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PubMed1976

[Parapsoriasis].

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Acute Disease↗
PubMed1985

Premycotic eruptions.

Virtually any longstanding, recalcitrant inflammatory dermatosis may evolve into a cutaneous T-cell lymphoma. Although several entities within the parapsoriasis group can undergo malignant degeneration, most cases of cutaneous T-cell lymphoma are not preceded by parapsoriasis; a preceding inflammatory dermatosis that is not a parapsoriasis may be much more common. Among the parapsoriasis, lymphomatoid papulosis and large-plaque parapsoriasis and its variant, retiform parapsoriasis, have a variable tendency to undergo malignant degeneration. For any dermatosis deemed to have a significant premalignant potential, a plan of aggressive management with relatively non-aggressive modalities (for example, topical steroids, UVB light, and psoralen plus UVA light) should be considered.

Antibodies, Monoclonal↗
PubMed1975

[Papulois lymphomatoide].

Clinical study and bibliographic review of the lymphomatoid papulosis (Macaulay-1968) and parapsoriasis varioliformis acute (Mucha-1916). A personal case is reported after a review of nosological location of these diseases and the variable prognosis. The authors reach the following conclusions: 1st) From the clinical point of view the small number of lesions in the lymphomatoid papulosis bring about a different clinical picture from that of parapsoriasis varioliformis acuta in here usually there is a considerable number of lesions. 2nd) There are concomitant lesions of parapsoriasis gutata in parapsoriasis varioliformis and none of the type in lymphomatoid papulosis. 3rd) Protracted course in lymphomatoid papulosis and short lived eruption in the parapsoriasis varioliformis acuta. 4th) From the histological point of view denser and atypical infiltrate in cases of parapsoriasis varioliformis.

Adult↗
PubMed1986

The nature of mycosis fungoides.

Thirty-four patients with a clinical diagnosis of plaque stage mycosis fungoides, poikiloderma atrophicans vasculare (poikiloderma) and parapsoriasis en plaques (parapsoriasis) were investigated for evidence of extracutaneous disease using a biochemical screen, blood films, bone marrow examination, chest radiograph, abdominal ultrasound, isotope liver scan, liver biopsy and lymphangiography. Skin biopsies were also taken from these patients and, in order to rule out non-specific histological change, from 29 controls with inflammatory skin disease; the slides were examined blind by two independent observers for evidence of mycosis fungoides or poikiloderma and graded accordingly. Both observers were able to differentiate significantly histological grades of mycosis fungoides corresponding to the clinical diagnosis although exact histological grades only corresponded on 35 per cent of slides. Features graded as classical or probable mycosis fungoides were found in between 22 and 67 per cent of patients with parapsoriasis and between 67 and 100 per cent of those with poikiloderma. We found no evidence of extracutaneous disease in any of our patients. Lymphangiograms were abnormal in 30 of 31 examinations but the changes were non-specific and did not correspond to disease type, duration or extent. Four patients had apparently unrelated co-existing disease including chronic lymphatic leukaemia in two, a monoclonal gammopathy and autoimmune haemolytic anaemia. This study shows that in its early stages mycosis fungoides is predominantly if not primarily a cutaneous disease. The findings also suggest that parapsoriasis and poikiloderma are part of the same disorder as mycosis fungoides or evolve into it. Aggressive treatment to prevent progression to mycosis fungoides plaque and tumour stage should therefore be tried. The findings support the idea that mycosis fungoides is a reactive rather than a neoplastic disorder.

Adolescent↗
PubMed1994

Th2 cytokine mRNA expression in skin in cutaneous T-cell lymphoma.

We have previously demonstrated that peripheral blood mononuclear cells from patients with Sézary syndrome, the leukemic form of cutaneous T-cell lymphoma which is accompanied by erythroderma and lymphadenopathy, have a Th2 cell cytokine [interleukin 4 (IL-4) and interleukin 5] production pattern. In this study, we extend these observations to demonstrate a correlation of the presence of a Th2 cytokine pattern with a malignant T-cell clone in different stages of cutaneous involvement among patients with cutaneous T-cell lymphoma (CTCL). Skin biopsies were obtained from 12 CTCL patients with various disease stages (three patch, three plaque, six tumor), three patients with parapsoriasis, four patients with inflammatory dermatoses, including two psoriasis and two lichen planus, and 12 normal controls. Total RNA was extracted, reverse transcribed, and PCR amplified with IL-2, IL-4, IL-5, interferon gamma (IFN-gamma), and beta-actin oligonucleotide primers. Although all skin specimens tested had detectable IL-2 and IFN-gamma mRNA, only specimens from patients with CTCL or parapsoriasis had demonstrable IL-4 and/or IL-5 mRNA. Specifically, IL-5 mRNA was detected in skin biopsies from five of six tumor-stage CTCL, two of three plaque-stage CTCL, one of three patch-stage CTCL, and 1 of 3 parapsoriasis patients, whereas IL-4 mRNA was demonstrated to be present in five of six tumor-stage, one of three plaque stage, none of three patch-stage CTCL, and none of three parapsoriasis patients. These results indicate that in all stages of cutaneous involvement of CTCL, encompassing patch stage through tumor stage, IL-4 and IL-5 mRNA is variably detectable. In tumor-stage skin lesions, typically characterized by a dense dermal infiltrate of malignant T cells, Th2 cytokine mRNA is virtually always detectable. The ability to detect Th2 cytokine mRNA in the skin of patients with CTCL supports our previous findings that the malignant T cells in CTCL possess a Th2-helper cell phenotype.

Base Sequence↗