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At least 307 records · Page 17Linked to original sources

[Kaspar Schwenckfeldt--a Silesian physician, Renaissance student of nature, and bibliophile].

Kaspar Schwenckfeldt (1563-1609) is numbered among the intellectual celebrities of the Age of Renaissance in Silesia. He was the first to describe the flora of this region. His work Stirpium et fossilium Silesiae catalogus, based on his own research, was the fundamental source of knowledge about those plants for almost two centuries. His work on Silesian mineralogy, Fossilium Silesiae catalogus, omnia generis mineralia, metalla, succos, terrae, lapillos, fontes medicatos et thermae continens, even at present day is a valuable source of information on the occurrence of minerals in Silesia in the distant past. On the basis of Theriothropeum Silesiae one can reconstruct the rich realm of Silesian fauna of 16th/17th centuries. The monography of cieplice Slaskie, Hirschbergischen warmen Bades, published in 1607, is one of the oldest descriptions of this spa. The analysis of the physical-chemical characteristics of the waters and the information about their possible medical application was the fullest expert's opinion of that time. Up to the present days, a hand-written register of his collection of books has been preserved in the Stadtarchiv in Görlitz. It contains 705 items, which include medical publications, works on magic and occultism, as well as books connected with the Reformation movement, studies in Old Greek and Latin philologies, books on the history of some European countries. His versatility and rich scientific output place him among the most outstanding minds of his age.

Austria↗

Effects of two formats of informed consent on knowledge amongst persons with advanced HIV disease in a clinical trial of didanosine.

To determine subjects' perception of the purpose of informed consent, 113 subjects were recruited from a dose-controlled clinical trial of didanosine (ddI). Subjects were surveyed regarding how they made decisions regarding their medical care in general, about how they obtained information about this trial in particular, and several aspects of the informed consent procedure. Subjects were then randomly allocated to receive information about the trial by either a written only format or a written and verbal format 1 week before commencement of the trial. An eight-item instrument assessed knowledge of ddI prior to and subsequent to receiving information. Most subjects obtained information about HIV-related issues from their specialist (70%) or general (51%) medical practitioner. A large proportion of subjects (88%) reported that they believed their specialist medical practitioner always acted in their best interest. The majority of subjects (79%) believed that subjects should be allowed the choice between participating in the clinical trial and receiving the drug outside the trial mechanism. Of the subjects, 96% believed that informed consent was necessary in clinical trials; however, their opinions of the purpose of informed consent varied widely. Although they signed the informed consent, 44% of the subjects stated that they did not understand 'all' of the information that was provided. We found that the provision of information by written mode alone, or written and verbal modes were both associated with significant increases in knowledge levels and that there was a significant interaction in the degree of change between the two methods, with the written plus verbal method showing the most improvement over time. There was an interaction between degree of improvement in knowledge of didanosine in subjects who received written information versus those who received written and verbal knowledge and time (pre- versus post-consent) and a significant main effect for time. All subjects were relatively well-informed about the drug and stated that specialist and general medical practitioners were their major source of knowledge for all aspects of their HIV health care.

Adult↗

One-and-a-half decades of HIV/AIDS in Tamil Nadu: how much do patients know now?

Tamil Nadu has experienced the impact of HIV/AIDS for one-and-a-half decades and is considered a trailblazer in India in terms of combating the infection. So what are the knowledge levels among 292 HIV patients at Government Hospital for Thoracic Medicine and Christian Medical College? Latent class analysis revealed that it was not adequate. Television and peer contact were found to be most effective as source of knowledge for HIV. Patients who were in contact with health personnel might be expected to have more information but they came out with low scores. Association of knowledge with socio-demographic characteristics revealed that education, occupation, income, place of residence, and age were important predictors. Future information, education and communication programmes need to consider the variation across different socio-demographic groups as a basis for targeting education programmes.

Adult↗

[AIDS-related knowledge among nurses in Mie Prefecture, Japan].

