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At least 307 records · Page 17Linked to original sources
PubMed1997

Estradiol masculinizes the number of accessory olfactory bulb mitral cells in the rat.

Orchidectomized males injected with a single dose of estradiol benzoate on the day of birth (D1) showed mitral cell numbers in the accessory olfactory bulb similar to those of control males. However, orchidectomized males that received no additional estradiol benzoate treatment and those orchidectomized and given a single dose of dihydrotestosterone on D1 showed decreases in the number of accessory olfactory bulb mitral cells compared with control males. These results support the notion that the presence of estradiol immediately after birth induces the masculinization of mitral cells number in the accessory olfactory bulb.

Animals↗
PubMed1998

In ovo treatment with an aromatase inhibitor masculinizes postnatal hormone levels, abdominal fat pad content, and GH pulsatility in broiler chickens.

Vorozole, a selective aromatase inhibitor, was administered in ovo to test the specific embryonic role of estrogen in conferring the sex distinction in GH release and body phenotype in broilers. On Day 6 of incubation, eggs were injected with saline or with different concentrations of vorozole. Postnatal blood samples were analyzed for T3, T4, GH, estradiol (E2), and testosterone (T). At the age of 4 wk, control and vorozole-treated birds were cannulated, and serial blood samples were withdrawn every 10 min for 5 hr, wherein GH pulsatility characteristics were determined using deconvolution analysis. The proportional abdominal fat pad weight was reduced significantly in the treated groups, especially in female birds. The vorozole treatment increased plasma T3, E2, T, and GH concentrations, and decreased T4. The frequency of the GH pulses was lower and the interval between the bursts (min) was higher in the vorozole-treated group, as were the mass secreted per burst (ng/ml), the amplitude (ng/ml/min) and the production rate (ng/ml/5 hr). In conclusion, early in ovo treatment with a potent aromatase inhibitor is able to increase the mean serum T3 and GH concentration and masculinize the GH pulse pattern, resulting in an economically favorable decrease in abdominal fat pad content in male and female broilers at slaughter age.

Adipose Tissue↗
PubMed1997

Neonatal androgen and estrogen treatments masculinize the size of motoneurons in the rat spinal nucleus of the bulbocavernosus.

1. Newborn female rats were injected with either a nonaromatizable androgen, dihydrotestosterone propionate (DHTP; 1 mg), or estrogen benzoate (EB; 100 micrograms), or both, or sesame oil vehicle only as a control. In the first experiment, females were injected only on the day of birth (day 1). In the second experiment, females were given daily injections on either days 1, 3, and 5 of life or on days 6, 8, and 10. At 60 days of age the animals were sacrificed and the size of the somata and nuclei of motoneurons in the spinal nucleus of the bulbocavernous (SNB) was determined. 2. As in earlier studies, neonatal EB had no effect on the adult numbers of SNB cells, and the present study demonstrated estrogen's ineffectiveness in this regard in either the absence or the presence of DHTP. Nor did neonatal estrogen influence the survival of the SNB target musculature. 3. In agreement with previous studies, early DHTP treatment resulted in more SNB cells in adulthood and both late and early neonatal treatment with DHTP also resulted in larger SNB cells in adulthood. 4. We report for the first time that neonatal EB treatment also resulted in larger adult SNB cells. EB exerted this effect after a single injection on the day of birth or after multiple injections during the early neonatal period (days 1-5) but not after late neonatal injections. 5. These data suggest that both androgens and estrogens normally act to masculinize the size of SNB motoneurons, while only androgens affect the number of SNB cells.

Age Factors↗
PubMed1991

Differentiated additive androgyny model: relations between masculinity, femininity, and multiple dimensions of self-concept.

Masculinity (M) and femininity (F) were related to multiple dimensions of self-concept in 2 large studies. Androgyny theory predicts that M and F contribute positively to self-concept, but the effect of F has been nil in research using global self measures. Here, consistent with the new differentiated additive model, the relative contribution of M and F varied substantially, depending on the area of self-concept; F contributed more positively to self-concept facets that were more stereotypically feminine. Support for the model was consistent across self-responses and responses by significant others (Study 1) and across 5 age groups in early-to-middle adolescence (Study 2).

Adolescent↗
PubMed2005

Power and the creation of patronizing environments: the stereotype-based behaviors of the powerful and their effects on female performance in masculine domains.

