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PubMed2006

Time monitoring and executive functioning in children and adults.

This study examined time-based prospective memory performance in relation to individual and developmental differences in executive functioning. School-age children and young adults completed six experimental tasks that tapped three basic components of executive functioning: inhibition, updating, and mental shifting. Monitoring performance was examined in a time-based prospective memory task in which participants indicated the passing of time every 5min while watching a movie. Separate analyses of the executive functioning data yielded a two-factor solution for both age groups, with the updating and inhibition tasks constituting a common factor and the shifting tasks constituting a separate factor. Both children and adults showed accelerating monitoring functions with low rates of clock checking during the early phase of each 5-min interval. However, compared with adults, children needed more clock checks for obtaining the same level of response accuracy. Executive functioning had selective effects on time-based prospective memory performance. In both children and adults, monitoring performance was related to the inhibition and updating components, but not to the shifting component, of executive functioning. We conclude that difficulties in temporary maintenance and updating of working memory contents may create discontinuities in sense of time, leading to an increased reliance on external cues for time keeping.

Adult↗
PubMed2004

Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration.

The early postnatal brain development, when many potentially sensitive processes occur, has been shown to be vulnerable to different pharmacological and environmental compounds. In the present investigation, four groups of neonatal NMRI male mice were administered the glutamate NMDA receptor antagonist ketamine (50 mg/kg, s.c.), or the GABA(A) receptor agonist diazepam (5 mg/kg, s.c.), or co-administered ketamine (50 mg/kg, s.c.) and diazepam (5 mg/kg, s.c.), or vehicle (0.9% saline, s.c.) on day 10 after birth. On day 11, mice from each treatment group were sacrificed and brains were taken for analysis of neuronal cell degeneration, using Fluoro-Jade staining technique. Ketamine, but not diazepam, induced a severe degeneration of cells in the parietal cortex. The opposite was observed for diazepam in the laterodorsal thalamus. The most pronounced cell degeneration was seen in parietal cortex of mice exposed to both ketamine and diazepam. At 2 months of age each treatment group was tested for motor activity and learning performance. Ketamine and ketamine + diazepam treated mice displayed severe deficits of habituation to the test chamber in the spontaneous motor activity test, marked deficits of acquisition learning and retention memory in the radial arm maze-learning task and less shift learning in the circular swim maze-learning task. This study indicates that the observed functional deficits can be related to cell degeneration induced during a critical stage of neonatal brain development. The potentiated apoptosis induced by ketamine and diazepam may have implications for the selection of drugs used in neonatal paediatric anaesthesia.

Animals↗
PubMed2004

Hierarchical switching with two types of judgment and two stimulus dimensions.

A number of recent studies have shown that shifting among four tasks that result from a factorial combination of two types of judgment with two judgment-to-response mappings results in a characteristics pattern of shift costs that indicates a hierarchical representation of the two task features judgment and mapping (e.g., Kleinsorge & Heuer, 1999). In the present study, two types of judgment were combined with two stimulus dimensions. With this task combination, the same basic shift-cost pattern was observed. This suggests that a combination of two types of judgment with two stimulus dimensions also results in a hierarchically structured task representation, indicating that such a task representation is readily adopted by participants when the combination of task features is suitable for a hierarchical organization.

Adult↗
PubMedDate not supplied

[Specific alterations in attention in the early stages of Parkinson's disease].

INTRODUCTION: The cognitive disorders presented by patients with Parkinson s disease (PD) have drawn attention to the role played by the basal ganglia in cognition. It has been suggested that through a system of cortico subcortical circuits they monitor the work done by the frontal regions by guiding the anterior and posterior attentional systems, whose functioning is necessary for the so called executive functions to be carried out. PATIENTS AND METHODS: We studied 10 patients with PD in developmental stages I and II according to the scale of Hoehn and Yahr, and 10 healthy paired controls. All of them were administered a test for simple sustained attention, complex sustained attention and attentional shift. RESULTS: In the simple sustained attention task there were no significant differences between groups. In the complex sustained attention test the patients committed more mistakes, and in the attentional shift task they committed more omissions and there was a significant increase in reaction time. CONCLUSIONS: Even in the early stages of the disease, patients suffering from Parkinson present cognitive disorders. These are concentrated in the detection and evaluation of new information, in the capability to shift attention between different spatial regions in a flexible manner and in choosing, inhibiting and activating motor programmes. In order to detect these alterations more sensitive and complex tests must be used.

Attention↗
PubMedDate not supplied

The left visual hemispace bias for the perception of chimeric faces: a further test of the difficulty of discrimination hypothesis.

