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Tomography of pelvic-abdominal masses during intravenous urography. An added dimension.

Experience with a wide variety of pelvic-abdominal masses indicates that good quality tomography during high dose urography permits separation of solid from cystic lesions in almost all cases, even with minimal mass opacification. Evaluation of surface contour, absence or presence of a wall and its features, opacification, calcification, and uterine status provides the framework for characterization of the mass. Multiple masses can be identified and evaluated separately. While titration of the above criteria permits an accurate assessment independent of the clinical diagnosis, the latter information is important in separating a probable abscess from other cystic lesions. Since urography continues to be a pivotal preoperative roentgenologic investigation (ureteral status, pelvic kidney exclusion, etc.), the addition of tomography provides an added dimension to its usefulness. With the exception of the premenopausal female in whom radiation exposure is a consideration, tomography appears to preclude the routine necessity for subsequent ultrasound study which has been used to separate cystic from solid lesions.

Abdomen↗

Electrocardiographic response to intravenous urography: prospective evaluation of 275 patients.

A total of 275 consecutive patients referred for intravenous urography were monitored for electrocardiographic changes during administration of Conray 400 or Renovist II in the form of either intravenous bolus or infusion. Three patients who received Conray (two bolus and one infusion) developed sustained ventricular tachycardia; they reverted to sinus rhythm with intravenous lidocaine. A statistically significant (P less than .05) number of patients developed a heart rate increase of 10 beats/min or more with bolus of either drug (65 of 128) compared to infusion (21 of 147). Depression of ST segment (greater than or equal to 0.5 mm) was encountered statistically more often (P less than .05) with bolus (20 of 128) compared to infusion (six of 147). Increase of corrected QT of 0.10 sec or more was observed more often (P less than .05) with bolus (43 of 128) compared to infusion (five of 147). Abnormal resting ECG, coronary artery disease, or congestive heart failure imposed a higher (P less than .05) risk for development of ventricular tachycardia, ST depression, or ectopic ventricular beats. It is concluded that a bolus injection be very cautiously administered to patients with risk factors such as abnormal ECG, coronary artery disease, or congestive heart failure during intravenous urography and that resuscitative facilities be available.

Adolescent↗

Urography in the child who wets.

Most children who wet have no underlying structural abnormality and will not benefit from urography. However, several conditions may mimic simple enuresis, and in children with clinical clues that suggest these diagnoses, urography can be confirmatory. The urogram should be conducted so as to exclude an anatomic cause for wetting. This is likely in females in the presence of a duplex collecting system, a nonfunctioning kidney, marked vaginal reflux, or a widened interpublic distance. In the urogram of a child of either sex, a spinal anomaly should be sought.

Child↗

Urography with metrizamide in children.

Noionic contrast material could have particular value in pediatric urography because of the absence of osmotic diuresis and associated fluid loss. Excretory urograms were obtained in 23 children using metrizamide at 300 mg l/ml and administered at a dose of 2.2 ml/kg. The radiographs gave excellent urinary tract opacification without changes in serum osmolality. The calyces appeared sharp but undistended, there was increased occurrence of ureteral ridging, and the urinary bladders often remained undistended at the completion of the studied. The dense opacification attainable with isoosmolar metrizamide also gave the opportunity for performing urography with higher than normal kilovoltage and thus reducing radiation exposure to the child. Also in vitro studies demonstrated the significant radiation dose reduction possible with the higher kilovoltage technique.

Blood↗

Excretory urography in patients with prostatism.

The value of performing routine screening excretory urography in patients with prostatism was prospectively evaluated in 180 patients (50 years old or older). All patients had signs and symptoms of prostatism or acute urinary retention, findings of benign prostatic hypertrophy on physical examination, and negative urine cultures. High-risk patients, such as those with hematuria, urinary tract infections, history of bladder tumors, or significant elevation of serum creatinine, were excluded. In four patients (2.2%), findings of excretory urography resulted in an alteration of patient management. Three of these had asymptomatic upper urinary tract malignancies. One had a complicated renal cyst. We conclude that routine screening of patients with prostatism is warranted.

Aged↗

Evaluation of lopamidol and diatrizoate in excretory urography: a double-blind clinical study.

