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PubMed2001

Pseudo-Meigs syndrome and elevated levels of tumor markers associated with benign ovarian tumors--two case reports.

Elevated tumor markers for a post-menopausal woman presenting with a multilocular adnexal mass, ascites, and pleural effusion were interpreted as being highly suspicious of malignancy. This paper describes two cases of ovarian tumors presenting with all signs of malignancy. Following surgical excision of the masses, and histopathological assay, a benign pure struma ovarii and a mucinous cystadenoma were diagnosed by pathologists. The immediate and complete resolution of symptoms were achieved post-operatively, and the previously-evident abnormal tumor markers rapidly declined to the normal range, the two tumors were subsequently classified as pseudo-Meigs' syndromes.

Aged↗
PubMed2002

Monodermal highly specialized teratoma of the ovary: a sebaceous gland tumor.

Teratomas are neoplasms that originate in pluripotential cells and contain representations of all three germ layers in a rather mature state. Specialized forms of teratoma with unilateral development of certain tissues, such as struma ovarii, argentaffin tumors, cholesteatoma, primary choriocarcinoma of the ovary, pseudomucinous cystoma and neurogenic cysts are known. In this paper we describe an ovarian teratoma consisting entirely of sebaceous glands.

Adult↗
PubMed2003

[Ovarian mature teratoma. Clinico-pathological study of 112 cases and review of the literature].

A retrospective, descriptive study of 112 patients diagnosed and treated of mature ovarian teratoma, between January 1995 and September 2001, at Reina Sofía University Hospital, was carried out. The patient's mean age is 36.2 years old (SD = 13.8). The most frequently symptom was abdominal pain (50.9%) though a high percentage of the cases (41.1%) the patients were asymptomatic. The mean size of the tumor was 76.2 mm (SD = 35.8) and 9.8% were bilateral. The most used diagnostic procedure was ultrasound with a right diagnostic of 47.6%, though 81.3% of the cases a surgery was performed, with a preview diagnostic of ovarian tumor and the 53.8% with the right diagnostic of benign teratoma. 18.7% of the tumors was found in a laparotomy for other cause. From the 123 tumors, 96% were benign ovarian cyst, 1.6% mature solids teratomas and 2.4% struma ovarii. The most frequent surgery was unilateral oophorectomy (54.5%) and 19.6% was total hysterectomy with bilateral oophorectomy, with the mean age of this last ones of 54.8 years old (SD = 12.0). The preservation of the ovarian function was in 75% of the patients. We will analyze our results and compare with the bibliography.

Adolescent↗
PubMed2004

Ovarian teratomas in Mangalore.

In the present study 122 ovarian teratomas, reported from the department of pathology, Kasturba Medical College, Mangalore, were predominantly (76%) seen in the age group below 40 years and the peak incidence was in the third decade (39%). Menstrual disturbances, pain abdomen, pregnancy and abdominal distension were the presenting symptoms. Histologically 113 (92.6%) were benign cystic teratomas showing mainly ectodermal tissue derivatives. Struma ovarii (4 cases) revealed colloid, both macro- and microscopically. Immature teratomas (2 cases) were solid and showed embroynal tissue elements. Teratomas with malignant transformations (3 cases) were grossly nodular and were squamous cell carcinomas.

Adult↗
PubMed1991

Clinical syndromes associated with tumors of the female genital tract.

Tumors of the female genital tract may be associated with a variety of unusual clinical manifestations. Uncommon endocrine and paraendocrine syndromes include production of human chorionic gonadotropin by tumors other than those of germ cell origin, hyperthyroidism associated with struma ovarii and gestational trophoblastic disease, the carcinoid syndrome, the Zollinger-Ellison syndrome, hypercalcemia, Cushing's syndrome, hypoglycemia, hypertension related to renin or aldosterone production, hyperprolactinemia, inappropriate secretion of antidiuretic hormone, and virilization associated with Nelson's syndrome and placental site trophoblastic tumor. Paraneoplastic syndromes associated with gynecological tumors include disorders of the nervous system, connective tissue, and skin, as well as hematologic abnormalities and the nephrotic syndrome. Heritable and other congenital syndromes associated with these tumors are the Peutz-Jeghers syndrome, the nevoid basal-cell carcinoma syndrome, Ollier's disease and Maffucci's syndrome, hereditary leiomyomatosis, ataxia-telangiectasia, von Hippel-Lindau's disease, thyroid abnormalities associated with Sertoli-Leydig cell tumors, and Carney's complex. Other syndromes associated with tumors of the female genital tract include Meigs' syndrome, hyperamylasemia, uveal melanocytic lesions, and pyrexia.