This work tested the following hypothesis: When powerful men stereotype their female subordinates in masculine domains, they behave in patronizing ways that affect the performance of their subordinates. Experiment 1 examined the stereotyping tendencies and patronizing behaviors of the powerful. Findings revealed that powerful men who stereotyped their female subordinates (i.e., those who were weakness focused) gave female subordinates few valued resources but much praise. In Experiment 2, low-power participants received resources (valued or devalued positions) and praise (high or low) from a powerful man. Subordinates who were assigned to a devalued position but received high praise (i.e., the patronizing behavior mirrored from Experiment 1) were angry. However, men performed better in the anger-inspiring situation, whereas women performed worse.

Anger↗
PubMed1992

Evidence from mosaic analysis of the masculinizing gene her-1 for cell interactions in C. elegans sex determination.

Sex in Caenorhabditis elegans is determined by a regulatory cascade of seven interacting autosomal genes controlled by three X-linked genes in response to the X chromosome-to-autosome (X/A) ratio. XX animals (high X/A) develop as self-fertile hermaphrodites, and XO animals (low X/A) develop as males. The activity of the first gene in the sex-determining cascade, her-1, is required for male sexual development. XO her-1 loss-of-function mutants develop as self-fertile hermaphrodites, whereas XX her-1 gain-of-function mutants develop as masculinized intersexes. By genetic mosaic analysis using a fused free duplication linking her-1 to a cell-autonomous marker gene, we show here that her-1 expression in a sexually dimorphic cell is neither necessary nor sufficient for that cell to adopt a male fate. Our results suggest that her-1 is expressed in many, possibly all, cells and that its gene product can function non-autonomously through cell interactions to determine male sexual development.

Animals↗
PubMed2000

Toward a transformed approach to prevention: breaking the link between masculinity and violence.

Men are disproportionately overrepresented among both perpetrators and victims of violent crime. Scholars from the men's studies movement have documented a clear link between socialization into stereotypical norms of hegemonic masculinity and an increased risk for experiencing violence. Despite this evidence, most campus prevention programs fail to recognize the link between men and violence and use only traditional approaches to violence prevention. The most that on-campus prevention programs provide are self-defense seminars for potential female victims of rape and general campus safety measures. In this article, the author describes a comprehensive, transformed approach to violence prevention. Data from a year-long case study of Men Against Violence, a peer education organization at a large university in the South, demonstrate the feasibility of meaningfully expanding male students' conceptions of manhood and appropriate gender roles and, thus, reducing the likelihood of men's engaging in sexually or physically violent behavior.

Adult↗
PubMedDate not supplied

Long-term users of psychotropic drugs: embodying masculinized stress and feminized nerves.

This article examines long-term users of psychotropic drugs (43 men and 57 women) and their views on women's and men's reasons for using these drugs. The data came from written statements (N= 56) given on open-ended questions from a survey of users and from taped interviews with 10 respondents. Men's accounts expressed a notion of men as experiencing external pressures which created "masculinized stress." On the one hand, this stress could be handled with alcohol, while, on the other hand, the use of psychotropic drugs indicated a loss of men's assumed self-regulatory power and autonomy. Women related the reasons for their psychotropic drug use to their experience of emotional labor. Nevertheless, they did not tend to identify the psychological consequences of their experience as related to work. Rather, they labelled these as health consequences--women being more "emotional" than men and suffering from "nerves." These lay accounts reflect the representations of gender-specific psychological distinctions and the effort to construct gender-specific etiologies.

Anti-Anxiety Agents↗
PubMed1997

The mutation masculinizer (man) defines a sex-determining gene with maternal and zygotic functions in Musca domestica L.

In Musca domestica, the primary signal for sex determination is the dominant factor M, which is assumed to regulate a postulated female-determining gene F. Presence of M prevents expression of F so that male development ensues. In the absence of M, F can become active, which dictates the female pathway. The existence of F is inferred from FD. a dominant factor that is epistatic to M. We describe a new mutation masculinizer, which has all the properties expected for a null or strongly hypomorphic allele of F: (1) it maps to the same chromosomal location as FD, (2) homozygous man/man animals develop as males, (3) homozygous man/man clones generated in man/+ female larvae differentiate male structures, (4) man has a sex-determining maternal effect. About a third of the morphological males synthesize yolk proteins, which indicates that they are intersexual in internal structures. The maternal effect of man is complete in offspring that derive from homozygous man/man pole cells transplanted into female hosts. In this case, all man/+ progeny become fertile males that do not produce yolk proteins A sex-determining maternal effect has previously been demonstrated for FD. Like F, maternal man' is needed for zygotic man' to become active, providing further evidence that man is a loss-of-function allele of F.

Animals↗
PubMed2005

Masculinities and young men's sex education needs in Ireland: problematizing client-centred health promotion approaches.

