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[Sensitivity study for sulfamides and antibiotics of 260 strains of Neisseria meningitidis isolated in Upper Volta].

260 strains of Neisseria meningitidis, collected on throat swabs performed systematically on healthy carriers, were tested for antibiotics and sulfonamides sensitivity. The M. I. C. for sulfonamides and antibiotics of each strain has been determined with the agar dilution technic. To study the sensitivity to sulfonamides 5% hemolysed horse blood has been added to the Mueller-Hinton medium. To study the sensitivity to antibiotics, 5% sheep blood has been added to Mueller-Hinton. Results may be so resumed:--Sulfadiazine: 80% of the strains are sensitive to 1 mcg/ml, 98% to 64 mcg/ml. --Chloramphenicol: 91% of the strains sensitive to 1 mcg/ml. --Penicillin and ampicillin: nearly 90% of the strains sensitive to 0.015 mcg/ml. --Cephalothin: 95% of the strains sensitive to 0.125 mcg/ml. --Tetracyclines: 88% of the strains sensitive to 0 5 mcg/ml. --Spiramycin: 98% of the strains sensitive to 4 mcg/ml. With each type of Meningococcus, distribution of the M. I. C. for each antibiotic has been studied. It appears that Meningococcus remains very sensitive to antibiotics. For sulfonamides sensitivity, this study doesn't show as frequent a resistance as some suggested. May be this is because of the technic of sulfamidogram using growing media containing inhibitors.

Anti-Bacterial Agents↗
PubMed1987

Synthesis of new heparinoids with high anticoagulant activity.

New heparinoids were synthesized by the chemical method starting from ring-opening polymerization of anhydro sugar derivatives. Sulfation of synthetic (1----6)-alpha-linked 3-amino-3-deoxy-D-glucopyranan and its copolymers gave dextran-type heparinoids having a sulfamide group on the C-3 carbon of the sugar unit. Heparinoids with different sulfamide contents indicated that the anticoagulant activity (35.3-41.3 units/mg) is independent of the sulfamide content, while an increase in sulfamide content lowered the toxicity. Sulfation of (1----5)-alpha-D-xylofuranan and -ribofuranan provided furanan-type heparinoids the anticoagulant activities of which were higher than those of the corresponding sulfated pyranan-type polysaccharides (1----4)-beta-D-xylopyranan and -ribopyranan. The highest activity (69.1 units/mg) was shown by sulfated (1----5)-alpha-D-xylofuranan. The dextran-type heparinoid having a sulfamide group showed a high anticoagulant activity also in vivo and high lipemia-clearing activity.

Animals↗