Cushing Syndrome↗
PubMed1987

[Thyroid carcinoma in an adult cystic teratoma of the ovary with bony metastases].

An oophorectomy specimen in a patient aged 36 showed a dermoid cyst with a struma ovarii and what was considered to be a folliculo-trabecular adenoma. Two osseous metastases appeared 4 and 8 years later respectively. The follow-up so far is 15 years. This is the twentieth reported case of mature cystic teratoma of the ovary containing metastating thyroid carcinoma.

Adult↗
PubMedDate not supplied

Teratomas in adult Nigerians.

Over a six-year period, 132 teratomas were seen at the Ahmadu Bello University Hospital in Zaria, Nigeria. Twenty-seven of these, comprising most of the extragonadal tumours were seen in infants and children. Of the 105 tumours found in adults, ninety-four were benign cystic teratomas of the ovary occurring mostly in the third and fourth decades of life. There were three instances of malignant transformation of a previously benign cystic ovarian teratoma and four cases of struma ovarii, one of which was admixed with trabecular carcinoid but none of which was associated with hyperthyroidism or carcinoma. This study confirms the rarity in adult Nigerians of the following tumours each of which occurred only once in the series: mediastinal, solid ovarian teratoma, testicular and sacrococcygeal teratoma. The latter two were malignant and the sacrococcygeal tumour has been reclassified as an endodermal sinus tumour.

Adult↗
PubMed1979

Pitfalls in the laboratory diagnosis of atypical hyperthyroidism.

When hyperthyroidism results from active thyroidal secretion, both serum hormonal levels and the radioactive iodine uptake (RAI) are elevated. Discordant results (increased serum hormone levels and a low RAI) are found either in the usual forms of hyperthyroidism when large quantities of iodide are ingested, or in atypical forms of hyperthyroidism, including spontaneously resolving hyperthyroidism of subacute thyroiditis, thyrotoxicosis factitia, toxic struma ovarii, and functioning metastatic thyroid cancer. Two patients are described who exemplify pitfalls in the interpretation of thyroid function test results in atypical hyperthyroidism. The following guidelines are helpful in avoiding these pitfalls: (1) An RAI should be performed in all thyrotoxic patients to confirm the presence of thyroidal hypersecretion, rather than atypical hyperthyroidism. (2) A positive response to thyroid-stimulating hormone stimulation is an important finding differentiating the other atypical forms of hyperthyroidism listed from subacute thyroiditis.

Adult↗
PubMed1995

[Pathogenesis, diagnosis and therapy of hyperthyroidism].

Different forms of hyperthyreosis have to be distinguished: Frequent forms: Basedow's disease (Graves' disease, autoimmunogenic hyperthyreosis), Plummer's disease (focal or disseminated functional autonomy). Rare forms: Hyperthyreosis with thyreoiditis. This 'morphologic' hyperthyreosis is due to a destruction caused by an infection combined with a release of the thyroid hormones. This transitory hyperthyreosis can be observed particularly in the beginning of a thyreoiditis De Quervain. The treatment of the inflammation eliminates the hyperthyreosis. Sometimes, a hyperthyreosis may also be observed during a Hashimoto-thyreoiditis which, however, will turn into a hypothyreosis. An increased TSH stimulation (secondary hyperthyreosis) is a rare disease which, i.e., may be due to a genetically caused hormone resistance in the periphery followed by an overproduction of TSH. The even more rare hyperthyreosis caused by a TSH producing tumor of the pituitary gland should also be mentioned. A hyperthyreosis during struma ovarii, trophoblast tumors and recently during interferon treatment are similarly rare. A 'hyperthyreosis factitia' in correlation with a permanent application of an overdose of thyroid hormones is observed only rarely in Germany. However, a hyperthyreosis caused by physicians is more frequent: The application of contrast mediums or other substances containing iodine during a hidden functional autonomy of the thyroid gland is taken into account for the diagnosis and treatment of the Plummer's disease.

Diagnosis, Differential↗
PubMed1997

Atypical Meigs' syndrome and bilateral ovarian stromal hyperplasia. A case report.