Levels of understanding and knowledge regarding AIDS were investigated for medical personnel working at general hospitals with more than 100 beds in Mie Prefecture by means of a questionnaire during May to June, 1990. The questionnaire covered general knowledge of AIDS, psychological response, attitudes and actions taken toward infected persons, and societal countermeasures against AIDS. Responses from 1,516 nurses and assistant nurses were statistically investigated among medicare persons. Mass media was the major source of knowledge on AIDS for the nurses and assistant nurses. Level of understanding on AIDS, however, appeared to be rather low, which may be due to difficulty in obtaining accurate information on AIDS and also due to lack of motivation to study. The responses of nurses were more positive than for assistant nurses for action taken in hypothetical cases of infection to themselves, spouses or familiar persons. Similar differences were also shown in responses regarding societal countermeasures against the disease.

Acquired Immunodeficiency Syndrome↗

Attitudes and concerns of Canadian animal health technologists toward postoperative pain management in dogs and cats.

Three hundred and twenty-two Canadian animal health technologists (AHTs) were surveyed to determine their attitudes toward postoperative pain management in dogs and cats following 6 surgical procedures, their concerns regarding the use of opioid analgesics, and their role within veterinary practices with respect to postoperative pain control. Two hundred and sixty-four (82%) returned the questionnaire. Pain perception was defined as the average of pain rankings for dogs and cats (on a scale of 1 to 10) following abdominal surgery, or the value for dogs or cats if the AHT worked with only 1 of the 2 species. Maximum concern about the risks associated with the postoperative use of morphine or oxymorphone was defined as the highest rating assigned to any of the 6 risks evaluated in either dogs or cats. Animal health technologists reported significantly higher pain perception scores than did veterinarians who completed a similar survey 2 years previously. Higher pain perception scores were associated with decreased satisfaction with the adequacy of analgesic therapy in their practice, higher pain control goals, and attendance at continuing education within the previous 12 months. The majority of AHTs (55%) agreed that one or more risks associated with the use of morphine or oxymorphone outweighed the benefits. The 3 issues that were perceived to pose the greatest risk were respiratory depression, bradycardia, and sedation and excitement, for dogs and cats, respectively. Most AHTs (68%) considered their knowledge related to the recognition and control of pain to be adequate, compared with 24% of veterinarians who responded to a similar previous survey. As for veterinarians, experience gained while in practice was ranked as the most important source of knowledge, while the technical program attended was ranked as least important. Over 88% of the AHTs provided nursing care during the postoperative period, monitored animals for side effects of postoperative analgesic therapy, informed veterinarians when animals were in pain, recommended analgesic therapy when they believed it was warranted, reported that animals received analgesics when they believed it was warranted, administered analgesics under the instruction of a veterinarian, and believed they were part of a team working to provide adequate postoperative pain control.

Animal Technicians↗

A knowledge-based architecture for protein sequence analysis and structure prediction.

Methods for analyzing the amino-acid sequence of a protein for the purposes of predicting its three-dimensional structure were systematically analyzed using knowledge engineering techniques. The resulting entities (data) and relations (processing methods and constraints) have been represented within a generalized dependency network consisting of 29 nodes and over 100 links. It is argued that such a representation meets the requirements of knowledge-based systems in molecular biology. This network is used as the architecture for a prototype knowledge-based system that simulates logically the processes used in protein structure prediction. Although developed specifically for applications in protein structure prediction, the network architecture provides a strategy for tackling the general problem of orchestrating and integrating the diverse sources of knowledge that are characteristic of many areas of science.

Amino Acid Sequence↗

Israeli youth and AIDS: knowledge and attitude changes among high school students following an AIDS education program.

A pilot project conducted in three Jerusalem schools in 1990-91 demonstrated that medical students who had received extensive training in teaching about AIDS and its prevention were able to influence the level of knowledge and attitudes on this subject among high school students. Research findings showed moderate to low knowledge levels in a sample group of 241 Jerusalem high school students on all AIDS-related questions. The average score was (mean +/- SD) 68.9 +/- 15.4, with significant differences (P < 0.01) between boys 77.2 +/- 8.6 and girls 65.9 +/- 16.4. The principal source of knowledge on AIDS among the sample population was the electronic media, 47% stating that their knowledge of HIV/AIDS came from television. After a series of four lessons in the "The Immune System and AIDS" program, there was a significant improvement in the students' knowledge. The average score rose to 78.8 +/- 13.9 with an improvement of up to 23% in the answers to the various subgroups of questions. The program succeeded in clarifying for the students the degree of personal risk from contracting HIV, but did not affect their fear of the disease--70% of the students stated that they were afraid of being ill with AIDS. The study did not examine the students' behavioral patterns.

