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At least 307 records · Page 17Linked to original sources
PubMed2004

["Using model organisms and phylogenetic conservation, the DrosoMan project combines high tech hand-made science and industrial know-how to target the Achilles heel of cancer cells. A comparative proteomic project that associates Academia and Biotech"].

The post-genomic era offers a huge challenge for scientists used to hand-made tailored approaches that can deal with deep insight into a small number of objects. Reciprocally, industry is used to undergo massively parallel approaches, dealing with large numbers but rather shallow insight. The complementation is obviously tantalizing, and Institut Curie and Hybrigenics (HGX) have signed an alliance in the field of cancer and signal transduction. A comparative proteomic approach was undertaken, where ortholog baits from Homo sapiens and flies were used to screen extremely complex two-hybrid cDNA libraries. New partners of "old" proteins have been identified, new networks have emerged, and unexpected connectors have been shown to link biological niches supposed to be independent.

Animals↗
PubMedDate not supplied

[Home care for the diabetic within the limits of project--object: pilot project integrated into the health education of the diabetic. Veneto Region].

Twenty one district-nurses working in 13 districts were handed a questionnaire (one questionnaire for each patient), to collect data on nursing interventions and main problems of the 382 diabetic patients cared for. The diabetic patients are a very demanding population with a mean age of 78 years; 314 (82%) have a comorbidity, 272 (71%) severe limits on their physical functioning and 233 (61%) the diabetic foot; 183 patients (47%) are not capable of taking autonomous decisions. The nursing interventions for these patients are both technical (drawing blood samples, diagnostic exams) and educational on how to manage and monitor self-administration of insulin (31 patients, 10%), on self monitoring techniques (116 patients, 30%), on alimentation in general and change in food habits (289 patients, 94.1%). The role of the nurse in promoting patients' independence and in preventing complications is highlighted.

Activities of Daily Living↗
PubMed1997

Nutrient intakes by young children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet. The STRIP Baby Project. Special Turku Coronary Risk Factor Intervention Project for Babies.

OBJECTIVE: To evaluate the impact of individualized and repeatedly given dietary counseling on fat intake and nutrient intake of children aged 8 months to 4 years. DESIGN: Prospective randomized clinical trial. PARTICIPANTS: Children (N = 1062) from 1054 families were randomized to an intervention (n = 540) or a control (n = 522) group when each child participant was 6 months old. INTERVENTIONS: The children in the intervention group were counseled to reduce their intake of saturated fat and cholesterol but to ensure their adequate energy intake. Dietary issues were discussed with the families of the children in the control group only briefly according to the current practice of well-baby clinics. MAIN OUTCOME MEASURES: Food consumption was evaluated by using 3- and 4-day food records that were kept at 5- to 12-month intervals, and nutrient intakes were analyzed with a Micro Nutrica computer program (Social Insurance Institution, Turku, Finland). RESULTS: The intake of fat (29% of the energy intake) and cholesterol (70 mg) showed no differences between the groups of children at 8 months of age. The fat intake in the children in the intervention group was then continuously 2% of the energy intake below that of the children in the control group (P < .001). After the age of 13 months, the cholesterol intake of the children in the control group exceeded that of the children in the intervention group by 20 mg (P < .001). The children in the intervention group consumed 3% (of the energy intake) less saturated (P < .001) and 1% (of the energy intake) more polyunsaturated fats (P < .001) than did the children in the control group at age 13 months and older. The carbohydrate intake was slightly higher in the children in the intervention group than in the children in the control group. Intakes of vitamins, minerals, and trace elements showed no differences between the 2 groups. CONCLUSIONS: The intakes of fat by the children in the intervention and control groups were markedly below values that were recommended for the first 2 years of life. Despite the low intake of fat, the intake of other nutrients fulfilled current recommendations, except for vitamin D and iron. Individualized dietary counseling that led to clear changes in the type of fat intake had a minimal effect on vitamin or mineral intakes.

Age Factors↗
PubMed2000

alpha-Oxymethyl Ketone Enolates for the Asymmetric Mannich Reaction. From Acetylene and N-Alkoxycarbonylimines to beta-Amino Acids This work was supported by the University of the Basque Country, the Basque Government (Projects UPV 170.215-G47/98, EX-1998-124) and in part by M. E. C. (Project PB 98-0549). Grants to A.S. and M.C.G. from the Basque Government, and to C.L. from the Government of Navarra and M.E.C. are acknowledged.

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Journal Article↗