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At least 307 records · Page 17Linked to original sources
PubMed1987

Intramuscular (infiltrating) lipoma of the tongue.

A patient with an intramuscular lipoma (infiltrating lipoma) located within the tongue is presented. There is only one previously reported case of an intramuscular lipoma located within the oral cavity. Because of its infiltrating nature, this tumor may be mistaken for a liposarcoma. Here, as in other sites, the important characteristics serving to distinguish an infiltrating lipoma from a liposarcoma are the absence of lipoblastic proliferation, myxoid differentiation, cellular pleomorphism, increased vascularity, and mitotic activity. Achievement of adequate surgical margins is essential, as the recurrence rate may be as high as 62.5% without complete excision.

Adult↗
PubMed1987

Magnetic resonance imaging: lumbosacral lipoma.

To evaluate the clinical efficacy of magnetic resonance imaging (MRI) of lumbosacral lipomas, the magnetic resonance images of nine patients were reviewed. T1- and T2-weighted spin echo sequences were used with a 0.5-T magnetic resonance system. The tethered or low-positioned conus medullaris, the lipoma itself, the lipoma--cord interface, the subarachnoid space, and hydromyelia were clearly disclosed. The nerve rootlets were not as clear. These results indicate the possible discontinuance of myelography and metrizamide computed tomography (CT) cisternography for such imaging. The diagnostic modalities of choice for lumbosacral lipoma imaging are plain spine films, plain CT scan, and MRI.

Adolescent↗
PubMed1987

Lipoma of the septum pellucidum: case report.

Intracranial lipomas are relatively rare maldevelopmental lesions that most characteristically occur in the corpus callosum. Although their occurrence in many other locations has been described, no report can be found of lipomas occurring in the septum pellucidum. A case is presented to document the occurrence of a lipoma of the septum pellucidum and to describe the magnetic resonance image appearance of an intracranial lipoma.

Adult↗
PubMed1989

Cytogenetic subtype involving chromosome 13 in lipoma. Report of three cases.

We report three lipomas with rearrangements of chromosome 13. The karyotype of the tumors studied were 45,XX,-8,+der(8)t(8;13)(q22;q12),del(10)(p12),-13; 46,XY,del(13)(q12q22), and 46,XY,t(11;12)(q23;q13),del(13)(q12q22), respectively, revealing common involvement of band 13q12 in the rearrangement. Three other lipomas with aberrations of bands 13q12-q13 have been reported, suggesting that such tumors with abnormalities of chromosome 13 could represent a subgroup of lipoma in addition to those already reported with abnormalities of chromosomes 12q and 6p. The rearrangements of #13 in all these cases also involved loss of the band 13q14 to which the antioncogene associated with retinoblastoma and osteosarcoma is localized. Detailed clinical, histopathologic, and molecular studies should help to further characterize the various cytogenetically defined subgroups of lipoma.

Chromosome Aberrations↗
PubMed1989

Lipoma of the sylvian region.

An exceptional case of lipoma of the sylvian region is described and the other seven reported cases are reviewed. The sylvian fissure is the most rare site of intracranial lipomas. Sylvian lipomas may be asymptomatic or present with epileptic seizures due to irritation of the cortex of the sylvian fissure. Only two previous cases have been diagnosed during life by computerized tomography and operated on; the deep location of these lipomas and their adherences to the sylvian cortex and the branches of the middle cerebral artery make radical removal impossible and dangerous.

Brain Neoplasms↗
PubMed1989

Composition of fat in different types of liposarcomas in comparison with lipomas.

Different types of liposarcomas, and for comparison, lipomas were investigated for their lipid composition. Triglycerides were the main components of lipomas and lipoma-like liposarcomas. Myxoid liposarcomas had a high water content and contained considerable amounts of free cholesterol and phospholipids. One pleomorphic liposarcoma resembled a myxoid liposarcoma in its lipid composition and water content. In 4 liposarcomas of mixed type the lipid composition resembled the main subtype. A glycerol ether-like fraction was found in all lipoma-like (well differentiated) liposarcomas, in one myxoid type but not in the other types.

Chemical Fractionation↗
PubMed1990

Cardiac lipoma: six-year follow-up with MRI characteristics, and a review of the literature.

A total of 63 cardiac lipomas have been reported to date. Although most of these rare tumors cause no symptoms, a few can have a detrimental effect on myocardial function as well as displacing and encasing the coronary arteries. This case of a cardiac lipoma was initially seen in 1982. The lipoma was found to be nonresectable at surgery due to involvement of the coronary arteries. This neoplasm was characterized with magnetic resonance imaging in 1989 on a follow-up visit. Magnetic resonance imaging is shown to be superior to computed tomography for identifying the relationship of the lipoma to the coronary arteries. This is a significant factor in determining resectability.

Adult↗
PubMedDate not supplied

Lipoma of the cerebellopontine angle.

