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Independence of sensitivity to relative reinforcement rate and discriminability in signal detection.

Six pigeons were trained to detect differences between two white stimuli, S1 and S2, differing in duration and arranged probabilistically on the center key of a three-key chamber. Detection performance was measured at two levels of discriminability. At one level, S1 was five seconds and S2 was thirty seconds. At the other level, S1 was twenty seconds and S2 was thirty seconds. The procedure was a standard signal-detection yes-no design in which stimulus-presentation probability was varied from .1 to .9 at both discriminability levels. On completion of the center-key stimulus, a peck on the center key darkened the center-key light and turned on the two red side keys. A left-key response was "correct" on S1 trials, and a right-key response was "correct" on S2 trials. Correct responses produced food reinforcement on a variable-ratio 1.3 schedule. Incorrect responses produced three second blackout. Discriminability was higher for the five-second versus thirty-second conditions than for the twenty-second versus thirty-second conditions, but there were no differences in sensitivity of behavior to reinforcement variation for the two stimulus pairs. Response bias was a function of the relative reinforcement rate for correct choice responses.

Animals↗

Signal-detection analysis of hemispheric differences in visual recognition memory.

In the present experiment, subjects decided on each trial whether or not a unilaterally presented probe digit was a member of a previously memorized set of two, three, or four digits. The probe was presented at a near-threshold duration and followed by a visual pattern mask. Signal-detection estimates of detectability and response bias were obtained from subjects' confidence ratings regarding their decisions. The detectability of the probe in memory was significantly better when the probe was presented to the right visual field-left hemisphere than when presented to the left visual field-right hemisphere. The response criterion became significantly more lax as memory-set size increased, but only for probes presented to the left visual field-right hemisphere. The present results are consistent with reaction-time studies using verbal stimuli that indicate a left hemisphere advantage in the efficiency of memory comparison.

Adult↗

A signal-detection-theory measure of pitch shifts in sinusoids as a function of intensity.

Pitch shifts in sinusoids as a function of intensity result in systematic response biases and differences in performance in forced-choice frequency-discrimination tasks. Two approaches are described for converting these effects to a measure of pitch shift in Hz using standard signal-detection-theory assumptions. To illustrate these approaches, forced-choice frequency-discrimination data were obtained for three listeners at 250 and 4000 Hz, with six intensities from 40 to 90 dB SPL. The resulting pitch-shift estimates are in good agreement with adjustment data obtained from the same listeners. Collection and analysis of the forced-choice data can be greatly simplified by using an adaptive procedure. Pitch-shift estimates obtained in this way for two of the three listeners are in good agreement with the other estimates.

Adolescent↗

[Effects of task attentiveness on task-irrelevant activity and boredom in the signal detection tasks].

It has been reported that subsidiary behavior, including body movements, and irrelevant thoughts occur spontaneously during a vigilance situation. These activities are called task-irrelevant activity. To examine the effects of task attentiveness on task-irrelevant activity and on the subjective feeling of boredom, 31 subjects were asked to engage in two types of signal detection tasks. The body movements were measured by recording the rotating angle of a swivel chair that the subject sat on. More task-irrelevant thoughts and subsidiary behavior occurred accompanied by higher subjective feeling of boredom in the low attentive task than in the high attentive task. These findings indicate the possibility of the task-irrelevant activity as an index of subjective boredom.

Attention↗

Multidimensional scaling of painful electrocutaneous stimulation: INDSCAL dimensions, signal detection theory indices, and the McGill Pain Questionnaire.

Individual-differences multidimensional scaling (INDSCAL) determined the dimensions underlying ratings of electrocutaneous stimuli, which ranged from innocuous levels to individual pain intolerance at each of three frequencies. Twenty-five healthy males made pairwise similarity judgments of these 15 stimuli for the INDSCAL procedure, and then rated each stimulus on nine property scales. Signal detection theory indices, as well as ratings on the McGill Pain Questionnaire (MPQ), were also obtained. A Sensory Magnitude dimension scaled the stimuli from lowest to highest perceived intensity; this dimension was related to sensory, affective, and arousal property scales. A Frequency dimension ordered the stimuli from lowest to highest frequency; this dimension was related to the Fast-Slow property. Compared to the Frequency dimension, the Sensory Magnitude dimension was more salient to subjects who better discriminated among painful stimulus intensities, set a more stoical pain report criterion, and were less apt to endorse frequency-related MPQ descriptors. Thus, variation of physical intensity and frequency elicited complementary dimensions of subjective judgment, which were related to perceptual and attitudinal differences among individuals.

