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PubMed2002

[The age of formation of Czech clinical medicine].

Era of Emperor Francis Joseph I is said to be a golden age for the Czech nation. It can be found in numerous panegyric articles to any jubilee of the emperor's rule. What was formally dictated by respect brought by education and by the system of the Greek and Roman tradition adopted in Austria in Middle Ages, seams to be valid today as most of the contemporary technical and economical progress roots within those days. The Czech cultures namely music and art reached international acknowledgement. Though with difficulties, Czech achieved in education and in science as a full-fledged language. After the year 1848 an average citizen was entitled to such freedom as never before. Technical, economical and cultural progress enabled real ascent of the Czech society and its social differentiation. In sixties, after the Austria-Hungary Alignment, Hapsburg government undertook no serious restrains. Such development was nothing unusual. Similar one underwent after the period of storms all European societies from south to north and form west to east. They brought ideas of the French revolution and years 1848/1849 are therefore called "the spring of European nations". In all countries where revolutionary ideas were represented and various countermeasures were accepted, governments were forced to accept temporary arrangements (in Austrian monarchy it was the promise of constitution, language compromise etc.). Nevertheless, in the second half of the 19th century the most important condition for further revival was the long period of peace and stability of international relations. The internal stability of the Austrian monarchy was achieved for long time by the Austria-Hungary Alignment in 1867. After the lost battle at Hradec Kralove in summer 1866 it became clear that contemporary centralistic organization of the state, balancing between absolutism and constitutionalism is not further tenable. Years long pressure of patriotic forces in the parliament brought about division of the Charles-Ferdinand University. Important role in the partition of the Czech Medical Faculty from the German one had the foundation of the Czech Medical Society and the Czech Medical Journal in 1862 patronaged by professors Purkynĕ, Eiselt, Grégr and others. That was the platform for the conception of the Czech medical terminology. Partition of faculties was decided by the law, which was accepted at February 28, 1882. The Czech Medical Faculty was opened only at 1883 because Emperor resolved that professors themselves had to decide to either faculty their clinics would belong. Only professor Eiselt with the First clinic of internal medicine, Weiss with the clinic of surgery and Streng with clinic of obstetrics were assigned to the Czech faculty. Till the official opening on October 15, 1882 all other departments and clinics had to be organized. Though Professor Vilem Weiss as the head of the department and dean of the faculty had his opening Czech lecture already on April 28, 1882, due to material and personal reasons the Czech Medical Faculty was opened only one year later than Faculties of law and philosophy. Most of the eminent members of the Medical faculty remained at the German faculty. However, having higher number of students the Czech faculty became larger and was attended by students from the whole Slavonic world.

Austria↗
PubMed1981

[Therapists and therapeutic choice (author's transl)].

The choice of an antidepressant drug, at the present time of our knowledge, doesn't proceed from any strict appropriateness between the clinical picture and the chemical substance. If we wish a more rational, less empiric use in the field of a pharmacokinetics and pharmacodynamics, one has to face the problem of the subjective dimension is a most interesting study of research so as to get away from the sterile opposition, that is often not subject to a dialectic approach between psychotherapeutists and chemotherapists and thus develop a pragmatic logic in the Art of Prescribing. This explains the tentative approach in the frame work of pluridisciplinary research to find a common language for concepts coming from fields as different as psychoanalysis and neurochemistry. Notions such as transference, whishes, drives (like an biopsychological interface) and an approach in prescribing of manifest meaning in the Freudian sense all could help throw a new light on the subject and permit a better contribution, not only of the therapeutic effects of molecules but also the various psychopharmacological mechanisms of actions.

Antidepressive Agents↗
PubMed1979

Some neurological observations on Leonardo da Vinci's handwriting.

The present study concerns neuropsychological aspects of the handwriting of Leonardo da Vinci. The evidence for Leonardo's left handedness is considered, and a critical appraisal of his mirror writing and its underlying mechanism is presented. The relationship between Leonardo's sinistrality, mirror writing and certain aspects of localisation of cerebral function are discussed. From these considerations and from new evidence obtained from contemporary historical sources, it is proposed that Leonardo's language skills were lateralised to the more unusual right hemisphere.

Art↗
PubMed2003

Artificial life: organization, adaptation and complexity from the bottom up.

Artificial life attempts to understand the essential general properties of living systems by synthesizing life-like behavior in software, hardware and biochemicals. As many of the essential abstract properties of living systems (e.g. autonomous adaptive and intelligent behavior) are also studied by cognitive science, artificial life and cognitive science have an essential overlap. This review highlights the state of the art in artificial life with respect to dynamical hierarchies, molecular self-organization, evolutionary robotics, the evolution of complexity and language, and other practical applications. It also speculates about future connections between artificial life and cognitive science.