Image opacification, patients' tolerance, and clinical and laboratory findings were evaluated in patients having excretory urography at three centers. In a double-blind, parallel study, iopamidol was compared with diatrizoate (50-ml dose), and in an open-label trial, the administration of a 100-ml dose of iopamidol was evaluated. In the double-blind study, a total of 84 patients received 50 ml of either iopamidol or diatrizoate. In the open-label study, another 42 patients received a 100-ml dose of iopamidol. Image opacification scores after the administration of the 50-ml doses showed better opacification with iopamidol than with diatrizoate in the renal calices (p less than .05) and in the composite kidney (p less than .05). Opacification scores were higher for 100-ml doses of iopamidol than for 50-ml doses in all anatomic regions as well as in the composite kidney (p = .0001). Patients' tolerance to iopamidol was significantly better than their tolerance to diatrizoate (p less than .025). Investigators observed adverse drug reactions in a total of 10 patients. In the double-blind study, one of 43 patients had transient bradycardia after the administration of iopamidol. In the same study, four of 41 patients who received diatrizoate had five minor adverse drug reactions. With 100-ml doses of iopamidol, five of 42 patients had adverse reactions. No adverse side effects required therapy in either study. There were no significant changes in vital signs or laboratory values after drug administration. The results of this study show that iopamidol is a suitable agent for excretory urography at doses of 50 and 100 ml. Patients report fewer unpleasant side effects with iopamidol than with diatrizoate. Overall image quality was better with iopamidol than with diatrizoate. Overall evaluation of drug performance was better with iopamidol than with diatrizoate.

Adolescent↗

Evaluation of transurethral cystoscopy and excretory urography for diagnosis of ectopic ureters in female dogs: 25 cases (1992-2000).

OBJECTIVE: To evaluate transurethral cystoscopy and excretory urography for diagnosis of ectopic ureter in female dogs and identify concurrent urogenital abnormalities. DESIGN: Retrospective study. ANIMALS: 25 female dogs. PROCEDURE: Medical records of female dogs that underwent transurethral cystoscopy, excretory urography, and ventral cystotomy were reviewed for signalment, history, physical examination findings, results of bacteriologic culture of urine, and surgical findings. Videotapes of transurethral cystoscopy and radiographic studies were reviewed systematically without knowledge of surgical findings. RESULTS: Ectopic ureters were diagnosed in 24 of 25 (96%) of the dogs, bilaterally in 22 of 24 (91.6%) dogs. Cystoscopic evaluation yielded a correct diagnosis in all dogs when results of ventral cystotomy were used as the diagnostic standard. Cystoscopic evaluation identified a terminal ureteral opening for all ureters. Urethral fenestrations, troughs, striping, and tenting were identified. Abnormalities of the vestibule were identified in all examinations available for review (24/25). The paramesonephric septal remnant and its association with ectopic ureters were identified and characterized by cystoscopy. Radiographic findings were discordant with surgical findings and correctly identified 36 of 46 (78.2%) ectopic ureters and 2 of 4 normal ureters. Hydroureter and renal abnormalities were associated with distal urethral ectopic ureters on radiographic evaluations. CONCLUSIONS AND CLINICAL RELEVANCE: Transurethral cystoscopy was accurate and minimally invasive for identification and classification of ectopic ureters in dogs. Contrast radiography had limitations in diagnosis of ectopic ureters. Cystoscopic findings and associated vaginal and vestibular abnormalities support abnormal embryologic development in the pathogenesis of ectopic ureters.

Animals↗

Ultrasonography versus urography as preoperative investigation prior to hysterectomy.

Ultrasonography (US) has been compared with urography (IVU) as a preoperative investigation prior to hysterectomy in 62 patients. In 38 patients the urinary tract was deemed normal by both US and IVU. US and IVU coincided in varying degrees of hydronephrosis in 8 patients and disagreed in one. Of 5 double ureters, US missed 2. IVU showed expansile lesions in 5 kidneys where US showed benign cysts. No severe contrast media reactions were observed. We recommend that preoperative urography should be replaced by preoperative ultrasonography when a screening examination of the upper urinary tract morphology is deemed necessary prior to hysterectomy.

Female↗

Acute side effects of iopromide and diatrizoate in urography.

PURPOSE: In a prospective study, we compared the acute (0-2 h) side effects of ionic and nonionic contrast media in 767 patients undergoing intravenous urography. MATERIAL AND METHODS: A nonionic contrast medium (iopromide) was compared to an ionic contrast medium (diatrizoate). RESULTS: Side effects occurred in 25 patients (7.9%) receiving iopromide and in 104 patients (23.1%) receiving diatrizoate (p < 0.01). The reactions in the iopromide group were mild in 11 patients, moderate in 5, and severe in 1. The reactions were 83, 19 and 2, respectively, in the diatrizoate group. The number of reactions that required treatment was equal in the two groups (p > 0.05). CONCLUSION: At intravenous urography, iopromide induced fewer side effects compared to diatrizoate.

Acute Disease↗

[A case of pheochromocytoma detected by hypertensive crisis immediately after drip infusion urography].

