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At least 307 records · Page 17Linked to original sources
PubMed2004

New discoveries in the basic science understanding of Peyronie's disease.

Peyronie's disease is an acquired benign condition representing localized fibrosis of the penis. The disease is caused by microvascular trauma to the penis, with subsequent fibrin deposition resulting in aberrant wound healing and possibly other etiologies. Histopathologic studies of the Peyronie's plaque have demonstrated the role of transforming growth factor-beta 1 in the pathologic development of penile plaque. Animal models have been developed to test pathophysiology and therapeutics. The role of inducible nitric oxide synthase and nitric oxide has been established to limit and counteract fibrosis. Differential gene expression studies have identified candidate up-regulated or down-regulated genes that are involved in the pathophysiology of Peyronie's disease.

Animals↗
PubMed1975

Replacement of tunica albuginea of corpus cavernosum penis using human dura. Experimental study on dogs.

The tunica albuginea of corpus cavernosum penis was excised and replaced with human dura in experiments on 11 dogs. The surface of the implant epithelialized within three weeks, and later the implant was replaced by autologous tissue with no scarring and shrinkage. After resection of placques in Peyronie's disease the tunica albuginea can be replaced with specially treated human dura.

Animals↗
PubMed1977

Experience with Devine-Horton dermal patch graft for Peyronie's disease.

Peyronie's disease is a malady frequently seen by the urologist. Many conservative treatment modalities have yeilded successful alleviation of symptoms in a significant number of these patients. A number, however, do not respond and are left with penile curvature and pain on erection such that intercourse is severely impaired. Devine and Horton have proposed resection of the plaque with replacement of the defect with a full-thickness dermal graft. They reported excellent results with minimal complications. Five patients were treated by this technique with successful penile straightening and alleviation of pain. To date, follow-up results have been gratifying, and the Devine-Horton dermal graft technique is suggested for use in treatment of patients with disabling Peyronie's disease.

Aged↗
PubMed1979

Peyronie disease: surgical treatment with muscular aponeurosis.

A new method for surgical correction of Peyronie disease by grafting autologous muscular aponeurosis was tried in 4 patients. Early results were encouraging, with disappearance of penile curvature and of pain on erection. The urologist can perform the operation without the assistance a plastic surgeon must usually give when dermal grafts are used.

Humans↗
PubMed1980

Is it worthwhile to treat Peyronie disease?

Several articles describing the natural history of Peyronie disease have shown that untreated patients seem to have spontaneous improvement. It has been suggested that this could be the reason for the success of so many different methods. A review of the literature and of our previous experience has been done, trying to clarifying this issue. Our findings indicate that although treatment does not increase appreciably the percentages of amelioration of symptoms over the spontaneous evolution, it accelerates the improvement. Analysis is made of several factors which we have found to be important when making a decision for treatment: type of symptoms, psychologic impact of them, possible complications of the different therapy methods, and time interval from beginning of symptoms to treatment. The question of the worthiness of treating Peyronie disease does not have a single answer. We believe there are definite indications and several factors to be considered.

Humans↗
PubMed1980

Peyronie disease and surgical treatment: a new concept.

Peyronie disease was treated with excision of the plaques and replacement of tunica albuginea with lyophilized human dura in younger patients and with implantation of a Small-Carrion prosthesis through an infrapubic approach without excision or incision of the plaques in elderly patients. This new concept has been satisfactory in 22 patients, with an observation time of up to four and one-half years.

Adult↗
PubMed1980

Surgical considerations in treatment of Peyronie disease.

A comparison is made of two groups of patients treated surgically in nonrandomized fashion for Peyronie disease. The first group was treated with excision of the plaque and dermal patch graft; the second with simple incision of the plaque and implantation of penile prostheses. Literature and personal experience comparing the two methods are discussed.

Humans↗
PubMed1981

Sonographic evaluation of Peyronie disease.

In this case report we illustrate and discuss the use of high frequency, superficial organ, real-time ultrasound scanning in the evaluation of patients with Peyronie disease.

Adult↗
PubMed1981

Sonographic demonstration of Peyronie plaques.

Patients with Peyronie disease have been evaluated with diagnostic ultrasonography to delineate the plaques and identify the presence of calcification. The advantages of this procedure are discussed. This is the first report of the use of diagnostic ultrasound in the evaluation of Peyronie disease.

Adult↗
PubMed1983

New surgical procedure for management of Peyronie disease.

Surgical excision of fibrotic plaques and replacement of the defect by grafts may be necessary in advanced Peyronie disease. Synthetic, absorbable mesh for grafting the defect was used in 6 mongrel dogs. An area of tunica albuginea 1.5 by 2.5 cm was removed from the corpus cavernosum, thus exposing the spongy cavernous tissue. A Dexon mesh of the same dimensions, woven in our laboratory from polyglycolic acid fibers of 308 denier thickness, was sutured to the defect by 3-0 Dexon sutures. The mesh caused hemostasis and the animals' postoperative course was uneventful. Posterection cavernosograms showed no curvature of the penis, bulging of the operative area, or obstruction of the corpora cavernosa. Histologic studies at three weeks, and two, four, and six months after surgery showed complete healing and gradual replacement of the Dexon mesh by fibrous connective tissue.

Animals↗