When people make judgments of visual-spatial forms, they generally perform better if the information is presented in their left visual hemispace (LVH), whereas for verbal material, they generally show a right visual hemispace (RVH) bias. For verbal material, the strength and direction of the effect also has been linked to task difficulty, with the bias shifting toward the RVH as task difficulty increases. Two experiments are presented that show the reverse direction of change for a nonverbal task; that is, when a nonverbal task is more difficult, the usual LVH effect shifts toward an RVH bias. Taking into account recent developments in theory and research on hemispheric differences in styles of information processing, we propose that task difficulty is related more generally to changes in processing style.

Adult↗
PubMed1989

Spatial performance and perceptual asymmetries in beginning readers: shift of hand advantage in dichhaptic tasks.

The stability of perceptual asymmetries was studied in two groups of 6-year-old, right-handed children (normal, NL, and poor, PL) learning reading, by means of two experiments occurring at a year's interval (Experiment I and Experiment II). A dichhaptic procedure derived from S. F. Witelson's method (1974, Cortex, 10, 3-17) was used. With group data, perceptual asymmetries were stable over time, whereas with individual data, perceptual asymmetries were highly variable. NL children demonstrated a left-hand advantage at the group level in both Experiment I and Experiment II, with relatively little individual evolution over time. No significant hand advantage was found in PL children in Experiment I, but dramatic alterations occurred in Experiment II where all PL children shifted to a left-hand advantage. This shift was accompanied by an improvement in spatial performance. Such changes in perceptual asymmetry might be of an adaptive nature. Individual changes across time may be related to developmental plasticity (cerebral maturation) and/or neurocognitive flexibility (differential activation of cerebral subsystems).

Attention↗
PubMed2001

Cued shifts of attention and memory encoding in partial report: a dual-task approach.

This study explores how cued shifts of visual attention and rapid encoding of visual information relate to limited-capacity processing mechanisms. Three experiments were conducted placing a partial-report task within a dual-task paradigm. Experiments 1 and 2 involved a simple speeded visual discrimination (Task 1) and then an unspeeded partial-report task (Task 2). Generally, Task 2 accuracy declined as the temporal overlap between the two tasks increased. In addition, in Experiment 1, varying the number of items in the partial-report display had an effect on performance regardless of overlap. In contrast, in Experiment 2, varying the type of probe had an effect only at long task overlap. The generality of the interference effect was tested in Experiment 3 using an auditory discrimination as Task 1. Again, Task 2 accuracy declined as the temporal overlap between the two tasks increased. In all cases, the observed interference had the properties of a processing bottleneck. It is argued that encoding information into memory and response selection for the first task both require general-purpose processing. The results are discussed in terms of the functional relationship between attention and memory.

Adolescent↗
PubMed2004

Dissociating the roles of right ventral lateral and dorsal lateral prefrontal cortex in generation and maintenance of hypotheses in set-shift problems.

Although patient data have traditionally implicated the left prefrontal cortex (PFC) in hypothesis generation, recent lesion data implicate right PFC in hypothesis generation tasks that involve set shifts (lateral transformations). To test the involvement of the right prefrontal cortex in a hypothesis generation task involving set shifts, we scanned 13 normal subjects with fMRI as they completed Match Problems (a classic divergent thinking task) and a baseline task. In Match Problems subjects determined the number of possible solutions for each trial. Successful solutions are indicative of set shifts. In the baseline condition subjects evaluated the accuracy of hypothetical solutions to match problems. A comparison of Match Problems versus baseline trials revealed activation in right ventral lateral PFC (BA 47) and left dorsal lateral PFC (BA 46). A further comparison of successfully versus unsuccessfully completed Match Problems revealed activation in right ventral lateral PFC (BA 47), left middle frontal gyrus (BA 9) and left frontal pole (BA 10), thus identifying the former as a critical component of the neural mechanisms of set-shift transformation. By contrast, activation in right dorsal lateral PFC (BA 46) covaried as a function of the number of solutions generated in Match Problems, possibly due to increased working memory demands to maintain multiple solutions 'on-line', conflict resolution, or progress monitoring. These results go beyond the patient data by identifying the ventral lateral (BA 47) aspect of right PFC as being a critical component of the neural systems underlying lateral transformations, and demonstrate a dissociation between right VLPFC and DLPFC in hypotheses generation and maintenance.

Adult↗
PubMed1975

Differential effect of task relevance on early and late components of cortical and subcortical somatic evoked potentials in man.