Acquired Immunodeficiency Syndrome↗

Herbal therapy use in a pediatric emergency department population: expect the unexpected.

BACKGROUND: In recent years investigators have reported widespread use of alternative medicine. Some herbal therapies have potentially harmful side effects as well as adverse interactions with medications. Data are lacking on the use in children and caregiver understanding of these products. OBJECTIVES: To determine the reported use of herbal products among a pediatric emergency department population and to evaluate the caregivers' understanding and source of information concerning these products. DESIGN/METHODS: A convenience sampling of pediatric emergency department patients and their caregivers occurred during a 3-month period in 2001. The interview consisted of 18 questions regarding the types of non-Food and Drug Administration-regulated herbal products and home remedies used, general product knowledge and sources of information used by the child's caregiver (including discussions with their child's primary physician). RESULTS: One hundred forty-two (93%) of 153 families approached participated in the study. The mean patient age was 5.3 years (range: 3 weeks-18 years). Forty-five percent of caregivers reported giving their child an herbal product, and 88% of these caregivers had at least 1 year of college education. Of the children receiving these therapies, 53% had been given 1 type and 27% were given 3 or more in the past year. The most common therapies reportedly used were aloe plant/juice (44%), echinacea (33%), and sweet oil (25%). The most dangerous potential herbal and prescription medication combination reported was ephedra and albuterol in an adolescent with asthma. The most unusual products reportedly used included turpentine, pine needles, and cowchips. Of all people interviewed, 77% did not believe or were uncertain if herbal products had any side effects and only 27% could name a potential side effect. Sixty-six percent were unsure or thought that herbal products did not interact with other medications and only 2 people correctly named a drug interaction. Of the people who used these therapies, 80% reported either friends or relatives as their primary source of information. Only 45% of those giving their children herbal products report discussing the use with their child's primary health care provider. CONCLUSION: Herbal and home therapies are commonly used in this pediatric population. An unexpectedly wide variety of products were reportedly given to this patient population. Caregivers reported limited knowledge regarding potential adverse medication interactions and side effects. Limited discussions with the child's primary health care provider were reported. It is therefore important for health care providers to have knowledge about herbal medications, to inquire about their use and to educate families about the risk/benefit as well as potential interactions these products may have with over-the-counter and prescription medications.

Adolescent↗

Constructing biological knowledge bases by extracting information from text sources.

Recently, there has been much effort in making databases for molecular biology more accessible and interoperable. However, information in text form, such as MEDLINE records, remains a greatly underutilized source of biological information. We have begun a research effort aimed at automatically mapping information from text sources into structured representations, such as knowledge bases. Our approach to this task is to use machine-learning methods to induce routines for extracting facts from text. We describe two learning methods that we have applied to this task--a statistical text classification method, and a relational learning method--and our initial experiments in learning such information-extraction routines. We also present an approach to decreasing the cost of learning information-extraction routines by learning from "weakly" labeled training data.

Artificial Intelligence↗

Whose evidence counts? An exploration of health professionals' perceptions of evidence-based practice, focusing on the maternity services.

OBJECTIVES: to gain an insight into how health professionals in the maternity services define evidence and how they perceive different types of evidence are valued in maternity care. DESIGN: using a qualitative approach data were collected by semi-structured interviews: the content of each was analysed thematically. SETTING: England. PARTICIPANTS: a purposeful sample of ten midwives, two obstetricians and one research nurse. FINDINGS: definitions of evidence vary widely among health practitioners. These definitions are affected by individuals' own beliefs and give rise to a hierarchy in which some types of evidence are valued above others. All the participants made direct or indirect reference to cultural beliefs inherent within the health service, and indicated that these beliefs determine the extent to which different types of evidence are seen as legitimate. IMPLICATIONS FOR PRACTICE: the concept of evidence-based practice is not value-free. Evidence that reinforces notions of authoritative knowledge may be transposed into clinical practice quickly and easily. Conversely, health practitioners may have difficulty putting evidence into practice that challenges the cultural norms of the profession. There is a need for further work to make explicit the values that underpin different sources of knowledge and expose the hierarchies of evidence that exist.

