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Results for “Light Coagulation”

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At least 307 records · Page 17Linked to original sources
PubMed1977

Management of retinoblastoma.

The management of 499 cases attending Moorfields Eye Hospital and St Bartholomew's Hospital, London, is described. The method of examination and differential diagnoses, together with the indications for treatment with light coagulation, cryosurgical techniques, cobalt plaque applications, cobalt beam therapy or the linear accelerator and chemotherapy, are listed in terms of the experience gained with this number of cases. Nowadays, the survival rate is approximately 90%.

Cobalt Radioisotopes↗
PubMed1977

[A variable pressure and distance impression funnel for fundus examination (author's transl)].

We describe a variable pressure and variable distance impression funnel for the Goldmann-3-mirror contact glass. The advantage of this apparatus lies in the possibility of denting the bulbus up to the equator for the diagnosis of holes while the retina is still attached. This funnel has proved itself especially in light coagulation through the contact glass with the slitlamp.

Cocaine↗
PubMed1998

[Laser applications in dermatology].

Over the past decades continuous wave laser systems have been used in dermatology for the photocoagulation and vaporization of vascular neoformations and malformations and to remove epithelial lesions. However, their mainly thermal effect can have negative impact on wound healing and scar formation due to thermal damage of adjacent tissue. More recent laser systems now permit more selective and more restrictive destruction of pathological tissue. They include pulsed and Q-switched lasers matched to the absorption characteristics of the target structures, which permit skin ablation and selective photothermolosysis of pigmented or vascular lesions. These technical innovations have expanded the therapeutic spectrum in dermatology and improved the quality of the results achieved. Nevertheless, these systems should be used only for carefully selected indications, in particular when corrective-aesthetic considerations are of importance. Furthermore, prior to treatment, it is mandatory for the dermatologist, to establish the proper diagnosis, especially in the case of pigmented lesions and skin changes of uncertain dignity.

Humans↗
PubMed1976

[Diathermy procedures, light and laser coagulation, cryocoagulation. Experimental and clinical considerations].

The clinical and experimental results from the methods of coagulation currently in use are presented. The advantages and disadvantages of trans-scleral methods (diathermy and cryopexy) and trans-ocular methods (Xenon arc and argon laser) are discussed. Experiments on absorption, the mode of action of intense light, the optimal time and method of application, the necessary intensity and the extent of the coagulated area are communicated. Of the trans-scleral methods, cryopexy is to be prefered. The trans-ocular methods have the advantage of a more exact localisation and dosage. Either route can often be chosen in any particular case, though at present no overriding advantage has been shown for either.

Cryosurgery↗
PubMed1962

Solar coagulation.

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Blood Coagulation↗
PubMed1962

Photocoagulation.

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Light Coagulation↗
PubMed1987

Association of a protein with membrane vesicles at the collisional limit: studies with blood coagulation factor Va light chain also suggest major differences between small and large unilamellar vesicles.

Vesicle size can be a very sensitive modulator of protein-membrane association. In addition, reactions at the collisional limit may be characteristic of many types of protein-membrane or protein-receptor interactions. To probe these effects quantitatively, we analyzed the association of blood clotting factor Va light chain (Va-LC) with phospholipid vesicles of 15-150-nm radius. The number of protein binding sites per vesicle was approximately proportional to vesicle surface area. Association rates approached the collisional limit, and the activation energy for the association reaction was 4.5 +/- 0.5 kcal/mol. In agreement with diffusional theory for this type of interaction at the collisional limit, the observed association rate constant for filling all sites was approximately proportional to the inverse of vesicle radius. This general property has important implications for many systems such as blood coagulation including possible slower association rates and higher Km values for reactions involving whole cells relative to those obtained for phospholipid vesicles. Dissociation rate constants for reactions that are near the collisional limit should also be proportional to the inverse of vesicle size if diffusional parameters are the only factors influencing dissociation. However, Va-LC bound to small unilamellar vesicles (SUVs, less than or equal to 15-nm radius) gave slower dissociation rates than Va-LC bound to large unilamellar vesicles (LUVs, greater than or equal to 35-nm radius). This indicated a change in KI, the intrinsic protein-phospholipid affinity constant for LUVs vs SUVs. The cumulative effect of association and dissociation rates resulted in higher affinity of Va-LC for SUVs than LUVs under equilibrium conditions. The latter was corroborated by competition binding studies. Furthermore, the temperature dependence of both rate constants indicated an entirely entropy-driven binding to LUVs but a largely enthalpy-driven binding to SUVs. Interactions which are largely entropic are thought to be ionic in nature. The differences observed between binding to LUVs and SUVs may reflect thermodynamic differences between these types of phospholipid structures.

Animals↗