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PubMed1964

CONVULSIONS.

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Epilepsy↗
PubMed1980

Acute isoniazid poisoning in childhood.

Acute isoniazid poisoning is uncommon in children. Only 27 cases, to our knowledge, have been reported in the literature. Often, the first observation is of uncontrollable convulsions. The metabolic alterations are often striking and the treatment has mainly been supportive, with the judicious use of pyridoxine hydrochloride in those cases in which a history of ingestion of isoniazid is obtained. The response to the administration of pyridoxine has been difficult to evaluate.

Adolescent↗
PubMed1976

Very high dose fluphenazine decanoate: a controlled trial in chronic schizophrenia.

In a double-blind trial of six months' duration, a very high dose (VHD) regimen of fluphenazine decanoate (250 mg weekly) was compared with a standard dose (SD) regimen (12.5 mg weekly) in 50 chronic schizophrenic patients. The rating scales used included the Brief Psychiatric Rating Scale and the Wing Ward Behavior Scale. Both treatment groups improved during the trial, but there was no significant difference between them. The VHD regimen, however, exerted better control of the psychosis in that it had fewer patient dropouts and fewer "additional treatments" prescribed. Some of the patients receiving standard doses were probably not receiving adequate antipsychotic drug dosage. No predictors of clinical response could be defined. Extrapyramidal side effects were not significantly higher in the VHD group.

Adolescent↗