Anecdotes as Topic↗

The perception of menopause among women in Taiwan.

OBJECTIVES: Hormone replacement therapy (HRT) has become a popular topic and the subject of many newspaper and magazine health articles in the last 5 years in Taiwan, so a great deal of knowledge about the menopause has been introduced to Taiwanese women. With this massive change, we wanted to know the current perception of the menopause among women in Taiwan and also evaluate the prevalence of various acute menopausal symptoms and women's attitudes toward receiving hormone replacement therapy. METHODS: We designed a cross-sectional study, using structured questionnaires, targeting women who attended the health information seminar on the menopause and HRT, held in an urban area in Taiwan. The audience was asked to fill out the questionnaire before the seminar began. More than 2000 questionnaires were collected, but only 386 women completed all items of the questionnaire and were included in this study. Among them, 161 women were postmenopausal and their answers to questions regarding acute menopausal symptoms were collected for statistical analysis. The other 225 women were non-menopausal and their perception of menopausal symptoms was also collected for analysis. Qualitative data, in the form of transcripts, were interpreted using text-based content analysis. RESULTS: Among these women, 375/386 (97%) had previously heard of the menopause, but only 207/386 (53%) knew the definition of the term. The most commonly indicated source of knowledge on the menopause was reading material, such as newspapers and magazines 283/386 (43%); less common sources of information were friends 141/386 (22%), medical personnel 114/386 (18%) and family members 49/386 (8%). Among these women, 276 (71%) thought they should receive therapy. The most common acute menopausal symptoms in postmenopausal women and perception of menopausal symptoms in non-menopausal women, respectively, were insomnia 68/161 (42%); 111/225 (49%), hot flushes 61/161 (38%); 115/225 (51%), heart palpitation 55/161 (34%); 103/225 (46%), an irritable temper 54/161 (34%); 138/225 (61%), dyspareunia 52/161 (32%); 100/225 (44%), headaches or dizziness 45/161 (28%); 74/225 (33%), a lack of energy 42/161 (26%); 73/225 (32%), depression 32/161 (20%); 114/225 (51%), night sweating 29/161 (18%); 61/225 (27%), and loss of bladder control 26/161 (16%); 37/225 (16%). CONCLUSIONS: According to this study, Taiwanese women have a much higher percentage of awareness of the menopause than other Asian women, as reported previously and a greater willingness to receive treatment. We also found that most of their knowledge of the menopause was obtained from reading material (43%) or friends (22%). Furthermore, the percentage of recognition of menopausal symptoms, especially of vasomotor symptoms, is lower than that of Western women and higher than that of women in Hong Kong and Southern China.

Adult↗

Expertise in practice: an ethnographic study exploring acquisition and use of knowledge in anaesthesia.

BACKGROUND: Expert professional practice in any field is known to rely on both explicit (formal) and tacit (personal) forms of knowledge. Current anaesthetic training programmes appear to favour explicit knowledge and measurable competencies. We aimed to describe and explore the way different types of knowledge are learned and used in anaesthetic practice. METHOD: Qualitative approach using non-participant observation of, and semi-structured interviews with, anaesthetic staff in two English hospitals. RESULTS: The development of expertise in anaesthesia rests on the ability to reconcile and interpret many sources of knowledge--clinical, social, electronic, and experiential--and formal theoretical learning. Experts have mastered technical skills but are also able to understand the dynamic and uncertain condition of the anaesthetized patient and respond to changes in it. This expertise is acquired by working with colleagues, and, importantly, by working independently, to develop personal routines. Routines mark the successful incorporation of new knowledge but also function as a defence against the inherent uncertainty of anaesthetic practice. The habits seen in experts' routines are preferred ways of working chosen from a larger repertoire of techniques which can also be mobilized as changing circumstances demand. CONCLUSIONS: Opportunities for developing expertise are linked to the independent development of personal routines. Evidence-based approaches to professional practice may obscure the role played by the interpretation of knowledge. We suggest that the restriction of apprenticeship-style training threatens the acquisition of anaesthetic expertise as defined in this paper.

