Pattern recognition methods for prediction of secondary structure of proteins. II. Elimination of "Contradicting" signs and prediction of turns of polypeptide chains in proteins.
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1. The rate of tetrazolium dye-reduction by fowl spermatozoa measured by an objective colourimetric assay was shown to correlate strongly with sperm motility, morphology, ATP content and fertilising ability. 2. Although dye-reduction appeared less well correlated with fertilising ability than the other variables, the method for its determination has many practical advantages for the assessment of semen quality in poultry.
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A database of chronic lowest observed adverse effect levels (LOAELs) for 234 compounds, previously compiled from different sources (Toxicology Letters79, 131-143 (1995)), was modelled using graph theoretical descriptors. This study reveals that data are not homogeneous. Only those data originating from the U.S. Environmental Protection Agency (EPA) reports could be well modelled by multilinear regression (MLR) and linear discriminant analysis (LDA). In contrast, data available from the specific procedures of the National Toxicology Program (NTP) database introduced noise and did not render good models either alone, or in combination with the EPA data.
The cascade of events that leads to the development of ovarian hyperstimulation syndrome (OHSS) is almost always accompanied by elevated estradiol (E(2)) levels. The role of estrogen level in OHSS has not been confirmed; however, it was shown repeatedly in the literature that elevated levels of E(2) constitute a risk for OHSS. Monitoring E(2) was found to be effective in reducing the incidence of OHSS. It was also reported that reducing the E(2) level by coasting helps to prevent OHSS. It is believed that irrespective of the debatable role of estrogen in the pathogenesis of OHSS, there is a general agreement that E(2) assay is an important marker to detect the majority of patients at risk of OHSS.
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