We report a rare case of a 60-year-old man with a pheochromocytoma detected by a hypertensive crisis immediately after drip infusion urography. The patient initially consulted our hospital complaining of dysuria. He underwent a drip infusion urography and experienced a hypertensive crisis. The next day he was diagnosed with paralytic ileus. An endocrinological examination, abdominal computed tomography and 123I-metaiodobenzyl-guanidine scintigraphy revealed a pheochromocytoma. The tumor mass was removed, and immediately his blood pressure became normal and the paralytic ileus improved; however, temporary postoperative hypoglycemia was seen. Frequent monitoring of his blood glucose and the administration of an appropriate solution of dextrose, both during and after the operation, were recommended.

Adrenal Gland Neoplasms↗

[Magnetic resonance urography: possibilities and prospects].

A new technique of urinary tracts visualization--magnetoresonance urography (MRU)--for a year (2000) was applied in examination of 25 patients aged 17 to 63 years with ureteral concrements (n = 11), ureteropelvic stenosis (n = 10), ureteral stenosis (n = 2), urinary bladder tumor (n = 1), Ormond's disease (n = 1). MRU provides the same information about the obstruction and dilatation of the urinary tracts as excretory urography (EU). In cases of EU contraindication (allergy, renal failure) or lack of contrast substance excretion, MRU allows to avoid additional invasive diagnostic procedures. It also enables visualization of non-dilated urinary tracts in medicinal polyuria. Non-invasiveness, no need to contrast, absence of radiation load open wide perspectives for MRU application in various groups of patients including pregnant women.

Adolescent↗

A case of renal ptosis treated with hochu-ekki-to with improvement confirmed by excretory urography.

A 59-year-old woman visited our clinic with complaints of right back dull pain. Excretory urography showed bilateral renal ptosis (a 6 cm decrease in position of the right kidney and a 5 cm decrease of the left kidney). She was treated with 7.5 g/day of Hochu-ekki-to. After 6 months, her symptoms improved and after 8 months excretory urography showed a 3 cm decrease in the position of both kidneys. Hochu-ekki-to might be useful for the conservative therapy of renal ptosis.

Drugs, Chinese Herbal↗

[Spiral CT urography and CT virtual endoscopy in detecting urological diseases].

OBJECTIVE: To evaluate spiral CT urography (SCTU) and CT virtual endoscopy (CTVE) in detecting urologic diseases. METHODS: SCTU was performed in 46 patients with urological diseases including renal neoplasms (2), paropelvic cysts (2), ureteral calculi (6), ureteral stenosis (4), ureteral neoplasms (2), double kidneys and ureter malformation (1), bladder neoplasms (28) and bladder endometreosis (1). The 6 patients with ureteral diseases and 29 patients with bladder diseases underwent CTVE based on spiral CT scan. All CTVE findings were compared with those of B-mode ultrosonography, intravenous urography (IVU), retrograde pyelography (RGP), conventional CT or cystoscopy. RESULTS: All upper urinary tract diseases and bladder diseases (28 cases) were detected by SCTU and CTVE scans and they were confirmed operatively or pathologically except one case of bladder neoplasm (diameter less than 5 mm) was missed. CONCLUSION: SCTU and CTVE have proved to be non-invasive and reliable in the diagnosis of urological diseases and are superior to IVU or conventional CT. CTVE can serve as a supplementary method to fiberoptic cystoscopy or ureteroscopy.

Adolescent↗

Ioversol in intravenous excretory urography. Evaluation of radiographic quality, patient tolerance and safety in four clinical studies.

Three randomized, parallel group, double-blind clinical trials (Study A, B and C) and one open-label, noncomparative clinical trial (Study D) were performed in adult patients to evaluate the radiographic quality, patient tolerance and safety of Optiray 300 (ioversol) in intravenous excretory urography. Comparative agents were iohexol (Study A and C) and iopamidol (Study B). Regarding the radiographic quality ioversol provided a statistically significant better ureter opacification (p = 0.029) compared to iohexol (Study A). In comparison to iopamidol (Study B) the mean degree of certainly with respect to the investigator's urogram-based diagnoses was statistically significant higher (p = 0.025) for ioversol. In these two studies the enhancement quality of regions visualized was higher in the ioversol groups than in the control groups. Regions investigated were: parenchyma, calyces, pelvis, ureters and the bladder. Ioversol, iohexol and iopamidol were found to be statistically comparable with regard to safety and patient tolerance. The results of these studies demonstrate that ioversol is an effective, well tolerated and safe contrast agent for intravenous excretory urography.

Adolescent↗

Maximizing opacification during excretory urography: effect of low-osmolarity contrast media.