Adolescent↗

Predictors of retention in methadone programs: a signal detection analysis.

Retention in Opioid Agonist Therapy (OAT) is associated with reductions in substance use, HIV risk behavior, and criminal activities in opioid dependent patients. To improve the effectiveness of treatment for opioid dependence, it is important to identify predisposing characteristics and provider-related variables that predict retention in OAT. Participants include 258 veterans enrolled in 8 outpatient methadone/l-alpha-acetylmethadol (LAAM) treatment programs. Signal detection analysis was utilized to identify variables predictive of 1-year retention and to identify the optimal cut-offs for significant predictors. Provider-related variables play a vital role in predicting retention in OAT programs, as higher methadone dose (> or =59 mg/day) and greater treatment satisfaction were among the strongest predictors of retention at 1-year follow-up.

Adult↗

A signal detection analysis of the effects of transcutaneous stimulation on pain.

Transcutaneous nerve stimulation (TNS) applied both ipsilaterally and contralaterally with a tonic pain stimulus was compared to a control condition to determine its effect on pain reports. The ipsilateral TNS condition significantly reduced ratings and increased pain thresholds relative to the contralateral and control conditions which did not significantly differ from each other. A Signal Detection Theory analysis of the data was employed to assess the sensitivity and response bias effects of the treatment conditions. Ipsilateral TNS significantly reduced pain sensitivity and response bias in the direction of showing a lesser tendency to report pain. The effects of ipsilateral TNS were most pronounced at the higher levels of stimulation. The results are consistent with Gate Control Theory which holds that ipsilateral TNS attenuates painful sensation. Most importantly, these results support the efficacy of TNS for the treatment of clinical pain.

Attention↗

Signal detection and threshold measures to loud tones and radiant heat in chronic low back pain patients and cohort controls.

Eleven chronic low back pain (CLBP) and 11 age- and sex-matched control subjects were tested during two separate sessions for the perception of radiant heat and uncomfortably loud tones. Following the determination of a subject's pain threshold (PT) for radiant heat, a standard signal detection methodology was used to present 26 trials each of 4 stimulus levels. The stimuli were rated on a 9-point scale ranging from 'nothing' to 'very strong pain.' A similar procedure was used for the tone stimuli with the 9-point scale ranging from 'nothing' to 'very strongly uncomfortable.' It was found that the CLBP group had both higher heat pain and tone discomfort thresholds than the control group. For radiant heat only, the CLBP group had poorer discrimination as determined by P(I). The results are discussed within the framework of the hypervigilance and adaptation theories of pain perception.

Adult↗

Short-term synaptic plasticity can enhance weak signal detectability in nonrenewal spike trains.

We study the encoding of weak signals in spike trains with interspike interval (ISI) correlations and the signals' subsequent detection in sensory neurons. Motivated by the observation of negative ISI correlations in auditory and electrosensory afferents, we assess the theoretical performance limits of an individual detector neuron receiving a weak signal distributed across multiple afferent inputs. We assess the functional role of ISI correlations in the detection process using statistical detection theory and derive two sequential likelihood ratio detector models: one for afferents with renewal statistics; the other for afferents with negatively correlated ISIs. We suggest a mechanism that might enable sensory neurons to implicitly compute conditional probabilities of presynaptic spikes by means of short-term synaptic plasticity. We demonstrate how this mechanism can enhance a postsynaptic neuron's sensitivity to weak signals by exploiting the correlation structure of the input spike trains. Our model not only captures fundamental aspects of early electrosensory signal processing in weakly electric fish, but may also bear relevance to the mammalian auditory system and other sensory modalities.

Action Potentials↗

Toward an objective characterization of an anhedonic phenotype: a signal-detection approach.

BACKGROUND: Difficulties in defining and characterizing phenotypes has hindered progress in psychiatric genetics and clinical neuroscience. Decreased approach-related behavior and anhedonia (lack of responsiveness to pleasure) are considered cardinal features of depression, but few studies have used laboratory-based measures to objectively characterize these constructs. METHODS: To assess hedonic capacity in relation to depressive, particularly anhedonic, symptoms, 62 participants completed a signal-detection task based on a differential reinforcement schedule. Anhedonia was operationalized as decreased reward responsiveness. RESULTS: Unequal frequency of reward between two correct responses produced a response bias (i.e., a systematic preference to identify the stimulus paired with the more frequent reward). Subjects with elevated depressive symptoms (Beck Depression Inventory scores >/= 16) failed to show a response bias. Impaired reward responsiveness predicted higher anhedonic symptoms 1 month later, after controlling for general negative affectivity. CONCLUSIONS: Impaired tendency to modulate behavior as a function of prior reinforcement might underline diminished hedonic capacity in depression. When applied to a clinical population, objective assessments of participants' propensity to modulate behavior as a function of reward might provide a powerful tool for improving the phenotypic definition of depression and thus offer a reliable behavioral screening approach for neuroscience studies of depression.