The effect of "task relevance" on early and late components of cortical and subcortical somatic evoked potentials (SEPs) was studied in a group of Parkinsonian patients operated on under local anesthesia for treatment of prominent unilateral tremor. 1. SEPs produced by median nerve stimulation were found at contralateral cortical (ss), thalamic (vcpci, vcai), lemniscal (Lm), postilemniscal (PoLm), prelemniscal (Raprl) and reticular (Ttc) regions. No SEPs were found in other contiguous thalamic (M,Pf, ce) and subthalamic (Q) regions. 2. Subcortical early SEP components consisted of two monophasic positive potentials distributed within a circumscribed thalamo-lemniscal region where electrical stimulation elicited consistent sensory responses circumscribed to contralateral hand and face. In contrast, subcortical late SEP components consisted of monophasic or polyphasic, positive or negative potentials distributed in a widespread, thalamic, lemniscal, prelemniscal and reticular region where elecrical stimulation elecited sensory or motor responses of various types. Subcortical early and late SEP components appeared together in lemniscal, thalamic and cortical regions but they wers separated at postlemniscal (only early) and prelemniscal and reticular ones (only late). 3. Significant amplitude changes in cortical and subcortical late SEP componets were found concomitant to variations in "task relevance": they decreased when patients shifted from novelty to habituation, they increased when patients shifted from habituation to attention and they decreased when patients shifted from attention to distraction. In contrast, no significant ampiltude changes in cortical and subcortical early components were found when patients shifted through these various "task relevance" conditions.

Adult↗
PubMed2003

Age stereotypes in younger and older women: analyses of accommodative shifts with a sentence-priming task.

A sentence-priming technique was used to examine whether older women (N = 39) share a more positive view of aging than younger women (N = 35). Situationally specified statements about older and younger persons were presented, followed either by a semantically related word, an unrelated word of the same valence, or a nonword. The accessibility of target words was measured by reaction times in a lexical decision task. Whereas a semantic priming effect for negatively connoted materials emerged for both groups, a priming effect for positively connoted materials was found for older women only. Furthermore, an affective priming effect was found for the older group, i.e., older women tended to respond relatively faster (slower) to semantically unrelated positive (negative) words following a sentence about an older person. The results are discussed within a coping-theoretical framework.

Adult↗
PubMedDate not supplied

Attentional deficits in Parkinson's disease: partial reversibility with naphtoxazine (SDZ NVI-085), a selective noradrenergic alpha 1 agonist.

Several authors have suggested that catecholamine depletion may affect attentional processes in human subjects and could be implicated in the frontal lobe syndrome that has been described in Parkinson's disease (PD). The present study reports the effects of a placebo and naphtoxazine (SDZ-NVI-085), a selective noradrenergic alpha 1 agonist. These substances were administered to nine parkinsonian patients who were assessed on measures of attention, including neuropsychological tests and evoked potentials. The results indicate that naphtoxazine may improve performance on some tests of "frontal functions," including the Stroop and the Odd-Man-Out tests, which have been previously found to be affected in PD. However, the results of some other neuropsychological tests of frontal function were not affected by naphtoxazine. Specific evoked potentials such as the Nd1 and Nd2 curves--which are thought to reflect attentional processes and which have been found to be affected in PD--were improved by naphtoxazine. Finally, naphtoxazine reduced the percentage of errors and restored the lateralization of N100 during the Shifting Reaction Time Task, suggesting that this substance may act on the processes underlying the shifting deficit in these patients. The results are discussed in terms of the specific cognitive processes that may be affected by naphtoxazine and in terms of the role of the noradrenaline in attentional deficits found in PD.

Adrenergic alpha-Agonists↗
PubMed2004

Inhibition and shifting in children with learning deficits in arithmetic and reading.

The executive functions of inhibition and shifting were studied in arithmetic-disabled children, reading-disabled children, reading plus arithmetic-disabled children, and controls (N = 74). Measures involved the rapid naming of objects, digits, letters, or quantities with or without additional task requirements that reflected inhibition or shifting. Also, the Making Trails task, reflecting shifting, was administered. For tasks without executive demands, arithmetic-disabled children were slower in the naming of digits and quantities, whereas reading-disabled children were slower in the naming of digits and letters. For the executive tasks, arithmetic-disabled children as well as reading plus arithmetic-disabled children were impaired on the Making Trails task and on an object naming task that required both inhibition and shifting. Reading-disabled children exhibited no problems in executive functioning. Furthermore, it was shown that reading plus arithmetic-disabled children experienced the combination of problems that characterize children with a single learning deficit.

Child↗
PubMed1992

Frontocentral DC-potential shifts predicting behavior with or without a motor task.