BACKGROUND: Atypical Meigs' syndrome has been observed in patients with dermoid tumors, struma ovarii, uterine leiomyomata and other benign pelvic tumors except for ovarian fibromas. Meigs' and atypical Meigs' syndrome present management decisions complicated by a high index of suspicion for malignancy. CASE: A 43-year-old woman, gravida 1, para 1, with ascites; a pleural effusion; radiologic evidence of enlarged, cystic adnexa; and a normal CA-125 level was found to have cortical stromal hyperplasia on bilateral ovarian pathologic evaluation. CONCLUSION: This is the first case of cortical stromal hyperplasia presenting with bilateral involvement of small ovaries, ascites and a pleural effusion. Meigs' syndrome and its variants develop with clinical pictures suggestive of malignancy. Thorough evaluation and individualized treatment are necessary.

Adult↗
PubMed1979

Immunocytochemical localization of calcitonin-producing cells in a strumal carcinoid with amyloid stroma.

A nonfunctioning strumal carcinoid arising in a 49-year-old woman was studied by histochemical and immunocytochemical techniques. All tumor cells, irrespective of their architectural arrangement, showed properties of neuroendocrine-programmed cells, without any evidence of thyroid follicular cell differentiation. Foci of calcitonin-producing C-cells were demonstrable by immunocytochemical technique and were closely associated with areas of amyloid stroma of the tumor. Efforts at localization of insulin and gastrin within the tumor cells gave negative results. While the results in the present case offer additional support for an APUD cell origin of strumal carcinoids, the presence of the calcitonin-producing C-cells within the tumor raises interesting histogenetic possibilities as to whether these lesions are derived from C-cells or represent an ovarian carcinoid with foci of C-cell differentiation.

Amyloid↗
PubMed1979

Strumal carcinoid of the ovary: an analysis of its components.

A strumal carcinoid of the ovary was studied by light and electron microscopy. Thyroglobulin was demonstrated within the strumal element by immunofluorescence, thus establishing the identity of the thyroid tissue. The carcinoid fulfilled the light and electron microscopic criteria for a mixed insular and trabecular example of this tumor. Intermediate zones between the two tissue elements showed mixed characteristics. No amyloid was found. Immunoreactive calcitonin was demonstrated in the tumor, suggesting the presence of C-cells or medullary carcinoma of the thyroid.

Aged↗
PubMed1985

Immunohistochemical demonstration of neuron-specific enolase in gynecologic malignant tumors.

Gynecologic malignant tumors were studied by the immunoperoxidase method for neuron-specific enolase (NSE). They included 22 argyrophil cell carcinomas of the endometrium, 6 argyrophil small cell carcinomas of the cervix, 21 argyrophil cell adenocarcinomas of the ovary (endometrioid type, 10; mucinous type, 11) and 3 ovarian carcinoids (strumal type, 2; insular type, 1). NSE was demonstrated in all cases of argyrophil small cell carcinomas of the cervix and ovarian carcinoids. On the other hand, NSE was positive only in four cases of endometrial carcinomas with argyrophil cells. Argyrophil cell adenocarcinomas of the cervix and the ovary were immunohistochemically negative for NSE. The current results suggest that argyrophil small cell carcinoma of the cervix, ovarian carcinoid, and some endometrial argyrophil cell carcinomas are related to APUDoma.

Adenocarcinoma↗
PubMed1993

Prostatic acid phosphatase in strumal carcinoids of the ovary. An immunohistochemical study.

BACKGROUND: Strumal carcinoids (SC) are ovarian tumors containing thyroid parenchyma admixed with carcinoid elements. Microscopically, the carcinoid component of SC usually presents a ribbon or trabecular pattern similar to the pattern exhibited by hindgut carcinoids. The authors designed an immunohistochemical study to ascertain further similarities of the carcinoid component of SC to rectal carcinoids. METHODS: Five cases of SC were examined by light microscopic study with hematoxylin and eosin and immunoperoxidase staining with a group of neurohormonal peptides, thyroglobulin, prostatic acid phosphatase, and prostate specific antigen. RESULTS: All tumors were positive for thyroglobulin, chromogranin, prostatic acid phosphatase (PAP), and glucagon. They were consistently negative for prostate specific antigen and variably positive to the other antibodies. CONCLUSIONS: The consistent positivity of the carcinoid component of SC to PAP immunostaining is a further similarity of these tumors to rectal carcinoids, in which positive immunostaining to PAP has been observed. The similarity is not well understood, however, as all evidence points to the origin of SC from germ cells in mature cystic teratomas without any embryologic relationship to the hindgut.

Acid Phosphatase↗