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[Surgical treatment of priapism: experience of 56 cases in an African setting].

Since priapism is uncommon, treatment is controversial and difficult. In this article we describe a practical, well-documented approach for management of priapism in countries with a high incidence of sickle cell disease. This approach is based on our experience including a total of 56 black patients (49 adults and 7 children) as well as on the results reported in the literature. The patients in our series were examined and treated by the same physician over an 18 year period in various African countries, i.e., Burkina (n = 8), Chad (n = 12), Gabon (n = 19), and Niger (n = 17). Etiologies and pathophysiology are reviewed. In all cases, surgical treatment involved diversion from corpora cavernosa. In the 51 cases with follow-up periods of 3 months or longer, results were considered as excellent in 17 cases (33 p. 100), partial in 5 (9.8 p. 100), and unsuccessful in 29 (56.8). Since 1984, needle drainage with a unilateral transglandular cavernosal-spongiosum shunt based on the technique described by Al Ghorab's has led to better results with immediate detumescence in 80 p. 100 of cases and a long-term success rate of 52 p. 100 (13/25 cases with sufficient follow-up). Except in cases involving sickle cell anemia in which concomitant medical treatment of priapism can be useful, immediate surgical treatment is the only technique effective in avoiding secondary impotence, which was common in our series (58.6). Our p. 100 needle drainage technique appears to be the method of choice for simplified achievement of a unilateral transglandular cavernosal-spongiosum shunt.

Adolescent↗

Post-traumatic, high-flow priapism treated with selective cavernous artery embolization and intracavernous streptokinase irrigation: a case report.

A 54-year-old man developed priapism shortly after a blunt perineal trauma. An arteriocavernous fistula caused the high-flow priapism, and was detected on both color Doppler sonography and selective phaloarteriography. Selective embolization of the left cavernous artery with Gelfoam was performed to seal the fistula, resulting in immediate detumescence. However, the penis remained firm despite returning to almost normal size. No fistula was detected by subsequent color Doppler sonography and phaloarteriography examination. Intracavernous irrigation with 200,000 U streptokinase was applied to treat residual firmness 2 weeks after embolization. Successful sexual intercourse was reported 3 months later. The combination of selective cavernous artery embolization and intracavernous streptokinase irrigation was effective for the treatment of the high-flow priapism in this case.

Arteries↗

[Incidence of priapism at the Marqués de Valdecilla University Hospital in Santander].

OBJECTIVE: Our experience in the management of priapism, its etiology, blood gas changes, treatment and outcome are presented. METHODS: The records of patients that had been treated at the Urology services of our hospital over the last 8 years were reviewed. During this period, patients with erectile dysfunction were treated according to a protocol. RESULTS: There were 9 episodes of priapism in 8 patients; all cases were low flow and the patients were aged 37-71 years. The duration of the prolonged erection ranged from 4 to 72 hours. Of these 9 cases, the etiology was intracavernosal PGE in 7, after trazodone administration in one case, and unknown in one case. Intracavernosal metoxamine was administered in all cases with excellent results, except one case that required a saphenous-cavernosal shunt and another case that was initially treated with adrenalin also with good results. CONCLUSIONS: Since intracavernosal agents have been utilized in the treatment of erectile dysfunction, priapism has become a more frequent urological emergency. Although a lower incidence has been reported for PGE, the dose should be well adjusted to avoid a higher incidence.

Adult↗

[Priapism secondary to chronic myeloid leukemia: value of initial treatment with cavernous lavage plus adjuvant methoxamine].

OBJECTIVE: To report a case of priapism secondary to leukemia, with special reference to the initial treatment in the emergency services. METHODS: A 53-year-old male with chronic myeloid leukemia presented with prolonged involuntary painful erection of 12 hours' duration. The physical examination and particularly the cavernosal blood gas study, indicated low flow priapism. Punction-lavage of the corpora cavernosa was performed. Because complete response was not achieved with this procedure, adjuvant intracavernous methoxamine was administered. RESULTS: Complete detumescence was achieved after the third dose of methoxamine. There was no recurrence and erectile function was preserved. CONCLUSIONS: We underscore the utility of combined cavernous lavage + adjuvant alpha-1 adrenergic agonist as initial therapy in priapism with this special etiology.

Adrenergic alpha-Agonists↗

[Priapism in the stallion].