This study was designed to investigate the predictive value of the event-related potentials (ERPs) preceding the initiation of a difficult perceptual-memory task and to investigate whether these ERPs require a motor movement on the part of the subject for their occurrence. Across 4 conditions the DC-potential shifts were recorded from 23 right-handed subjects using DC amplifiers. Although the start of each trial began with a ready signal, the conditions differed in that the subjects initiated the task by a button press in 2 conditions and the computer initiated it in 2 others without a press. The results showed that, especially in the frontocentral electrode sites, the DC-potential shifts which began those trials ending in correct performance were more negative relative to those trials ending in an incorrect response. Those conditions which required the subjects to self-initiate the trial and those which were initiated by the computer showed similar results indicating that the negative DC-potential shifts preceding correct performance are neither produced by nor depend on a task initiating motor movement. The onset of the DC-potential shifts preceded task initiation by up to 4.1 sec indicating that they were more than the Bereitschaftspotential.

Adult↗
PubMed2002

Examination of the role of the pedunculopontine tegmental nucleus in radial maze tasks with or without a delay.

Two radial maze tasks, random foraging and delayed spatial win-shift, have been used to investigate, in rats, the functions and inter-relationships of structures connected through the corticostriatal loops, such as the prelimbic cortex, nucleus accumbens, ventral pallidum and mediodorsal thalamus. The random foraging task is designed to investigate animals' ability to use spatial information to guide foraging on-line. The delayed spatial win-shift task requires, in addition, that animals hold spatially relevant information in working memory across a delay period. The pedunculopontine tegmental nucleus receives direct output from ventral striatal systems and might therefore be expected to share functional properties with them. In the present experiments we have examined the performance of rats bearing bilateral excitotoxic lesions of the pedunculopontine tegmental nucleus on both of these tasks. In acquisition tests rats were given bilateral lesions before any training took place, while in retention tests appropriate training to predetermined criterion levels of performance took place before lesions were made. In both tasks, and in both acquisition (no prelesion training) and retention (prelesion training) tests, rats with pedunculopontine lesions made significantly more errors in selecting arms to enter than did control rats. There was no motor impairment present in pedunculopontine tegmental nucleus-lesioned rats - on the contrary, on measures of speed (latency to make first arm choice and the mean time for subsequent choices) pedunculopontine-lesioned rats were slightly faster than control rats. We suggest that the pedunculopontine tegmental nucleus shares functional properties with frontostriatal systems and that it forms part of a brainstem-directed stream of striatal outflow different to the cortical re-entrant system via the thalamus.

Animals↗
PubMed2002

Processes of task-set reconfiguration: switching operations and implementation operations.

When participants are asked to shift between four dimensionally organized tasks which differ in the type of judgment (numerical vs. spatial) and/or the judgment-to-response mapping (compatible vs. incompatible), a characteristic profile of shift costs can be observed. It can be accounted for in terms of two different types of operations: generalizing switching operations on a dimensionally organized set of task representations and implementation operations [T. Kleinsorge, H. Heuer, Psycholog. Res. 62 (1999) 300]. In a first experiment we corroborated our previous findings by way of a new procedure that makes it possible to estimate shift costs unconfounded by a number of factors that are likely to affect estimates of shift costs based on more conventional procedures. In a second experiment we investigated the endogenous and exogenous nature of the postulated types of operations. The characteristic profile of shift costs disappeared when long precue intervals (PCIs) were used. Augmented by a formal analysis, this finding suggests that both switching and implementation operations are endogenously controlled. In addition, there remained some residual shift costs which were essentially insensitive to the nature of the task shift but depended on the difficulty of the new task. Most likely they reflect a process of consolidation of an already configured task set.

Adolescent↗
PubMed1990

Activation of the noradrenergic system facilitates an attentional shift in the rat.

The noradrenergic system was pharmacologically activated with the alpha 2 receptor antagonist, idazoxan (2 mg/kg i.p.), during the acquisition of a complex appetitive task requiring a shift in attention to stimulus dimension and in response strategy. Rats first learned a fixed path of 6 successive choices in a linear maze. The task was then changed to a visual discrimination task in which the spatial configuration of the correct path was indicated by visual cues and changed on each daily trial. During this part of the task, the rats were injected before each trial with idazoxan, a drug which increases the firing rate of neurons in the locus coeruleus and the release of noradrenaline in the cortex and hippocampus. Two control experiments showed that the drug treatment had no effect on the acquisition of either component of the task - the successive place learning or the visual discrimination. The drug was found to be effective only during the shift phase of the experiment, the idazoxan-treated rats taking fewer trials to reach criterion than the saline. A second experiment showed that idazoxan increased the amount of time spent investigating novel and unexpected objects in a familiar hole board. These results implicate the noradrenergic system in problem-solving which requires an attentional shift or a shift in responding from familiar to novel stimuli.

Animals↗