Because of improved patient tolerance and decreased risks of idiosyncratic reaction, low-osmolarity contrast media are increasingly used for excretory urography. However, physiologic differences among patients may affect the optimal time for acquiring diagnostic radiographs during the pyelographic phase of the examination. A prospective, randomized, physician-blinded comparative study of 60 adult patients was undertaken to determine if the time to peak opacification of the pyelocaliceal systems differs with different doses of nonionic and ionic contrast media. Three doses of contrast media were used: a high dose (based on body weight) of a high-osmolarity ionic contrast medium, a high dose (based on body weight) of a low-osmolarity non-ionic contrast medium and a lower, fixed dose of a low-osmolarity nonionic contrast medium. The diagnostic quality of the radiographs did not differ statistically with the dose or the contrast medium. However, acquiring an additional radiograph during abdominal compression greatly increased the chance of obtaining at least one radiograph with maximal diagnostic information during the pyelographic phase. Despite potential differences among contrast media in the degree of pyelocaliceal opacification or distension and diuresis, it is not necessary to modify the timing of film acquisitions during excretory urography when lower doses of low-osmolarity agents are administered.

Adult↗

[Diagnostic value of HASTE technique and excretory MR urography in urinary system obstructions].

PURPOSE: To compare the diagnostic value of static-liquid magnetic resonance urography (MRU) in T2-weighted HASTE (half-fourier acquisition single-shot turbo spinecho) sequences and T1-weighted excretory MRU with i.v. diuretic and contrast material injection. MATERIALS AND METHODS: The study included 29 patients (15 men, 14 women). Thirty-one urinary obstructions were detected on intravenous urography (IVU) two of which were due to bilateral obstructions. The cases were evaluated by T2 HASTE sequences combined with T1-weighted FLASH 3D sequences after i.v. diuretics and gadolinium DTPA injection. RESULTS: Thirty-one urinary obstructions were detected on IVU. Thirty of which were confirmed by T2-weighted MRU and all were confirmed by excretory MRU. In one nonobstructive case, unilateral grade 1 ureteropelvicaliectasis related to ureteral stone was falsely interpreted by both sequences. There were no statistical differences among IVU, T2-weighted MRU and excretory MRU in detecting the obstruction levels. In 22 cases with ureteral stones, 12 of which were confirmed by T2-weighted MRU and 18 cases were confirmed by excretory MRU. Sensitivity and specificity fo detecting the ureteral stones as a cause of obstruction with T2-weighted MRU were 50%and 89% and with excretory MRU were 77% and 89% respectively. In 9 obstructive cases due to causes other than the stones, 8 of which were detected by T2-weighted MRU and all of which were detected by excretory MRU. Sensitivity and specificity for detecting the causes other than the stones with T2-weighted MRU were 96% and 100% and with excretory MRU were 100% and 100% respectively. CONCLUSION: MRU is a useful thechnique revealing high-quality images to determine the urinary system obstructions to obtain the causes of obstructions. MRU should be used as an alternative imaging technique in cases which IVU can not be applied. The existence and the causes of obstruction can be detected by HASTE MRU. Excretory MRU can supply additional information in cases with functional kidneys where the cause of obstruction can not be revealed by HASTE MRU.

Adolescent↗

Renal pelvis haemangioma demonstrated by MSCT urography with ureteral compression and 3D reconstruction.

A rare case of renal haemangioma of the renal pelvis is reported. The 40-year-old patient classically presented with recurrent hematuria. The small pyelic tumour was clearly delineated by msCT urography obtained during compression of the uretera with rubber balloons classically used during IVP In the absence of a definite histological diagnosis--pyeloscopy being unsuccessful--the patient underwent radical nephrectomy. The literature concerning renal haemangioma is briefly reviewed and the role of compression assisted msCT urography as a possible method for the detection of small pyelocaliceal tumours is emphasized.

Adult↗

Iopentol in urography. A clinical comparison between iopentol and metrizoate including delayed reactions.

A double-blind comparative study of the nonionic contrast medium iopentol and the ionic contrast medium metrizoate for urography was carried out in 200 adult outpatients. Significantly less discomfort and other side effects were observed following iopentol than following metrizoate. No serious adverse reactions and no clinically significant alterations in heart rate or blood pressure were observed. A questionnaire was used to record delayed symptoms, from 30 min after contrast medium injection and for one week. The response rate was 92% and delayed adverse events were reported by 45%. The incidence of delayed reactions was significantly lower following iopentol than following metrizoate, i.e., delayed arm pain, fatigue, headache, diarrhea, nasal congestion, and rash. Delayed arm pain was probably due to contrast medium induced thrombosis in 1% following iopentol and in 8% following metrizoate. Most other symptoms were probably related to a combination of nocebo effect and coincidentally occurring symptoms. The urograms with both media were of similar high quality. Iopentol was found a suitable contrast medium for urography.

Adult↗