A review of the literature is given concerning the anatomy and pathophysiology of the equine penis with regard to priapism: a prolonged erection of the penis not associated with sexual arousal. Several treatment options, such as flushing of the corpus cavernosum penis with heparinized saline and the creation of shunt between the corpus cavernosum penis and the corpus spongiosum penis are discussed. Subsequently, a case of priapism in a stallion following the injection of acepromazine, is discussed. The priapism resolved after the corpus cavernosum penis was flushed with the stallion under general anaesthesia.

Acepromazine↗

Priapism--a rare presentation in chronic myeloid leukemia: case report and review of the literature.

Priapism is a complication rarely seen in leukemia. We report a 21-year-old man presented with persistent painful erection of penis for 19 hours at home. The patient had undergone immediate irrigation and decompression of priapism by urologist at emergency department. This approach resulted in a flaccid penis later. During hospitalization, peripheral blood smear and bone marrow aspiration was confirmatory of chronic myeloid leukemia. No impotency nor other sequela was noted after his discharge. This case illustrates the importance of all physicians in the diagnosis and management of patients with priapism.

Adult↗

[Arterial priapism in a prepuberal patient. Conservative treatment].

OBJECTIVES: To report the case of a 7-year-old patient with high flow priapism solved with conservative treatment. METHODS: We performed history and physical examination, complementary tests including general blood tests (serum ions, hemogram and coagulation tests), peripheral blood smear, Doppler ultrasound and selective arteriography which led to the diagnosis of high flow priapism. Due to the absence of arteriovenous fistula conservative treatment was chosen. RESULTS: Patient improved clinically after five days, with penile detumescence and spontaneous erections were preserved. CONCLUSIONS: Conservative treatment is a valid option in patients with arterial priapism, mainly in those cases in whom performing embolization of a small fistula seen on arteriography is not possible or when such AV communication is not demonstrated.

Arteries↗

[Priapism].

Priapism is a rare disease, characterized by a prolonged erection unrelated to sexual stimulus or desire. There are two distinct types of priapism with different etiologies, pathophysiology, treatment and complications. A better understanding of these two clinical entities brought about, in recent years, some progress in their treatment. The authors make a retrospective analysis of the 17 cases of priapism diagnosed in this centre in the last twelve years. From this experience they review the standard approach to this disease, both diagnostic and therapeutic.

Adult↗

[Priapism and activated protein C resistance].

Priapism is a rare disease that can be secondary to a clotting disorder. The authors report the first published case of priapism due to a heterozygous mutation of factor V Leiden responsible for activated protein C resistance in a patient treated with low molecular weight heparin. A similar case has already been reported, but with a homozygous mutation. Priapism must therefore be considered to be a thromboembolic event and the presence of a clotting disorder should be systematically investigated in the absence of an obvious aetiology.

Activated Protein C Resistance↗

Post-traumatic high flow priapism percutaneously treated with transcatheter embolisation.

PURPOSE: The aim of this paper is to present our experience in the percutaneous management of high-flow priapism with transcatheter embolisation and gelfoam. MATERIALS AND METHODS: We present three clinical cases in which an acute trauma caused the development of high-flow priapism. After differing initial management, all cases underwent arteriography, followed by demonstration of the arterial-lacunar fistula and embolisation with gelfoam. RESULTS: Near immediate detumescence after the procedure confirmed the success of embolisation, which was supported by clinical and instrumental follow-up. DISCUSSION: In high-flow priapism, the best therapeutic solution remains transcatheter arterial embolisation, with ultra-selective catheterisation by microcatheter and embolisation of the pudendal artery only, which is responsible for the post-traumatic arterial-lacunar fistula. This manoeuvre is not always technically easy, and requires experience and remarkable dexterity. Technical failure is always possible owing to the spasm of a peripheral arteriole that cannot be resolved with papaverine, and to the possible rehabilitation by the downstream contralateral circulation. Furthermore, the apprehension of the operator carrying out the procedure in this anatomical context may make the immediate result seem satisfactory, even if it is not optimal. All these considerations stress the need for a rigorous clinical and instrumental follow-up to guide later diagnostic and therapeutic choices.

Adult↗

[Priapism in childhood--case report of 14-year-old boy].

In this article, a 14-year-old boy with priapism is presented. A secondary low-flow type of priapism, persisting 11 hours, as a result of olanzapine and methylphenidate therapy was diagnosted. There was a good response to conservative treatment (diazepam, metamisolum), detumescence appeared in 3 hours. No recurrence of priapism was observed, after the olanzapine and methylphenidate therapy was stopped.