Lipomas of the cerebellopontine angle (CPA) are unusual tumors that typically present with hearing loss, tinnitus, dizziness, and occasionally facial neuropathies. We describe the case of a healthy 42-year-old woman who presented with left-sided hearing loss and facial synkinesis. T1-weighted magnetic resonance imaging revealed an enhancing lesion of the left CPA with no signal on fat suppression sequences. Despite conservative therapy, the patient developed progressive hemifacial spasm, and a suboccipital craniotomy approach was used to debulk the tumor, which encased cranial nerves V, VII, VIII, IX, X, and XI. Surgical histopathology demonstrated mature adipocytes, consistent with lipoma. Two years after surgery, the patient remains free of facial nerve symptoms. Cerebellopontine angle lipomas are rare lesions of the skull base and are reliably diagnosed with T1-weighted and fat suppression magnetic resonance sequences, which we recommend in the routine radiologic workup of CPA tumors. Accurate preoperative diagnosis is crucial because most CPA lipomas should be managed conservatively. Partial surgical resection is indicated only to alleviate intractable cranial neuropathies or relieve brainstem compression.

Adult↗
PubMed2004

Lipoma arborescens of the knee.

Lipoma arborescens are rare lesions, typically located in the knee. They have a predilection for the suprapatellar pouch in the knee joint, but can also occur in any area of the knee joint. Magnetic resonance imaging of lipoma arborescens often reveals subchondral bone cyst and/or bone erosions, and there may appear to be a correlation between lipoma arborescens and osteoarthritis. We describe a case of histologically proven lipoma arborescens in the suprapatellar pouch and infrapatellar area of the knee with no damage to the posterior compartment and bone erosion in the proximal tibia without osteoarthritis.

Adipose Tissue↗
PubMed2006

Intercostal neuralgia caused by a parosteal lipoma of the rib.

Parosteal lipoma is an extremely rare benign tumor that is composed mainly of mature adipose tissue, and it has an intimate relationship to the underlying periosteal bone. We believe that only three cases have been previously reported that have described parosteal lipoma of the rib. Although parosteal lipoma is asymptomatic, motor and sensory function deficits have been reported that were caused by the tumor compressing the neuromuscular bundles in the proximal forearm and the sciatic nerve. We present here an exceedingly rare case of intercostal neuralgia caused by a parosteal lipoma of the rib.

Adipose Tissue↗
PubMed2004

Periungual lipoma: about three cases.

Lipomas are one of the most common benign soft tissue tumors. The usual development sites are the neck, the torso, and the legs. Lipomas of the nail unit are extremely rare. Only five cases have been reported up to now, four in subungual locations and one in the lateral nail fold. We report three cases of peri-ungual lipomas, one on the digit and two on the toes. Two of them exhibited the histological features of perisudoral lipomas.

Aged↗
PubMed2005

Quadrigeminal cistern lipoma.

Intracranial lipomas are rare benign congenital neoplasms accounting for 0.1 to 0.5% of all primary brain tumours. Approximately 50% are associated with other cerebral developmental disorders. These slow growing benign lesions are usually asymptomatic and rarely require surgery. We report the case of a 37 year old woman presented with signs of raised intracranial pressure. Computerized tomography and magnetic resonance imaging demonstrated a quadrigeminal cistern lipoma compressing the aqueduct of Sylvius. The patient underwent surgery and a distinct plane of cleavage between the lipoma and the adjacent neural structures was found, allowing total removal of the lesion. Postoperatively, the patient was relieved of her original symptoms but developed akinetic mutism which lasted for two weeks. Intracranial lipomas rarely become symptomatic and surgery is seldom required. If the lesion progresses and causes symptoms of raised intracranial pressure or compression of neural structures, surgical intervention is indicated. Total removal should not be attempted unless a plain of cleavage between the lesion and adjacent neural structures is present. Surgical manipulation should be minimised to avoid complications.

Adult↗
PubMed2006

Excision of subcutaneous facial cysts and lipomas using cosmetic approaches.

PURPOSE: The excisional biopsy of subcutaneoous facial cysts and lipomas can be problematic due to the high esthetic nature of the affected area. Remote scar placement has advantages in allowing access to subcutaneous pathology while placing incision lines in cosmetic locations. This article will review excisional biopsies of subcutaneous facial cysts and lipomas using cosmetic approaches. PATIENTS AND METHODS: Patients with superficial facial cysts or lipomas undergoing excisional biopsies utilizing contemporary cosmetic surgery approaches (rhytidectomy, lower blepharoplasty, and submental) with tumescent anesthesia and either intravenous sedation or general anesthesia. RESULTS: All patients had successful removal of superficial facial pathology with good cosmetic results. CONCLUSION: The use of contemporary cosmetic surgical approaches for the excisional biopsy of superficial facial cysts and lipomas provides adequate surgical access, a cosmetically acceptable result, and is well-tolerated by patients.