In recent decades, dominant discourses in health promotion have emphasized empowerment, client participation and the notion of people identifying and being facilitated to meet their own health needs. However, there has been little analysis of the concept of 'need' and the possibility, at least, that the fulfillment of some such self-defined needs are not in the interest of social justice and equality. In this article, we present an account of the sex education needs of secondary school pupils from their own perspectives, and problematize the concept of self-identified needs in health education. Twenty-nine focus group interviews were conducted with 226 secondary school pupils in Ireland, and data were subjected to a qualitative analysis. Findings suggested that young men tended to prioritize practical guidance that would provide them with the skills and confidence to take the lead in sexual encounters, and display competence in the act of penetrative sex. We argue that these self-defined sex education needs emanate from a culture of traditional masculinity where, for a male, one's place in the pecking order is derived from one's capacity to conquer, lead and display mastery with regard to sex. In the discussion, we attempt to unpack the notion of clients identifying their own needs and the concept of empowerment as it relates to our data, in the context of gender-based structural inequalities.

Adolescent↗
PubMed2004

Contextualizing smoking: masculinity, femininity and class differences in smoking in men and women from three generations in the west of Scotland.

The epidemiology of smoking, and contemporary and historical accounts of tobacco consumption, together suggest that the patterning of smoking by class, gender and gender role identities may differ markedly for people born at different stages in the establishment and demise of smoking in the 20th century. Here, we report an analysis that examines this assertion using empirical data collected from men and women living in the west of Scotland, an area with high rates of smoking, who were born in the 1930s, 1950s and 1970s. Class trends in smoking were less apparent for men than for women in the older two cohorts and there was little evidence of class patterning in either sex in the youngest participants. There was little relationship between the measures of gender role orientation and current smoking amongst men. Amongst women, the strongest association was between smoking and a well-validated measure of 'femininity' in the 1950s cohort; each unit increase in 'femininity' score increased the odds of being a smoker by 46%. In this same cohort of women, there was also a weaker relationship between smoking and higher masculinity scores. These results are discussed in the context of continuing use of gendered imagery to exploit new markets in the developing world.

Adult↗
PubMed1976

Masculinizing ovarian tumors.

In a study of 194 masculinizing ovarian tumors from the Ovarian Tumor Registry, the criteria for reclassifying these tumors on a histologic basis are discussed. It is proposed that the terms "gynandroblastoma" and "arrhenoblastoma" be discarded in favor of "gonadal stromal," and that the general classification of "lipoid tumor" can be avoided if careful search is made for specific histologic structures. Finally, it is suggested that the malignancy rate for gonadal stromal tumors, Sertoli-Leydig tumors, hilus cell tumors and adrenal rest tumors is closer to 5% rather than 25-30%.

Adolescent↗
PubMed1992

Bilateral rotated buttock flaps for vaginal atresia in severely masculinized females with adrenogenital syndrome.

The addition of large bilateral rotated buttock flaps to the flap vaginoplasty enhances the introitus in severely masculinized patients with high vaginal atresia. The flaps are rotated medially to create the distal aspect of the lateral and anterior vaginal wall. The inferior advancement of the labioscrotal folds aids in closing the donor defect, while at the same time creating the appearance of labia majora. Finally, the use of these local tissues will result, in later life, in a vaginal reconstruction free of unwanted hair. This reconstruction technique should obviate dilatation in the older child and prevent further stenosis.

Adrenal Hyperplasia, Congenital↗
PubMed1997

Gender-confirming facial surgery: considerations on the masculinity and femininity of faces.

While aesthetic facial surgery performed for reasons of undesired facial masculinity or femininity has had some attention in the literature, there is a lack of information on gender-confirming facial surgery as part of an overall surgical sex reassignment program. In this paper we try to capture some of the sex differences, respectively, of skeleton, musculature and other subcutaneous soft tissues, integument and frame of the face. From this, we come to a description of some general differences of facial appearance between the sexes. In restructuring the skeletal architecture and facial proportions to match the desired gender, these factors should be taken into account.

Cephalometry↗
PubMedDate not supplied

The effects of masculinity and social support on recovery from myocardial infarction.

Ninety post-myocardial infarction (MI) patients were interviewed to assess masculinity/femininity and social support shortly before hospital discharge. Patients were contacted 1 year following MI to obtain information about rehospitalization and/or death, post-MI chest pain, and perceived health. After controlling for traditional coronary risk factors, MI severity, and psychological distress, lack of disclosure to one's spouse predicted worse recovery on all three indices. Exploratory analyses revealed that males (n = 63) who disclosed to their spouses were rehospitalized less often than females (n = 14) who disclosed to their spouses, and married patients who engaged in less spouse disclosure (n = 32) were significantly more likely to be rehospitalized than either unmarried patients (n = 14) or married patients who engaged in more spouse disclosure (n = 41). Masculinity predicted more severe post-MI chest pain but was unrelated to rehospitalization and perceived health.