Adolescent↗

Priapism and quetiapine: a case report.

Priapism is a "persistent erection not accompanied by sexual desire or stimulation, usually lasting more than six hours and typically involving only the corpora cavernosa." Here we report on a gay male patient from our HIV/AIDS mental health clinic who developed serious priapism on quetiapine and recreational amphetamine. Gay men are at high risk for amphetamine use, and as such, this potential association between priapism, quetiapine, and amphetamine use should be considered in making prescription decisions with these patients.

Amphetamine↗

[Priapism of low flow].

The results obtained after treating 13 patients with low flow priapism diagnosed by cavernous gasometry, penile ecodoppler and cavernosography are explained. Seven cases of priapism (53%) developed following intracavernous injection of vasoactive drugs and had a good response to aspiration lavage and alpha-agonist medication. None of the cases needed shunt technique to achieve detumescence and all showed good evolution with regard to the erectile function. Six cases of priapism (47%) were idiopathic and they all needed some type of venous by-pass. Later, only one had normal erections.

Adult↗

Haematological parameters associated with priapism in Nigerian patients with homozygous sickle cell disease.

Haematological indices in 23 male homozygous sickle cell disease (SCD) patients with priapism were the subject of this study. Patients with priapism showed significantly higher haemoglobin and haematocrit levels than in controls (P less than 0.0005 in both cases). Fetal haemoglobin levels were significantly higher in the control group than in SCD patients with priapism (P less than 0.0005). The implications of these findings are discussed and it is suggested that the practice of managing some of these patients conservatively by the transfusion of packed red blood cells to build up their haemoglobin and haematocrit levels needs to be reviewed critically.

Adult↗

[Priapism with malignant lymphoma: a case report].

A case with priapism in a 66-year-old male due to malignant lymphoma is reported. Physical examination revealed an erected penis and enlarged lymph nodes in left neck and bilateral inguinal areas. Rectal digital examination of prostate revealed an irregular surface and swollen hard left lobe. Open biopsy of the bladder and vesicostomy were carried out. Several nodular lesions in the trigone and in the left wall were excised. Pathologically the diagnosis was malignant lymphoma, diffuse, large cell type and clinical stage was stage IV. CHOP therapy with bleomycin and methotrexate was performed. Priapism disappeared 7 days after the initiation of the chemotherapy, but impotence has been noticed after the chemotherapy for more than one year. This will be the first case with priapism due to malignant lymphoma reported in Japan so far.

Aged↗

[Priapism. New diagnostic and therapeutic methods].

Priapism (P) may develop from unknown causes or may occur secondary to other disease or as a side effect of medication. The occurrence of pharmacologically induced erection by intracavernous injection of drugs has resulted in a number of cases of iatrogenic priapism. Priapism may be ischaemic or non-ischaemic and determination of the acid-base status in the cavernous blood may be of value in the choice of treatment. The non-ischaemic cases should be treated primarily by aspiration of blood, possibly followed by intracavernous injection of a vaso-constrictive agent, eg 15 micrograms adrenaline or noradrenaline, repeated if necessary. Cases which do not respond to this and severe ischaemic cases should be treated with glando-cavernous anastomosis.

Humans↗

Priapism after castration in a cat.

Priapism developed in a cat 2 days after castration and strangury. The priapism was unresponsive to massage and antimicrobial treatment. Because of penile engorgement and necrosis, a perineal urethrostomy was performed. Clinical signs of priapism resolved after urethrostomy. Histologic examination of tissues revealed vascular stasis within the corpus cavernosum penis and funiculitis of the right spermatic cord.

Animals↗

[A case of priapism caused by disseminated intravascular coagulopathy].

A case is presented of priapism resulting from disseminated intravascular coagulopathy (DIC), which was diagnosed by pathological studies of the amputated penis and skin biopsy. To our knowledge, this is the first case reported in Japan. This 72-year-old-man visited a hospital complaining of fever and cough, and was administrated for treatment of bronchitis and liver cirrhosis. A few days after admission, multiple purpura with edema and pain appeared over the skin regions on the bilateral knee joint, foot joint and upper extremities. A week after purpura appeared, priapism began. Regardless of irrigation and aspiration of corpora cavernosa and glans-cavernosa-fistula creation, penile necrosis developed. We had to perform penile amputation. The pathology of the amputated penis and skin, and blood coagulative examination suggested that DIC resulted in priapism. DIC was controllable by the use of FOY and heparin. He was discharged and is an outpatient.

Aged↗