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PubMed1997

[Qualitative and quantitative kidney function testing in dogs using MAG3 clearance].

In the presented study 99mTc-MAG3 clearance measurements were undertaken in 14 dogs during renal scintigraphic examination. Of these dogs, 10 showed no renal impairment, the other 4 exhibited clinically manifested nephropathy. It was the aim of these examinations to determine if this type of clearance measurement that is routinely used in human medicine is suitable for diagnosis of canine nephropathy. An algorithm for the calculation of the MAG3-Clearance developed for humans was modified. The clearance measurement can be performed during the renal scintigraphic procedure without any difficulties. In the group of dogs with no renal impairment the clearance values ranged between 6.4 and 8.0 ml/min/kg, whereas in the group of patients exhibiting nephropathies the values ranged between 2.0 and 2.7 ml/min/kg. The suitability of the method for its use in dogs needs to be confirmed with higher patient numbers. In addition, further studies are necessary to precisely assess the correlation between measured clearance values and effective renal plasma flow in dogs.

Animals↗
PubMed1984

[Studies and results of the use of nuclear medicine methods in kidney function tests].

It is sought for alternative methods for the endogenous creatinine clearance as parameters for the GFR. For this purpose served investigations with Tc-99m-Sn-DTPA. It was found a good reproducibility for the slope clearance with 3 blood takings between 60 and 120 minutes. When combined with the camera function scintigraphy a side-separated quantitative statement of the clearance equivalent is possible. The inulin clearance serves as reference method. The investigations at the gamma-camera with Tc-99m-Sn-DTPA also allow the determination of the perfusion which is particularly of interest in patients with hypertension. According to the comparison at the gamma camera a diagnostic schema is recommended.

Adult↗
PubMed1996

[Kidney function tests in horses--methods and reference values in healthy animals].

Investigations of renal function have been done on the basis of renal clearance (Clr) and excretion (E) of endogenous creatinine in healthy horses of different body weight (23 female, 7 male). Creatinine was measured by enzymatic PAP-method. Creatinine-E of female horses was poor positively correlated with body weight. The creatinine-Clr was highly correlated with the inulin-Clr (r = 0,896, p < 0,001). The excretion of creatinine was 35% higher than the filtration of creatinine, determined by inulin-Clr. That demonstrate a tubular net secretion of 26% of the total creatinine excretion. However the creatinine-Clr may be considered representative enough for the glomerular filtration rate (GFR). Water, sodium, glucose and L-lactate were absorbed in the renal tubules nearly completely, with a fractional excretion (FE) lower 2%. So they are suitable as endogenous markers for insufficient tubular absorption. Other electrolytes were absorbed incompletely depending on the supply of these substances (calcium-FE and magnesium-FE: 1-50%, potassium-FE: 10-120%, phosphate-FE: 0-5%). An extremely variable part of the filtered urea was reabsorbed in the tubuli (urea-FE 8-85%). For that reason urea is not appropriate for the diagnostic of disturbances of renal functions. A method for clinical determination of renal function by measurement of concentrations of metabolites and electrolytes in blood plasma and spontaneous urine is described and evaluated. The method is based on the supposed constant excretion of the creatinine (0,17 mumol/min/kg) and allows especially the examination of male and sick animals without quantitative sampling of urine. Reference-values for the renal excretion of electrolytes and metabolites of healthy horses are given.

Animals↗