Aged↗
PubMed2006

Cutaneous lipoma in children: 5 cases with Bannayan-Riley-Ruvalcaba syndrome.

Cutaneous lipoma is rare in children, but it can be part of a syndrome such as the Bannayan-Riley-Ruvalcaba syndrome (BRRS). The BRRS is a dominant autosomal disorder characterized by cutaneous lipomas, macrocephaly, intestinal polyps, and developmental delay associated with PTEN gene mutations. This syndrome is thought to represent a pediatric form of the Cowden syndrome, characterized among other features by an increased risk of cancer. We report 5 cases of BRRS, all diagnosed in children with lipoma and macrocephaly. Children presenting with lipomas need a complete physical examination to look for other signs of BRRS, because they may need further follow-up for tumor screening in adulthood.

Abnormalities, Multiple↗
PubMed2006

Intramedullary lipoma of the cervicodorsal spinal cord with intracranial extension: case report.

BACKGROUND: An unusual case of an extensive intramedullary lipoma of the cervicodorsal spinal cord with intracranial extension causing compression of spinal cord and brainstem is described. CASE DESCRIPTION: A 3-year-old child with lack of limb movement since birth, the cause of which had remained obscure, developed opisthotonos and episodes of severe respiratory difficulty with brief periods of apnea. Craniospinal computed tomography and magnetic resonance imaging (MRI) were diagnostic of lipoma. Urgent occipitocervical decompression and subtotal removal of the posterior fossa and cervical spinal cord lipoma resulted in lasting resolution of symptoms. CONCLUSIONS: Extensive spinal cord lipomas with intracranial extension can present with alarming spinal cord/medullary compression and respiratory symptoms. Computed tomographic scan and MRI are diagnostic. Total removal is not feasible, or necessary, because subtotal removal and decompression give long-lasting resolution of symptoms.

Brain Stem↗
PubMed2004

Ultrasonographic appearance of lipoma in the oral and maxillofacial region.

OBJECTIVE: To summarize the clinical situation, ultrasonographic appearance, diagnosis, and treatment experience of lipoma in the oral and maxillofacial region. STUDY DESIGN: Twenty-two patients with lipoma in the oral and maxillofacial region were retrospectively investigated in regards to clinical appearance, ultrasonographic appearance, and treatment. RESULTS: Among the 22 patients, the ratio between males and females was 2.67:1. The age ranged from 21 to 72 years with a mean age of 47 years. The most common location was the submandibular region. Ultrasonographic appearance of lipoma in the oral and maxillofacial region was round or elliptical in shape with intact or mostly intact capsule. The internal architecture in the majority of patients was hypoechoic with echogenic lines or spots. Complete surgical resection was performed, and no recurrence occurred during the follow-up period. CONCLUSION: Diagnosis of lipoma in the oral and maxillofacial region can be made based on the clinical examination and ultrasonography. Complete surgical resection is the treatment of choice.

Adult↗
PubMed2006

Altered expression of master regulatory genes of adipogenesis in lipomas from patients bearing tRNA(Lys) point mutations in mitochondrial DNA.

The mechanisms underlying the appearance of lipomas in patients bearing mutations in the tRNA(Lys) gene of mitochondrial DNA are unknown. We investigated changes in gene expression patterns in lipomas from three patients bearing A8344G or G8363A tRNA(Lys) gene mutations. Uncoupling protein-1 mRNA was detected in the lipomas, in contrast with undetectable expression in normal adipose tissue. However, expression of other markers of brown fat, such as PGC-1alpha, was unaltered. PPARgamma and retinoblastoma gene expression was down regulated in the lipomas, but C/EBPalpha mRNA was not affected. The expression of Pref-1 was dramatically down regulated. Thus, lipomatosis due to tRNA(Lys) mutations is associated with a pattern of altered expression of master regulators of adipogenesis consistent with enhanced proliferation but maintenance of adipocyte features, and with a distorted pattern of brown versus white adipocyte differentiation.

Adipogenesis↗
PubMed2005

[Lipoma of the skull base. A case report].

OBJECTIVES: Intra osseous lipomas are rare benign tumours that occur most frequently within the metaphysis of long bones. Involvement of the skull base is exceptional. We report a case of a lipoma of the skull base discovered incidentally. METHODS: A 45 year-old female patient consulted for galactorrhea with Hyperprolactinemia. RESULTS: MRI showed, in addition to the microadenoma, a high signal intensity T1 and T2 and fat saturated expansive lesion of the body and the right greater wing of the sphenoid. CT-scan of the skull base showed that this lesion was a well circumscribed fat containing and trabeculated lytic lesion leading to the diagnosis of a lipoma of the sphenoid. CONCLUSIONS: Lipomas of the skull base are exceptional. They are well recognized on CT-scan and MRI and in typical cases biopsies are not necessary. No treatment is necessary for asymptomatic lesions.

Female↗