Adolescent↗

Quantitative analysis of attention and detection signals during visual search.

Prior work has distinguished regions in the intraparietal sulcus (IPs) and frontal eye field (FEF) involved in the voluntary control of attention, from more ventral regions in the temporoparietal junction (TPJ) involved in target detection. The present results show that when subjects search for and detect a visual target stimulus among nontargets, these regions show sensory-, search-, and detection-related signals that both confirm and refine these functional distinctions. The different signals were isolated by an additive model that accounted for a large fraction of BOLD (blood oxygenation level-dependent) signal modulation over the brain. Both IPs and FEF were activated during search through nontargets, consistent with a role in maintaining attention-related signals during search. However, unlike FEF, IPs also showed stimulus-related activations, and may combine signals related to sensory and task-dependent components of salience. Although IPs-FEF showed search-related activations, the TPJ was deactivated during search. TPJ activations were confined to detection-related signals. These results provide a much stronger dissociation between the TPJ and IPs-FEF than previous work, while indicating functional differences between frontal and parietal regions that are often coactivated in studies of attention. Finally, continuous flow models of information processing predict that during search, signals from missed targets should be fed from sensory to associative regions rather than being gated by the decision criterion. Correspondingly, missed targets significantly activated parietal (e.g., right TPJ) and frontal (e.g., anterior insula, anterior cingulate) regions, although with a smaller magnitude than detected targets. Surprisingly, many cortical regions showed equivalent signals from detected targets and the completion of target-absent trials, reflecting a widespread signal unrelated to motor execution.

Attention↗

A signal detection approach to patient-doctor communication and doctor-shopping behaviour among Japanese patients.

OBJECTIVES: As one of the factors related to doctor-shopping behaviour (i.e. consulting multiple doctors with regard to the same illness episode), very little has been revealed about the role of doctor explanation. We examined therefore the association between doctor explanation and doctor-shopping behaviour. METHODS: The subjects were internist-patient pairs in Japan. Signal detection analysis (SDA) was used for the data analysis. RESULTS: Of the 303 patients, 84 patients engaged in doctor shopping (27.7%). The following results were obtained: (1) of the 19 relevant variables, the 'level of doctor explanation: treatment' was the most significant predictor of doctor-shopping behaviour (P < 0.01), and (2) with regard to their subjective evaluations of the sufficiency of their explanations about treatment or testing, the evaluations of the doctors, rather than those of the patient, were significant predictors of doctor-shopping behaviour. CONCLUSIONS: These results imply the following: (1) a patient's inability to understand a doctor's explanation about treatment, which results from a large gap between the perceptions of the patient and those of the doctor, is the most significant predictor of doctor-shopping behaviour, and (2) in the context of favourable patient-doctor interactions, when doctors feel their explanations are insufficient, they may be able to prevent doctor-shopping behaviour by providing relatively thorough explanations about treatment.

Adolescent↗

Application of visual signal detection concepts to clinical decision analysis.

The performance of both clinical diagnostic and mass screening tests is commonly measured in terms of the two basic parameters, sensitivity and specificity. Selection of cut-off points, balancing the sensitivity-specificity trade-off, and comparison with alternative tests are often a matter of arbitrary decisions and are frequently made without consideration of outcome. Some of the concepts used in the analysis of visual signal detection systems can be helpful in this aspect of screening test selection and evaluation. A simplified version of these concepts is developed and its application to clinical and public health optometry is illustrated.

Cost-Benefit Analysis↗

Enhanced pitch sensitivity in individuals with autism: a signal detection analysis.

