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PubMed2000

Novel Type of Thermostable Channel Clathrate Hydrate Formed by Heptakis(2,6-di-O-methyl)-beta-cyclodextrin small middle dot15 H(2)O-A Paradigm of the Hydrophobic Effect Topography of Cyclodextrin Inclusion Complexes, Part 47. This work was financed by a scholarship under the Development and Promotion of Science and Technology Talents Project (DPST) by the Royal Thai Government Agencies and the Institute for the Promotion of Teaching Science and Technology (IPST) to T. Aree, by the Deutsche Forschungsgemeinschaft, and by Fonds der Chemischen Industrie. We are grateful to Prof. Dr. H. Hartl for the DSC measurements. For Part 46, see T. Aree, H. Hoier, B. Schulz, G. Reck, W. Saenger, Carbohydr. Res. 1999, 320, 120 - 128.

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PubMed2001

Rhodium-Catalyzed Hydrophosphorylation of Terminal Alkynes Leading to Highly Selective Formation of (E)-Alkenylphosphonates: Complete Reversal of Regioselectivity to the Palladium-Catalyzed Counterpart We are grateful to the Japan Science and Technology Corporation (JST) for financial support through the CREST (Core Research for Evolutional Science and Technology) program and for a postdoctoral fellowship to C.-Q.Z.

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PubMedDate not supplied

Response to xenograft technology: a new frontier in medicine. Xenograft technology: proceed with caution.

Many Americans do not deal well with aging or preparing for death as a natural part of life. One indication of this is that only about 15% of the population have completed advance directives. Growing old gracefully and dying with dignity are not foremost considerations in our culture. We ask our government and private industry to spend billions of health care dollars to prolong our lives at all costs. Organ xenotransplantation has the potential of being a very complex, high tech, and expensive way of saving lives from the jaws of death--for a few more months or years. Derenge and Bartucci (1999) pointedly ask, "...should we instead be providing support and comfort to those who are dying and not intervene?" (p. 432). Finally, Dr. Margaret Somerville from the McGill Centre of Medicine, Ethics, and Law reminds us of the importance of addressing ethical issues early during the research process. Somerville (1998) states, "It is not enough to do ethics as an add-on at the end of having done your science." Science, medicine, and ethics, in the case of xenotransplantation, must progress together. Leaders in social policy should address the issues presented here before xenotransplantation is undertaken in the United States.

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