Journal Article↗
PubMed1987

Acquired dysarthria in childhood: an analysis of dysarthric features in relation to neurologic deficits.

We analyzed the dysarthria of four children with bilateral supranuclear facial palsy and four with bilateral peripheral facial palsy. The children with peripheral lesions had only moderate dysarthria, characterized mainly by weakened vowels and consonants and by hypernasality. In contrast, children with supranuclear lesions were anarthric at first, followed by severe dysarthria with reduced stress and many pauses. Although there was a relation between severity of dysarthria and neurologic disorders, anarthria can be seen in children with bilateral supranuclear lesions and only slight neurologic disability. Damage to cortical or brainstem control mechanisms may be responsible.

Adolescent↗
PubMed1988

Knowledge-engineering software. A demonstration of a high-end tool.

Many investigators wanting to apply knowledge-based systems (KBSs) as consultants for cancer diagnosis have turned to tools running on personal computers. While some of these tools serve well for small tasks, they lack the power available with such high-end KBS tools as KEE (Knowledge Engineering Environment) and ART (Automated Reasoning Tool). These tools were originally developed on Lisp machines and have the full functionality of the Lisp language as well as many additional features. They provide a rich and highly productive environment for the software developer. This paper illustrates the capability of one of these high-end tools. First, a table showing the classification of benign soft tissue tumors was converted into a KEE knowledge base. The tools available in KEE were then used to identify the tumor type for a hypothetical patient.

Age Factors↗
PubMed2006

["In the beginning was the word...": language and medicine].

The attempt to thoroughly comprehend words used in medicine inevitably leads into the prophetic maelstrom of the poet. In psychotherapy and medicine attempts are made to heal or alleviate suffering through the concrete relationship between two people. Substantial support is achieved by the occupation with questions of religion, art and literature and to attain the necessary caution with the knowledge of how difficult it is to put feelings into words, especially at the sickbed.

Communication↗
PubMed2004

"Making special": a framework for understanding the art of holistic nursing.

Holistic nurses demonstrate interest in and concern for aesthetics in nursing; however, the relationship of holistic nursing to aesthetics in nursing lacks clarity. Challenges to the study of aesthetics in nursing arise from too little discourse on the topic and lack of consensus on language and methods of inquiry. Nevertheless, aesthetic knowing is a fundamental pattern of knowing in nursing and the one that mediates and integrates all other patterns of knowing in nursing action. A behavioral theory of aesthetics provides a framework for exploring the relationship of holistic nursing to aesthetic knowing and the art of nursing. Synthesis of this framework with holistic nursing core values and standards of practice suggests that holistic nursing is more than perspective; it is an aesthetic.

Esthetics↗
PubMed2026

CodonMoE: DNA language models for codon-dependent mRNA prediction.

MOTIVATION: Genomic language models (gLMs) face a fundamental efficiency challenge: one must either maintain separate specialized models for each biological modality (DNA and RNA) or develop large multimodal architectures. Both approaches impose significant computational burdens-modality-specific models require redundant infrastructure despite inherent biological connections, while multi-modal architectures demand increased parameter counts and extensive cross-modality pretraining. RESULTS: To address this limitation, we introduce CodonMoE (Adaptive Mixture of Codon Reformative Experts), a lightweight adapter that transforms DNA language models into effective RNA analyzers without RNA-specific pretraining. Our theoretical analysis establishes CodonMoE as a universal approximator at the codon level, capable of mapping arbitrary functions from codon sequences to codon-dependent RNA properties given sufficient expert capacity. Across four RNA prediction tasks spanning stability, expression, and regulation, DNA models augmented with CodonMoE significantly outperform their unmodified counterparts, with the HyenaDNA+CodonMoE series achieving state-of-the-art results using 80% fewer parameters than specialized RNA models. By maintaining sub-quadratic complexity while achieving superior performance, our approach provides a principled path toward unifying genomic language modeling, leveraging more abundant DNA data and reducing computational overhead while preserving modality-specific performance advantages. AVAILABILITY AND IMPLEMENTATION: Source code for the method and to reproduce the results is available at https://github.com/Kingsford-Group/CodonMoE.

Codon↗
PubMed1999

Early dissociation of verbal and nonverbal gestural ability in an epileptic deaf child.

Studies of sign language aphasia in deaf adults have provided the evidence for two separable verbal and nonverbal manual gesture systems. We report a congenitally deaf child with a idiopathic focal epilepsy of childhood who showed specific language impairment in French sign language. The child's amazing performances in miming or sketching pictures she was unable to sign support the notion of an early dissociation of the two gestural systems.

Adult↗
PubMed1985

Neuropsychology qua interface.

