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Differential growth and healing of bones and teeth.

A series of experiments was performed in turtles, rodents, lagomorphs, dogs, and monkeys to determine and correlate differential growth and healing of bones and teeth. Vital stains, radiopaque implants in conjunction with serial radiography, autoradiography, histology, and other methods were employed. Histologic differences and rate of endochondral (tibia, rib, base of skull, and mandibular condyle) and nasal cartilaginous septal growth were noted. Similarly, differences were observed in growth between five facial sutures and also for the same suture at different times. The nasal bone side of the frontonasal suture grew about twice as fast as the frontal bone side. In the turtle shell the midsagittal suture grew faster than a transverse suture. A variety of differences in rate of appositional (and resorptive) growth were noted at different sites of the mandible and nasal bone region. Generally, there was deposition of bone along the posterior border of the mandibular ramus and resorption of bone along the anterior border. Variations in the volume of the orbital contents influenced orbital growth. Bone was highly reactive, while enamel and dentin were nonreactive, to trauma.

Animals↗

The status of the developing occlusion of 8-9 year-old children from a lower socio-economic group in a developing country.

The aim of this study was to determine the percentage of developing malocclusions that are present at the age of 8-9 years. This data will be used for a follow-up study on the same sample two years hence, in order to formulate soundly based recommendations to Public Health Authorities on the implementation of a community directed, preventive and interceptive orthodontic programme. A total of 936 children were examined by 3 investigators, at 9 primary schools in the lower socio-economic suburbs of a large urban area. The majority of subjects (66.5 per cent) presented with Class I malocclusions. A significantly higher percentage of white children however, presented with Class II malocclusions, while black children showed a higher tendency toward Class III malocclusion. Well circumscribed anterior openbites were found in 27.8 per cent of black children, but no specific causative factors could be identified. Early loss of primary molars and canines occurred in both groups. There was a statistically significant difference (p < 0.05) between the mean posterior arch lengths of the two groups, the black children having on average 2.2 mm longer arch lengths.

Child↗

[Nonspecific body resistance in the acetylator phenotype of patients with odontogenic inflammatory processes in the maxillofacial area].

Nonspecific resistance of the body, intensity of acetylation processes, and acetylator phenotype were studied in adults and children aged 3 to 16, suffering from maxillofacial odontogenic inflammations. The findings evidence that irrespective of the patient's age, development of maxillofacial inflammations is associated with a reduction of the body nonspecific resistance and of acetylation processes intensity, this reduction being the most marked in the patients with acute and chronic osteomyelitis. Patients with the slow acetylation type predominated among the examinees, permitting a hypothesis that this acetylation type favors the development of odontogenic inflammations.

Abscess↗

[Immunocorrection in the combined treatment of patients with osteomyelitis developing following combined injuries to the maxillofacial and craniocerebral areas].

Twenty-one of the forty-two patients with osteomyelitis developing after a combined maxillofacial and craniocerebral injury were administered thymogen, an immunocorrective drug, as a component of combined therapy; immunologic indications for the prescription of such an agent were present in all these patients. Depressed T-cellular immunity was the principal disorder of the immunologic reactivity of this patient population; they also developed elevated counts of NK cells and increased interleukin synthesis by the macrophages, this reflecting a high activity of inflammation. Thymogen therapy was conducive to normalization of the immunologic and nonspecific reactivity and enhanced the treatment efficacy on the whole.

Adjuvants, Immunologic↗