Past research has shown a superiority of participants with high-functioning autism over comparison groups in memorizing picture-pitch associations and in detecting pitch changes in melodies. A subset of individuals with autism, known as "musical savants," is also known to possess absolute pitch. This superiority might be due to an abnormally high sensitivity to fine-grained pitch differences in sounds. To test this hypothesis, psychoacoustic tasks were devised so as to use a signal detection methodology. Participants were all musically untrained and were divided into a group of 12 high-functioning individuals with autism and a group of 12 normally developing individuals. Their task was to judge the pitch of pure tones in a "same-different" discrimination task and in a "high-low" categorization task. In both tasks, the obtained psychometric functions revealed higher pitch sensitivity for subjects with autism, with a more pronounced advantage over control participants in the categorization task. These findings confirm that pitch processing is enhanced in "high-functioning" autism. Superior performance in pitch discrimination and categorization extends previous findings of enhanced visual performance to the auditory domain. Thus, and as predicted by the enhanced perceptual functioning model for peaks of ability in autism (Mottron & Burack, 2001), autistic individuals outperform typically developing population in a variety of low-level perceptual tasks.

Adolescent↗

Embedding of large specimens in glycol methacrylate: prerequisites for multi-signal detection and high-resolution imaging.

Acrylic resin mixtures are commonly used to study microscopic sections of biological specimens, giving the advantage of good morphological preservation. Existing embedding protocols, however, are suitable for tissue blocks, not exceeding 1 mm in thickness. We have developed a protocol to embed larger specimens (up to 2 cm(3)) in Technovit 8100. This medium allowed us to perform classic histological (trichrome), silver, as well as immunohistochemical staining, needed for multi-signal detection at high-resolution imaging to reconstruct a three-dimensional interpretation of a serially sectioned muscle. The technique was applied to reconstruct the semitendinosus muscle of a fetal pig, 44 days post conception, featuring connective tissue, intramuscular nerves, blood vessels, and muscle fibre types. For the reconstruction, a technique was used that enabled us to insert high-resolution images of histological details into low-resolution images of the entire muscle.

Animals↗

A signal detection approach to social perception: identification of negative and positive behaviors by parents of normal and problem children.

The present experiment was designed to investigate differences in the perception of social behavior between parents of normal and problem children and to relate these differences to behavior observed in the home environment. Subjects were brought into the laboratory and asked to identify positive and negative behaviors on a written script portraying family interactions. Correct and incorrect responses were analyzed using signal detection procedures to produce measures of sensitivity and response bias for positive and negative behaviors. These analyses revealed that parents of normal children were better able to discriminate positive behavior than were parents of problem children. Correlations between these responses and data obtained for a subset of the subjects from 1-hour home observations, using a newly developed home observational coding system, revealed a number of relationships between these sets of variables.

Aggression↗

Perceptual and decisional contributions to audiovisual interactions in the perception of apparent motion: a signal detection study.

Motion information available to different sensory modalities can interact at both perceptual and post-perceptual (i.e., decisional) stages of processing. However, to date, researchers have only been able to demonstrate the influence of one of these components at any given time, hence the relationship between them remains uncertain. We addressed the interplay between the perceptual and post-perceptual components of information processing by assessing their influence on performance within the same experimental paradigm. We used signal detection theory to discriminate changes in perceptual sensitivity (d') from shifts in response criterion (c) in performance on a detection (Experiment 1) and a classification (Experiment 2) task regarding the direction of auditory apparent motion streams presented in noise. In the critical conditions, a visual motion distractor moving either leftward or rightward was presented together with the auditory motion. The results demonstrated a significant decrease in sensitivity to the direction of the auditory targets in the crossmodal conditions as compared to the unimodal baseline conditions that was independent of the relative direction of the visual distractor. In addition, we also observed significant shifts in response criterion, which were dependent on the relative direction of the distractor apparent motion. These results support the view that the perceptual and decisional components involved in audiovisual interactions in motion processing can coexist but are largely independent of one another.

Adolescent↗

Dissociating spontaneous and deliberate expressions of pain: signal detection analyses.

Neuro-anatomical and behavioral findings suggest that spontaneous and deliberate facial expressions are regulated by separate systems. The present study examined whether spontaneous and deliberate expressions of pain could be distinguished and, if so, the dimensions on which they differ. Forty subjects were exposed to electric shocks that varied from painless to strong pain. They also simulated facial reactions to the same levels. Observers rated the apparent pain in subjects' expressions and whether they were feigned or genuine. Signal detection analyses indicated that the intensity of deliberate expressions was greater than spontaneous expressions at levels below strong pain. Observers were able to distinguish between deliberate and spontaneous expressions to a modest degree. The intensity of deliberate expressions was related to role-playing ability. The results suggest that deliberate and spontaneous expressions of pain probably differ in intensity, topography and temporal features. They suggest that facial expressions of pain have different determinants than other forms of pain behavior.

Adult↗