This paper focuses on the multidisciplinary nature and requirements of neuropsychology. It illustrates two approaches to this convergence of neuropsychology and its complementary disciplines: the relationship between the dissociated visual-perceptual and spatial disorders consequent upon focal lesions of the right cerebral hemisphere in man and the evidence (neuroanatomical, neurophysiological, and behavioural) of two major cortico-cortical pathways for processing visual information in monkey; and the evolution of information-processing models (derived from cognitive psychology, linguistics, and pathophysiological data) to delineate the functional architecture of reading and speech production. It cites the study of attention and frontal-lobe function as a major target for research; and it invokes the need to encompass the art of medicine in neuropsychological research and practice.

Animals↗
PubMedDate not supplied

The world's longest surviving paediatric practices: some themes of Aboriginal medical ethnobotany in Australia.

Contemporary paediatric practices of Australian Aboriginal men and women, in more than 100 Aboriginal Language Groups, comprise a living discipline whose origins predate Western medicine by tens of millennia. The history of paediatrics acknowledges this surviving continuum of the world's oldest child-care practices. Because of the inextricable nexus between Aboriginal men and women and the land in which they live, medical ethnobotany forms a major part of the medical aspects of Aboriginal child care. Traditional tribal healers, called 'Nungungi' in some language groups of Central Australia, are identified as such whilst still young children and are given special education in the healing arts, especially that of medical ethnobotany, by older healers. Distinct from this specialized role, all Aboriginal men and women (and in particular grandmothers) in traditional communities use a sophisticated botanical materia medica in the treatment of sick and injured children. In cultures in transition, medical ethnobotanical practices may persist long after the local use of flora as sources of traditional food, weaponry, totemic identity and religious rites have disappeared. Some selected botanical 'cures' were adopted by early European settlers and a number of such relict uses have become part of mainstream Western life today, particularly as this applies to self-medication. Drugs and medicaments used in the treatment of children are obtained from leaves, bark, roots and flowers, usually as fresh preparations. They are prepared as infusions, decoctions and macerations and may be enjoined with emollients such as emu or kangaroo fat for topical application. Botanical drugs and medicaments are usually prepared fresh for each administration and are rarely stored. Contemporary Australian ethnobotany exploits the medicinal properties of more than 100 genera - using such extracts as antiseptics, analgesics, astringents, antipyretics, sedatives, hypnotics, expectorants and carminatives. Their widespread use, by the world's oldest surviving cultures, reflect perhaps 50 millennia of acute observation and clinical interpretation, trial and error, serendipidity and experimentation. Australian medical ethnobotany generally, and that used specifically for children, is characterized by several features including (i) the multipurpose or 'broad-spectrum' use of many floral species; (ii) a paradigm of the use of botanical material to treat symptoms and symptom-complexes rather than disease-based treatment; (iii) the widespread and universal medical knowledge of botanical remedies by all members of local Aboriginal communities, not only traditional community or tribal healers and (iv) the use of botanical material in the context of preventive medicine. Seventy per cent of the world's population uses traditional herbal remedies in the treatment of sick or injured children. In this context, the detailed and extensive ethnobotanical pharmacopoeia of the Aboriginal Peoples of Australia holds an important place.

Australia↗
PubMed2005

Maximum likelihood set for estimating a probability mass function.

We propose a new method for estimating the probability mass function (pmf) of a discrete and finite random variable from a small sample. We focus on the observed counts--the number of times each value appears in the sample--and define the maximum likelihood set (MLS) as the set of pmfs that put more mass on the observed counts than on any other set of counts possible for the same sample size. We characterize the MLS in detail in this article. We show that the MLS is a diamond-shaped subset of the probability simplex [0,1]k bounded by at most k x (k-1) hyper-planes, where k is the number of possible values of the random variable. The MLS always contains the empirical distribution, as well as a family of Bayesian estimators based on a Dirichlet prior, particularly the well-known Laplace estimator. We propose to select from the MLS the pmf that is closest to a fixed pmf that encodes prior knowledge. When using Kullback-Leibler distance for this selection, the optimization problem comprises finding the minimum of a convex function over a domain defined by linear inequalities, for which standard numerical procedures are available. We apply this estimate to language modeling using Zipf's law to encode prior knowledge and show that this method permits obtaining state-of-the-art results while being conceptually simpler than most competing methods.

Journal Article↗
PubMed2003

Art and the brain: the influence of frontotemporal dementia on an accomplished artist.

A talented artist developed a progressive aphasia syndrome associated with frontotemporal dementia (FTD). As her disease progressed, language and executive skills declined, but her paintings became freer and more original. She demonstrates that artistic development can occur in the setting of language-dominant types of FTD. The study of artistic development in the setting of FTD suggests that language is not required for, and may even inhibit, certain types of visual creativity.

Aphasia↗