieval, namely in abilities that do not need attentional effort. By contrast, they were unimpaired in encoding and intentional retrieval, which require a purposeful effort. The automatic-voluntary dissociation of Parkinson's disease patients' motor behaviour is, therefore, paralleled by some features of their memory performance.
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