Toxic psychosis caused by preludin.
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This article focuses on the treatment of depression with special reference to pharmacotherapy. The treatment-resistant case and the possible means of resolving its problems are highlighted. The role of ECT will be considered. Long-term maintenance treatment with antidepressant medication for patients with cyclic occurrences is recommended.
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Trends in drug use and criminal charges of 44,223 consecutive admissions to the District of Columbia Superior Court lock-up between December 1971 and April 1975 were analyzed. While the number of persons arrested and admitted to the lock-up remained relatively constant during this time, drug use as measured by positive urinalysis declined substantially in 1973 and remained at a lower level through 1975. Heroin use showed a decline similar to the overall trends in 1973, but began to increase in mid-1974. Arrestees who were drug positive were generally less likely to be charged with major crimes of violence than those who were drug negative. Exceptions to this pattern as well as trends in drug use and crime in the arrested population are discussed.
A minority of alcohol abusers develop severe cerebral dysfunction in the form of Wernicke-Korsakoff syndrome. There is also evidence to suggest that cerebral dysfunction, particularly impaired abstracting ability, occurs in that larger population of heavy drinkers who do not go on to develop the Wernicke-Korsakoff syndrome. There is no consistent evidence that long-term marijuana, hallucinogen, or sedative use causes lasting neuropsychological disturbance. The deficits in abstract thinking reported by some LSD studies are similar to deficits others have reported among alcoholics. Since the LSD studies were not controlled for alcohol use, their interpretation is difficult. It appears that cerebrovascular accidents occur more frequently and at a younger age among amphetamine abusers. There is no reliable information about possible other long-term effects of stimulants on the brain per se (i.e., nonvascular complications). Abuse of intravenous narcotics has been associated with case reports of transverse myelitis and encephalitis. It is not known whether this pathology is a direct or hypersensitivity effect of narcotic drugs, of adulterants, or of infection.
Phendimetrazine is an anorectic agent which recently has been detected in three medical examiner's cases. In one instance death was attributed to this drug. Methods of detecting and identifying this drug in urine and blood are discussed. In the one instance where death was attributed to this substance, the blood concentration was 300 ng/ml.
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