Adult↗
PubMed2005

Masculinizing genitoplasty in intersex patients.

PURPOSE: We reviewed cosmetic and functional outcome of masculinizing genitoplasty (MPG) in intersex patients assigned as a male performed in our service for more than 12 years. MATERIALS AND METHODS: A total of 57 patients underwent MPG in our department during a 20-year period. Of these cases MPG was performed using modern 1-stage surgical techniques from 1991 to 2003 in 39 (68%). Of the 39 children 8 (21%) had 17beta-hydroxysteroid dehydrogenase deficiency, 2 (5%) had 3beta-hydroxysteroid dehydrogenase deficiency, 8 (21%) had 5alpha-reductase deficiency, 2 (5%) had mixed gonadal dysgenesis, 1 (2.6%) was a true hermaphrodite, 1 (2.6%) had Klinefelter's syndrome, 1 (2.6%) had partially androgen insensitivity syndrome and 16 (41%) had idiopathic male pseudohermaphroditism. The presenting disease was severe proximal penoscrotal hypospadias in 30 cases (77%), perineal hypospadias in 9 (23%) and müllerian duct opening in the perineum along with the urethral meatus in 16 (28%). Median patient age at surgery was 1.8 years. MPG was performed with a transverse pedicled preputial island flap as an onlay in 29 cases (74%). The remaining 10 patients (26%) underwent tubularization of the mucosa in the perineal area and end-to-end anastomosis to a tube made from the pedicled prepuce. Scrotal transposition as well as orchiopexy was performed in some patients as an independent operation so as not to jeopardize the perineal and preputial flaps. RESULTS: In 23 (59%) of the 39 children 1 operation achieved satisfactory cosmetic and functional results in terms of good urinary stream and straight phallus during erection. Three (7%) children presented with various degrees of breakdown of the urethroplasty and required a repeat operation. In 5 patients (12.8%) a small urethral fistula developed and closure was performed. CONCLUSIONS: A 1-stage male genitoplasty for male pseudohermaphroditism is accompanied by a reasonable incidence of major complications. It should be performed in early childhood to avoid psychological and social anxiety by the child and parents.

Adolescent↗
PubMed1999

Genetic and environmental influences on individual differences in masculinity, femininity, and gender diagnosticity: analyzing data from a classic twin study.

Analyzing data from Loehlin and Nichols's (1976) classic twin study, we computed measures of Masculine Instrumentality (M), Feminine Expressiveness (F), and Gender Diagnosticity (GD). Quantitative genetic modeling analyses of within-sex individual differences in M, F, and GD indicated that: (1) Additive genetic factors contribute significantly to individual differences in M, F, and GD. (2) The environmental effects on M, F, and GD tend to be nonshared. (3) The genetic and environmental components of individual differences in M, F, and GD tend not to show gender differences. Finally, (4) the estimated within-sex heritability of GD (.53) is significantly greater than the estimated within-sex heritabilities of either M (.36) or F (.38).

Adult↗
PubMed2004

Neonatal 5HT activity antagonizes the masculinizing effect of testosterone on the luteinizing hormone release response to gonadal steroids and on brain structures in rats.

Hypothalamic 5HT concentrations are transiently lower in male compared to female Wistar rats in the second week post partum (pp) and our previous findings have shown that pharmacologically potentiating 5HT activity over this period feminizes certain aspects of sexually differentiated behaviours in adult males and androgenized females. In order to investigate whether neonatal testosterone and 5HT interact to influence physiological and morphological brain sexual differences, females, androgenized females and males were treated with the 5HT2 agonist (-) [2,5 dimethoxy-4-iodophenyl]-2-amino propane HCl [(-) DOI], over days 8-16 pp. In androgenized females (250 microg testosterone proprionate, day 2 pp) (-) DOI prevented the delay in vaginal opening, but did not prevent the androgen-induced constant oestrus in females treated with 100 microg TP, day 2 pp. (-) DOI overcame the neonatal androgen effect in suppressing the positive feedback of ovarian steroids in a few males and androgenized females. (-) DOI had a feminizing effect on the volume of the anteroventral periventricular nucleus (normally smaller in males), by significantly increasing its volume in male and androgenized females. It also had a significant antagonistic effect on the testosterone-induced increase in the volume of the sexually dimorphic nucleus of the preoptic area in males and androgenized females. These findings support the view that raised 5HT activity in the second week of life antagonizes the masculinizing effect of neonatal testosterone.

Animals↗