Anesthesia↗

An expert system for the analysis and interpretation of evoked potentials based on fuzzy classification: application to brainstem auditory evoked potentials.

EPEXS is an expert system for evoked potential analysis and interpretation (a medical examination performed in clinical neurophysiology laboratories), working from available clinical records and numerical data extracted from evoked potential traces. EPEXS integrates two formalisms of knowledge representation: rules and structured objects. The rules represent the elementary concepts (shallow knowledge) and include a model of possibility based on the Dubois and Prade default reasoning and possibility theory. The structured objects (prototypes) are organized as hierarchical taxonomies (underlying knowledge). These allow the description of both the objects and their relationships. The heuristics used to interpret knowledge are based on two hypotheses: the unicity of the pathological process leading to several given symptoms and the progression from the general to the specific, leading to the adoption or rejection of a class of diagnoses. This avoids the problem of the differential diagnosis. These sources of knowledge are used in a dynamical way that could be described as a four-step process: acquisition of clinical data in order to define the nosological frame of the pathology, production of hypotheses about the nature and topography of lesions, interpretation of data in accordance with these hypotheses, and finally evaluation of their likelihood. The validation shows that EPEXS topographic diagnoses were correct in 100% of cases and 92% of it nosologic diagnoses were correct, and no pathological record was interpreted as normal. When examined on a given pathology basis EPEXS was not significantly different from human experts as regards to performance, specificity, and sensitivity.

Computer Simulation↗

The perception of fluent speech.

The perception of fluent speech involves both acoustic-driven and knowledge-driven sources of information. Acoustic sources that directly convey information about higher-order linguistic characteristics include the suprasegmental aspects of speech, associated with the acoustic cues of fundamental frequency, duration, and intensity. From the standpoint of cochlear prostheses, interest in listeners' perception of these suprasegmentals is heightened by the fact that these properties are typically among the best preserved sources of speech information in the sensorineural hearing-impaired. Studies with normal listeners indicate that suprasegmentals provide cues to such linguistic factors as word stress, syntactic structure, and semantic interpretation. In addition, they supply information about many nonlinguistic characteristics of the speaker. Research on knowledge-driven processes indicates that normal listeners utilize knowledge of lexical, syntactic, and semantic constraints of the language to guide the segmentation of speech into word-like units and to select among candidate word choices. These findings are related to research with hearing-impaired listeners and prosthesis testing.

Cochlear Implants↗

Basic Gene Grammars and DNA-ChartParser for language processing of Escherichia coli promoter DNA sequences.

MOTIVATION: The field of 'DNA linguistics' has emerged from pioneering work in computational linguistics and molecular biology. Most formal grammars in this field are expressed using Definite Clause Grammars but these have computational limitations which must be overcome. The present study provides a new DNA parsing system, comprising a logic grammar formalism called Basic Gene Grammars and a bidirectional chart parser DNA-ChartParser. RESULTS: The use of Basic Gene Grammars is demonstrated in representing many formulations of the knowledge of Escherichia coli promoters, including knowledge acquired from human experts, consensus sequences, statistics (weight matrices), symbolic learning, and neural network learning. The DNA-ChartParser provides bidirectional parsing facilities for BGGs in handling overlapping categories, gap categories, approximate pattern matching, and constraints. Basic Gene Grammars and the DNA-ChartParser allowed different sources of knowledge for recognizing E.coli promoters to be combined to achieve better accuracy as assessed by parsing these DNA sequences in real-world data sets.

DNA, Bacterial↗

[Parents' participation in sex education of children].

A sociological study was carried out among parents with children aged 2-11 years in order to evaluate their knowledge of psychosexual development and medical activity with regard to sexual education of their children. The results indicate scanty knowledge of special publications on sexual education: 54% parents never read such books, and 42% of those who read, do not use the information they get. One-third of parents consider that sexual education is not their responsibility. According to parents' opinions, TV remains the main source of knowledge of sex for their children. Less than half of respondents ever spoke to their children about sexual behavior. Hence, improvement of the knowledge of parents, particularly mothers, of psychosexual education of children is an important task.

Adolescent↗