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Angle-resolved UV photoelectron spectra (UPS) of thin films of perylene-3,4,9,10-tetracarboxylic dianhydride on MoS(2).

Angle-resolved UV photoelectron spectra (ARUPS) were measured for thin films of perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) deposited on cleaved MoS(2) surfaces. The take-off angle (theta) dependence of the photoelectron intensity of the highest pi band showed a sharp maximum at theta = 32-34 degrees. A spectral feature of the binding energy at approximately 8.9 eV, which is believed to originate from a pi state, showed a remarkably different theta dependence from that of the pi band. A quantitative analysis of the observed theta dependencies clearly indicates that (a) the feature at approximately 8.9 eV originates from the oxygen 2p non-bonding states and (b) the molecules lie flat on the substrate surface.

Journal Article↗

The ups and downs of attributional ambiguity: stereotype vulnerability and the academic self-knowledge of African American college students.

This research examined whether stereotype vulnerability-the tendency to expect, perceive, and be influenced by negative stereotypes about one's social category-is associated with uncertainty about one's academic self-knowledge in two important ways. We predicted that stereotype-vulnerable African American students would (a) know less about how much they know than less vulnerable students do and (b) have unstable academic efficacy. In Study 1, Black and White participants took a verbal test and indicated the probability that each of their answers was correct. As expected, stereotype-vulnerable Black participants were more miscalibrated than other participants. In Study 2, participants completed measures of self-efficacy twice daily for 8 days. Also as expected, the academic efficacy of stereotype-vulnerable Blacks fluctuated more-and more extremely-than that of other participants. The results suggest that, in addition to undermining intellectual performance, stigma interferes with academic self-knowledge.

Black or African American↗

CD34 stem cell top-ups without conditioning after initial haematopoietic stem cell transplantation for correction of incomplete haematopoietic and immunological recovery in severe congenital immunodeficiencies.

Haematopoietic stem cell transplantation can be limited by ineffective haematopoiesis and poor immune recovery. A CD34(+) cell infusion without conditioning has the potential to improve stem cell function with limited toxicity. Eighteen patients with congenital immunodeficiencies received CD34(+) boosts for various defects. When given <1 year after the original graft, six of seven cytopenic patients achieved transfusion independence. A second cohort (n = 11) received boosts >1 year after the original graft; only minimal changes in immune function or chimaerism were noted. Unconditioned stem cell boosts have limited toxicity but should be given early after the original graft to be effective.

Adolescent↗

Benefit assessment of preventive medical check-ups in patients suffering from chronic granulomatous disease (CGD).

BACKGROUND: Chronic granulomatous disease (CGD) patients are susceptible to recurrent opportunistic infections and to recurrent or chronic inflammations of presumably non-infectious origin. Both types of manifestations are often accompanied by granuloma formation. Both can remain unnoticed until they deteriorate considerably and can become life-threatening if not treated in time. OBJECTIVE: To evaluate the effectiveness of regular follow-up visits in CGD patients. METHODS: Findings of imaging (ultrasound, radiographs, computer-tomography, magnetic resonance imaging), lung function tests, histopathological and microbiological assessments of biopsies have been reviewed. RESULTS: A total of 32 CGD patients have been evaluated within 15 years. Of these eight patients have been checked regularly for more than 5 years. Early detection prior to specific clinical signs and consecutive treatment of six lung manifestations and one liver manifestation such as interstitial pneumonia with formation of small granulomas, formation of large granulomas, fibrosis, Aspergillus infections, and abscesses could presumably prevent considerable aggravation in seemingly healthy or mildly symptomatic patients. In contrast, patients without surveillance who presented with severe symptoms (seven manifestations) often had irreversible organ damage or even died. CONCLUSIONS: Regular follow-up visits can help prevent or mitigate clinical manifestations, improve life quality and expectancy and weigh indication for bone marrow transplantation in CGD patients.

Adult↗

Esophageal impedance monitoring: the ups and downs of a new test.

Impedance monitoring was first proposed as a method for gastrointestinal motility 10 yr ago. It detects changes in resistance to current flow when a bolus traverses an electrode pair, and can distinguish liquid (low-impedance) from gas (high-impedance) boluses (1). Electrode pairs placed at multiple sites on a standard solid-state esophageal manometry catheter can track antegrade bolus transit through the esophagus to correlate with manometry findings. In contrast, the electrode pairs placed at multiple sites on a standard pH probe can track retrograde bolus transit from the stomach to the esophagus to correlate with pH. This issue of The American Journal of Gastroenterology contains reports that relate to each of these two distinct applications of impedance monitoring.

Electric Impedance↗

Ups and downs for salivary IgA.

IgA levels in saliva differed 15-fold between different individuals. The correlation between IgA in repeated stimulated saliva samples was good in both a short and a 2-yr period. The correlation between resting and stimulated samples was low, in particular when output of IgA over time was considered. Physical exercise affected salivary protein concentrations and also percentage of IgA to protein. The elevated IgA levels in saliva at pregnancy were not accompanied by a similar change of IgA activity against specific bacteria.

Adult↗

Psychological consequences of neonatal screening for alpha 1 antitrypsin deficiency (ATD). Parental attitudes toward "ATD-check-ups" and parental recommendations regarding future screening.

The parents of 61 children with ATD typically attended repeated doctor's appointments concerning the child's ATD during the first years of life. Many (30-40%) of the parents felt somewhat relieved about the ATD after the first appointment. Parental attitudes toward the appointments varied considerably within the sample, being related to the physician's reported knowledgeability-understandability regarding ATD and emotional supportiveness (toward mothers). Most parents were positive and few were negative toward the child's ATD having been identified at this age. Repeated blood tests for the child's liver function were experienced negatively by most parents. The parents' recommendations concerning screening and follow-up of ATD in children are presented.

Attitude↗