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[Drug therapy of psychiatric patients in the middle of the 19th century: the drug armamentarium of Ludwig Binswanger sen. in his "Asyl Bellevue" ].

This paper examines the drugs used in Ludwig Binswanger's private sanatorium "Bellevue" in Kreuzlingen on the Lake of Constance between 1857 and 1870. The available patient records have revealed the administrated drugs, prescriptions have been transcribed, and the guidelines for the use of the drugs have been reconstructed by means of the literature. It becomes obvious that the armamentarium of drugs prescribed was limited and can be connected with the treatment of physical ailments which the "somatist" Binswanger considered as the main cause for psychic disorders. Binswanger was very careful when prescribing one of the few available "psychotropic" drugs like opium and morphine. This restraint in using drugs is in contrast with many recommendations and habits of Binswanger's contemporaries and shows that he put higher emphasis on the effectiveness of the "therapeutic milieu" than on a pharmacotherapy of insanity.

History, 19th Century↗

Effect of HAART on SEN virus infected HIV positive patients.

Since it has been demonstrated that concomitant infections could influence the outcome of antiviral treatment, we investigated whether the presence of SENV infection may interfere with highly active antiretroviral therapy (HAART) in HIV+ coinfected patients. In spite of persistent fluctuations in SENV-A positivity we could not find any correlation between SENV-DNA and the immunological and virologic parameters found in the patients, suggesting SENV has no apparent clinical relevance during highly active antiretroviral therapy.

Antiretroviral Therapy, Highly Active↗

[Detection of SEN virus (subtype D/H) infection in Shenzhen].

OBJECTIVE: To investigate the prevalence of newly identified single-chain DNA virus (SENV) infection in Shenzhen. METHODS: Nested polymerase chain reaction (nPCR) was established using primers from ORF1 region of SENV genome. Six hundred and one sera samples from different populations were detected for SENV DNA (D and H subtype) by nPCR. Products of PCR were cloned into T-vector and sequenced. RESULTS: The positive rates of SENV DNA in different populations were as followed: 27.8% in patients with hepatitis B, 22.2% in patients with hepatitis C, 26.9% in hemodialysis patients and 39.3% in IDUs. Among blood donors, the positive rates of SENV DNA were 28.1% in unqualified blood donors, 31.3% in blood donors with an elevated ALT levels and 15.1% in qualified blood donors. The infection rates of SENV in unqualified blood donors and blood donors with an elevated ALT levels were obviously higher than in qualified blood donors (chi(2) = 8.29, P < 0.01 and chi(2) = 6.03, P < 0.01). There was a 6.8% difference of nucleotide between SENV-D standard subtype and 6 isolates with 13.5% difference of nucleotide between SENV-H standard subtype and 4 isolates from Shenzhen. CONCLUSION: Results suggested that SENV infection was common in high-risk groups in Shenzhen.

Base Sequence↗